{"title":"Nucleosides \u0026 Nucleobases","description":"\u003cdiv style=\"max-width:700px;font-family:Georgia,serif;color:#222;margin-bottom:32px;\"\u003e\n\n  \u003cdiv style=\"background:#002147;border:1px solid #002147;border-radius:8px;padding:16px 20px;margin-bottom:20px;\"\u003e\n    \u003cp style=\"margin:0 0 6px 0;font-size:13px;letter-spacing:0.08em;text-transform:uppercase;color:#7fa8cc;\"\u003eCatalogue\u003c\/p\u003e\n    \u003cp style=\"margin:0 0 12px 0;font-size:22px;font-weight:bold;color:#ffffff;\"\u003eNucleosides \u0026amp; Nucleobases\u003c\/p\u003e\n    \u003cp style=\"margin:0;font-size:15px;line-height:1.7;color:#ffffff;\"\u003eHigh-purity modified nucleobases, nucleosides, and structural analogues for advanced nucleic acid research. Essential building blocks for mRNA technology, oligonucleotide synthesis, antisense chemistry, CRISPR workflows, and chemical biology — supplied at research grade for reproducible, high-fidelity results.\u003c\/p\u003e\n  \u003c\/div\u003e\n\n  \u003cdiv style=\"display:grid;grid-template-columns:1fr 1fr;gap:12px;margin-bottom:20px;\"\u003e\n    \u003cdiv style=\"background:#e8e7e2;border:1px solid #c8c7c2;border-radius:8px;padding:16px;\"\u003e\n      \u003cp style=\"margin:0 0 6px 0;font-size:11px;letter-spacing:0.08em;text-transform:uppercase;color:#999;\"\u003eApplications\u003c\/p\u003e\n      \u003cp style=\"margin:0;font-size:13px;color:#555;line-height:1.9;\"\u003emRNA and oligonucleotide chemistry\u003cbr\u003eAntisense and siRNA research\u003cbr\u003eNucleobase derivatisation\u003cbr\u003eChemical biology and epigenetics\u003cbr\u003eAnalytical method development\u003c\/p\u003e\n    \u003c\/div\u003e\n    \u003cdiv style=\"background:#e8e7e2;border:1px solid #c8c7c2;border-radius:8px;padding:16px;\"\u003e\n      \u003cp style=\"margin:0 0 6px 0;font-size:11px;letter-spacing:0.08em;text-transform:uppercase;color:#999;\"\u003eEvery shipment includes\u003c\/p\u003e\n      \u003cp style=\"margin:0;font-size:13px;color:#555;line-height:1.9;\"\u003eBatch-specific CoA\u003cbr\u003eSDS — EU CLP\/GHS compliant\u003cbr\u003eCommercial invoice\u003cbr\u003eDDP service available worldwide\u003cbr\u003eShipped from Helsinki, Finland\u003c\/p\u003e\n    \u003c\/div\u003e\n  \u003c\/div\u003e\n\n  \u003cp style=\"font-size:12px;color:#888;line-height:1.6;\"\u003eAll products are Research Use Only (RUO). Not for use in humans or animals, and not for diagnostic, therapeutic, or clinical applications.\u003c\/p\u003e\n\n\u003c\/div\u003e","products":[{"product_id":"beta-nicotinamide-mononucleotide","title":"β-Nicotinamide Mononucleotide | CAS 1094-61-7 | ≥99.0%","description":"\u003cdiv style=\"margin-bottom: 28px;\"\u003e\n\u003cdiv style=\"background: #002147; padding: 10px 20px; margin-bottom: 0;\"\u003e  \u003ch3 style=\"margin: 0; font-family: 'Helvetica Neue', Helvetica, Arial, sans-serif; font-size: 0.70em; font-weight: 700; letter-spacing: 0.12em; text-transform: uppercase; color: #fff;\"\u003eTechnical Specifications\u003c\/h3\u003e\n\u003c\/div\u003e\n\u003ctable style=\"width: 100%; border-collapse: collapse; font-size: 0.95em; border: 1px solid #e4e8f0; border-top: none; font-family: 'Helvetica Neue', Helvetica, Arial, sans-serif;\"\u003e\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eCAS Number\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e1094-61-7\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eEC \/ EINECS Number\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e214-136-5\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eMDL Number\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003eMFCD00038748\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eSMILES\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0; word-break: break-all;\"\u003eC1=CC(=C[N+](=C1)[C@H]2[C@@H]([C@@H]([C@H](O2)COP(=O)(O)[O-])O)O)C(=O)N\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eInChI\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0; word-break: break-all;\"\u003eInChI=1S\/C11H15N2O8P\/c12-10(16)6-2-1-3-13(4-6)11-9(15)8(14)7(21-11)5-20-22(17,18)19\/h1-4,7-9,11,14-15H,5H2,(H3-,12,16,17,18,19)\/t7-,8-,9-,11-\/m1\/s1\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eInChIKey\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0; word-break: break-all;\"\u003eDAYLJWODMCOQEW-TURQNECASA-N\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003ePubChem CID\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e14180\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eMolecular Formula\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003eC₁₁H₁₅N₂O₈P\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eMolecular Weight\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e334.25 g\/mol\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eMelting Point\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e166 °C (dec.)\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eSolubility\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e~50 mg\/mL in water (25 °C)\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003ePurity\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e≥99%\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003ePhysical Form\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003eWhite crystalline powder\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eHS Code\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e2934.99\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eCountry of Origin\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003eFinland\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eShelf Life\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003eRetest period: 36 months from date of manufacture\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eStorage Conditions\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003eStore refrigerated (2–8 °C) in a tightly sealed container\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\u003c\/table\u003e\n\u003c\/div\u003e\u003cdiv style=\"margin-bottom: 28px;\"\u003e\n\u003cdiv style=\"background: #002147; padding: 10px 20px; margin-bottom: 0;\"\u003e  \u003ch3 style=\"margin: 0; font-family: 'Helvetica Neue', Helvetica, Arial, sans-serif; font-size: 0.70em; font-weight: 700; letter-spacing: 0.12em; text-transform: uppercase; color: #fff;\"\u003eProduct Description \u0026amp; Scientific Applications\u003c\/h3\u003e\n\u003c\/div\u003e\n\u003cdiv style=\"padding: 16px 20px; border: 1px solid #e4e8f0; border-top: none; font-family: Georgia, 'Times New Roman', serif; font-size: 0.95em; line-height: 1.65; color: #333;\"\u003e\n\u003cp\u003e\u003cstrong\u003eβ-Nicotinamide Mononucleotide\u003c\/strong\u003e (β-NMN; nicotinamide ribotide; CAS 1094-61-7) is the biologically common β-anomer of nicotinamide mononucleotide, a pyridine nucleotide and central intermediate in nicotinamide adenine dinucleotide (NAD⁺) biosynthesis. It is distinguished from the α-anomer (α-NMN), which differs in stereochemistry and analytical behaviour. In the mammalian salvage pathway, nicotinamide phosphoribosyltransferase (NAMPT) converts nicotinamide and 5-phosphoribosyl-1-pyrophosphate into β-NMN, which nicotinamide mononucleotide adenylyltransferase (NMNAT) enzymes adenylate to NAD⁺. It is supplied as a white to light-yellow powder, soluble in water.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eEnzymatic Intermediate in NAD⁺ Biosynthesis Research\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eNMN is a direct substrate for ATP-dependent, NMNAT-catalysed NAD⁺ formation. Mammalian systems contain three NMNAT isoforms — NMNAT1, NMNAT2, and NMNAT3 — differing in tissue distribution, subcellular localisation, and catalytic properties. It also supports steady-state kinetic and substrate-specificity measurements, and pathway-flux experiments distinguishing salvage-pathway intermediates from downstream dinucleotides and related pyridine nucleotide metabolites.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eBiochemical Tool for NAD⁺-Dependent Enzymology\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eNAD⁺ is consumed by enzyme families including sirtuin deacylases, poly(ADP-ribose) polymerases, and CD38-family ectoenzymes. NMN is used in studies connecting precursor availability with NAD⁺-dependent activity.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eNoncanonical Redox Cofactor in Engineered Biocatalysis\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eOxidised NMN and reduced NMNH have been developed as a noncanonical redox cofactor pair for engineered enzymatic systems. In cell-free and engineered-cell platforms, the NMN⁺\/NMNH cycle can be separated from natural NAD(P)⁺\/NAD(P)H pools, letting researchers design orthogonal redox pathways and tune cofactor specificity.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eAnalytical and Molecular Biology Applications\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eNMN serves as an analytical reference compound in LC-MS\/MS, UHPLC-MS\/MS, and HPLC methods quantifying NAD⁺ metabolites and related pyridine nucleotide intermediates. It is polar and chemically labile; analytical workflows attend to chromatographic retention and isomer separation. NMN is also used in RNA aptamer binding studies and ribozyme activation research involving β-NMN-responsive or β-NMN-activated RNA systems.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\u003cdiv style=\"margin-bottom: 28px;\"\u003e\n\u003cdiv style=\"background: #002147; padding: 10px 20px; margin-bottom: 0;\"\u003e  \u003ch3 style=\"margin: 0; font-family: 'Helvetica Neue', Helvetica, Arial, sans-serif; font-size: 0.70em; font-weight: 700; letter-spacing: 0.12em; text-transform: uppercase; color: #fff;\"\u003eShipping Destinations\u003c\/h3\u003e\n\u003c\/div\u003e\n\u003cdiv style=\"border: 1px solid #e4e8f0; border-top: none; padding: 12px 16px; font-family: 'Helvetica Neue', Helvetica, Arial, sans-serif; font-size: 0.95em;\"\u003e\u003cul style=\"margin: 0; padding: 0; list-style: none;\"\u003e\n\u003cli style=\"padding: 5px 0; border-bottom: 1px solid #f0f0f0;\"\u003e\n\u003cspan style=\"display: inline-block; width: 7px; height: 7px; background: #002147; border-radius: 50%; margin-right: 10px; vertical-align: middle;\"\u003e\u003c\/span\u003eEU \u0026amp; UK: Priority delivery, 2–5 business days.\u003c\/li\u003e\n\u003cli style=\"padding: 5px 0; border-bottom: 1px solid #f0f0f0;\"\u003e\n\u003cspan style=\"display: inline-block; width: 7px; height: 7px; background: #002147; border-radius: 50%; margin-right: 10px; vertical-align: middle;\"\u003e\u003c\/span\u003eNorway (DDP): 3–7 business days, duties and taxes prepaid.\u003c\/li\u003e\n\u003cli style=\"padding: 5px 0; border-bottom: 1px solid #f0f0f0;\"\u003e\n\u003cspan style=\"display: inline-block; width: 7px; height: 7px; background: #002147; border-radius: 50%; margin-right: 10px; vertical-align: middle;\"\u003e\u003c\/span\u003eSwitzerland (DDP): 3–7 business days, duties and taxes prepaid.\u003c\/li\u003e\n\u003c\/ul\u003e\u003c\/div\u003e\n\u003c\/div\u003e","brand":"NorrChemica™","offers":[{"title":"10 g","offer_id":52206834352465,"sku":"NOR-1094617-10g","price":49.9,"currency_code":"EUR","in_stock":true},{"title":"25 g","offer_id":52206834385233,"sku":"NOR-1094617-25g","price":89.2,"currency_code":"EUR","in_stock":true},{"title":"50 g","offer_id":52206834418001,"sku":"NOR-1094617-50g","price":175.2,"currency_code":"EUR","in_stock":true},{"title":"100 g","offer_id":52206834450769,"sku":"NOR-1094617-100g","price":349.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0954\/6357\/1793\/files\/NorrChemica_NMN.png?v=1782682174"},{"product_id":"uridine-cas-58-96-8","title":"Uridine | CAS 58-96-8 | ≥98.0%","description":"\u003cdiv style=\"margin-bottom: 28px;\"\u003e\n\u003cdiv style=\"background: #002147; padding: 10px 20px; margin-bottom: 0;\"\u003e  \u003ch3 style=\"margin: 0; font-family: 'Helvetica Neue', Helvetica, Arial, sans-serif; font-size: 0.70em; font-weight: 700; letter-spacing: 0.12em; text-transform: uppercase; color: #fff;\"\u003eTechnical Specifications\u003c\/h3\u003e\n\u003c\/div\u003e\n\u003ctable style=\"width: 100%; border-collapse: collapse; font-size: 0.95em; border: 1px solid #e4e8f0; border-top: none; font-family: 'Helvetica Neue', Helvetica, Arial, sans-serif;\"\u003e\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eCAS Number\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e58-96-8\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eEC \/ EINECS Number\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e200-407-5\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eMDL Number\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003eMFCD00006526\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eRTECS Number\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003eYR1450000\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eSMILES\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0; word-break: break-all;\"\u003eC1=CN(C(=O)NC1=O)[C@H]2[C@@H]([C@@H]([C@H](O2)CO)O)O\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eInChI\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0; word-break: break-all;\"\u003eInChI=1S\/C9H12N2O6\/c12-3-4-6(14)7(15)8(17-4)11-2-1-5(13)10-9(11)16\/h1-2,4,6-8,12,14-15H,3H2,(H,10,13,16)\/t4-,6-,7-,8-\/m1\/s1\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eInChIKey\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0; word-break: break-all;\"\u003eDRTQHJPVMGBUCF-XVFCMESISA-N\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003ePubChem CID\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e6029\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eMolecular Formula\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003eC₉H₁₂N₂O₆\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eMolecular Weight\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e244.2 g\/mol\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eMelting Point\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e165–167 °C\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eSolubility\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003eFreely soluble in water; soluble in DMSO; slightly soluble in ethanol\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003ePurity\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e≥98.0%\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003ePhysical Form\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003eWhite crystalline powder\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eHS Code\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e2934.99\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eCountry of Origin\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003eFinland\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eShelf Life\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003eRetest period: 36 months from date of manufacture\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eStorage Conditions\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003eStore at room temperature in a tightly sealed container\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\u003c\/table\u003e\n\u003c\/div\u003e\u003cdiv style=\"margin-bottom: 28px;\"\u003e\n\u003cdiv style=\"background: #002147; padding: 10px 20px; margin-bottom: 0;\"\u003e  \u003ch3 style=\"margin: 0; font-family: 'Helvetica Neue', Helvetica, Arial, sans-serif; font-size: 0.70em; font-weight: 700; letter-spacing: 0.12em; text-transform: uppercase; color: #fff;\"\u003eProduct Description \u0026amp; Scientific Applications\u003c\/h3\u003e\n\u003c\/div\u003e\n\u003cdiv style=\"padding: 16px 20px; border: 1px solid #e4e8f0; border-top: none; font-family: Georgia, 'Times New Roman', serif; font-size: 0.95em; line-height: 1.65; color: #333;\"\u003e\n\u003cp\u003e\u003cstrong\u003eUridine\u003c\/strong\u003e is a naturally occurring pyrimidine ribonucleoside, uracil linked to D-ribofuranose through a β-N1-glycosidic bond. This pyrimidine linkage is markedly more acid-hydrolysis-resistant than the purine N9-glycosidic bonds of adenosine and guanosine, making uridine compatible with the mildly acidic mobile phases of reversed-phase HPLC and LC-MS; an absorbance maximum near 262 nm and a molar extinction coefficient near 10,100 M⁻¹ cm⁻¹ in neutral aqueous solution underpin its spectrophotometric and chromatographic quantification. One of the four canonical RNA nucleosides, it is a fundamental RNA building block and a central entry into pyrimidine nucleotide metabolism: phosphorylation by uridine-cytidine kinase (UCK1\/UCK2; EC 2.7.1.48) gives UMP, which nucleoside-monophosphate and nucleoside-diphosphate kinases raise to UDP and UTP. UTP and CTP supply RNA-polymerase substrates, regulate pyrimidine-pool feedback, and feed UDP-sugar formation for glycoconjugate biosynthesis. Cellular uptake is mediated by the SLC28 concentrative, Na⁺-dependent CNT and SLC29 equilibrative ENT transporter families, while uridine phosphorylase (UPP1\/UPP2; EC 2.4.2.3) catalyses the reversible phosphorolysis of uridine to uracil and ribose-1-phosphate. It is supplied as a white to off-white crystalline powder, soluble in water.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eCell-culture supplementation and pyrimidine salvage in mitochondrial biology.\u003c\/strong\u003e Uridine is the standard supplement for mammalian cells with impaired de novo pyrimidine biosynthesis. The de novo pathway is split between cytosol and mitochondrion: the trifunctional cytosolic CAD complex (carbamoyl phosphate synthetase II, aspartate transcarbamoylase, dihydroorotase) makes dihydroorotate from glutamine, ATP, bicarbonate, and aspartate; the mitochondrial inner-membrane dihydroorotate dehydrogenase (DHODH; EC 1.3.5.2) oxidises dihydroorotate to orotate, passing electrons to ubiquinone; and cytosolic UMP synthase (UMPS) couples orotate to PRPP and decarboxylates it to UMP. Because DHODH's ubiquinol must be reoxidised by Complex III, de novo synthesis is hard-wired to a functional electron-transport chain: disrupting mitochondrial respiration — mtDNA depletion in ρ⁰ cells, Complex III inhibition by antimycin A or myxothiazol, OXPHOS dysfunction, or loss of cytochrome bc₁ assembly — collapses pyrimidine output even with CAD and UMPS intact. Exogenous uridine bypasses this bottleneck, entering through SLC28\/SLC29 and feeding the UCK1\/UCK2 salvage step to UMP independently of respiration. In the canonical ρ⁰ framework it is co-supplemented with pyruvate, which regenerates cytosolic NAD⁺ via lactate dehydrogenase to restore the electron-acceptor availability needed for aspartate biosynthesis. The combination is foundational in mitochondrial biology, OXPHOS research, electron-transport-chain mutant analysis, mtDNA-depleted cell-line maintenance, and metabolic-flux studies of respiration-deficient systems.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eNascent-RNA click-chemistry labelling with 5-ethynyluridine.\u003c\/strong\u003e 5-Ethynyluridine (EU), the C5-alkynyl analogue, is the most widely used non-radioactive metabolic label for nascent RNA. It enters through the same SLC28\/SLC29 transporters, is phosphorylated by UCK1\/UCK2 and onward kinases to EUTP, and is incorporated by RNA polymerases I, II, and III into newly transcribed RNA at an average of one EU per 35 uridine positions in total RNA. The terminal alkyne is then ligated to fluorescent or biotinylated azides by the copper-catalysed azide–alkyne cycloaddition (CuAAC), the canonical click reaction — a non-denaturing, fluorophore-flexible alternative to ³H-uridine autoradiography and BrU\/anti-BrU immunolabelling for transcription-rate measurement, RNA-turnover kinetics, single-cell transcription imaging, and whole-mount visualisation of newly synthesised RNA in tissues and embryos.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003e4-Thiouridine photocrosslinking and metabolic sequencing.\u003c\/strong\u003e 4-Thiouridine (s⁴U), the C4-thiocarbonyl analogue, anchors a chemistry portfolio on the nucleophilicity and photoreactivity of the thiocarbonyl. UV-365 nm irradiation forms a covalent zero-distance crosslink between s⁴U-labelled RNA and contacting RNA-binding proteins, underpinning PAR-CLIP-class transcriptome-wide RBP target mapping. The same thiocarbonyl supports orthogonal recoding chemistries that read s⁴U incorporation as a sequencing-detectable T-to-C substitution, distinguishing nascent from steady-state transcripts at single-nucleotide resolution: iodoacetamide alkylation (SLAM-seq), osmium-tetroxide-mediated thiouridine-to-cytidine conversion (TUC-seq), and oxidative trifluoroethylamine-mediated recoding (TimeLapse-seq). With EU, s⁴U has redefined transcriptomic measurement of RNA synthesis, processing, and decay. Uridine itself remains the standard substrate and reference compound for uridine kinase activity, uridine phosphorylase kinetics, and SLC28\/SLC29-mediated transport, and the entry-point reference for metabolic-labelling studies of pyrimidine-pool regulation, nucleotide turnover, and pathway flux.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eModified-nucleoside synthesis and RNA chemistry.\u003c\/strong\u003e Uridine is a key starting material and reference nucleoside for modified uridine derivatives. Selective protection and functionalisation of the ribose 2′-, 3′-, and 5′-hydroxyls and of the C5 and C4 positions of uracil gives scaffolds including 2′-O-methyluridine, 2′-fluoro-2′-deoxyuridine, 5-bromouridine, 5-iodouridine, 5-aminoallyluridine, 5-ethynyluridine, and 4-thiouridine. Pseudouridine and N1-methylpseudouridine — the C-5 glycoside isomer of uridine and its N1-methyl derivative — are best treated as a separate class, prepared by dedicated chemical or biocatalytic routes rather than direct functionalisation; N1-methylpseudouridine substitution alters RNA hydrogen-bonding, decoding, and innate RNA-sensing relative to unmodified uridine, a distinct benchmark modification in synthetic mRNA research. These materials support synthetic RNA chemistry, antisense-oligonucleotide and siRNA development, modified-mRNA studies, RNA structure analysis, RNA–protein interaction work, and analytical comparison of natural and modified pyrimidine ribosides by HPLC, LC-MS, and NMR.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eUDP-sugar biosynthesis and glycoconjugate research.\u003c\/strong\u003e Uridine nucleotides drive glycosylation through conversion into UDP-activated sugar donors. UDP-glucose, UDP-galactose, UDP-glucuronic acid, UDP-N-acetylglucosamine (UDP-GlcNAc), UDP-N-acetylgalactosamine (UDP-GalNAc), UDP-xylose, and UDP-rhamnose serve the glycosyltransferases that build N- and O-linked glycoproteins, glycolipids, proteoglycans, glycosaminoglycans, plant cell-wall polysaccharides, and bacterial capsular polysaccharides. Uridine availability therefore bears on glycoengineering, carbohydrate metabolism, and cellular biosynthesis wherever UDP-sugar pool size, glycosyltransferase activity, hexosamine-pathway flux to UDP-GlcNAc, and glycan composition matter. The same chemistry underpins chemoenzymatic UDP-sugar synthesis, in which uridine or UMP is converted through pyrophosphorylase or kinase cascades to isotopically labelled or non-natural UDP-sugars for in vitro glycosylation.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eFurther applications.\u003c\/strong\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eReference compound in HPLC, LC-MS, and capillary electrophoresis of nucleosides and metabolites.\u003c\/li\u003e\n\u003cli\u003eStandard pyrimidine ribonucleoside in NMR, X-ray, and computational structural studies of nucleic-acid–protein and nucleic-acid–small-molecule interactions.\u003c\/li\u003e\n\u003cli\u003eReference standard for quantitative analysis of pyrimidine pools in metabolomics and isotope-tracing workflows.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\u003cdiv style=\"margin-bottom: 28px;\"\u003e\n\u003cdiv style=\"background: #002147; padding: 10px 20px; margin-bottom: 0;\"\u003e  \u003ch3 style=\"margin: 0; font-family: 'Helvetica Neue', Helvetica, Arial, sans-serif; font-size: 0.70em; font-weight: 700; letter-spacing: 0.12em; text-transform: uppercase; color: #fff;\"\u003eShipping Destinations\u003c\/h3\u003e\n\u003c\/div\u003e\n\u003cdiv style=\"border: 1px solid #e4e8f0; border-top: none; padding: 12px 16px; font-family: 'Helvetica Neue', Helvetica, Arial, sans-serif; font-size: 0.95em;\"\u003e\u003cul style=\"margin: 0; padding: 0; list-style: none;\"\u003e\n\u003cli style=\"padding: 5px 0; border-bottom: 1px solid #f0f0f0;\"\u003e\n\u003cspan style=\"display: inline-block; width: 7px; height: 7px; background: #002147; border-radius: 50%; margin-right: 10px; vertical-align: middle;\"\u003e\u003c\/span\u003eEU \u0026amp; UK: Priority delivery, 2–5 business days.\u003c\/li\u003e\n\u003cli style=\"padding: 5px 0; border-bottom: 1px solid #f0f0f0;\"\u003e\n\u003cspan style=\"display: inline-block; width: 7px; height: 7px; background: #002147; border-radius: 50%; margin-right: 10px; vertical-align: middle;\"\u003e\u003c\/span\u003eUnited States (DDP): 3–7 business days, duties and taxes prepaid.\u003c\/li\u003e\n\u003cli style=\"padding: 5px 0; border-bottom: 1px solid #f0f0f0;\"\u003e\n\u003cspan style=\"display: inline-block; width: 7px; height: 7px; background: #002147; border-radius: 50%; margin-right: 10px; vertical-align: middle;\"\u003e\u003c\/span\u003eEFTA Countries (DDP): 3–7 business days, duties and taxes prepaid.\u003c\/li\u003e\n\u003cli style=\"padding: 5px 0; border-bottom: 1px solid #f0f0f0;\"\u003e\n\u003cspan style=\"display: inline-block; width: 7px; height: 7px; background: #002147; border-radius: 50%; margin-right: 10px; vertical-align: middle;\"\u003e\u003c\/span\u003eWorldwide: 7–14 business days, selected locations.\u003c\/li\u003e\n\u003c\/ul\u003e\u003c\/div\u003e\n\u003c\/div\u003e","brand":"NorrChemica™","offers":[{"title":"10 g","offer_id":52426985013585,"sku":"NOR-58968-10g","price":39.2,"currency_code":"EUR","in_stock":true},{"title":"25 g","offer_id":52426985046353,"sku":"NOR-58968-25g","price":49.2,"currency_code":"EUR","in_stock":true},{"title":"50 g","offer_id":52426985079121,"sku":"NOR-58968-50g","price":89.9,"currency_code":"EUR","in_stock":true},{"title":"100 g","offer_id":52426985111889,"sku":"NOR-58968-100g","price":79.2,"currency_code":"EUR","in_stock":true},{"title":"250 g","offer_id":52426985144657,"sku":"NOR-58968-250g","price":149.2,"currency_code":"EUR","in_stock":true},{"title":"500 g","offer_id":52426985177425,"sku":"NOR-58968-500g","price":298.2,"currency_code":"EUR","in_stock":true},{"title":"1000 g","offer_id":52426985210193,"sku":"NOR-58968-1kg","price":449.2,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0954\/6357\/1793\/files\/NorrChemica_Uridine.png?v=1782694721"},{"product_id":"thymidine-cas-50-89-5","title":"Thymidine | CAS 50-89-5 | ≥99%","description":"\u003cdiv style=\"margin-bottom: 28px;\"\u003e\n\u003cdiv style=\"background: #002147; padding: 10px 20px; margin-bottom: 0;\"\u003e  \u003ch3 style=\"margin: 0; font-family: 'Helvetica Neue', Helvetica, Arial, sans-serif; font-size: 0.70em; font-weight: 700; letter-spacing: 0.12em; text-transform: uppercase; color: #fff;\"\u003eTechnical Specifications\u003c\/h3\u003e\n\u003c\/div\u003e\n\u003ctable style=\"width: 100%; border-collapse: collapse; font-size: 0.95em; border: 1px solid #e4e8f0; border-top: none; font-family: 'Helvetica Neue', Helvetica, Arial, sans-serif;\"\u003e\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eCAS Number\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e50-89-5\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eEC \/ EINECS Number\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e200-070-4\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eMDL Number\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003eMFCD00006537\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eRTECS Number\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003eXP2071000\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eSMILES\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0; word-break: break-all;\"\u003eCC1=CN(C(=O)NC1=O)[C@H]2C[C@@H]([C@H](O2)CO)O\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eInChI\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0; word-break: break-all;\"\u003eInChI=1S\/C10H14N2O5\/c1-5-3-12(10(16)11-9(5)15)8-2-6(14)7(4-13)17-8\/h3,6-8,13-14H,2,4H2,1H3,(H,11,15,16)\/t6-,7+,8+\/m0\/s1\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eInChIKey\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0; word-break: break-all;\"\u003eIQFYYKKMVGJFEH-XLPZGREQSA-N\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003ePubChem CID\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e5789\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eMolecular Formula\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003eC₁₀H₁₄N₂O₅\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eMolecular Weight\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e242.23 g\/mol\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eMelting Point\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e186–188 °C\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eSolubility\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003eFreely soluble in water (~50 mg\/mL); soluble in ethanol, methanol, DMSO\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003ePurity\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e≥99.0%\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003ePhysical Form\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003eWhite crystalline powder\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eHS Code\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e2934.99\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eCountry of Origin\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003eFinland\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eShelf Life\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003eRetest period: 36 months from date of manufacture\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eStorage Conditions\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003eStore at room temperature in a tightly sealed container\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\u003c\/table\u003e\n\u003c\/div\u003e\u003cdiv style=\"margin-bottom: 28px;\"\u003e\n\u003cdiv style=\"background: #002147; padding: 10px 20px; margin-bottom: 0;\"\u003e  \u003ch3 style=\"margin: 0; font-family: 'Helvetica Neue', Helvetica, Arial, sans-serif; font-size: 0.70em; font-weight: 700; letter-spacing: 0.12em; text-transform: uppercase; color: #fff;\"\u003eProduct Description \u0026amp; Scientific Applications\u003c\/h3\u003e\n\u003c\/div\u003e\n\u003cdiv style=\"padding: 16px 20px; border: 1px solid #e4e8f0; border-top: none; font-family: Georgia, 'Times New Roman', serif; font-size: 0.95em; line-height: 1.65; color: #333;\"\u003e\n\u003cp\u003e\u003cstrong\u003eThymidine\u003c\/strong\u003e (2′-deoxythymidine; dT) is a naturally occurring pyrimidine 2′-deoxyribonucleoside — thymine joined to 2-deoxy-D-ribofuranose through a β-N1-glycosidic bond. One of the four canonical DNA deoxyribonucleosides, it pairs with deoxyadenosine in the double helix and enters the thymidine salvage pathway: cytosolic thymidine kinase 1 (TK1) and mitochondrial thymidine kinase 2 (TK2) phosphorylate it to thymidine 5′-monophosphate (dTMP), thymidylate kinase to dTDP, and nucleoside diphosphate kinase to thymidine 5′-triphosphate (dTTP) for nuclear and mitochondrial DNA synthesis. Cellular uptake proceeds through the equilibrative nucleoside transporters hENT1 and hENT2 (SLC29A1\/A2) and the concentrative transporters hCNT1 (pyrimidine-preferring) and hCNT3 (broad-selectivity).\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eCell cycle synchronisation and dNTP pool manipulation.\u003c\/strong\u003e Thymidine synchronises mammalian cell populations at the G1\/S boundary and early S phase. Excess intracellular thymidine is phosphorylated to dTTP, which binds the specificity site (s-site) of ribonucleotide reductase (RNR) and allosterically shifts the α2β2 holoenzyme toward GDP reduction at the expense of CDP and UDP reduction. Suppressed de novo dCDP\/dCTP synthesis collapses the dCTP pool; dTTP and other dNTP pools become imbalanced, stalling DNA replication. The double-thymidine block exploits this reversible arrest — typically 16–18 h in 2 mM thymidine, 8–9 h release, then a second 16–18 h block — to release a synchronised S-phase population for studies of replication timing, origin firing, mitotic entry, checkpoint activation, and dNTP-pool homeostasis. Release is achieved by removing thymidine or adding exogenous deoxycytidine, which replenishes cytidine deoxynucleotide pools through the deoxycytidine-kinase (dCK) salvage route, bypassing the inhibited RNR pathway.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eDNA synthesis and cell proliferation assays.\u003c\/strong\u003e Tritiated thymidine ([³H]-thymidine) incorporation is the classical method for measuring DNA synthesis and cell proliferation in cultured cells, primary explants, and tissue specimens. After uptake and thymidine kinase-catalysed phosphorylation to [³H]-dTMP, [³H]-dTTP is incorporated into newly synthesised chromosomal DNA, and acid-precipitable radioactivity is quantified by liquid scintillation counting. The same incorporation principle underlies the non-radioactive analogues 5-bromo-2′-deoxyuridine (BrdU) and 5-ethynyl-2′-deoxyuridine (EdU), detected respectively by antibody-based immunofluorescence\/immunohistochemistry and by copper-catalysed azide–alkyne (CuAAC) click chemistry. These assays support proliferation profiling in cultured cells, lymphocyte-activation experiments in immunology, cell-cycle phase-distribution studies by flow cytometry, and quantitative DNA-replication timing.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eThymidine kinase substrate and pyrimidine salvage studies.\u003c\/strong\u003e Thymidine is the physiological substrate of thymidine kinase, the rate-limiting first step of the salvage pathway, and serves as a probe substrate in TK kinetic and selectivity assays. Mammalian cells express two isoforms with distinct compartmentalisation and regulation. Cytosolic TK1 is S-phase-regulated, its natural-substrate specificity restricted to thymidine and deoxyuridine; its catalytic efficiency rises roughly 200-fold during S phase through an ATP- and enzyme-concentration-dependent transition from a low-activity dimer to a high-activity tetramer, and is feedback-inhibited by the end-product dTTP. Mitochondrial TK2 is a constitutively expressed homodimer that phosphorylates thymidine, deoxycytidine, and deoxyuridine, supplying the dNTPs for mtDNA replication and maintenance in post-mitotic tissues. Thymidine is therefore a standard reagent for biochemical characterisation of TK1 and TK2 kinetics, isoform-discriminating substrate analogues, deoxyribonucleotidase substrate-cycling studies between TK1\/dNT-1 and TK2\/dNT-2, nuclear\/mitochondrial dNTP-pool partitioning by [³H]-thymidine flux, nucleoside-transporter assays, and quantitative-PCR-based mtDNA copy-number readouts.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eStarting material for modified deoxynucleoside and oligonucleotide chemistry.\u003c\/strong\u003e Thymidine is a chiral starting material and reference 2′-deoxyribonucleoside in synthetic nucleoside chemistry. Its defined β-N1-glycosidic stereochemistry, free 3′- and 5′-hydroxyls, and chemically tractable thymine base provide handles for selective 5′-O protection, 3′-O activation, and base functionalisation. These support the preparation of 5′-O-DMTr-thymidine 3′-O-(N,N-diisopropyl)-β-cyanoethyl phosphoramidite — the standard dT monomer of solid-phase oligonucleotide synthesis — and of modified thymidine analogues: 5-substituted, sugar-modified, alkyne-, azide-, and thiol-functionalised variants for click-chemistry conjugation, fluorescent base analogues, phosphorothioate\/phosphoramidate backbone research, and structural probes for X-ray crystallography and NMR.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eFurther applications.\u003c\/strong\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eReference compound for HPLC, UHPLC, and LC-MS analysis of deoxyribonucleosides in nucleic-acid-hydrolysate profiling and nucleoside-pool measurement.\u003c\/li\u003e\n\u003cli\u003eSubstrate in thymidine phosphorylase kinetic assays and equilibrium studies of phosphorolysis to thymine + 2-deoxyribose-1-phosphate.\u003c\/li\u003e\n\u003cli\u003eReference standard in NMR and X-ray structural studies of pyrimidine 2′-deoxyribosides — hydrogen-bonding, glycosyl torsion (anti\/syn), and sugar-pucker (north\/south).\u003c\/li\u003e\n\u003cli\u003eMetabolic precursor in DNA-replication and DNA-repair studies, including base-excision repair, mismatch repair, and replication-fork dynamics under nucleotide-pool perturbation.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\u003cdiv style=\"margin-bottom: 28px;\"\u003e\n\u003cdiv style=\"background: #002147; padding: 10px 20px; margin-bottom: 0;\"\u003e  \u003ch3 style=\"margin: 0; font-family: 'Helvetica Neue', Helvetica, Arial, sans-serif; font-size: 0.70em; font-weight: 700; letter-spacing: 0.12em; text-transform: uppercase; color: #fff;\"\u003eShipping Destinations\u003c\/h3\u003e\n\u003c\/div\u003e\n\u003cdiv style=\"border: 1px solid #e4e8f0; border-top: none; padding: 12px 16px; font-family: 'Helvetica Neue', Helvetica, Arial, sans-serif; font-size: 0.95em;\"\u003e\u003cul style=\"margin: 0; padding: 0; list-style: none;\"\u003e\n\u003cli style=\"padding: 5px 0; border-bottom: 1px solid #f0f0f0;\"\u003e\n\u003cspan style=\"display: inline-block; width: 7px; height: 7px; background: #002147; border-radius: 50%; margin-right: 10px; vertical-align: middle;\"\u003e\u003c\/span\u003eEU \u0026amp; UK: Priority delivery, 2–5 business days.\u003c\/li\u003e\n\u003cli style=\"padding: 5px 0; border-bottom: 1px solid #f0f0f0;\"\u003e\n\u003cspan style=\"display: inline-block; width: 7px; height: 7px; background: #002147; border-radius: 50%; margin-right: 10px; vertical-align: middle;\"\u003e\u003c\/span\u003eUnited States (DDP): 3–7 business days, duties and taxes prepaid.\u003c\/li\u003e\n\u003cli style=\"padding: 5px 0; border-bottom: 1px solid #f0f0f0;\"\u003e\n\u003cspan style=\"display: inline-block; width: 7px; height: 7px; background: #002147; border-radius: 50%; margin-right: 10px; vertical-align: middle;\"\u003e\u003c\/span\u003eEFTA Countries (DDP): 3–7 business days, duties and taxes prepaid.\u003c\/li\u003e\n\u003cli style=\"padding: 5px 0; border-bottom: 1px solid #f0f0f0;\"\u003e\n\u003cspan style=\"display: inline-block; width: 7px; height: 7px; background: #002147; border-radius: 50%; margin-right: 10px; vertical-align: middle;\"\u003e\u003c\/span\u003eWorldwide: 7–14 business days, selected locations.\u003c\/li\u003e\n\u003c\/ul\u003e\u003c\/div\u003e\n\u003c\/div\u003e","brand":"NorrChemica™","offers":[{"title":"10 g","offer_id":52429500121425,"sku":"NOR-50895-10g","price":34.2,"currency_code":"EUR","in_stock":true},{"title":"25 g","offer_id":52429500154193,"sku":"NOR-50895-25g","price":49.9,"currency_code":"EUR","in_stock":true},{"title":"50 g","offer_id":52429500186961,"sku":"NOR-50895-50g","price":64.2,"currency_code":"EUR","in_stock":true},{"title":"100 g","offer_id":52429500219729,"sku":"NOR-50895-100g","price":79.2,"currency_code":"EUR","in_stock":true},{"title":"250 g","offer_id":52429500252497,"sku":"NOR-50895-250g","price":129.2,"currency_code":"EUR","in_stock":true},{"title":"500 g","offer_id":52429500285265,"sku":"NOR-50895-500g","price":249.2,"currency_code":"EUR","in_stock":true},{"title":"1 kg","offer_id":52429500318033,"sku":"NOR-50895-1kg","price":429.2,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0954\/6357\/1793\/files\/NorrChemica_thymidine.png?v=1782694686"},{"product_id":"cytidine-cas-65-46-3","title":"Cytidine | CAS 65-46-3 | ≥98%","description":"\u003cdiv style=\"margin-bottom: 28px;\"\u003e\n\u003cdiv style=\"background: #002147; padding: 10px 20px; margin-bottom: 0;\"\u003e  \u003ch3 style=\"margin: 0; font-family: 'Helvetica Neue', Helvetica, Arial, sans-serif; font-size: 0.70em; font-weight: 700; letter-spacing: 0.12em; text-transform: uppercase; color: #fff;\"\u003eTechnical Specifications\u003c\/h3\u003e\n\u003c\/div\u003e\n\u003ctable style=\"width: 100%; border-collapse: collapse; font-size: 0.95em; border: 1px solid #e4e8f0; border-top: none; font-family: 'Helvetica Neue', Helvetica, Arial, sans-serif;\"\u003e\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eCAS Number\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e65-46-3\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eEC \/ EINECS Number\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e200-610-9\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eMDL Number\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003eMFCD00006545\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eSMILES\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0; word-break: break-all;\"\u003eC1=CN(C(=O)N=C1N)[C@H]2[C@@H]([C@@H]([C@H](O2)CO)O)O\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eInChI\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0; word-break: break-all;\"\u003eInChI=1S\/C9H13N3O5\/c10-5-1-2-12(9(16)11-5)8-7(15)6(14)4(3-13)17-8\/h1-2,4,6-8,13-15H,3H2,(H2,10,11,16)\/t4-,6-,7-,8-\/m1\/s1\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eInChIKey\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0; word-break: break-all;\"\u003eUHDGCWIWMRVCDJ-XVFCMESISA-N\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003ePubChem CID\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e6175\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eMolecular Formula\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003eC₉H₁₃N₃O₅\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eMolecular Weight\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e243.22 g\/mol\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eMelting Point\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e210–220 °C (dec.)\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eSolubility\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003eFreely soluble in water (~50 mg\/mL); slightly soluble in ethanol\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003ePurity\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e≥98%\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003ePhysical Form\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003eWhite to off-white crystalline powder\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eHS Code\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e2934.99\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eCountry of Origin\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003eFinland\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eShelf Life\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003eRetest period: 36 months from date of manufacture\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eStorage Conditions\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003eStore refrigerated (2–8 °C) in a tightly sealed container\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\u003c\/table\u003e\n\u003c\/div\u003e\u003cdiv style=\"margin-bottom: 28px;\"\u003e\n\u003cdiv style=\"background: #002147; padding: 10px 20px; margin-bottom: 0;\"\u003e  \u003ch3 style=\"margin: 0; font-family: 'Helvetica Neue', Helvetica, Arial, sans-serif; font-size: 0.70em; font-weight: 700; letter-spacing: 0.12em; text-transform: uppercase; color: #fff;\"\u003eProduct Description \u0026amp; Scientific Applications\u003c\/h3\u003e\n\u003c\/div\u003e\n\u003cdiv style=\"padding: 16px 20px; border: 1px solid #e4e8f0; border-top: none; font-family: Georgia, 'Times New Roman', serif; font-size: 0.95em; line-height: 1.65; color: #333;\"\u003e\n\u003cp\u003e\u003cstrong\u003eCytidine\u003c\/strong\u003e (β-D-cytidine; Cyd) is a naturally occurring pyrimidine ribonucleoside of cytosine joined to D-ribofuranose through a β-N1-glycosidic bond. One of the four canonical RNA ribonucleosides, it pairs with guanosine and enters the cytidine salvage pathway through phosphorylation by uridine-cytidine kinases UCK1 and UCK2 (EC 2.7.1.48), the rate-limiting step yielding cytidine 5′-monophosphate (CMP); CMP is phosphorylated by CMP kinase to CDP and by nucleoside diphosphate kinase to cytidine 5′-triphosphate (CTP). CTP supports RNA synthesis and supplies the cytidylyl group for CMP-Neu5Ac formation by CMP-sialic acid synthase (CMAS; EC 2.7.7.43), the donor for sialyltransferase-mediated glycoprotein and glycolipid sialylation. Cellular uptake proceeds through equilibrative nucleoside transporters hENT1 and hENT2 (SLC29A1\/A2) and concentrative transporters hCNT1 (pyrimidine-preferring) and hCNT3 (broad selectivity).\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003ePhospholipid biosynthesis.\u003c\/strong\u003e In the Kennedy pathway for de novo synthesis of the major membrane phospholipids phosphatidylcholine (PC) and phosphatidylethanolamine (PE), CTP activates phosphocholine and phosphoethanolamine in the cytidylyltransferase reactions catalysed by CCT (PCYT1) and ECT (PCYT2) to give CDP-choline and CDP-ethanolamine; the head groups are then condensed with diacylglycerol by the phosphotransferases CHPT1, CEPT1 and EPT1 at the ER and Golgi to give PC and PE. This supports studies of membrane phospholipid metabolism, neuronal-membrane biochemistry, lipid remodelling and phospholipid-pool regulation.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eCell-culture supplementation.\u003c\/strong\u003e Cytidine is a pyrimidine ribonucleoside supplement for cell-culture and metabolic research requiring salvage-pathway support or defined nucleoside availability, particularly where salvage metabolism must be separated from de novo pyrimidine synthesis. Phosphorylation through UCK1 and\/or UCK2 varies with cell type and proliferative state. Uses include defined-media optimisation, salvage-dependent culture of primary and stem cells, and quantitative study of pyrimidine uptake, phosphorylation kinetics and nucleotide-pool regulation by mass spectrometry or radioisotope tracing.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eCytidine deaminase substrate.\u003c\/strong\u003e Cytidine is the physiological substrate of cytidine deaminase (CDA, EC 3.5.4.5), a zinc-dependent homotetrameric hydrolase whose ~15 kDa subunits each carry a catalytic Zn²⁺ coordinated by three cysteines (C65, C99, C102), with Glu67 as the proton shuttle; the Zn²⁺-activated water performs nucleophilic attack at C4 of the cytosine ring. CDA catalyses the irreversible hydrolytic deamination of cytidine and 2′-deoxycytidine to uridine and 2′-deoxyuridine, linking the salvage and degradation arms of pyrimidine metabolism and feeding uridine pools. It is a reference substrate in CDA kinetic and mechanistic assays, transition-state-analogue screens, zinc-coordination studies, and comparative research across the cytidine\/deoxycytidine deaminase family.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eOligonucleotide and analogue synthesis.\u003c\/strong\u003e Cytidine is a chiral starting material and reference ribonucleoside in synthetic RNA chemistry. Its N4-amino group, C5 position and 2′-, 3′- and 5′-hydroxyls provide established sites for selective protection (DMTr at 5′-OH; TBDMS or ACE at 2′-OH; benzoyl on N4), activation and base-functionalisation. These support preparation of the standard 5′-O-DMTr-N4-benzoyl, 2′-O-TBDMS-protected cytidine 3′-phosphoramidite monomer of solid-phase RNA oligonucleotide synthesis, and of modified cytidine analogues including 5-methylcytidine, N4-modified cytidines, 2′-O-methylcytidine, 2′-fluoro and LNA cytidines, and click-chemistry handles for modified-RNA structure-function research and RNA-aptamer chemistry.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eRNA epigenetics.\u003c\/strong\u003e Cytidine residues in RNA undergo enzymatic post-transcriptional modification to chemically distinct nucleosides, a major branch of the epitranscriptome. 5-Methylcytidine (m5C) is installed by NSUN-family methyltransferases — NSUN2 on cytoplasmic mRNA, NSUN3 on mitochondrial tRNA, NSUN\/NOP2-family enzymes on rRNA — and recognised by m5C-binding proteins such as ALYREF and YBX1. The oxidised derivatives 5-hydroxymethylcytidine (hm5C) and 5-formylcytidine (f5C) arise through Fe(II)\/α-KG-dependent dioxygenase activity, with ALKBH1 the major RNA hm5C\/f5C-forming enzyme; the canonical NSUN3 → ALKBH1 cascade generates f5C at the wobble position of mt-tRNA-Met, with TET-family dioxygenases proposed in additional RNA contexts. N4-acetylcytidine (ac4C) is installed by the acetyltransferase NAT10 on rRNA, tRNA and mRNA, and influences RNA stability, translation efficiency, tRNA integrity and ribosomal RNA biology.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eFurther applications\u003c\/strong\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eReference standard for HPLC, UHPLC and LC-MS analysis of nucleosides in nucleic-acid hydrolysates and intracellular nucleoside pools, and for RNA-bisulfite-sequencing and nucleoside-mapping workflows comparing canonical and modified cytidine species\u003c\/li\u003e\n\u003cli\u003eSubstrate in uridine-cytidine kinase (UCK1\/UCK2) and nucleoside-transporter (hENT\/hCNT) assays\u003c\/li\u003e\n\u003cli\u003eStandard pyrimidine riboside in NMR and X-ray structural studies of RNA building blocks, including base hydrogen-bonding, glycosyl torsion (anti\/syn) and sugar pucker (north\/south)\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\u003cdiv style=\"margin-bottom: 28px;\"\u003e\n\u003cdiv style=\"background: #002147; padding: 10px 20px; margin-bottom: 0;\"\u003e  \u003ch3 style=\"margin: 0; font-family: 'Helvetica Neue', Helvetica, Arial, sans-serif; font-size: 0.70em; font-weight: 700; letter-spacing: 0.12em; text-transform: uppercase; color: #fff;\"\u003eShipping Destinations\u003c\/h3\u003e\n\u003c\/div\u003e\n\u003cdiv style=\"border: 1px solid #e4e8f0; border-top: none; padding: 12px 16px; font-family: 'Helvetica Neue', Helvetica, Arial, sans-serif; font-size: 0.95em;\"\u003e\u003cul style=\"margin: 0; padding: 0; list-style: none;\"\u003e\n\u003cli style=\"padding: 5px 0; border-bottom: 1px solid #f0f0f0;\"\u003e\n\u003cspan style=\"display: inline-block; width: 7px; height: 7px; background: #002147; border-radius: 50%; margin-right: 10px; vertical-align: middle;\"\u003e\u003c\/span\u003eEU \u0026amp; UK: Priority delivery, 2–5 business days.\u003c\/li\u003e\n\u003cli style=\"padding: 5px 0; border-bottom: 1px solid #f0f0f0;\"\u003e\n\u003cspan style=\"display: inline-block; width: 7px; height: 7px; background: #002147; border-radius: 50%; margin-right: 10px; vertical-align: middle;\"\u003e\u003c\/span\u003eUnited States (DDP): 3–7 business days, duties and taxes prepaid.\u003c\/li\u003e\n\u003cli style=\"padding: 5px 0; border-bottom: 1px solid #f0f0f0;\"\u003e\n\u003cspan style=\"display: inline-block; width: 7px; height: 7px; background: #002147; border-radius: 50%; margin-right: 10px; vertical-align: middle;\"\u003e\u003c\/span\u003eEFTA Countries (DDP): 3–7 business days, duties and taxes prepaid.\u003c\/li\u003e\n\u003cli style=\"padding: 5px 0; border-bottom: 1px solid #f0f0f0;\"\u003e\n\u003cspan style=\"display: inline-block; width: 7px; height: 7px; background: #002147; border-radius: 50%; margin-right: 10px; vertical-align: middle;\"\u003e\u003c\/span\u003eWorldwide: 7–14 business days, selected locations.\u003c\/li\u003e\n\u003c\/ul\u003e\u003c\/div\u003e\n\u003c\/div\u003e","brand":"NorrChemica™","offers":[{"title":"10 g","offer_id":52439278354769,"sku":"NOR-65463-10g","price":34.2,"currency_code":"EUR","in_stock":true},{"title":"25 g","offer_id":52439278387537,"sku":"NOR-65463-25g","price":45.2,"currency_code":"EUR","in_stock":true},{"title":"50 g","offer_id":52439278420305,"sku":"NOR-65463-50g","price":54.2,"currency_code":"EUR","in_stock":true},{"title":"100 g","offer_id":52439278453073,"sku":"NOR-65463-100g","price":79.2,"currency_code":"EUR","in_stock":true},{"title":"250 g","offer_id":52439278485841,"sku":"NOR-65463-250g","price":109.2,"currency_code":"EUR","in_stock":true},{"title":"500 g","offer_id":52439278518609,"sku":"NOR-65463-500g","price":159.2,"currency_code":"EUR","in_stock":true},{"title":"1 kg","offer_id":55044461003089,"sku":"NOR-65463-1000g","price":298.2,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0954\/6357\/1793\/files\/NorrChemica_cytidine.png?v=1782694841"},{"product_id":"adenosine-cas-58-61-7","title":"Adenosine | CAS 58-61-7 | ≥98%","description":"\u003cdiv style=\"margin-bottom: 28px;\"\u003e\n\u003cdiv style=\"background: #002147; padding: 10px 20px; margin-bottom: 0;\"\u003e  \u003ch3 style=\"margin: 0; font-family: 'Helvetica Neue', Helvetica, Arial, sans-serif; font-size: 0.70em; font-weight: 700; letter-spacing: 0.12em; text-transform: uppercase; color: #fff;\"\u003eTechnical Specifications\u003c\/h3\u003e\n\u003c\/div\u003e\n\u003ctable style=\"width: 100%; border-collapse: collapse; font-size: 0.95em; border: 1px solid #e4e8f0; border-top: none; font-family: 'Helvetica Neue', Helvetica, Arial, sans-serif;\"\u003e\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eCAS Number\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e58-61-7\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eEC \/ EINECS Number\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e200-389-9\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eMDL Number\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003eMFCD00005752\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eSMILES\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0; word-break: break-all;\"\u003eC1=NC(=C2C(=N1)N(C=N2)[C@H]3[C@@H]([C@@H]([C@H](O3)CO)O)O)N\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eInChI\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0; word-break: break-all;\"\u003eInChI=1S\/C10H13N5O4\/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(18)6(17)4(1-16)19-10\/h2-4,6-7,10,16-18H,1H2,(H2,11,12,13)\/t4-,6-,7-,10-\/m1\/s1\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eInChIKey\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0; word-break: break-all;\"\u003eOIRDTQYFTABQOQ-KQYNXXCUSA-N\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003ePubChem CID\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e60961\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eMolecular Formula\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003eC₁₀H₁₃N₅O₄\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eMolecular Weight\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e267.24 g\/mol\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eMelting Point\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e234–236 °C\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eSolubility\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003eSoluble in water; slightly soluble in ethanol; soluble in DMSO\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003ePurity\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e≥98%\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003ePhysical Form\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003eWhite crystalline powder\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eHS Code\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e2934.99\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eCountry of Origin\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003eFinland\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eShelf Life\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003eRetest period: 36 months from date of manufacture\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eStorage Conditions\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003eStore refrigerated (2–8 °C) in a tightly sealed container under inert atmosphere, protected from light\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\u003c\/table\u003e\n\u003c\/div\u003e\u003cdiv style=\"margin-bottom: 28px;\"\u003e\n\u003cdiv style=\"background: #002147; padding: 10px 20px; margin-bottom: 0;\"\u003e  \u003ch3 style=\"margin: 0; font-family: 'Helvetica Neue', Helvetica, Arial, sans-serif; font-size: 0.70em; font-weight: 700; letter-spacing: 0.12em; text-transform: uppercase; color: #fff;\"\u003eProduct Description \u0026amp; Scientific Applications\u003c\/h3\u003e\n\u003c\/div\u003e\n\u003cdiv style=\"padding: 16px 20px; border: 1px solid #e4e8f0; border-top: none; font-family: Georgia, 'Times New Roman', serif; font-size: 0.95em; line-height: 1.65; color: #333;\"\u003e\n\u003cp\u003e\u003cstrong\u003eAdenosine\u003c\/strong\u003e (β-D-adenosine, Ado) is the purine ribonucleoside formed by adenine linked to D-ribofuranose through a β-N9-glycosidic bond. In RNA it pairs with uridine through Watson–Crick hydrogen bonding and adopts the anti glycosidic orientation and C3'-endo sugar pucker of A-form helices. Its adenylate unit is a structural component of cAMP, S-adenosylmethionine, NAD⁺, FAD, and coenzyme A, placing it across nucleic-acid, energy, signalling, and cofactor chemistry.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eAdenine Nucleotide Pool and Energy Charge.\u003c\/strong\u003e Adenosine kinase (ADK; EC 2.7.1.20) is a high-affinity, low-capacity ATP:adenosine 5'-phosphotransferase, with reported Kₘ values in the submicromolar-to-low-micromolar range, that drives the committed step of purine ribonucleoside salvage: ATP + adenosine → ADP + AMP. The reverse step is run by cytosolic 5'-nucleotidase (cN-I; EC 3.1.3.5); the two enzymes form a substrate cycle in which small changes in ADK activity produce large changes in ambient adenosine. Intracellular AMP\/ADP\/ATP sit in the millimolar range and free adenosine in the nanomolar range, so ADK holds the cytosol as a sink for extracellular adenosine. Adenosine is therefore a defining substrate in ADK kinetic assays, in adenine-nucleotide-pool profiling, and in studies of energy-charge homeostasis under hypoxia or metabolic stress.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003ecAMP Generation and P1 (Adenosine) Receptor Signalling.\u003c\/strong\u003e ATP is the direct substrate of adenylyl cyclase, which generates 3',5'-cyclic AMP and pyrophosphate; cAMP is then hydrolysed by phosphodiesterases to 5'-AMP. Adenosine is the endogenous agonist of the four P1 receptor GPCRs (A1, A2A, A2B, A3). Extracellular ecto-5'-nucleotidase (CD73) generates the local adenosine that feeds these receptors. Adenosine serves as the reference agonist in P1-receptor pharmacology, used alongside subtype-selective ligands, phosphodiesterase inhibitors, and adenylyl-cyclase activators to separate cyclic-nucleotide synthesis from degradation.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eSAM\/SAH Methylation Cycle.\u003c\/strong\u003e S-adenosylmethionine (SAM) is the principal biological methyl donor; more than fifty SAM-dependent methyltransferases transfer its activated methyl group to DNA, RNA, histone, protein, lipid, and small-molecule substrates, releasing S-adenosylhomocysteine (SAH) as the obligate by-product. SAH is hydrolysed to adenosine and L-homocysteine by S-adenosylhomocysteine hydrolase (SAHH\/AHCY; EC 3.13.2.1), an NAD⁺-dependent tetrameric enzyme whose intrinsic equilibrium favours SAH synthesis; the reaction runs hydrolytically in vivo only because adenosine is removed by ADK and adenosine deaminase (ADA; EC 3.5.4.4) and homocysteine by transsulfuration and remethylation. Adenosine accumulation therefore drives SAH up, depresses the SAM\/SAH ratio, and product-inhibits cellular methyltransferases. Adenosine is the product standard in SAHH activity assays and in LC-MS profiling of one-carbon and methionine-cycle metabolites.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eAdenylyl Transfer in NAD⁺, FAD, and Coenzyme A Biosynthesis.\u003c\/strong\u003e The adenylyl group donated by ATP is transferred onto three cofactor systems. Nicotinamide mononucleotide adenylyltransferase (NMNAT; EC 2.7.7.1) condenses NMN with ATP to give NAD⁺ and pyrophosphate; FAD synthetase (FADS\/FLAD1; EC 2.7.7.2) performs the equivalent reaction on FMN to give FAD; phosphopantetheine adenylyltransferase (PPAT; EC 2.7.7.3) adenylylates 4'-phosphopantetheine en route to coenzyme A. Adenylyl transfer with pyrophosphate displacement is the shared chemistry across this family. Adenosine and its nucleotides are therefore reference materials in studies of NAD⁺ biosynthesis and salvage, FAD-dependent oxidoreductases, and CoA-mediated acyl transfer.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eSpectroscopic and Chemoenzymatic Reference.\u003c\/strong\u003e Adenosine has a UV absorption maximum near 260 nm with ε ≈ 15,400 M⁻¹cm⁻¹ at neutral pH, giving direct concentration determination by UV spectrophotometry and serving as the per-base extinction reference for A-rich oligonucleotide quantification. Its ¹H NMR signatures are diagnostic: the H1' anomeric proton at δ ≈ 5.9–6.0 ppm in D₂O, and the adenine H8 and H2 singlets at δ 8.1–8.4 ppm. Reverse-phase C18 HPLC at 254\/260 nm and ion-pair LC-MS use adenosine as a retention and quantitation standard for purine ribonucleosides. ADK accepts a broad range of base- and sugar-modified analogues, and SAHH accommodates 3'-modified analogues such as cordycepin (3'-deoxyadenosine), making adenosine a benchmark substrate for chemoenzymatic preparation of AMP, ADP, ATP, cAMP, NAD⁺, and modified adenine derivatives for synthetic RNA chemistry.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eOther Applications\u003c\/strong\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eSubstrate for adenosine-deaminase (ADA) activity assays\u003c\/li\u003e\n\u003cli\u003ePurine ribonucleoside supplement in defined-media and salvage-dependent culture systems\u003c\/li\u003e\n\u003cli\u003eReference compound for ¹H, ¹³C, and ³¹P NMR studies of nucleoside conformation and glycosidic-bond geometry\u003c\/li\u003e\n\u003cli\u003eBuilding block for solid-phase oligonucleotide synthesis via N6-protected, 5'-O-DMTr, 2'-O-protected, 3'-O-phosphoramidite derivatives\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\u003cdiv style=\"margin-bottom: 28px;\"\u003e\n\u003cdiv style=\"background: #002147; padding: 10px 20px; margin-bottom: 0;\"\u003e  \u003ch3 style=\"margin: 0; font-family: 'Helvetica Neue', Helvetica, Arial, sans-serif; font-size: 0.70em; font-weight: 700; letter-spacing: 0.12em; text-transform: uppercase; color: #fff;\"\u003eShipping Destinations\u003c\/h3\u003e\n\u003c\/div\u003e\n\u003cdiv style=\"border: 1px solid #e4e8f0; border-top: none; padding: 12px 16px; font-family: 'Helvetica Neue', Helvetica, Arial, sans-serif; font-size: 0.95em;\"\u003e\u003cul style=\"margin: 0; padding: 0; list-style: none;\"\u003e\n\u003cli style=\"padding: 5px 0; border-bottom: 1px solid #f0f0f0;\"\u003e\n\u003cspan style=\"display: inline-block; width: 7px; height: 7px; background: #002147; border-radius: 50%; margin-right: 10px; vertical-align: middle;\"\u003e\u003c\/span\u003eEU \u0026amp; UK: Priority delivery, 2–5 business days.\u003c\/li\u003e\n\u003cli style=\"padding: 5px 0; border-bottom: 1px solid #f0f0f0;\"\u003e\n\u003cspan style=\"display: inline-block; width: 7px; height: 7px; background: #002147; border-radius: 50%; margin-right: 10px; vertical-align: middle;\"\u003e\u003c\/span\u003eUnited States (DDP): 3–7 business days, duties and taxes prepaid.\u003c\/li\u003e\n\u003cli style=\"padding: 5px 0; border-bottom: 1px solid #f0f0f0;\"\u003e\n\u003cspan style=\"display: inline-block; width: 7px; height: 7px; background: #002147; border-radius: 50%; margin-right: 10px; vertical-align: middle;\"\u003e\u003c\/span\u003eEFTA Countries (DDP): 3–7 business days, duties and taxes prepaid.\u003c\/li\u003e\n\u003cli style=\"padding: 5px 0; border-bottom: 1px solid #f0f0f0;\"\u003e\n\u003cspan style=\"display: inline-block; width: 7px; height: 7px; background: #002147; border-radius: 50%; margin-right: 10px; vertical-align: middle;\"\u003e\u003c\/span\u003eWorldwide: 7–14 business days, selected locations.\u003c\/li\u003e\n\u003c\/ul\u003e\u003c\/div\u003e\n\u003c\/div\u003e","brand":"NorrChemica™","offers":[{"title":"25 g","offer_id":52441955107153,"sku":"NOR-58617-25g","price":34.2,"currency_code":"EUR","in_stock":true},{"title":"50 g","offer_id":52441955139921,"sku":"NOR-58617-50g","price":45.2,"currency_code":"EUR","in_stock":true},{"title":"100 g","offer_id":52441955172689,"sku":"NOR-58617-100g","price":59.2,"currency_code":"EUR","in_stock":true},{"title":"250 g","offer_id":52441955205457,"sku":"NOR-58617-250g","price":74.2,"currency_code":"EUR","in_stock":true},{"title":"500 g","offer_id":52441955238225,"sku":"NOR-58617-500g","price":109.2,"currency_code":"EUR","in_stock":true},{"title":"1 kg","offer_id":52441982107985,"sku":"NOR-58617-1000g","price":149.2,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0954\/6357\/1793\/files\/NorrChemica_adenosine.png?v=1782694877"},{"product_id":"guanosine-cas-118-00-3","title":"Guanosine | CAS 118-00-3 | ≥98.0%","description":"\u003cdiv style=\"margin-bottom: 28px;\"\u003e\n\u003cdiv style=\"background: #002147; padding: 10px 20px; margin-bottom: 0;\"\u003e  \u003ch3 style=\"margin: 0; font-family: 'Helvetica Neue', Helvetica, Arial, sans-serif; font-size: 0.70em; font-weight: 700; letter-spacing: 0.12em; text-transform: uppercase; color: #fff;\"\u003eTechnical Specifications\u003c\/h3\u003e\n\u003c\/div\u003e\n\u003ctable style=\"width: 100%; border-collapse: collapse; font-size: 0.95em; border: 1px solid #e4e8f0; border-top: none; font-family: 'Helvetica Neue', Helvetica, Arial, sans-serif;\"\u003e\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eCAS Number\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e118-00-3\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eEC \/ EINECS Number\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e204-227-8\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eMDL Number\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003eMFCD00010182\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eRTECS Number\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003eMF8750000\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eSMILES\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0; word-break: break-all;\"\u003eC1=NC2=C(N1[C@H]3[C@@H]([C@@H]([C@H](O3)CO)O)O)N=C(NC2=O)N\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eInChI\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0; word-break: break-all;\"\u003eInChI=1S\/C10H13N5O5\/c11-10-13-7-4(8(19)14-10)12-2-15(7)9-6(18)5(17)3(1-16)20-9\/h2-3,5-6,9,16-18H,1H2,(H3,11,13,14,19)\/t3-,5-,6-,9-\/m1\/s1\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eInChIKey\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0; word-break: break-all;\"\u003eNYHBQMYGNKIUIF-UUOKFMHZSA-N\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003ePubChem CID\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e135398635\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eMolecular Formula\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003eC₁₀H₁₃N₅O₅\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eMolecular Weight\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e283.24 g\/mol\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eMelting Point\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e250 °C (dec.)\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eSolubility\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003eSparingly soluble in water; practically insoluble in ethanol\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003ePurity\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e≥98.0%\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003ePhysical Form\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003eWhite crystalline powder\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eHS Code\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e2934.99\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eCountry of Origin\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003eFinland\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eShelf Life\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003eRetest period: 36 months from date of manufacture\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eStorage Conditions\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003eStore at room temperature in a tightly sealed container, protected from light and moisture\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\u003c\/table\u003e\n\u003c\/div\u003e\u003cdiv style=\"margin-bottom: 28px;\"\u003e\n\u003cdiv style=\"background: #002147; padding: 10px 20px; margin-bottom: 0;\"\u003e  \u003ch3 style=\"margin: 0; font-family: 'Helvetica Neue', Helvetica, Arial, sans-serif; font-size: 0.70em; font-weight: 700; letter-spacing: 0.12em; text-transform: uppercase; color: #fff;\"\u003eProduct Description \u0026amp; Scientific Applications\u003c\/h3\u003e\n\u003c\/div\u003e\n\u003cdiv style=\"padding: 16px 20px; border: 1px solid #e4e8f0; border-top: none; font-family: Georgia, 'Times New Roman', serif; font-size: 0.95em; line-height: 1.65; color: #333;\"\u003e\n\u003cp\u003e\u003cstrong\u003eGuanosine\u003c\/strong\u003e (β-D-guanosine; Guo) is the canonical purine ribonucleoside of RNA, with guanine joined to D-ribofuranose through a β-N9-glycosidic bond. In mammalian purine salvage it is converted to GMP via PNP-mediated phosphorolysis to guanine, then HGPRT-mediated phosphoribosylation; GMP is phosphorylated by guanylate kinase to GDP and nucleoside diphosphate kinase to GTP. The guanine base presents H-bond donors and acceptors arrayed for cyclic Hoogsteen pairing, the basis of its G-tetrad and G-quadruplex chemistry.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eGTP biochemistry, translation, and cGMP signalling.\u003c\/strong\u003e Once converted to GTP, guanosine-derived nucleotides drive ribosomal initiation, elongation (EF-Tu, EF-G), and termination factors, αβ-tubulin polymerisation, and the small-GTPase switch families (Ras, Rho, Rab, Ran, Arf) that gate signal transduction, vesicle trafficking, nuclear transport, and cytoskeletal remodelling. GTP is the direct substrate for guanylyl cyclase (EC 4.6.1.2), producing 3′,5′-cyclic GMP. Guanosine and its phosphorylated derivatives feature in GTPase-cycle assays, GEF\/GAP\/GDI biochemistry, guanylyl cyclase activity assays, and HPLC or LC-MS quantification of guanine-nucleotide pools.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003ePurine salvage and nucleoside phosphorylase studies.\u003c\/strong\u003e Guanosine is the canonical 6-oxopurine substrate for purine nucleoside phosphorylase (PNP, EC 2.4.2.1), which catalyses reversible phosphorolysis of the N-glycosidic bond to give guanine and α-D-ribose-1-phosphate. PNP follows a substrate-assisted, dissociative mechanism through an oxocarbenium-ion transition state. The salvage circuit completes through hypoxanthine-guanine phosphoribosyltransferase (HGPRT, EC 2.4.2.8), which transfers a 5-phosphoribosyl group from PRPP to guanine to give GMP. Guanosine serves as a substrate in PNP kinetic and transition-state-analogue design and binding assays, and as a starting material for chemoenzymatic transglycosylation routes that exploit reversible phosphorolysis.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eModified guanosine synthesis and oligonucleotide chemistry.\u003c\/strong\u003e Guanosine is the reference scaffold for the modified-guanosine toolbox used in synthetic RNA chemistry, RNA structure-function studies, and epitranscriptomics research. The N2-amine, the C8 position of the purine ring, the O6 carbonyl, and the 2′-, 3′-, and 5′-hydroxyls each support distinct protection and functionalisation chemistry. C8 is electrophilically brominated with Br2 or NBS to give 8-bromoguanosine, the standard handle for postsynthetic Suzuki–Miyaura, Sonogashira, and Stille modification and a route into syn-biased, fluorescent, and Z-DNA-favouring nucleosides. O6 protection (typically 2-(p-nitrophenyl)ethyl, NPE) matters mechanistically: activated phosphoramidites phosphitylate the unprotected O6 lactam, and on I2\/H2O oxidation this O6 modification is converted via O6→N7 phosphorus migration into a depurination-prone N7-modified guanine that cleaves the chain during deprotection. The N2-amine is masked as isobutyryl, dimethylformamidine, or acetyl during phosphoramidite synthesis, while RNA building blocks add a 2′-OH silyl layer (TBDMS or TOM). These site-specific handles support phosphoramidite preparation, fluorescent and isotopically labelled nucleoside synthesis, 5′-cap analogue chemistry, and 8-oxo-, 8-aryl-, and N2-modified guanosine probes for nucleic-acid damage and structure studies.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eG-quartet self-assembly and supramolecular materials.\u003c\/strong\u003e Guanosine self-associates through cyclic Hoogsteen hydrogen bonding — N1H and N2H of one base donating to O6 and N7 of the next — to form a square-planar G-tetrad with eight hydrogen bonds and four convergent O6 carbonyls at the centre. Stacked tetrads form a G-quadruplex stabilised by a monovalent cation in the central channel, with the canonical selectivity K+ \u0026gt; Na+ \u0026gt; Li+ tracking ionic radius and dehydration energetics. This chemistry underpins telomeric, promoter, and untranslated-region G-quadruplex research, RNA G-quadruplex studies, and G4-ligand binding assays by CD, NMR, FRET-melting, and ITC. In materials chemistry, mixing guanosine with 0.5 equiv KB(OH)4 gives a guanosine-borate hydrogel in which borate diester linkages between two guanosines, together with cation-templated G4·K+ stacks, drive nanowire formation and macroscopic gelation; switching to NaB(OH)4 or LiB(OH)4 progressively weakens the gel. Arylboronic-acid and diboronic-acid crosslinkers extend the same cis-diol\/boronate logic into Mg2+-bridged guanosine hydrogel systems for cell-growth-compatible scaffold and responsive-materials studies.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eFurther applications.\u003c\/strong\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eReference compound in HPLC and LC-MS analysis of purine ribonucleosides and nucleotides.\u003c\/li\u003e\n\u003cli\u003eProbe nucleoside in hENT1\/hENT2 and hCNT2\/hCNT3 nucleoside-transporter flux assays.\u003c\/li\u003e\n\u003cli\u003eStarting material for chemoenzymatic synthesis of guanine nucleotides and labelled nucleosides.\u003c\/li\u003e\n\u003cli\u003eStandard purine riboside in NMR and structural studies of base-pairing, glycosyl torsion, and sugar-pucker behaviour.\u003c\/li\u003e\n\u003cli\u003ePurine ribonucleoside additive in salvage-dependent culture systems.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\u003cdiv style=\"margin-bottom: 28px;\"\u003e\n\u003cdiv style=\"background: #002147; padding: 10px 20px; margin-bottom: 0;\"\u003e  \u003ch3 style=\"margin: 0; font-family: 'Helvetica Neue', Helvetica, Arial, sans-serif; font-size: 0.70em; font-weight: 700; letter-spacing: 0.12em; text-transform: uppercase; color: #fff;\"\u003eShipping Destinations\u003c\/h3\u003e\n\u003c\/div\u003e\n\u003cdiv style=\"border: 1px solid #e4e8f0; border-top: none; padding: 12px 16px; font-family: 'Helvetica Neue', Helvetica, Arial, sans-serif; font-size: 0.95em;\"\u003e\u003cul style=\"margin: 0; padding: 0; list-style: none;\"\u003e\n\u003cli style=\"padding: 5px 0; border-bottom: 1px solid #f0f0f0;\"\u003e\n\u003cspan style=\"display: inline-block; width: 7px; height: 7px; background: #002147; border-radius: 50%; margin-right: 10px; vertical-align: middle;\"\u003e\u003c\/span\u003eEU \u0026amp; UK: Priority delivery, 2–5 business days.\u003c\/li\u003e\n\u003cli style=\"padding: 5px 0; border-bottom: 1px solid #f0f0f0;\"\u003e\n\u003cspan style=\"display: inline-block; width: 7px; height: 7px; background: #002147; border-radius: 50%; margin-right: 10px; vertical-align: middle;\"\u003e\u003c\/span\u003eUnited States (DDP): 3–7 business days, duties and taxes prepaid.\u003c\/li\u003e\n\u003cli style=\"padding: 5px 0; border-bottom: 1px solid #f0f0f0;\"\u003e\n\u003cspan style=\"display: inline-block; width: 7px; height: 7px; background: #002147; border-radius: 50%; margin-right: 10px; vertical-align: middle;\"\u003e\u003c\/span\u003eEFTA Countries (DDP): 3–7 business days, duties and taxes prepaid.\u003c\/li\u003e\n\u003cli style=\"padding: 5px 0; border-bottom: 1px solid #f0f0f0;\"\u003e\n\u003cspan style=\"display: inline-block; width: 7px; height: 7px; background: #002147; border-radius: 50%; margin-right: 10px; vertical-align: middle;\"\u003e\u003c\/span\u003eWorldwide: 7–14 business days, selected locations.\u003c\/li\u003e\n\u003c\/ul\u003e\u003c\/div\u003e\n\u003c\/div\u003e","brand":"NorrChemica™","offers":[{"title":"25 g","offer_id":52442594836817,"sku":"NOR-118003-25g","price":44.2,"currency_code":"EUR","in_stock":true},{"title":"50 g","offer_id":52442594869585,"sku":"NOR-118003-50g","price":64.2,"currency_code":"EUR","in_stock":true},{"title":"100 g","offer_id":52442594902353,"sku":"NOR-118003-100g","price":84.2,"currency_code":"EUR","in_stock":true},{"title":"250 g","offer_id":52442594935121,"sku":"NOR-118003-250g","price":129.2,"currency_code":"EUR","in_stock":true},{"title":"500 g","offer_id":52442594967889,"sku":"NOR-118003-500g","price":179.2,"currency_code":"EUR","in_stock":true},{"title":"1000 g","offer_id":55044933058897,"sku":"NOR-118003-1000g","price":249.2,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0954\/6357\/1793\/files\/NorrChemica_Guanosine.png?v=1782695583"},{"product_id":"inosine-cas-58-63-9","title":"Inosine | CAS 58-63-9 | ≥98%","description":"\u003cdiv style=\"margin-bottom: 28px;\"\u003e\n\u003cdiv style=\"background: #002147; padding: 10px 20px; margin-bottom: 0;\"\u003e  \u003ch3 style=\"margin: 0; font-family: 'Helvetica Neue', Helvetica, Arial, sans-serif; font-size: 0.70em; font-weight: 700; letter-spacing: 0.12em; text-transform: uppercase; color: #fff;\"\u003eTechnical Specifications\u003c\/h3\u003e\n\u003c\/div\u003e\n\u003ctable style=\"width: 100%; border-collapse: collapse; font-size: 0.95em; border: 1px solid #e4e8f0; border-top: none; font-family: 'Helvetica Neue', Helvetica, Arial, sans-serif;\"\u003e\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eCAS Number\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e58-63-9\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eEC \/ EINECS Number\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e200-390-4\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eMDL Number\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003eMFCD00066770\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eRTECS Number\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003eNM7460000\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eSMILES\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0; word-break: break-all;\"\u003eC1=NC2=C(C(=O)N1)N=CN2[C@H]3[C@@H]([C@@H]([C@H](O3)CO)O)O\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eInChI\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0; word-break: break-all;\"\u003eInChI=1S\/C10H12N4O5\/c15-1-4-6(16)7(17)10(19-4)14-3-13-5-8(14)11-2-12-9(5)18\/h2-4,6-7,10,15-17H,1H2,(H,11,12,18)\/t4-,6-,7-,10-\/m1\/s1\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eInChIKey\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0; word-break: break-all;\"\u003eUGQMRVRMYYASKQ-KQYNXXCUSA-N\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003ePubChem CID\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e135398641\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eMolecular Formula\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003eC₁₀H₁₂N₄O₅\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eMolecular Weight\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e268.23 g\/mol\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eMelting Point\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e222–226 °C (dec.)\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eSolubility\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003eSparingly soluble in water; soluble in dilute acids and DMSO; practically insoluble in ethanol\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003ePurity\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e≥98%\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003ePhysical Form\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003eWhite crystalline powder\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eHS Code\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e2934.99\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eCountry of Origin\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003eFinland\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eShelf Life\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003eRetest period: 36 months from date of manufacture\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eStorage Conditions\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003eStore at room temperature in a tightly sealed container, protected from light and moisture\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\u003c\/table\u003e\n\u003c\/div\u003e\u003cdiv style=\"margin-bottom: 28px;\"\u003e\n\u003cdiv style=\"background: #002147; padding: 10px 20px; margin-bottom: 0;\"\u003e  \u003ch3 style=\"margin: 0; font-family: 'Helvetica Neue', Helvetica, Arial, sans-serif; font-size: 0.70em; font-weight: 700; letter-spacing: 0.12em; text-transform: uppercase; color: #fff;\"\u003eProduct Description \u0026amp; Scientific Applications\u003c\/h3\u003e\n\u003c\/div\u003e\n\u003cdiv style=\"padding: 16px 20px; border: 1px solid #e4e8f0; border-top: none; font-family: Georgia, 'Times New Roman', serif; font-size: 0.95em; line-height: 1.65; color: #333;\"\u003e\n\u003cp\u003e\u003cstrong\u003eInosine\u003c\/strong\u003e (hypoxanthine 9-β-D-ribofuranoside; Ino) is a purine ribonucleoside of hypoxanthine, linked to D-ribofuranose through a β-N9-glycosidic bond. In mammalian purine metabolism it is generated by irreversible hydrolytic deamination of adenosine by adenosine deaminase (ADA; EC 3.5.4.4) and cleaved by purine nucleoside phosphorylase (PNP; EC 2.4.2.1) en route to IMP.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eA-to-I RNA editing.\u003c\/strong\u003e Inosine is the product of adenosine-to-inosine (A-to-I) RNA editing, one of the most abundant post-transcriptional modifications in the mammalian transcriptome, catalysed by the ADAR family (ADAR1–3) through hydrolytic C6 deamination of adenosines in double-stranded RNA. Because inosine is read as guanosine in reverse transcription and primarily decoded as guanosine in translation, A-to-I editing can recode amino acids, alter splice-site recognition, modulate microRNA biogenesis and targeting, and mark endogenous double-stranded RNA as \"self\" relative to MDA5-mediated cytosolic dsRNA sensing. It is the analytical target in epitranscriptomic mapping by ICE-seq, Endonuclease V-mediated cleavage and high-resolution LC-MS\/MS.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eWobble tRNA decoding.\u003c\/strong\u003e Inosine forms at the wobble position (position 34) of eukaryotic tRNA anticodons, where adenosine is deaminated to inosine by the ADAT2\/ADAT3 heterodimer. A single tRNA carrying I34 decodes three synonymous codons (NNU, NNC, NNA), expanding codon-recognition capacity and compressing the tRNA repertoire. The bacterial homologue TadA has been adapted as the deaminase module of adenine base editors (ABEs) for programmable A-to-G genome editing.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003ePurine salvage and chemoenzymatic synthesis.\u003c\/strong\u003e Inosine is a substrate for purine salvage and a starting material for chemoenzymatic nucleoside synthesis. Mammalian PNP, highly specific for 6-oxopurine nucleosides, catalyses reversible phosphorolysis of inosine to hypoxanthine and α-D-ribose-1-phosphate; hypoxanthine is condensed with PRPP by HGPRT (EC 2.4.2.8) to give IMP, the gateway to AMP and GMP nucleotide pools. This reversibility lets trans-glycosylation through the α-D-ribose-1-phosphate intermediate transfer the sugar to modified purine bases, giving purine nucleoside analogues; pyrimidine analogues require a pyrimidine-specific nucleoside phosphorylase coupled with PNP.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eDegenerate oligonucleotide design.\u003c\/strong\u003e Inosine and 2'-deoxyinosine pair with all four canonical bases, making them useful as \"wobble positions\" in degenerate primer and probe design. In deoxyinosine-containing DNA duplexes pairing stability follows I:C \u0026gt; I:A \u0026gt; I:T ≈ I:G. They reduce the number of oligonucleotides needed to cover sequence variants in consensus primer design across divergent species, conserved-region targeting and probe rescue, but are most useful at positions of true sequence ambiguity, not as a substitute for full specificity.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eAnalytical and spectroscopic reference.\u003c\/strong\u003e Inosine has a UV absorption maximum near 248–250 nm (ε ≈ 12,000 M⁻¹cm⁻¹ at neutral pH) and a monoisotopic mass of 268.08 Da, and serves as a retention and quantitation standard in reverse-phase and LC-MS analysis of purine nucleosides and nucleotides. Diagnostic ¹H NMR signals include the H1' anomeric proton (δ ≈ 5.9–6.1 ppm, D₂O) and the hypoxanthine H8 and H2 singlets (δ ≈ 8.2–8.3 ppm).\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eEnzyme-assay reagent.\u003c\/strong\u003e Inosine is a substrate for PNP assays and a product or reference standard in ADA, ADAR and ADAT workflows.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\u003cdiv style=\"margin-bottom: 28px;\"\u003e\n\u003cdiv style=\"background: #002147; padding: 10px 20px; margin-bottom: 0;\"\u003e  \u003ch3 style=\"margin: 0; font-family: 'Helvetica Neue', Helvetica, Arial, sans-serif; font-size: 0.70em; font-weight: 700; letter-spacing: 0.12em; text-transform: uppercase; color: #fff;\"\u003eShipping Destinations\u003c\/h3\u003e\n\u003c\/div\u003e\n\u003cdiv style=\"border: 1px solid #e4e8f0; border-top: none; padding: 12px 16px; font-family: 'Helvetica Neue', Helvetica, Arial, sans-serif; font-size: 0.95em;\"\u003e\u003cul style=\"margin: 0; padding: 0; list-style: none;\"\u003e\n\u003cli style=\"padding: 5px 0; border-bottom: 1px solid #f0f0f0;\"\u003e\n\u003cspan style=\"display: inline-block; width: 7px; height: 7px; background: #002147; border-radius: 50%; margin-right: 10px; vertical-align: middle;\"\u003e\u003c\/span\u003eEU \u0026amp; UK: Priority delivery, 2–5 business days.\u003c\/li\u003e\n\u003cli style=\"padding: 5px 0; border-bottom: 1px solid #f0f0f0;\"\u003e\n\u003cspan style=\"display: inline-block; width: 7px; height: 7px; background: #002147; border-radius: 50%; margin-right: 10px; vertical-align: middle;\"\u003e\u003c\/span\u003eUnited States (DDP): 3–7 business days, duties and taxes prepaid.\u003c\/li\u003e\n\u003cli style=\"padding: 5px 0; border-bottom: 1px solid #f0f0f0;\"\u003e\n\u003cspan style=\"display: inline-block; width: 7px; height: 7px; background: #002147; border-radius: 50%; margin-right: 10px; vertical-align: middle;\"\u003e\u003c\/span\u003eEFTA Countries (DDP): 3–7 business days, duties and taxes prepaid.\u003c\/li\u003e\n\u003cli style=\"padding: 5px 0; border-bottom: 1px solid #f0f0f0;\"\u003e\n\u003cspan style=\"display: inline-block; width: 7px; height: 7px; background: #002147; border-radius: 50%; margin-right: 10px; vertical-align: middle;\"\u003e\u003c\/span\u003eWorldwide: 7–14 business days, selected locations.\u003c\/li\u003e\n\u003c\/ul\u003e\u003c\/div\u003e\n\u003c\/div\u003e","brand":"NorrChemica™","offers":[{"title":"25 g","offer_id":52443097301329,"sku":"NOR-58639-25g","price":34.2,"currency_code":"EUR","in_stock":true},{"title":"50 g","offer_id":52443097334097,"sku":"NOR-58639-50g","price":49.2,"currency_code":"EUR","in_stock":true},{"title":"100 g","offer_id":52443097366865,"sku":"NOR-58639-100g","price":59.2,"currency_code":"EUR","in_stock":true},{"title":"250 g","offer_id":52443097399633,"sku":"NOR-58639-250g","price":74.2,"currency_code":"EUR","in_stock":true},{"title":"500 g","offer_id":52443097432401,"sku":"NOR-58639-500g","price":98.2,"currency_code":"EUR","in_stock":true},{"title":"1 kg","offer_id":52443097465169,"sku":"NOR-58639-1kg","price":129.2,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0954\/6357\/1793\/files\/Inosine_NORRCHEMICA.png?v=1782520532"},{"product_id":"n3-benzoylthymine-cas-4330-20-5","title":"N3-Benzoylthymine | CAS 4330-20-5 | ≥98%","description":"\u003cdiv style=\"margin-bottom: 28px;\"\u003e\n\u003cdiv style=\"background: #002147; padding: 10px 20px; margin-bottom: 0;\"\u003e\n\u003ch3 style=\"margin: 0; font-family: 'Helvetica Neue', Helvetica, Arial, sans-serif; font-size: 0.70em; font-weight: bold; letter-spacing: 0.12em; text-transform: uppercase; color: #fff;\"\u003eTechnical Specifications\u003c\/h3\u003e\n\u003c\/div\u003e\n\u003ctable style=\"width: 100%; border-collapse: collapse; font-size: 0.95em; border: 1px solid #e4e8f0; border-top: none; font-family: 'Helvetica Neue', Helvetica, Arial, sans-serif;\"\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eCAS Number\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e4330-20-5\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eMDL Number\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003eMFCD12546342\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eSMILES\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0; word-break: break-all;\"\u003eCC1=CNC(=O)N(C1=O)C(=O)C2=CC=CC=C2\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eInChI\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0; word-break: break-all;\"\u003eInChI=1S\/C12H10N2O3\/c1-8-7-13-12(17)14(10(8)15)11(16)9-5-3-2-4-6-9\/h2-7H,1H3,(H,13,17)\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eInChIKey\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0; word-break: break-all;\"\u003eFCQCLMZIGUFTQR-UHFFFAOYSA-N\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003ePubChem CID\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e10933275\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eMolecular Formula\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003eC₁₂H₁₀N₂O₃\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eMolecular Weight\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e230.22 g\/mol\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eMelting Point\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e~100 °C\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eSolubility\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003eSoluble in DMF, acetonitrile, and DMSO; limited solubility in water\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003ePurity\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e≥98%\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003ePhysical Form\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003eWhite to off-white crystalline powder\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eHS Code\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e2933.59\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eCountry of Origin\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003eFinland\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eShelf Life\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003eRetest period: 36 months from date of manufacture\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eStorage Conditions\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003eStore at room temperature in a tightly sealed container, protected from moisture\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003c\/div\u003e\n\u003cdiv style=\"margin-bottom: 28px;\"\u003e\n\u003cdiv style=\"background: #002147; padding: 10px 20px; margin-bottom: 0;\"\u003e\n\u003ch3 style=\"margin: 0; font-family: 'Helvetica Neue', Helvetica, Arial, sans-serif; font-size: 0.70em; font-weight: bold; letter-spacing: 0.12em; text-transform: uppercase; color: #fff;\"\u003eProduct Description \u0026amp; Scientific Applications\u003c\/h3\u003e\n\u003c\/div\u003e\n\u003cdiv style=\"padding: 16px 20px; border: 1px solid #e4e8f0; border-top: none; font-family: Georgia, 'Times New Roman', serif; font-size: 0.95em; line-height: 1.65; color: #333;\"\u003e\n\u003cp\u003e\u003cstrong\u003e3-Benzoylthymine\u003c\/strong\u003e is one of the main substrates for the synthesis of modified thymine derivatives. The electron-withdrawing benzoyl group renders the thymine ring more electron-poor and, by protecting the N3 imide, allows regioselective functionalisation at N1. The protecting group is readily removed with aqueous ammonia.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eMitsunobu coupling.\u003c\/strong\u003e As a pronucleophile it couples with non-sugar alcohols to build carbocyclic and homologated thymine nucleosides; this route has delivered targets as demanding as the conformationally locked bicyclo[3.1.0]hexene stavudine analogue N-MCD4T, active against both HIV-1 and HIV-2.\u003c\/p\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal\"\u003e\u003cstrong\u003eN1-alkylation with benzyl and primary alkyl halides (not secondary or tertiary).\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003ePalladium-catalysed allylic substitution.\u003c\/strong\u003e With allylic esters and carbonates it serves as the nucleobase in the assembly of further carbocyclic pyrimidine nucleosides; coupling proceeds with retention of configuration.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eOligonucleotide synthesis.\u003c\/strong\u003e Benzoylation of the thymine imide protects it against the irreversible side reactions that synthesis reagents would otherwise cause during chain assembly. The N3-benzoyl is cleaved under milder basic conditions than the N-acyl groups used on the purine bases, because the pyrimidine imide anion is stabilised by the flanking C2 and C4 carbonyls.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cdiv style=\"margin-bottom: 28px;\"\u003e\n\u003cdiv style=\"background: #002147; padding: 10px 20px; margin-bottom: 0;\"\u003e\n\u003ch3 style=\"margin: 0; font-family: 'Helvetica Neue', Helvetica, Arial, sans-serif; font-size: 0.70em; font-weight: bold; letter-spacing: 0.12em; text-transform: uppercase; color: #fff;\"\u003eShipping Destinations\u003c\/h3\u003e\n\u003c\/div\u003e\n\u003cdiv style=\"border: 1px solid #e4e8f0; border-top: none; padding: 12px 16px; font-family: 'Helvetica Neue', Helvetica, Arial, sans-serif; font-size: 0.95em;\"\u003e\n\u003cul style=\"margin: 0; padding: 0; list-style: none;\"\u003e\n\u003cli style=\"padding: 5px 0; border-bottom: 1px solid #f0f0f0;\"\u003e\n\u003cspan style=\"display: inline-block; width: 7px; height: 7px; background: #002147; border-radius: 50%; margin-right: 10px; vertical-align: middle;\"\u003e\u003c\/span\u003eEU \u0026amp; UK: Priority delivery, 2–5 business days.\u003c\/li\u003e\n\u003cli style=\"padding: 5px 0; border-bottom: 1px solid #f0f0f0;\"\u003e\n\u003cspan style=\"display: inline-block; width: 7px; height: 7px; background: #002147; border-radius: 50%; margin-right: 10px; vertical-align: middle;\"\u003e\u003c\/span\u003eUnited States (DDP): 3–7 business days, duties and taxes prepaid.\u003c\/li\u003e\n\u003cli style=\"padding: 5px 0; border-bottom: 1px solid #f0f0f0;\"\u003e\n\u003cspan style=\"display: inline-block; width: 7px; height: 7px; background: #002147; border-radius: 50%; margin-right: 10px; vertical-align: middle;\"\u003e\u003c\/span\u003eEFTA Countries (DDP): 3–7 business days, duties and taxes prepaid.\u003c\/li\u003e\n\u003cli style=\"padding: 5px 0; border-bottom: 1px solid #f0f0f0;\"\u003e\n\u003cspan style=\"display: inline-block; width: 7px; height: 7px; background: #002147; border-radius: 50%; margin-right: 10px; vertical-align: middle;\"\u003e\u003c\/span\u003eWorldwide: 7–14 business days, selected locations.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e","brand":"NorrChemica™","offers":[{"title":"5.0 g","offer_id":52556701892945,"sku":"NOR-4330205-5g","price":59.2,"currency_code":"EUR","in_stock":true},{"title":"10 g","offer_id":52556701925713,"sku":"NOR-4330205-10g","price":98.2,"currency_code":"EUR","in_stock":true},{"title":"25 g","offer_id":52556701958481,"sku":"NOR-4330205-25g","price":198.2,"currency_code":"EUR","in_stock":true},{"title":"100 g","offer_id":53785570771281,"sku":"NOR-4330205-100g","price":498.2,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0954\/6357\/1793\/files\/NorrChemica_N3_Bz_Thymine.png?v=1782695807"},{"product_id":"n-9h-purin-6-yl-acetamide-n6-acetyladenine-cas-6034-68-0","title":"N6-Acetyladenine | CAS 6034-68-0 | ≥98%","description":"\u003cdiv style=\"margin-bottom: 28px;\"\u003e\n\u003cdiv style=\"background: #002147; padding: 10px 20px; margin-bottom: 0;\"\u003e  \u003ch3 style=\"margin: 0; font-family: 'Helvetica Neue', Helvetica, Arial, sans-serif; font-size: 0.70em; font-weight: 700; letter-spacing: 0.12em; text-transform: uppercase; color: #fff;\"\u003eTechnical Specifications\u003c\/h3\u003e\n\u003c\/div\u003e\n\u003ctable style=\"width: 100%; border-collapse: collapse; font-size: 0.95em; border: 1px solid #e4e8f0; border-top: none; font-family: 'Helvetica Neue', Helvetica, Arial, sans-serif;\"\u003e\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eCAS Number\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e6034-68-0\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eMDL Number\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003eMFCD01317877\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eSMILES\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0; word-break: break-all;\"\u003eCC(=O)NC1=NC=NC2=C1NC=N2\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eInChI\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0; word-break: break-all;\"\u003eInChI=1S\/C7H7N5O\/c1-4(13)12-7-5-6(9-2-8-5)10-3-11-7\/h2-3H,1H3,(H2,8,9,10,11,12,13)\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eInChIKey\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0; word-break: break-all;\"\u003eZURGFCUYILNMNA-UHFFFAOYSA-N\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003ePubChem CID\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e748208\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eMolecular Formula\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003eC₇H₇N₅O\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eMolecular Weight\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e177.16 g\/mol\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eMelting Point\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e\u0026gt;260 °C (subl.)\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003ePurity\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e≥98%\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003ePhysical Form\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003eWhite to off-white crystalline powder\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eHS Code\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e2933.59\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eCountry of Origin\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003eFinland\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eShelf Life\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003eRetest period: 36 months from date of manufacture\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eStorage Conditions\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003eStore at room temperature in a tightly sealed container, protected from light.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\u003c\/table\u003e\n\u003c\/div\u003e\u003cdiv style=\"margin-bottom: 28px;\"\u003e\n\u003cdiv style=\"background: #002147; padding: 10px 20px; margin-bottom: 0;\"\u003e  \u003ch3 style=\"margin: 0; font-family: 'Helvetica Neue', Helvetica, Arial, sans-serif; font-size: 0.70em; font-weight: 700; letter-spacing: 0.12em; text-transform: uppercase; color: #fff;\"\u003eProduct Description \u0026amp; Scientific Applications\u003c\/h3\u003e\n\u003c\/div\u003e\n\u003cdiv style=\"padding: 16px 20px; border: 1px solid #e4e8f0; border-top: none; font-family: Georgia, 'Times New Roman', serif; font-size: 0.95em; line-height: 1.65; color: #333;\"\u003e\n\u003cp\u003e\u003cstrong\u003eN-(9H-Purin-6-yl)acetamide (N6-acetyladenine)\u003c\/strong\u003e is an adenine derivative in which the exocyclic 6-amino group is masked as an acetamide, lowering the nucleophilicity and hydrogen-bonding capacity of that amine during glycosylation, alkylation, and acylation while leaving the purine ring available for building adenosine analogues and N-substituted purine scaffolds. The N-acetyl group, it is cleaved under basic conditions more readily than the benzoyl group. It can serve as a model compound for testing selective removal of an N-acyl group in the presence of the sugar, phosphate, ester, or silyl protections of a nucleoside target.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eProtected partner in N-glycosylation.\u003c\/strong\u003e Unprotected adenine can react at N9, N7, N3, and the exocyclic N6, with the distribution set by electrophile, base, solvent, and temperature. In silyl-Hilbert-Johnson \/ Vorbrüggen coupling, a silylated nucleobase (BSA or HMDS) reacts with a Lewis-acid-activated (TMSOTf, SnCl4) peracylated sugar donor; a neighbouring 2′-acyl group can favour 1,2-trans, β-selective coupling. Masking the exocyclic amine can improve regiocontrol relative to unprotected adenine. The N7-versus-N9 outcome remains condition-dependent.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eN-alkylation and displacement.\u003c\/strong\u003e For N-substituted adenosine targets, the amine is masked while a ring nitrogen is alkylated by Mitsunobu coupling (PPh3 with DIAD or DEAD, Walden inversion) or by displacement from activated precursors. N9-versus-N7 selectivity is substrate- and condition-dependent, so regiochemistry should be confirmed analytically.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eAnalytical reference.\u003c\/strong\u003e It is offered as an impurity reference standard associated with ribavirin, and as a marker for HPLC and LC-MS profiling of N-acetylated adenine species.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\u003cdiv style=\"margin-bottom: 28px;\"\u003e\n\u003cdiv style=\"background: #002147; padding: 10px 20px; margin-bottom: 0;\"\u003e  \u003ch3 style=\"margin: 0; font-family: 'Helvetica Neue', Helvetica, Arial, sans-serif; font-size: 0.70em; font-weight: 700; letter-spacing: 0.12em; text-transform: uppercase; color: #fff;\"\u003eShipping Destinations\u003c\/h3\u003e\n\u003c\/div\u003e\n\u003cdiv style=\"border: 1px solid #e4e8f0; border-top: none; padding: 12px 16px; font-family: 'Helvetica Neue', Helvetica, Arial, sans-serif; font-size: 0.95em;\"\u003e\u003cul style=\"margin: 0; padding: 0; list-style: none;\"\u003e\n\u003cli style=\"padding: 5px 0; border-bottom: 1px solid #f0f0f0;\"\u003e\n\u003cspan style=\"display: inline-block; width: 7px; height: 7px; background: #002147; border-radius: 50%; margin-right: 10px; vertical-align: middle;\"\u003e\u003c\/span\u003eEU \u0026amp; UK: Priority delivery, 2–5 business days.\u003c\/li\u003e\n\u003cli style=\"padding: 5px 0; border-bottom: 1px solid #f0f0f0;\"\u003e\n\u003cspan style=\"display: inline-block; width: 7px; height: 7px; background: #002147; border-radius: 50%; margin-right: 10px; vertical-align: middle;\"\u003e\u003c\/span\u003eUnited States (DDP): 3–7 business days, duties and taxes prepaid.\u003c\/li\u003e\n\u003cli style=\"padding: 5px 0; border-bottom: 1px solid #f0f0f0;\"\u003e\n\u003cspan style=\"display: inline-block; width: 7px; height: 7px; background: #002147; border-radius: 50%; margin-right: 10px; vertical-align: middle;\"\u003e\u003c\/span\u003eEFTA Countries (DDP): 3–7 business days, duties and taxes prepaid.\u003c\/li\u003e\n\u003cli style=\"padding: 5px 0; border-bottom: 1px solid #f0f0f0;\"\u003e\n\u003cspan style=\"display: inline-block; width: 7px; height: 7px; background: #002147; border-radius: 50%; margin-right: 10px; vertical-align: middle;\"\u003e\u003c\/span\u003eWorldwide: 7–14 business days, selected locations.\u003c\/li\u003e\n\u003c\/ul\u003e\u003c\/div\u003e\n\u003c\/div\u003e","brand":"NorrChemica™","offers":[{"title":"100 mg","offer_id":52557909164369,"sku":"NOR-6034680-100mg","price":44.9,"currency_code":"EUR","in_stock":true},{"title":"250 mg","offer_id":52557909197137,"sku":"NOR-6034680-250mg","price":74.9,"currency_code":"EUR","in_stock":true},{"title":"500 mg","offer_id":52557909229905,"sku":"NOR-6034680-500mg","price":99.9,"currency_code":"EUR","in_stock":true},{"title":"1.0 g","offer_id":52557909262673,"sku":"NOR-6034680-1g","price":198.2,"currency_code":"EUR","in_stock":true},{"title":"2.0 g","offer_id":52557909295441,"sku":"NOR-6034680-2g","price":279.2,"currency_code":"EUR","in_stock":true},{"title":"5.0 g","offer_id":52557909328209,"sku":"NOR-6034680-5g","price":398.8,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0954\/6357\/1793\/files\/NorrChemica_N6-Acetyladenine.png?v=1782696081"},{"product_id":"n3-benzoyluracil-cas-2775-87-3","title":"N3-Benzoyluracil | CAS 2775-87-3 | ≥98%","description":"\u003cdiv style=\"margin-bottom: 28px;\"\u003e\n\u003cdiv style=\"background: #002147; padding: 10px 20px; margin-bottom: 0;\"\u003e  \u003ch3 style=\"margin: 0; font-family: 'Helvetica Neue', Helvetica, Arial, sans-serif; font-size: 0.70em; font-weight: 700; letter-spacing: 0.12em; text-transform: uppercase; color: #fff;\"\u003eTechnical Specifications\u003c\/h3\u003e\n\u003c\/div\u003e\n\u003ctable style=\"width: 100%; border-collapse: collapse; font-size: 0.95em; border: 1px solid #e4e8f0; border-top: none; font-family: 'Helvetica Neue', Helvetica, Arial, sans-serif;\"\u003e\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eCAS Number\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e2775-87-3\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eMDL Number\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003eMFCD00525660\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eSMILES\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0; word-break: break-all;\"\u003eC1=CC=C(C=C1)C(=O)N2C(=O)C=CNC2=O\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eInChI\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0; word-break: break-all;\"\u003eInChI=1S\/C11H8N2O3\/c14-9-6-7-12-11(16)13(9)10(15)8-4-2-1-3-5-8\/h1-7H,(H,12,16)\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eInChIKey\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0; word-break: break-all;\"\u003eRJAJHSYADHZMNA-UHFFFAOYSA-N\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003ePubChem CID\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e569513\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eMolecular Formula\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003eC₁₁H₈N₂O₃\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eMolecular Weight\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e216.19 g\/mol\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eMelting Point\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e214-217 °C\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eSolubility\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003eSoluble in DMF, acetonitrile, and DMSO; limited solubility in water\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003ePurity\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e≥98%\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003ePhysical Form\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003eWhite to off-white crystalline powder\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eHS Code\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e2933.59\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eShelf Life\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003eRetest period: 36 months from date of manufacture\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eStorage Conditions\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003eStore at room temperature in a tightly sealed container, protected from moisture\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\u003c\/table\u003e\n\u003c\/div\u003e\u003cdiv style=\"margin-bottom: 28px;\"\u003e\n\u003cdiv style=\"background: #002147; padding: 10px 20px; margin-bottom: 0;\"\u003e  \u003ch3 style=\"margin: 0; font-family: 'Helvetica Neue', Helvetica, Arial, sans-serif; font-size: 0.70em; font-weight: 700; letter-spacing: 0.12em; text-transform: uppercase; color: #fff;\"\u003eProduct Description \u0026amp; Scientific Applications\u003c\/h3\u003e\n\u003c\/div\u003e\n\u003cdiv style=\"padding: 16px 20px; border: 1px solid #e4e8f0; border-top: none; font-family: Georgia, 'Times New Roman', serif; font-size: 0.95em; line-height: 1.65; color: #333;\"\u003e\n\u003cp\u003e\u003cstrong\u003eN3-Benzoyluracil\u003c\/strong\u003e (3-benzoyl-1\u003cem\u003eH\u003c\/em\u003e-pyrimidine-2,4-dione) is uracil with the N3 imide protected as a benzamide. The benzoyl makes the ring electron-poor and, by blocking N3, directs functionalisation to the free N1. It is the pyrimidine counterpart to N3-benzoylthymine for parallel methodology development across the uracil and thymine series, and is observably more base-labile than N3-benzoylthymine under matched deprotection conditions.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eMitsunobu coupling.\u003c\/strong\u003e As an N1 pronucleophile it couples to primary and secondary alcohols with inversion, building carbocyclic and acyclic uracil nucleoside analogues. N1 versus O2 alkylation is substrate-dependent, so each case is confirmed by NMR or LC-MS; the N3-benzoyl can also be partially lost on long thermal steps.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003ePalladium-catalysed allylic substitution.\u003c\/strong\u003e With allylic esters and carbonates it serves as the nucleobase in carbocyclic uracil nucleoside assembly through a π-allyl Pd intermediate; double inversion gives net retention at the allylic carbon, opposite to Mitsunobu.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eN1-alkylation with benzyl and primary alkyl halides (not secondary or tertiary).\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eDebenzoylation.\u003c\/strong\u003e Aqueous or methanolic ammonia cleaves the benzamide by addition–elimination, N3 departing as an amide anion stabilised by the flanking C2 and C4 carbonyls.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\u003cdiv style=\"margin-bottom: 28px;\"\u003e\n\u003cdiv style=\"background: #002147; padding: 10px 20px; margin-bottom: 0;\"\u003e  \u003ch3 style=\"margin: 0; font-family: 'Helvetica Neue', Helvetica, Arial, sans-serif; font-size: 0.70em; font-weight: 700; letter-spacing: 0.12em; text-transform: uppercase; color: #fff;\"\u003eShipping Destinations\u003c\/h3\u003e\n\u003c\/div\u003e\n\u003cdiv style=\"border: 1px solid #e4e8f0; border-top: none; padding: 12px 16px; font-family: 'Helvetica Neue', Helvetica, Arial, sans-serif; font-size: 0.95em;\"\u003e\u003cul style=\"margin: 0; padding: 0; list-style: none;\"\u003e\n\u003cli style=\"padding: 5px 0; border-bottom: 1px solid #f0f0f0;\"\u003e\n\u003cspan style=\"display: inline-block; width: 7px; height: 7px; background: #002147; border-radius: 50%; margin-right: 10px; vertical-align: middle;\"\u003e\u003c\/span\u003eEU \u0026amp; UK: Priority delivery, 2–5 business days.\u003c\/li\u003e\n\u003cli style=\"padding: 5px 0; border-bottom: 1px solid #f0f0f0;\"\u003e\n\u003cspan style=\"display: inline-block; width: 7px; height: 7px; background: #002147; border-radius: 50%; margin-right: 10px; vertical-align: middle;\"\u003e\u003c\/span\u003eUnited States (DDP): 3–7 business days, duties and taxes prepaid.\u003c\/li\u003e\n\u003cli style=\"padding: 5px 0; border-bottom: 1px solid #f0f0f0;\"\u003e\n\u003cspan style=\"display: inline-block; width: 7px; height: 7px; background: #002147; border-radius: 50%; margin-right: 10px; vertical-align: middle;\"\u003e\u003c\/span\u003eEFTA Countries (DDP): 3–7 business days, duties and taxes prepaid.\u003c\/li\u003e\n\u003cli style=\"padding: 5px 0; border-bottom: 1px solid #f0f0f0;\"\u003e\n\u003cspan style=\"display: inline-block; width: 7px; height: 7px; background: #002147; border-radius: 50%; margin-right: 10px; vertical-align: middle;\"\u003e\u003c\/span\u003eWorldwide: 7–14 business days, selected locations.\u003c\/li\u003e\n\u003c\/ul\u003e\u003c\/div\u003e\n\u003c\/div\u003e","brand":"NorrChemica™","offers":[{"title":"500 mg","offer_id":52567530406225,"sku":"NOR-2775873-500mg","price":59.0,"currency_code":"EUR","in_stock":true},{"title":"1.0 g","offer_id":52567530438993,"sku":"NOR-2775873-1g","price":98.0,"currency_code":"EUR","in_stock":true},{"title":"2.5 g","offer_id":52567530471761,"sku":"NOR-2775873-2.5g","price":189.0,"currency_code":"EUR","in_stock":true},{"title":"5.0 g","offer_id":52567530504529,"sku":"NOR-2775873-5g","price":325.0,"currency_code":"EUR","in_stock":true},{"title":"10 g","offer_id":52567530537297,"sku":"NOR-2775873-10g","price":549.0,"currency_code":"EUR","in_stock":true},{"title":"25 g","offer_id":52567530570065,"sku":"NOR-2775873-25g","price":895.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0954\/6357\/1793\/files\/NorrChemica_N3-Benzoyluracil.png?v=1782696207"},{"product_id":"bis-o-tbdms-thymidine-cas-40733-26-4","title":"3′,5′-Bis-O-(tert-butyldimethylsilyl)thymidine | CAS 40733-26-4 | ≥98%","description":"\u003cdiv style=\"margin-bottom: 28px;\"\u003e\n\u003cdiv style=\"background: #002147; padding: 10px 20px; margin-bottom: 0;\"\u003e  \u003ch3 style=\"margin: 0; font-family: 'Helvetica Neue', Helvetica, Arial, sans-serif; font-size: 0.70em; font-weight: 700; letter-spacing: 0.12em; text-transform: uppercase; color: #fff;\"\u003eTechnical Specifications\u003c\/h3\u003e\n\u003c\/div\u003e\n\u003ctable style=\"width: 100%; border-collapse: collapse; font-size: 0.95em; border: 1px solid #e4e8f0; border-top: none; font-family: 'Helvetica Neue', Helvetica, Arial, sans-serif;\"\u003e\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eCAS Number\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e40733-26-4\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eMDL Number\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003eMFCD01631042\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eSMILES\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0; word-break: break-all;\"\u003eCC1=CN(C(=O)NC1=O)[C@H]2C[C@@H]([C@H](O2)CO[Si](C)(C)C(C)(C)C)O[Si](C)(C)C(C)(C)C\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eInChI\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0; word-break: break-all;\"\u003eInChI=1S\/C22H42N2O5Si2\/c1-15-13-24(20(26)23-19(15)25)18-12-16(29-31(10,11)22(5,6)7)17(28-18)14-27-30(8,9)21(2,3)4\/h13,16-18H,12,14H2,1-11H3,(H,23,25,26)\/t16-,17+,18+\/m0\/s1\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eInChIKey\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0; word-break: break-all;\"\u003eDDLOCFSZSYGOPG-RCCFBDPRSA-N\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003ePubChem CID\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e10459624\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eMolecular Formula\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003eC₂₂H₄₂N₂O₅Si₂\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eMolecular Weight\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e470.75 g\/mol\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eSolubility\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003eSoluble in dichloromethane, chloroform, ethyl acetate, and THF; practically insoluble in water\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003ePurity\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e≥98%\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003ePhysical Form\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003eWhite to off-white crystalline solid\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eHS Code\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e2934.99\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eShelf Life\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003eRetest period: 24 months from date of manufacture\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eStorage Conditions\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003eStore at 2-8°C in a tightly sealed container, protected from moisture\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\u003c\/table\u003e\n\u003c\/div\u003e\u003cdiv style=\"margin-bottom: 28px;\"\u003e\n\u003cdiv style=\"background: #002147; padding: 10px 20px; margin-bottom: 0;\"\u003e  \u003ch3 style=\"margin: 0; font-family: 'Helvetica Neue', Helvetica, Arial, sans-serif; font-size: 0.70em; font-weight: 700; letter-spacing: 0.12em; text-transform: uppercase; color: #fff;\"\u003eProduct Description \u0026amp; Scientific Applications\u003c\/h3\u003e\n\u003c\/div\u003e\n\u003cdiv style=\"padding: 16px 20px; border: 1px solid #e4e8f0; border-top: none; font-family: Georgia, 'Times New Roman', serif; font-size: 0.95em; line-height: 1.65; color: #333;\"\u003e\n\u003cp\u003e\u003cstrong\u003e3′,5′-Bis-O-(tert-butyldimethylsilyl)thymidine\u003c\/strong\u003e (3′,5′-bis-O-TBDMS-thymidine) is a fully sugar-protected thymidine derivative in which both the 3′- and 5′-hydroxyls of the 2′-deoxyribose are masked as TBDMS ethers. The protection holds through neutral, basic, and acylating conditions, while retaining the acid- and fluoride-lability of TBDMS ethers. Fluoride (TBAF or triethylamine trihydrofluoride) removes both silyl groups; controlled acidic hydrolysis removes the more accessible primary 5′-TBDMS ether selectively, giving 3′-O-TBDMS-thymidine with a free 5′-OH.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eNucleobase modification.\u003c\/strong\u003e With both sugar hydroxyls masked, base-directed chemistry proceeds without competing reaction at the 3′- or 5′-OH. The thymine ring is functionalised through N3-alkylation or temporary N3 acyl\/carbamate protection. The C5-methyl group is an entry point for side-chain chemistry: radical bromination gives the bromomethyl intermediate, which displaces with O-, N-, S-, or C-nucleophiles to install ether, amine, thioether, or carbon-linked substituents. Fluoride deprotection then gives the base-modified thymidine.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eSugar modification.\u003c\/strong\u003e Selective 5′-desilylation gives a mono-protected intermediate for stepwise sugar work. The free 5′-OH is phosphorylated, tritylated, acylated, or tagged while the 3′-OH stays protected. In the free-3′ regiochemistry the 3′-OH is activated by mesylation, tosylation, oxidation-reduction, or fluorination, and sugar-modification chemistry delivers 3′-azido, 3′-fluoro, 3′-amino, 3′-deoxy, and 2′,3′-didehydro analogues. Fluoride desilylation releases the free analogue.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eMonomer preparation.\u003c\/strong\u003e The compound is a modular intermediate for modified thymidine monomers, not the ordinary dT phosphoramidite precursor. After 5′-deprotection and installation of a 5′ handle, the 3′-TBDMS is removed and the 3′-OH converted into a phosphoramidite, H-phosphonate, phosphotriester, phosphorothioate, phosphorodithioate, or phosphoramidate precursor, including for sugar- or base-modified nucleotide analogues.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\u003cdiv style=\"margin-bottom: 28px;\"\u003e\n\u003cdiv style=\"background: #002147; padding: 10px 20px; margin-bottom: 0;\"\u003e  \u003ch3 style=\"margin: 0; font-family: 'Helvetica Neue', Helvetica, Arial, sans-serif; font-size: 0.70em; font-weight: 700; letter-spacing: 0.12em; text-transform: uppercase; color: #fff;\"\u003eShipping Destinations\u003c\/h3\u003e\n\u003c\/div\u003e\n\u003cdiv style=\"border: 1px solid #e4e8f0; border-top: none; padding: 12px 16px; font-family: 'Helvetica Neue', Helvetica, Arial, sans-serif; font-size: 0.95em;\"\u003e\u003cul style=\"margin: 0; padding: 0; list-style: none;\"\u003e\n\u003cli style=\"padding: 5px 0; border-bottom: 1px solid #f0f0f0;\"\u003e\n\u003cspan style=\"display: inline-block; width: 7px; height: 7px; background: #002147; border-radius: 50%; margin-right: 10px; vertical-align: middle;\"\u003e\u003c\/span\u003eEU \u0026amp; UK: Priority delivery, 2–5 business days.\u003c\/li\u003e\n\u003cli style=\"padding: 5px 0; border-bottom: 1px solid #f0f0f0;\"\u003e\n\u003cspan style=\"display: inline-block; width: 7px; height: 7px; background: #002147; border-radius: 50%; margin-right: 10px; vertical-align: middle;\"\u003e\u003c\/span\u003eUnited States (DDP): 3–7 business days, duties and taxes prepaid.\u003c\/li\u003e\n\u003cli style=\"padding: 5px 0; border-bottom: 1px solid #f0f0f0;\"\u003e\n\u003cspan style=\"display: inline-block; width: 7px; height: 7px; background: #002147; border-radius: 50%; margin-right: 10px; vertical-align: middle;\"\u003e\u003c\/span\u003eEFTA Countries (DDP): 3–7 business days, duties and taxes prepaid.\u003c\/li\u003e\n\u003cli style=\"padding: 5px 0; border-bottom: 1px solid #f0f0f0;\"\u003e\n\u003cspan style=\"display: inline-block; width: 7px; height: 7px; background: #002147; border-radius: 50%; margin-right: 10px; vertical-align: middle;\"\u003e\u003c\/span\u003eWorldwide: 7–14 business days, selected locations.\u003c\/li\u003e\n\u003c\/ul\u003e\u003c\/div\u003e\n\u003c\/div\u003e","brand":"NorrChemica™","offers":[{"title":"1.0 g","offer_id":52574357553489,"sku":"NOR-40733264-1g","price":98.2,"currency_code":"EUR","in_stock":true},{"title":"2.0 g","offer_id":52574357586257,"sku":"NOR-40733264-2g","price":198.2,"currency_code":"EUR","in_stock":true},{"title":"5.0 g","offer_id":52574357619025,"sku":"NOR-40733264-5g","price":345.0,"currency_code":"EUR","in_stock":true},{"title":"10 g","offer_id":52574357651793,"sku":"NOR-40733264-10g","price":625.0,"currency_code":"EUR","in_stock":true},{"title":"25 g","offer_id":52574357684561,"sku":"NOR-40733264-25g","price":1095.0,"currency_code":"EUR","in_stock":true},{"title":"50 g","offer_id":55059118162257,"sku":"NOR-40733264-50g","price":1995.0,"currency_code":"EUR","in_stock":true},{"title":"100 g","offer_id":55059118195025,"sku":"NOR-40733264-100g","price":3795.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0954\/6357\/1793\/files\/NorrChemica_3-5-Bis-O-_tert-butyldimethylsilyl_thymidine.png?v=1782683270"},{"product_id":"ethyl-thymin-1-yl-acetate-cas-55036-34-5","title":"Ethyl (Thymin-1-yl)acetate | CAS 55036-34-5 | ≥98%","description":"\u003cdiv style=\"margin-bottom: 28px;\"\u003e\n\u003cdiv style=\"background: #002147; padding: 10px 20px; margin-bottom: 0;\"\u003e  \u003ch3 style=\"margin: 0; font-family: 'Helvetica Neue', Helvetica, Arial, sans-serif; font-size: 0.70em; font-weight: 700; letter-spacing: 0.12em; text-transform: uppercase; color: #fff;\"\u003eTechnical Specifications\u003c\/h3\u003e\n\u003c\/div\u003e\n\u003ctable style=\"width: 100%; border-collapse: collapse; font-size: 0.95em; border: 1px solid #e4e8f0; border-top: none; font-family: 'Helvetica Neue', Helvetica, Arial, sans-serif;\"\u003e\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eCAS Number\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e55036-34-5\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eMDL Number\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003eMFCD07200411\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eSMILES\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0; word-break: break-all;\"\u003eCCOC(=O)CN1C=C(C(=O)NC1=O)C\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eInChI\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0; word-break: break-all;\"\u003eInChI=1S\/C9H12N2O4\/c1-3-15-7(12)5-11-4-6(2)8(13)10-9(11)14\/h4H,3,5H2,1-2H3,(H,10,13,14)\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eInChIKey\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0; word-break: break-all;\"\u003ePZOFYXHUJOBREJ-UHFFFAOYSA-N\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003ePubChem CID\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e565853\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eMolecular Formula\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003eC₉H₁₂N₂O₄\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eMolecular Weight\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e212.2 g\/mol\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eMelting Point\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e173-174 °C\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eSolubility\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003eSoluble in ethanol, DMF, DMSO, and ethyl acetate; sparingly soluble in water\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003ePurity\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e≥98%\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003ePhysical Form\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003eWhite to off-white crystalline powder\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eHS Code\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e2933.59\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eShelf Life\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003eRetest period: 36 months from date of manufacture\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eStorage Conditions\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003eStore at room temperature in a tightly sealed container, protected from moisture\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\u003c\/table\u003e\n\u003c\/div\u003e\u003cdiv style=\"margin-bottom: 28px;\"\u003e\n\u003cdiv style=\"background: #002147; padding: 10px 20px; margin-bottom: 0;\"\u003e  \u003ch3 style=\"margin: 0; font-family: 'Helvetica Neue', Helvetica, Arial, sans-serif; font-size: 0.70em; font-weight: 700; letter-spacing: 0.12em; text-transform: uppercase; color: #fff;\"\u003eProduct Description \u0026amp; Scientific Applications\u003c\/h3\u003e\n\u003c\/div\u003e\n\u003cdiv style=\"padding: 16px 20px; border: 1px solid #e4e8f0; border-top: none; font-family: Georgia, 'Times New Roman', serif; font-size: 0.95em; line-height: 1.65; color: #333;\"\u003e\n\u003cp\u003e\u003cstrong\u003eEthyl (thymin-1-yl)acetate\u003c\/strong\u003e is an N1-alkylated thymine bearing an acetic-acid ethyl-ester tether — the canonical entry point to the thymine nucleobase acetic-acid building block. Alkaline hydrolysis (LiOH or NaOH in aqueous EtOH or THF) releases thymin-1-ylacetic acid, which couples through standard peptide chemistry (HBTU, HATU, EDC, DCC, or PyBOP with a non-nucleophilic base) to amine partners.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003ePNA monomer synthesis (the principal use).\u003c\/strong\u003e The liberated acid couples to orthogonally protected N-(2-aminoethyl)glycine (AEG) — Boc-AEG-OEt\/OBn for t-Boc\/Cbz, Fmoc-AEG-OBn for Fmoc\/Bhoc — to give the protected thymine PNA monomer. Thymine is the only canonical PNA nucleobase needing no exocyclic-amine protection, making this the shortest of the four monomer routes. The resulting oligomers hybridise sequence-specifically with DNA and RNA by Watson–Crick pairing; the uncharged polyamide backbone removes phosphate–phosphate repulsion and gives high nuclease\/protease stability.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eAdenine receptors.\u003c\/strong\u003e Coupled to amine-functionalised macrocyclic, peptidic, or polymeric scaffolds, the thymine units recognise adenine, adenosine, AMP, and ATP by Watson–Crick hydrogen bonding in organic or mixed aqueous media. Mono- and bis-thymine calix[4]arenes are a documented example.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eNucleobase-functionalised polymers.\u003c\/strong\u003e Grafted onto polymer backbones to install thymine hydrogen-bonding sites for non-covalent self-assembly. Thymine-terminated PEG undergoes heterocomplementary supramolecular polymerisation with diamino-triazine PEG; complementary pairing with adenine- or triazine-bearing partners creates reversible cross-links for template-directed polymerisation and adenine-responsive materials.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003ePseudopeptide backbones.\u003c\/strong\u003e Coupled to natural and non-natural amino acids, reduced-peptide-bond pseudodipeptides, and chiral amino-alcohol scaffolds to deliver conformationally constrained PNA-style monomers and thymine–peptide hybrids.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eC5-methyl functionalisation.\u003c\/strong\u003e Radical bromination (NBS\/AIBN) gives bromomethyl intermediates for displacement by O-, N-, S-, or C-nucleophiles, installing fluorescent, affinity-tag, or other substituents en route to 5-substituted PNA monomers; the ester protects the carboxylate, then hydrolyses.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\u003cdiv style=\"margin-bottom: 28px;\"\u003e\n\u003cdiv style=\"background: #002147; padding: 10px 20px; margin-bottom: 0;\"\u003e  \u003ch3 style=\"margin: 0; font-family: 'Helvetica Neue', Helvetica, Arial, sans-serif; font-size: 0.70em; font-weight: 700; letter-spacing: 0.12em; text-transform: uppercase; color: #fff;\"\u003eShipping Destinations\u003c\/h3\u003e\n\u003c\/div\u003e\n\u003cdiv style=\"border: 1px solid #e4e8f0; border-top: none; padding: 12px 16px; font-family: 'Helvetica Neue', Helvetica, Arial, sans-serif; font-size: 0.95em;\"\u003e\u003cul style=\"margin: 0; padding: 0; list-style: none;\"\u003e\n\u003cli style=\"padding: 5px 0; border-bottom: 1px solid #f0f0f0;\"\u003e\n\u003cspan style=\"display: inline-block; width: 7px; height: 7px; background: #002147; border-radius: 50%; margin-right: 10px; vertical-align: middle;\"\u003e\u003c\/span\u003eEU \u0026amp; UK: Priority delivery, 2–5 business days.\u003c\/li\u003e\n\u003cli style=\"padding: 5px 0; border-bottom: 1px solid #f0f0f0;\"\u003e\n\u003cspan style=\"display: inline-block; width: 7px; height: 7px; background: #002147; border-radius: 50%; margin-right: 10px; vertical-align: middle;\"\u003e\u003c\/span\u003eUnited States (DDP): 3–7 business days, duties and taxes prepaid.\u003c\/li\u003e\n\u003cli style=\"padding: 5px 0; border-bottom: 1px solid #f0f0f0;\"\u003e\n\u003cspan style=\"display: inline-block; width: 7px; height: 7px; background: #002147; border-radius: 50%; margin-right: 10px; vertical-align: middle;\"\u003e\u003c\/span\u003eEFTA Countries (DDP): 3–7 business days, duties and taxes prepaid.\u003c\/li\u003e\n\u003cli style=\"padding: 5px 0; border-bottom: 1px solid #f0f0f0;\"\u003e\n\u003cspan style=\"display: inline-block; width: 7px; height: 7px; background: #002147; border-radius: 50%; margin-right: 10px; vertical-align: middle;\"\u003e\u003c\/span\u003eWorldwide: 7–14 business days, selected locations.\u003c\/li\u003e\n\u003c\/ul\u003e\u003c\/div\u003e\n\u003c\/div\u003e","brand":"NorrChemica™","offers":[{"title":"500 mg","offer_id":52846183285073,"sku":"NOR-55036345-500mg","price":80.0,"currency_code":"EUR","in_stock":true},{"title":"1.0 g","offer_id":52575756288337,"sku":"NOR-55036345-1g","price":145.0,"currency_code":"EUR","in_stock":true},{"title":"5.0 g","offer_id":52575756321105,"sku":"NOR-55036345-5g","price":495.0,"currency_code":"EUR","in_stock":true},{"title":"10 g","offer_id":52575756353873,"sku":"NOR-55036345-10g","price":995.0,"currency_code":"EUR","in_stock":true},{"title":"25 g","offer_id":55059415892305,"sku":"NOR-55036345-25g","price":1695.0,"currency_code":"EUR","in_stock":true},{"title":"50 g","offer_id":55059415925073,"sku":"NOR-55036345-50g","price":2995.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0954\/6357\/1793\/files\/NorrChemica_Ethyl_Thymin-1-yl_acetate.png?v=1782683270"},{"product_id":"2-deoxycytidine-cas-951-77-9","title":"2′-Deoxycytidine | CAS 951-77-9 | ≥98%","description":"\u003cdiv style=\"margin-bottom: 28px;\"\u003e\n\u003cdiv style=\"background: #002147; padding: 10px 20px; margin-bottom: 0;\"\u003e  \u003ch3 style=\"margin: 0; font-family: 'Helvetica Neue', Helvetica, Arial, sans-serif; font-size: 0.70em; font-weight: 700; letter-spacing: 0.12em; text-transform: uppercase; color: #fff;\"\u003eTechnical Specifications\u003c\/h3\u003e\n\u003c\/div\u003e\n\u003ctable style=\"width: 100%; border-collapse: collapse; font-size: 0.95em; border: 1px solid #e4e8f0; border-top: none; font-family: 'Helvetica Neue', Helvetica, Arial, sans-serif;\"\u003e\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eCAS Number\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e951-77-9\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eEC \/ EINECS Number\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e213-454-1\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eMDL Number\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003eMFCD00006547\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eRTECS Number\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003eHA3800000\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eSMILES\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0; word-break: break-all;\"\u003eC1[C@@H]([C@H](O[C@H]1N2C=CC(=NC2=O)N)CO)O\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eInChI\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0; word-break: break-all;\"\u003eInChI=1S\/C9H13N3O4\/c10-7-1-2-12(9(15)11-7)8-3-5(14)6(4-13)16-8\/h1-2,5-6,8,13-14H,3-4H2,(H2,10,11,15)\/t5-,6+,8+\/m0\/s1\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eInChIKey\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0; word-break: break-all;\"\u003eCKTSBUTUHBMZGZ-SHYZEUOFSA-N\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003ePubChem CID\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e13711\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eMolecular Formula\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003eC₉H₁₃N₃O₄\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eMolecular Weight\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e227.22 g\/mol\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eMelting Point\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e192–202 °C\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eSolubility\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003eSoluble in water; sparingly soluble in ethanol; practically insoluble in diethyl ether\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003ePurity\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e≥98%\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003ePhysical Form\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003eWhite to off-white crystalline powder\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eHS Code\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e2934.99\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eShelf Life\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003eRetest period: 36 months from date of manufacture\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eStorage Conditions\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003eStore at room temperature in a tightly sealed container, protected from moisture\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\u003c\/table\u003e\n\u003c\/div\u003e\u003cdiv style=\"margin-bottom: 28px;\"\u003e\n\u003cdiv style=\"background: #002147; padding: 10px 20px; margin-bottom: 0;\"\u003e  \u003ch3 style=\"margin: 0; font-family: 'Helvetica Neue', Helvetica, Arial, sans-serif; font-size: 0.70em; font-weight: 700; letter-spacing: 0.12em; text-transform: uppercase; color: #fff;\"\u003eProduct Description \u0026amp; Scientific Applications\u003c\/h3\u003e\n\u003c\/div\u003e\n\u003cdiv style=\"padding: 16px 20px; border: 1px solid #e4e8f0; border-top: none; font-family: Georgia, 'Times New Roman', serif; font-size: 0.95em; line-height: 1.65; color: #333;\"\u003e\n\u003cp\u003e\u003cstrong\u003e2′-Deoxycytidine\u003c\/strong\u003e (dC, dCyd) is one of the four canonical DNA deoxyribonucleosides: cytosine linked to 2-deoxy-β-D-ribofuranose by a β-N1-glycosidic bond. Deoxycytidine kinase (dCK) phosphorylates it to dCMP, which downstream kinases convert to dCDP and dCTP for DNA replication and repair. UV absorption peaks at λmax ≈ 271 nm; cytosine N3 protonates with pKa ≈ 4.2–4.3, the handle for low-pH ion-exchange separation.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eAnalytical reference standard.\u003c\/strong\u003e dC is a primary standard for HPLC, LC-MS, and LC-MS\/MS quantification of canonical deoxyribonucleosides in DNA digests, cell extracts, and pool studies, resolving dC, dA, dG, dT, dU, and modified deoxycytidines in one run. Co-quantification of dC and 2′-deoxyuridine reads out CDA deamination flux directly.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003edCK substrate.\u003c\/strong\u003e dC is the principal substrate of deoxycytidine kinase, the rate-limiting kinase that initiates pyrimidine deoxyribonucleoside salvage, with KM(dC) ≈ 0.94 μM. It is the benchmark in dCK kinetic and mechanistic studies.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eCDA substrate.\u003c\/strong\u003e dC is a substrate of cytidine deaminase, a Zn²⁺-dependent hydrolase that deaminates it to 2′-deoxyuridine; the resulting dU feeds the thymidylate route, making dC→dU a regulatory junction in dCTP\/dTTP balance.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eSpontaneous deamination.\u003c\/strong\u003e Non-enzymatic deamination of cytosine to uracil is a major mutagenic DNA lesion, running at roughly 100–500 events per cell per day; the U:G mismatch is corrected by base excision repair (UNG), and unrepaired events drive C→T transitions. The same chemistry on 5-methyl-dC gives thymine, making methylated CpG sites mutational hotspots.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eMethylation standard.\u003c\/strong\u003e dC is the unmethylated parent of 5-methyl-dC and the TET-derived oxidised forms; the dC:5-mdC ratio by LC-MS gives a direct methylation readout, and dC is the target base of cytidine base editors that deliver programmed C→T edits.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eCell culture.\u003c\/strong\u003e dC is a salvage-pathway supplement for controlled dNTP-pool manipulation.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\u003cdiv style=\"margin-bottom: 28px;\"\u003e\n\u003cdiv style=\"background: #002147; padding: 10px 20px; margin-bottom: 0;\"\u003e  \u003ch3 style=\"margin: 0; font-family: 'Helvetica Neue', Helvetica, Arial, sans-serif; font-size: 0.70em; font-weight: 700; letter-spacing: 0.12em; text-transform: uppercase; color: #fff;\"\u003eShipping Destinations\u003c\/h3\u003e\n\u003c\/div\u003e\n\u003cdiv style=\"border: 1px solid #e4e8f0; border-top: none; padding: 12px 16px; font-family: 'Helvetica Neue', Helvetica, Arial, sans-serif; font-size: 0.95em;\"\u003e\u003cul style=\"margin: 0; padding: 0; list-style: none;\"\u003e\n\u003cli style=\"padding: 5px 0; border-bottom: 1px solid #f0f0f0;\"\u003e\n\u003cspan style=\"display: inline-block; width: 7px; height: 7px; background: #002147; border-radius: 50%; margin-right: 10px; vertical-align: middle;\"\u003e\u003c\/span\u003eEU \u0026amp; UK: Priority delivery, 2–5 business days.\u003c\/li\u003e\n\u003cli style=\"padding: 5px 0; border-bottom: 1px solid #f0f0f0;\"\u003e\n\u003cspan style=\"display: inline-block; width: 7px; height: 7px; background: #002147; border-radius: 50%; margin-right: 10px; vertical-align: middle;\"\u003e\u003c\/span\u003eUnited States (DDP): 3–7 business days, duties and taxes prepaid.\u003c\/li\u003e\n\u003cli style=\"padding: 5px 0; border-bottom: 1px solid #f0f0f0;\"\u003e\n\u003cspan style=\"display: inline-block; width: 7px; height: 7px; background: #002147; border-radius: 50%; margin-right: 10px; vertical-align: middle;\"\u003e\u003c\/span\u003eEFTA Countries (DDP): 3–7 business days, duties and taxes prepaid.\u003c\/li\u003e\n\u003cli style=\"padding: 5px 0; border-bottom: 1px solid #f0f0f0;\"\u003e\n\u003cspan style=\"display: inline-block; width: 7px; height: 7px; background: #002147; border-radius: 50%; margin-right: 10px; vertical-align: middle;\"\u003e\u003c\/span\u003eWorldwide: 7–14 business days, selected locations.\u003c\/li\u003e\n\u003c\/ul\u003e\u003c\/div\u003e\n\u003c\/div\u003e","brand":"NorrChemica™","offers":[{"title":"2.0 g","offer_id":52690413781329,"sku":"NOR-951779-2g","price":34.2,"currency_code":"EUR","in_stock":true},{"title":"5.0 g","offer_id":52690413814097,"sku":"NOR-951779-5g","price":47.2,"currency_code":"EUR","in_stock":true},{"title":"10 g","offer_id":52690413846865,"sku":"NOR-951779-10g","price":64.2,"currency_code":"EUR","in_stock":true},{"title":"25 g","offer_id":52690413879633,"sku":"NOR-951779-25g","price":98.2,"currency_code":"EUR","in_stock":true},{"title":"50 g","offer_id":52690413912401,"sku":"NOR-951779-50g","price":179.2,"currency_code":"EUR","in_stock":true},{"title":"100 g","offer_id":52690413945169,"sku":"NOR-951779-100g","price":269.2,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0954\/6357\/1793\/files\/NorrChemica_2-Deoxycytidine.png?v=1782683270"},{"product_id":"thymine-5-methyluracil-cas-65-71-4","title":"Thymine | CAS 65-71-4 | ≥99%","description":"\u003cdiv style=\"margin-bottom: 28px;\"\u003e\n\u003cdiv style=\"background: #002147; padding: 10px 20px; margin-bottom: 0;\"\u003e  \u003ch3 style=\"margin: 0; font-family: 'Helvetica Neue', Helvetica, Arial, sans-serif; font-size: 0.70em; font-weight: 700; letter-spacing: 0.12em; text-transform: uppercase; color: #fff;\"\u003eTechnical Specifications\u003c\/h3\u003e\n\u003c\/div\u003e\n\u003ctable style=\"width: 100%; border-collapse: collapse; font-size: 0.95em; border: 1px solid #e4e8f0; border-top: none; font-family: 'Helvetica Neue', Helvetica, Arial, sans-serif;\"\u003e\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eCAS Number\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e65-71-4\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eEC \/ EINECS Number\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e200-616-1\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eMDL Number\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003eMFCD00006026\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eRTECS Number\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003eXP2100000\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eSMILES\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0; word-break: break-all;\"\u003eCC1=CNC(=O)NC1=O\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eInChI\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0; word-break: break-all;\"\u003eInChI=1S\/C5H6N2O2\/c1-3-2-6-5(9)7-4(3)8\/h2H,1H3,(H2,6,7,8,9)\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eInChIKey\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0; word-break: break-all;\"\u003eRWQNBRDOKXIBIV-UHFFFAOYSA-N\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003ePubChem CID\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e1135\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eMolecular Formula\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003eC₅H₆N₂O₂\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eMolecular Weight\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e126.11 g\/mol\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eMelting Point\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e320–330 °C\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eSolubility\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003eSparingly soluble in water at RT; soluble in dilute alkali, dilute acid, and DMF; slightly soluble in ethanol\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003ePurity\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e≥99%\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003ePhysical Form\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003eWhite crystalline powder\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eHS Code\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e2933.59\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eShelf Life\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003eRetest period: 36 months from date of manufacture\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eStorage Conditions\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003eStore at room temperature in a tightly sealed container, protected from moisture\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\u003c\/table\u003e\n\u003c\/div\u003e\u003cdiv style=\"margin-bottom: 28px;\"\u003e\n\u003cdiv style=\"background: #002147; padding: 10px 20px; margin-bottom: 0;\"\u003e  \u003ch3 style=\"margin: 0; font-family: 'Helvetica Neue', Helvetica, Arial, sans-serif; font-size: 0.70em; font-weight: 700; letter-spacing: 0.12em; text-transform: uppercase; color: #fff;\"\u003eProduct Description \u0026amp; Scientific Applications\u003c\/h3\u003e\n\u003c\/div\u003e\n\u003cdiv style=\"padding: 16px 20px; border: 1px solid #e4e8f0; border-top: none; font-family: Georgia, 'Times New Roman', serif; font-size: 0.95em; line-height: 1.65; color: #333;\"\u003e\n\u003cp\u003e\u003cstrong\u003eThymine\u003c\/strong\u003e (5-methylpyrimidine-2,4(1\u003cem\u003eH\u003c\/em\u003e,3\u003cem\u003eH\u003c\/em\u003e)-dione; 5-methyluracil) is one of the four canonical DNA nucleobases and the adenine partner in the Watson–Crick T·A pair (N3-H···N1 and C4=O···H-N6). The C5-methyl distinguishes it from uracil and is the marker by which repair recognises uracil from cytosine deamination as abnormal. UV absorption peaks at 263.8 nm; the fluorescence quantum yield is low (ΦF ≈ 1×10−4), from ultrafast non-radiative decay.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eUV photochemistry and pyrimidine dimers.\u003c\/strong\u003e Thymine is the standard model for UV photochemistry. At adjacent pyrimidines, cyclobutane pyrimidine dimers form by [2+2] cycloaddition of two stacked C5=C6 bonds — cis-syn dominant in B-DNA, barrierless, complete in ~1 ps, quantum yield ~1%. Pyrimidine (6-4) photoproducts form by a Paternò–Büchi reaction between the 5′-C5=C6 bond and the 3′-C4 carbonyl via an oxetane; they are less abundant, more efficiently excised by nucleotide excision repair, and isomerise to Dewar forms under UVA. Thymine, thymidine, and TpT model dimer kinetics, photoreversal, and photolyase recognition.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eWatson–Crick recognition.\u003c\/strong\u003e The T·A pair is the benchmark two-bond pair for base-pair thermodynamics, and thymine is built into receptors, macrocycles, and supramolecular assemblies that recognise adenine and ATP.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eNucleoside synthesis.\u003c\/strong\u003e Persilylated thymine (HMDS or BSA) couples to a peracylated sugar under TMSOTf or SnCl4 in acetonitrile or 1,2-dichloroethane to give thymidine and modified analogues; unprotected thymine can give the N3-glycoside, so N3 is masked as the N3-benzoyl when regiocontrol matters.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003ePNA monomer.\u003c\/strong\u003e N1-alkylation with bromo- or chloroacetate, hydrolysis, and coupling to the aminoethylglycine backbone give the thymine PNA monomer. Lacking an exocyclic amine, thymine needs no base protection — the shortest of the four canonical PNA monomer routes.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eAnalytical standard.\u003c\/strong\u003e Reference for HPLC-UV and LC-MS\/MS quantification of pyrimidine bases and catabolites, with labelled thymine as internal standard.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\u003cdiv style=\"margin-bottom: 28px;\"\u003e\n\u003cdiv style=\"background: #002147; padding: 10px 20px; margin-bottom: 0;\"\u003e  \u003ch3 style=\"margin: 0; font-family: 'Helvetica Neue', Helvetica, Arial, sans-serif; font-size: 0.70em; font-weight: 700; letter-spacing: 0.12em; text-transform: uppercase; color: #fff;\"\u003eShipping Destinations\u003c\/h3\u003e\n\u003c\/div\u003e\n\u003cdiv style=\"border: 1px solid #e4e8f0; border-top: none; padding: 12px 16px; font-family: 'Helvetica Neue', Helvetica, Arial, sans-serif; font-size: 0.95em;\"\u003e\u003cul style=\"margin: 0; padding: 0; list-style: none;\"\u003e\n\u003cli style=\"padding: 5px 0; border-bottom: 1px solid #f0f0f0;\"\u003e\n\u003cspan style=\"display: inline-block; width: 7px; height: 7px; background: #002147; border-radius: 50%; margin-right: 10px; vertical-align: middle;\"\u003e\u003c\/span\u003eEU \u0026amp; UK: Priority delivery, 2–5 business days.\u003c\/li\u003e\n\u003cli style=\"padding: 5px 0; border-bottom: 1px solid #f0f0f0;\"\u003e\n\u003cspan style=\"display: inline-block; width: 7px; height: 7px; background: #002147; border-radius: 50%; margin-right: 10px; vertical-align: middle;\"\u003e\u003c\/span\u003eUnited States (DDP): 3–7 business days, duties and taxes prepaid.\u003c\/li\u003e\n\u003cli style=\"padding: 5px 0; border-bottom: 1px solid #f0f0f0;\"\u003e\n\u003cspan style=\"display: inline-block; width: 7px; height: 7px; background: #002147; border-radius: 50%; margin-right: 10px; vertical-align: middle;\"\u003e\u003c\/span\u003eEFTA Countries (DDP): 3–7 business days, duties and taxes prepaid.\u003c\/li\u003e\n\u003cli style=\"padding: 5px 0; border-bottom: 1px solid #f0f0f0;\"\u003e\n\u003cspan style=\"display: inline-block; width: 7px; height: 7px; background: #002147; border-radius: 50%; margin-right: 10px; vertical-align: middle;\"\u003e\u003c\/span\u003eWorldwide: 7–14 business days, selected locations.\u003c\/li\u003e\n\u003c\/ul\u003e\u003c\/div\u003e\n\u003c\/div\u003e","brand":"NorrChemica™","offers":[{"title":"25 g","offer_id":52690517426513,"sku":"NOR-65714-25g","price":34.2,"currency_code":"EUR","in_stock":true},{"title":"50 g","offer_id":52690517459281,"sku":"NOR-65714-50g","price":43.2,"currency_code":"EUR","in_stock":true},{"title":"100 g","offer_id":52690517492049,"sku":"NOR-65714-100g","price":54.2,"currency_code":"EUR","in_stock":true},{"title":"250 g","offer_id":52690517524817,"sku":"NOR-65714-250g","price":69.2,"currency_code":"EUR","in_stock":true},{"title":"500 g","offer_id":52690517557585,"sku":"NOR-65714-500g","price":109.2,"currency_code":"EUR","in_stock":true},{"title":"1 kg","offer_id":52690517590353,"sku":"NOR-65714-1kg","price":198.2,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0954\/6357\/1793\/files\/NorrChemica_Thymine.png?v=1782683270"},{"product_id":"uracil-cas-66-22-8","title":"Uracil | CAS 66-22-8 | ≥99%","description":"\u003cdiv style=\"margin-bottom: 28px;\"\u003e\n\u003cdiv style=\"background: #002147; padding: 10px 20px; margin-bottom: 0;\"\u003e  \u003ch3 style=\"margin: 0; font-family: 'Helvetica Neue', Helvetica, Arial, sans-serif; font-size: 0.70em; font-weight: 700; letter-spacing: 0.12em; text-transform: uppercase; color: #fff;\"\u003eTechnical Specifications\u003c\/h3\u003e\n\u003c\/div\u003e\n\u003ctable style=\"width: 100%; border-collapse: collapse; font-size: 0.95em; border: 1px solid #e4e8f0; border-top: none; font-family: 'Helvetica Neue', Helvetica, Arial, sans-serif;\"\u003e\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eCAS Number\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e66-22-8\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eEC \/ EINECS Number\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e200-621-9\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eMDL Number\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003eMFCD00006016\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eRTECS Number\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003eYQ8650000\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eSMILES\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0; word-break: break-all;\"\u003eC1=CNC(=O)NC1=O\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eInChI\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0; word-break: break-all;\"\u003eInChI=1S\/C4H4N2O2\/c7-3-1-2-5-4(8)6-3\/h1-2H,(H2,5,6,7,8)\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eInChIKey\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0; word-break: break-all;\"\u003eISAKRJDGNUQOIC-UHFFFAOYSA-N\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003ePubChem CID\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e1174\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eMolecular Formula\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003eC₄H₄N₂O₂\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eMolecular Weight\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e112.09 g\/mol\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eMelting Point\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e\u0026gt;300 °C (dec.)\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eSolubility\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003eSparingly soluble in water at RT; soluble in dilute alkali, dilute acid, and ammonia; practically insoluble in ethanol and diethyl ether\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003ePurity\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e≥99%\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003ePhysical Form\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003eWhite crystalline powder\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eHS Code\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e2933.59\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eShelf Life\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003eRetest period: 36 months from date of manufacture\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eStorage Conditions\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003eStore at room temperature in a tightly sealed container under inert atmosphere\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\u003c\/table\u003e\n\u003c\/div\u003e\u003cdiv style=\"margin-bottom: 28px;\"\u003e\n\u003cdiv style=\"background: #002147; padding: 10px 20px; margin-bottom: 0;\"\u003e  \u003ch3 style=\"margin: 0; font-family: 'Helvetica Neue', Helvetica, Arial, sans-serif; font-size: 0.70em; font-weight: 700; letter-spacing: 0.12em; text-transform: uppercase; color: #fff;\"\u003eProduct Description \u0026amp; Scientific Applications\u003c\/h3\u003e\n\u003c\/div\u003e\n\u003cdiv style=\"padding: 16px 20px; border: 1px solid #e4e8f0; border-top: none; font-family: Georgia, 'Times New Roman', serif; font-size: 0.95em; line-height: 1.65; color: #333;\"\u003e\n\u003cp\u003e\u003cstrong\u003eUracil (pyrimidine-2,4(1\u003c\/strong\u003e\u003cstrong\u003e\u003cem\u003eH\u003c\/em\u003e\u003c\/strong\u003e\u003cstrong\u003e,3\u003c\/strong\u003e\u003cstrong\u003e\u003cem\u003eH\u003c\/em\u003e\u003c\/strong\u003e\u003cstrong\u003e)-dione) \u003c\/strong\u003eis a canonical RNA nucleobase, pairing with adenine through two hydrogen bonds (N3-H···N1 and C4=O···H-N6). It differs from thymine only in lacking the C5-methyl group; the free C5-H position is a handle for C5 halogenation and electrophilic derivatisation. UV absorption peaks at 258.3 nm (ε ≈ 8,200 M⁻¹cm⁻¹), with very low fluorescence quantum yield.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eNucleoside synthesis.\u003c\/strong\u003e Parent nucleobase for uridine, 2′-deoxyuridine, and modified uridine analogues by Vorbrüggen \/ silyl-Hilbert-Johnson glycosylation: uracil is silylated (HMDS, BSA, or TMSCl\/HMDS), then coupled with a peracylated sugar donor under TMSOTf or SnCl4. N3-benzoyluracil masks N3 for N1 regiocontrol. Products are elaborated to uridine 5′-phosphates and oligoribonucleotide phosphoramidite building blocks. Uracil also gives uracil-PNA monomers, which need no nucleobase amine protection.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eYeast URA3 selection.\u003c\/strong\u003e Standard supplement for synthetic defined media culturing \u003cem\u003eSaccharomyces cerevisiae\u003c\/em\u003e ura3 strains, which cannot generate UMP and depend on exogenous uracil. URA3 (orotidine-5′-phosphate decarboxylase) is a widely used selectable marker on SC−Ura media and enables 5-fluoroorotic acid counter-selection.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eWatson–Crick model.\u003c\/strong\u003e Benchmark nucleobase for the uracil·adenine pair in RNA duplex thermodynamics, base-pair kinetics, and mismatch discrimination, and a hydrogen-bonding handle in synthetic receptors that recognise adenine, AMP, and ATP.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003ePyrimidine catabolism.\u003c\/strong\u003e Uracil and its metabolite dihydrouracil are the analyte pair for dihydropyrimidine dehydrogenase (DPD) activity; the plasma uracil:dihydrouracil ratio is a surrogate readout of DPD status by HPLC and LC-MS\/MS.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eAnalytical reference standard.\u003c\/strong\u003e Standard void-volume \/ dead-time marker for reversed-phase C18 method development, combining weak retention with a strong UV chromophore at 260 nm; included in NIST SRM 870. Also a calibration standard for HPLC and LC-MS quantification of free pyrimidine bases and genomic-uracil incorporation.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\u003cdiv style=\"margin-bottom: 28px;\"\u003e\n\u003cdiv style=\"background: #002147; padding: 10px 20px; margin-bottom: 0;\"\u003e  \u003ch3 style=\"margin: 0; font-family: 'Helvetica Neue', Helvetica, Arial, sans-serif; font-size: 0.70em; font-weight: 700; letter-spacing: 0.12em; text-transform: uppercase; color: #fff;\"\u003eShipping Destinations\u003c\/h3\u003e\n\u003c\/div\u003e\n\u003cdiv style=\"border: 1px solid #e4e8f0; border-top: none; padding: 12px 16px; font-family: 'Helvetica Neue', Helvetica, Arial, sans-serif; font-size: 0.95em;\"\u003e\u003cul style=\"margin: 0; padding: 0; list-style: none;\"\u003e\n\u003cli style=\"padding: 5px 0; border-bottom: 1px solid #f0f0f0;\"\u003e\n\u003cspan style=\"display: inline-block; width: 7px; height: 7px; background: #002147; border-radius: 50%; margin-right: 10px; vertical-align: middle;\"\u003e\u003c\/span\u003eEU \u0026amp; UK: Priority delivery, 2–5 business days.\u003c\/li\u003e\n\u003cli style=\"padding: 5px 0; border-bottom: 1px solid #f0f0f0;\"\u003e\n\u003cspan style=\"display: inline-block; width: 7px; height: 7px; background: #002147; border-radius: 50%; margin-right: 10px; vertical-align: middle;\"\u003e\u003c\/span\u003eUnited States (DDP): 3–7 business days, duties and taxes prepaid.\u003c\/li\u003e\n\u003cli style=\"padding: 5px 0; border-bottom: 1px solid #f0f0f0;\"\u003e\n\u003cspan style=\"display: inline-block; width: 7px; height: 7px; background: #002147; border-radius: 50%; margin-right: 10px; vertical-align: middle;\"\u003e\u003c\/span\u003eEFTA Countries (DDP): 3–7 business days, duties and taxes prepaid.\u003c\/li\u003e\n\u003cli style=\"padding: 5px 0; border-bottom: 1px solid #f0f0f0;\"\u003e\n\u003cspan style=\"display: inline-block; width: 7px; height: 7px; background: #002147; border-radius: 50%; margin-right: 10px; vertical-align: middle;\"\u003e\u003c\/span\u003eWorldwide: 7–14 business days, selected locations.\u003c\/li\u003e\n\u003c\/ul\u003e\u003c\/div\u003e\n\u003c\/div\u003e","brand":"NorrChemica™","offers":[{"title":"25 g","offer_id":52691016122705,"sku":"NOR-66228-25g","price":39.9,"currency_code":"EUR","in_stock":true},{"title":"50 g","offer_id":52691016155473,"sku":"NOR-66228-50g","price":49.0,"currency_code":"EUR","in_stock":true},{"title":"100 g","offer_id":52691016188241,"sku":"NOR-66228-100g","price":59.9,"currency_code":"EUR","in_stock":true},{"title":"250 g","offer_id":52691148505425,"sku":"NOR-66228-250g","price":69.2,"currency_code":"EUR","in_stock":true},{"title":"500 g","offer_id":52691016221009,"sku":"NOR-66228-500g","price":98.2,"currency_code":"EUR","in_stock":true},{"title":"1 kg","offer_id":52691016253777,"sku":"NOR-66228-1kg","price":154.2,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0954\/6357\/1793\/files\/NorrChemica_Uracil.png?v=1782683270"},{"product_id":"n1-acetylthymine-cas-13251-16-6","title":"N1-Acetylthymine | CAS 13251-16-6 | ≥99%","description":"\u003cdiv style=\"margin-bottom: 28px;\"\u003e\n\u003cdiv style=\"background: #002147; padding: 10px 20px; margin-bottom: 0;\"\u003e  \u003ch3 style=\"margin: 0; font-family: 'Helvetica Neue', Helvetica, Arial, sans-serif; font-size: 0.70em; font-weight: 700; letter-spacing: 0.12em; text-transform: uppercase; color: #fff;\"\u003eTechnical Specifications\u003c\/h3\u003e\n\u003c\/div\u003e\n\u003ctable style=\"width: 100%; border-collapse: collapse; font-size: 0.95em; border: 1px solid #e4e8f0; border-top: none; font-family: 'Helvetica Neue', Helvetica, Arial, sans-serif;\"\u003e\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eCAS Number\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e13251-16-6\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eMDL Number\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003eMFCD00887709\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eSMILES\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0; word-break: break-all;\"\u003eCC1=CN(C(=O)NC1=O)C(=O)C\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eInChI\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0; word-break: break-all;\"\u003eInChI=1S\/C7H8N2O3\/c1-4-3-9(5(2)10)7(12)8-6(4)11\/h3H,1-2H3,(H,8,11,12)\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eInChIKey\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0; word-break: break-all;\"\u003eYBXJEAPQVULNKE-UHFFFAOYSA-N\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003ePubChem CID\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e667607\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eMolecular Formula\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003eC₇H₈N₂O₃\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eMolecular Weight\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e168.15 g\/mol\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eSolubility\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003eSoluble in DMF, DMSO, and ethanol; sparingly soluble in water\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003ePurity\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e≥99%\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003ePhysical Form\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003eWhite to off-white crystalline powder\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eHS Code\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e2933.59\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eShelf Life\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003eRetest period: 36 months from date of manufacture\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eStorage Conditions\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003eStore at room temperature in a tightly sealed container, protected from moisture\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\u003c\/table\u003e\n\u003c\/div\u003e\u003cdiv style=\"margin-bottom: 28px;\"\u003e\n\u003cdiv style=\"background: #002147; padding: 10px 20px; margin-bottom: 0;\"\u003e  \u003ch3 style=\"margin: 0; font-family: 'Helvetica Neue', Helvetica, Arial, sans-serif; font-size: 0.70em; font-weight: 700; letter-spacing: 0.12em; text-transform: uppercase; color: #fff;\"\u003eProduct Description \u0026amp; Scientific Applications\u003c\/h3\u003e\n\u003c\/div\u003e\n\u003cdiv style=\"padding: 16px 20px; border: 1px solid #e4e8f0; border-top: none; font-family: Georgia, 'Times New Roman', serif; font-size: 0.95em; line-height: 1.65; color: #333;\"\u003e\n\u003cp\u003e\u003cstrong\u003eN1-Acetylthymine\u003c\/strong\u003e blocks N1 tautomerism, inverts the usual thymine preferential reactivity at N1 and leaves the N3 imide as the only N-H site amenable for deprotonation under basic conditions and trapping with alkylating, acylating, or linker reagents. The acetyl is labile enough that careful control of the reaction conditions allows either the direct obtention of N1-acetyl-N3-substituted thymine derivatives or the acetyl acting as a transient protecting group that is concomitantly removed yielding the N3-substituted derivatives.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eMild acetyl-transfer reagent.\u003c\/strong\u003e The N1-acetyl sits in an N-acyl pyrimidinone\/acyl-imide environment rather than an ordinary dialkylamide — an activated acyl donor transferring to nucleophiles under mild conditions, softer than acetic anhydride or acetyl chloride for sensitive substrates, and a model for the N-acyl pyrimidinone class. Transfer regenerates thymine and is followed by HPLC, LC-MS, or NMR.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eDeacetylation methodology.\u003c\/strong\u003e The N1-acetyl is a model handle for screening N-acetyl cleavage rates and checking whether N3 substituents, C5 side chains, or other sensitive groups survive basic or nucleophilic work-up, and for tracking N-acyl migration and over-acylation.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eC5-methyl chemistry.\u003c\/strong\u003e With N1 silent, the C5-methyl remains open to bromomethyl, hydroxymethyl, formyl, aminomethyl, thiomethyl, and related derivatives, each tested on the scaffold since N-acyl protection, acidity, and work-up can change the outcome.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\u003cdiv style=\"margin-bottom: 28px;\"\u003e\n\u003cdiv style=\"background: #002147; padding: 10px 20px; margin-bottom: 0;\"\u003e  \u003ch3 style=\"margin: 0; font-family: 'Helvetica Neue', Helvetica, Arial, sans-serif; font-size: 0.70em; font-weight: 700; letter-spacing: 0.12em; text-transform: uppercase; color: #fff;\"\u003eShipping Destinations\u003c\/h3\u003e\n\u003c\/div\u003e\n\u003cdiv style=\"border: 1px solid #e4e8f0; border-top: none; padding: 12px 16px; font-family: 'Helvetica Neue', Helvetica, Arial, sans-serif; font-size: 0.95em;\"\u003e\u003cul style=\"margin: 0; padding: 0; list-style: none;\"\u003e\n\u003cli style=\"padding: 5px 0; border-bottom: 1px solid #f0f0f0;\"\u003e\n\u003cspan style=\"display: inline-block; width: 7px; height: 7px; background: #002147; border-radius: 50%; margin-right: 10px; vertical-align: middle;\"\u003e\u003c\/span\u003eEU \u0026amp; UK: Priority delivery, 2–5 business days.\u003c\/li\u003e\n\u003cli style=\"padding: 5px 0; border-bottom: 1px solid #f0f0f0;\"\u003e\n\u003cspan style=\"display: inline-block; width: 7px; height: 7px; background: #002147; border-radius: 50%; margin-right: 10px; vertical-align: middle;\"\u003e\u003c\/span\u003eUnited States (DDP): 3–7 business days, duties and taxes prepaid.\u003c\/li\u003e\n\u003cli style=\"padding: 5px 0; border-bottom: 1px solid #f0f0f0;\"\u003e\n\u003cspan style=\"display: inline-block; width: 7px; height: 7px; background: #002147; border-radius: 50%; margin-right: 10px; vertical-align: middle;\"\u003e\u003c\/span\u003eEFTA Countries (DDP): 3–7 business days, duties and taxes prepaid.\u003c\/li\u003e\n\u003cli style=\"padding: 5px 0; border-bottom: 1px solid #f0f0f0;\"\u003e\n\u003cspan style=\"display: inline-block; width: 7px; height: 7px; background: #002147; border-radius: 50%; margin-right: 10px; vertical-align: middle;\"\u003e\u003c\/span\u003eWorldwide: 7–14 business days, selected locations.\u003c\/li\u003e\n\u003c\/ul\u003e\u003c\/div\u003e\n\u003c\/div\u003e","brand":"NorrChemica™","offers":[{"title":"500 mg","offer_id":53785069420881,"sku":"NOR-13251166-500mg","price":49.8,"currency_code":"EUR","in_stock":true},{"title":"1.0 g","offer_id":52693786394961,"sku":"NOR-13251166-1g","price":89.2,"currency_code":"EUR","in_stock":true},{"title":"5.0 g","offer_id":52693723185489,"sku":"NOR-13251166-5g","price":198.2,"currency_code":"EUR","in_stock":true},{"title":"10 g","offer_id":52693723152721,"sku":"NOR-13251166-10g","price":349.2,"currency_code":"EUR","in_stock":true},{"title":"25 g","offer_id":52693723119953,"sku":"NOR-13251166-25g","price":629.2,"currency_code":"EUR","in_stock":true},{"title":"50 g","offer_id":52693786427729,"sku":"NOR-13251166-50g","price":1195.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0954\/6357\/1793\/files\/NorrChemica_N1-Acetylthymine.png?v=1782683270"},{"product_id":"tbs-isopropylidene-d-ribonolactone-cas-75467-36-6","title":"TBS-Isopropylidene-D-ribonolactone | CAS 75467-36-6 | ≥97%","description":"\u003cdiv style=\"margin-bottom: 28px;\"\u003e\n\u003cdiv style=\"background: #002147; padding: 10px 20px; margin-bottom: 0;\"\u003e  \u003ch3 style=\"margin: 0; font-family: 'Helvetica Neue', Helvetica, Arial, sans-serif; font-size: 0.70em; font-weight: 700; letter-spacing: 0.12em; text-transform: uppercase; color: #fff;\"\u003eTechnical Specifications\u003c\/h3\u003e\n\u003c\/div\u003e\n\u003ctable style=\"width: 100%; border-collapse: collapse; font-size: 0.95em; border: 1px solid #e4e8f0; border-top: none; font-family: 'Helvetica Neue', Helvetica, Arial, sans-serif;\"\u003e\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eCAS Number\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e75467-36-6\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eEC \/ EINECS Number\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e623-023-3\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eMDL Number\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003eMFCD00216623\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eSMILES\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0; word-break: break-all;\"\u003eCC1(O[C@@H]2[C@H](OC(=O)[C@@H]2O1)CO[Si](C)(C)C(C)(C)C)C\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eInChI\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0; word-break: break-all;\"\u003eInChI=1S\/C14H26O5Si\/c1-13(2,3)20(6,7)16-8-9-10-11(12(15)17-9)19-14(4,5)18-10\/h9-11H,8H2,1-7H3\/t9-,10-,11-\/m1\/s1\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eInChIKey\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0; word-break: break-all;\"\u003eVBPYRQYBEKHPKA-GMTAPVOTSA-N\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003ePubChem CID\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e10913693\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eMolecular Formula\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003eC₁₄H₂₆O₅Si\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eMolecular Weight\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e302.44 g\/mol\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eMelting Point\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e72-74 °C\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eSolubility\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003eSoluble in common organic solvents\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eLog P\u003csub\u003eow\u003c\/sub\u003e\n\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e2.45 (predicted, XLogP3)\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003ePurity\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e≥97%\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003ePhysical Form\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003eWhite crystalline powder\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eHS Code\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e2932.20\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eShelf Life\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003eRetest period: 24 months from date of manufacture\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eStorage Conditions\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003eStore at 2-8 °C in a tightly sealed container in a dry place\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\u003c\/table\u003e\n\u003c\/div\u003e\u003cdiv style=\"margin-bottom: 28px;\"\u003e\n\u003cdiv style=\"background: #002147; padding: 10px 20px; margin-bottom: 0;\"\u003e  \u003ch3 style=\"margin: 0; font-family: 'Helvetica Neue', Helvetica, Arial, sans-serif; font-size: 0.70em; font-weight: 700; letter-spacing: 0.12em; text-transform: uppercase; color: #fff;\"\u003eProduct Description \u0026amp; Scientific Applications\u003c\/h3\u003e\n\u003c\/div\u003e\n\u003cdiv style=\"padding: 16px 20px; border: 1px solid #e4e8f0; border-top: none; font-family: Georgia, 'Times New Roman', serif; font-size: 0.95em; line-height: 1.65; color: #333;\"\u003e\n\u003cp\u003e\u003cstrong\u003eTBS-Isopropylidene-D-ribonolactone\u003c\/strong\u003e (5-\u003cem\u003eO\u003c\/em\u003e-(\u003cem\u003etert\u003c\/em\u003e-butyldimethylsilyl)-2,3-\u003cem\u003eO\u003c\/em\u003e-isopropylidene-D-ribono-1,4-lactone) is a dual-protected D-ribose-derived γ-lactone. The 5-hydroxyl is a fluoride-labile TBS ether, the 2,3-diol an acid-labile isopropylidene acetal, and the lactone carbonyl is free for C–C bond formation, reduction, and ring-opening. The bicyclic acetonide-fused ring holds the C2, C3, and C4 stereochemistry of D-ribose while C1 is elaborated — a rigid chiral-pool scaffold that biases facial selectivity at the carbonyl.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eC-nucleoside synthesis.\u003c\/strong\u003e A carbon nucleophile — lithiated heteroarenes or Grignard reagents — adds to the lactone carbonyl to give a lactol, which is deoxygenated through a Lewis-acid oxocarbenium ion trapped by hydride or carbon to give the C-glycoside, replacing the natural C–N linkage with a C–C bond. Anomeric selectivity is set at the addition and at the oxocarbenium step, governed by the oxocarbenium conformation and the C2\/C3 substituents; α:β is route-specific. The sequence builds uracil, maleimide, deazapurine, pyrazolopyrimidine, and pyrrolotriazine C-glycoside scaffolds.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eLactone elaboration.\u003c\/strong\u003e Low-temperature DIBAL-H reduction gives the lactol, a branch point for further C-nucleophile addition, reductive deoxygenation with triethylsilane and a Lewis acid, or \u003cem\u003eO\u003c\/em\u003e-acetylation or fluoride at the anomeric position. Stronger reduction opens the lactone to protected polyols, and olefination or homologation extends the ribose skeleton — routes to branched-chain sugars, deoxy-ribose variants, and protected polyhydroxylated targets.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eOrthogonal deprotection.\u003c\/strong\u003e The TBS ether comes off with fluoride (TBAF, HF·pyridine, or triethylamine trihydrofluoride) to expose the primary 5-OH for oxidation, phosphorylation, or chain extension; the acetonide comes off under mild acid to reveal the 2,3-cis-diol. The two handles are staged independently, so the 5-OH, the diol, and the lactone each enter the sequence on demand.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\u003cdiv style=\"margin-bottom: 28px;\"\u003e\n\u003cdiv style=\"background: #002147; padding: 10px 20px; margin-bottom: 0;\"\u003e  \u003ch3 style=\"margin: 0; font-family: 'Helvetica Neue', Helvetica, Arial, sans-serif; font-size: 0.70em; font-weight: 700; letter-spacing: 0.12em; text-transform: uppercase; color: #fff;\"\u003eShipping Destinations\u003c\/h3\u003e\n\u003c\/div\u003e\n\u003cdiv style=\"border: 1px solid #e4e8f0; border-top: none; padding: 12px 16px; font-family: 'Helvetica Neue', Helvetica, Arial, sans-serif; font-size: 0.95em;\"\u003e\u003cul style=\"margin: 0; padding: 0; list-style: none;\"\u003e\n\u003cli style=\"padding: 5px 0; border-bottom: 1px solid #f0f0f0;\"\u003e\n\u003cspan style=\"display: inline-block; width: 7px; height: 7px; background: #002147; border-radius: 50%; margin-right: 10px; vertical-align: middle;\"\u003e\u003c\/span\u003eEU \u0026amp; UK: Priority delivery, 2–5 business days.\u003c\/li\u003e\n\u003cli style=\"padding: 5px 0; border-bottom: 1px solid #f0f0f0;\"\u003e\n\u003cspan style=\"display: inline-block; width: 7px; height: 7px; background: #002147; border-radius: 50%; margin-right: 10px; vertical-align: middle;\"\u003e\u003c\/span\u003eUnited States (DDP): 3–7 business days, duties and taxes prepaid.\u003c\/li\u003e\n\u003cli style=\"padding: 5px 0; border-bottom: 1px solid #f0f0f0;\"\u003e\n\u003cspan style=\"display: inline-block; width: 7px; height: 7px; background: #002147; border-radius: 50%; margin-right: 10px; vertical-align: middle;\"\u003e\u003c\/span\u003eEFTA Countries (DDP): 3–7 business days, duties and taxes prepaid.\u003c\/li\u003e\n\u003cli style=\"padding: 5px 0; border-bottom: 1px solid #f0f0f0;\"\u003e\n\u003cspan style=\"display: inline-block; width: 7px; height: 7px; background: #002147; border-radius: 50%; margin-right: 10px; vertical-align: middle;\"\u003e\u003c\/span\u003eWorldwide: 7–14 business days, selected locations.\u003c\/li\u003e\n\u003c\/ul\u003e\u003c\/div\u003e\n\u003c\/div\u003e","brand":"NorrChemica™","offers":[{"title":"1.0 g","offer_id":52695987454289,"sku":"NOR-75467366-1g","price":69.9,"currency_code":"EUR","in_stock":true},{"title":"2.0 g","offer_id":52695987487057,"sku":"NOR-75467366-2g","price":98.8,"currency_code":"EUR","in_stock":true},{"title":"5.0 g","offer_id":52695987519825,"sku":"NOR-75467366-5g","price":198.8,"currency_code":"EUR","in_stock":true},{"title":"10 g","offer_id":52695987552593,"sku":"NOR-75467366-10g","price":329.55,"currency_code":"EUR","in_stock":true},{"title":"25 g","offer_id":52695987585361,"sku":"NOR-75467366-25g","price":625.0,"currency_code":"EUR","in_stock":true},{"title":"50 g","offer_id":52695987618129,"sku":"NOR-75467366-50g","price":1100.0,"currency_code":"EUR","in_stock":true},{"title":"100 g","offer_id":52696033100113,"sku":"NOR-75467366-100g","price":1900.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0954\/6357\/1793\/files\/NorrChemica_TBS-Isopropylidene-D-ribonolactone.png?v=1782683270"},{"product_id":"5-fluorouracil-cas-51-21-8","title":"5-Fluorouracil (5-FU) | CAS 51-21-8 | ≥99%","description":"\u003cdiv style=\"margin-bottom: 28px;\"\u003e\n\u003cdiv style=\"background: #002147; padding: 10px 20px; margin-bottom: 0;\"\u003e  \u003ch3 style=\"margin: 0; font-family: 'Helvetica Neue', Helvetica, Arial, sans-serif; font-size: 0.70em; font-weight: 700; letter-spacing: 0.12em; text-transform: uppercase; color: #fff;\"\u003eTechnical Specifications\u003c\/h3\u003e\n\u003c\/div\u003e\n\u003ctable style=\"width: 100%; border-collapse: collapse; font-size: 0.95em; border: 1px solid #e4e8f0; border-top: none; font-family: 'Helvetica Neue', Helvetica, Arial, sans-serif;\"\u003e\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eCAS Number\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e51-21-8\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eEC \/ EINECS Number\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e200-085-6\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eMDL Number\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003eMFCD00006018\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eRTECS Number\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003eYR0350000\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eSMILES\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0; word-break: break-all;\"\u003eC1=C(C(=O)NC(=O)N1)F\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eInChI\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0; word-break: break-all;\"\u003eInChI=1S\/C4H3FN2O2\/c5-2-1-6-4(9)7-3(2)8\/h1H,(H2,6,7,8,9)\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eInChIKey\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0; word-break: break-all;\"\u003eGHASVSINZRGABV-UHFFFAOYSA-N\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003ePubChem CID\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e3385\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eMolecular Formula\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003eC₄H₃FN₂O₂\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eMolecular Weight\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e130.08 g\/mol\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eMelting Point\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e282-286 °C (dec.)\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eSolubility\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003eSoluble in water (~12 g\/L at 20 °C); slightly soluble in ethanol; soluble in dilute HCl and NaOH\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eLog P\u003csub\u003eow\u003c\/sub\u003e\n\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e-0.9\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003ePurity\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e≥99%\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003ePhysical Form\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003eWhite crystalline solid\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eHS Code\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e2933.59\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eShelf Life\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003eRetest period: 36 months from date of manufacture\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eStorage Conditions\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003eStore at room temperature in a tightly sealed container in a dry place, protected from light\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\u003c\/table\u003e\n\u003c\/div\u003e\u003cdiv style=\"margin-bottom: 28px;\"\u003e\n\u003cdiv style=\"background: #002147; padding: 10px 20px; margin-bottom: 0;\"\u003e  \u003ch3 style=\"margin: 0; font-family: 'Helvetica Neue', Helvetica, Arial, sans-serif; font-size: 0.70em; font-weight: 700; letter-spacing: 0.12em; text-transform: uppercase; color: #fff;\"\u003eProduct Description \u0026amp; Scientific Applications\u003c\/h3\u003e\n\u003c\/div\u003e\n\u003cdiv style=\"padding: 16px 20px; border: 1px solid #e4e8f0; border-top: none; font-family: Georgia, 'Times New Roman', serif; font-size: 0.95em; line-height: 1.65; color: #333;\"\u003e\n\u003cp\u003e\u003cstrong\u003e5-Fluorouracil \u003c\/strong\u003e(5-fluoro-2,4(1\u003cem\u003eH\u003c\/em\u003e,3\u003cem\u003eH\u003c\/em\u003e)-pyrimidinedione; 5-FU) is the C5-fluorinated analogue of uracil, used as a research probe in pyrimidine biochemistry and ¹⁹F NMR nucleic-acid work. Fluorine replaces the C5 hydrogen, preserving the uracil hydrogen-bonding face while adding a strong C–F bond, an electron-withdrawing substituent, and a spin-active ¹⁹F nucleus. Its van der Waals radius (~1.46 Å) is close to hydrogen (~1.20 Å) and far smaller than methyl, so 5-FU mimics uracil at enzyme active sites with limited steric perturbation.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eThymidylate synthase.\u003c\/strong\u003e The metabolite FdUMP (5-fluoro-2′-deoxyuridine 5′-monophosphate) mimics dUMP at thymidylate synthase (TS, EC 2.1.1.45). With 5,10-methylenetetrahydrofolate and the active-site cysteine it forms a stable covalent ternary complex that traps TS in a catalytic-intermediate-like state — the basis for TS crystallography, active-site mapping, kinetics, and ¹⁹F NMR binding studies.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eDPD catabolism.\u003c\/strong\u003e Substrate for dihydropyrimidine dehydrogenase (DPD, EC 1.3.1.2), reduced NADPH-dependently to 5-fluoro-5,6-dihydrouracil and onward to α-fluoro-β-alanine. Used for DPD kinetics and DPYD variant characterisation; the fluorine label distinguishes fluorinated catabolites from endogenous uracil metabolites by LC-MS\/MS and NMR.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eBacterial pyrimidine signalling.\u003c\/strong\u003e As a uracil analogue it perturbs uracil-linked regulatory pathways and alters biofilm formation. In \u003cem\u003eEscherichia coli\u003c\/em\u003e K-12 it reduces biofilm through the global regulator AriR; related work links it to biofilm and quorum-sensing phenotypes in \u003cem\u003ePseudomonas aeruginosa\u003c\/em\u003e.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003e¹⁹F NMR probe.\u003c\/strong\u003e Incorporated as 5-fluorouracil, 5-fluorouridine, or 5-fluoro-2′-deoxyuridine into RNA or DNA, the C5 fluorine reports local base pairing, stacking, and conformational exchange through ¹⁹F shift and linewidth, resolvable in proton-crowded spectra of tRNA and RNA models.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eAnalytical reference standard.\u003c\/strong\u003e Reference compound for fluorinated-pyrimidine quantification by HPLC-UV, LC-MS\/MS, and capillary electrophoresis — calibration, retention-time assignment, and quality control in environmental-water, hospital-effluent, and biological matrices, anchoring identification of 5-fluoro-5,6-dihydrouracil and downstream catabolites.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\u003cdiv style=\"margin-bottom: 28px;\"\u003e\n\u003cdiv style=\"background: #002147; padding: 10px 20px; margin-bottom: 0;\"\u003e  \u003ch3 style=\"margin: 0; font-family: 'Helvetica Neue', Helvetica, Arial, sans-serif; font-size: 0.70em; font-weight: 700; letter-spacing: 0.12em; text-transform: uppercase; color: #fff;\"\u003eShipping Destinations\u003c\/h3\u003e\n\u003c\/div\u003e\n\u003cdiv style=\"border: 1px solid #e4e8f0; border-top: none; padding: 12px 16px; font-family: 'Helvetica Neue', Helvetica, Arial, sans-serif; font-size: 0.95em;\"\u003e\u003cul style=\"margin: 0; padding: 0; list-style: none;\"\u003e\u003cli style=\"padding: 5px 0; border-bottom: 1px solid #f0f0f0;\"\u003e\n\u003cspan style=\"display: inline-block; width: 7px; height: 7px; background: #002147; border-radius: 50%; margin-right: 10px; vertical-align: middle;\"\u003e\u003c\/span\u003eEU, UK \u0026amp; Switzerland only: 2–7 business days\u003c\/li\u003e\u003c\/ul\u003e\u003c\/div\u003e\n\u003c\/div\u003e","brand":"NorrChemica™","offers":[{"title":"10 g","offer_id":52699134558545,"sku":"NOR-51218-10g","price":39.0,"currency_code":"EUR","in_stock":true},{"title":"25 g","offer_id":52699134591313,"sku":"NOR-51218-25g","price":49.2,"currency_code":"EUR","in_stock":true},{"title":"50 g","offer_id":52699134624081,"sku":"NOR-51218-50g","price":89.2,"currency_code":"EUR","in_stock":true},{"title":"100 g","offer_id":52699134656849,"sku":"NOR-51218-100g","price":109.0,"currency_code":"EUR","in_stock":true},{"title":"250 g","offer_id":52699134689617,"sku":"NOR-51218-250g","price":198.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0954\/6357\/1793\/files\/NorrChemica_5-Fluorouracil_5-FU.png?v=1782683270"},{"product_id":"3-methylthymidine-cas-958-74-7","title":"3-Methylthymidine | CAS 958-74-7 | ≥98%","description":"\u003cdiv style=\"margin-bottom: 28px;\"\u003e\n\u003cdiv style=\"background: #002147; padding: 10px 20px; margin-bottom: 0;\"\u003e  \u003ch3 style=\"margin: 0; font-family: 'Helvetica Neue', Helvetica, Arial, sans-serif; font-size: 0.70em; font-weight: 700; letter-spacing: 0.12em; text-transform: uppercase; color: #fff;\"\u003eTechnical Specifications\u003c\/h3\u003e\n\u003c\/div\u003e\n\u003ctable style=\"width: 100%; border-collapse: collapse; font-size: 0.95em; border: 1px solid #e4e8f0; border-top: none; font-family: 'Helvetica Neue', Helvetica, Arial, sans-serif;\"\u003e\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eCAS Number\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e958-74-7\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eMDL Number\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003eMFCD00010573\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eSMILES\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0; word-break: break-all;\"\u003eCC1=CN(C(=O)N(C1=O)C)[C@H]2C[C@@H]([C@H](O2)CO)O\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eInChI\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0; word-break: break-all;\"\u003eInChI=1S\/C11H16N2O5\/c1-6-4-13(11(17)12(2)10(6)16)9-3-7(15)8(5-14)18-9\/h4,7-9,14-15H,3,5H2,1-2H3\/t7-,8+,9+\/m0\/s1\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eInChIKey\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0; word-break: break-all;\"\u003eJCVDICFLPGDHAT-DJLDLDEBSA-N\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003ePubChem CID\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e65062\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eMolecular Formula\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003eC₁₁H₁₆N₂O₅\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eMolecular Weight\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e256.26 g\/mol\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eMelting Point\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e130-133 °C\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eSolubility\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003eSoluble in water; soluble in DMSO and methanol\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eLog P\u003csub\u003eow\u003c\/sub\u003e\n\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e-1.0\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003ePurity\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e≥98%\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003ePhysical Form\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003eWhite solid\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eHS Code\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e2934.99\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eShelf Life\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003eRetest period: 36 months from date of manufacture\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eStorage Conditions\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003eStore at 2-8 °C in a tightly sealed container, protected from light and moisture\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\u003c\/table\u003e\n\u003c\/div\u003e\u003cdiv style=\"margin-bottom: 28px;\"\u003e\n\u003cdiv style=\"background: #002147; padding: 10px 20px; margin-bottom: 0;\"\u003e  \u003ch3 style=\"margin: 0; font-family: 'Helvetica Neue', Helvetica, Arial, sans-serif; font-size: 0.70em; font-weight: 700; letter-spacing: 0.12em; text-transform: uppercase; color: #fff;\"\u003eProduct Description \u0026amp; Scientific Applications\u003c\/h3\u003e\n\u003c\/div\u003e\n\u003cdiv style=\"padding: 16px 20px; border: 1px solid #e4e8f0; border-top: none; font-family: Georgia, 'Times New Roman', serif; font-size: 0.95em; line-height: 1.65; color: #333;\"\u003e\n\u003cp\u003e\u003cstrong\u003e3-Methylthymidine\u003c\/strong\u003e is 2′-deoxythymidine carrying a methyl group on N3 — the Watson-Crick hydrogen-bond donor that forms the thymine N3–H···N1 contact in A·T pairing. The methyl sits on the base-pairing face, abolishing the donor interaction and making the residue a defined N3-alkylation lesion inside DNA; this is the key distinction from C5- or sugar-modified thymidine analogues. The N3-methyl is reversed by Fe(II)\/α-ketoglutarate-dependent dioxygenases of the AlkB family, which hydroxylate the methyl to a hydroxymethyl intermediate that loses formaldehyde, restoring the unmodified thymidine.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eAlkB-family demethylase substrate.\u003c\/strong\u003e 3-Methylthymine in DNA is repaired by bacterial AlkB and the human homologues ABH2 and ABH3 — ABH2 biased toward duplex DNA, AlkB and ABH3 active in single- and double-stranded formats. FTO is reported with 3-meT in ssDNA, 3-meU in ssRNA, and a mononucleotide complex, disfavouring duplex, and is treated separately. Use the nucleoside for analytical assignment and substrate preparation, and 3-meT oligonucleotides for kinetic profiling, AlkB\/ABH2\/ABH3 comparison, and enzyme–substrate structural work.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eDefined replication-blocking lesion.\u003c\/strong\u003e Loss of the adenine-pairing donor blocks template reading. Use the nucleoside to place a single 3-methylthymine lesion at a chosen oligonucleotide position — a clean context for polymerase stalling, primer-extension blockage, AlkB-mediated reversal, and the consequences of unrepaired N3-alkylation, without the noise of mixed chemically methylated DNA.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eAnalytical reference standard.\u003c\/strong\u003e Authentic 3-methylthymidine supports retention-time assignment and mass-spectral confirmation of methylated nucleosides released from digested DNA, where low-abundance peaks cannot be assigned by mass alone; isotope-labelled material enables absolute quantification. For damage-spectrum calibration it distinguishes methylating agents — SN2-like MMS favouring ring-nitrogen methylation (N7-methylguanine, N3-methyladenine), SN1-like MNU raising oxygen adducts (O6-methylguanine, O4-methylthymine) — with 3-methylthymine a minor product tracked against the dominant N7 and N3 lesions.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\u003cdiv style=\"margin-bottom: 28px;\"\u003e\n\u003cdiv style=\"background: #002147; padding: 10px 20px; margin-bottom: 0;\"\u003e  \u003ch3 style=\"margin: 0; font-family: 'Helvetica Neue', Helvetica, Arial, sans-serif; font-size: 0.70em; font-weight: 700; letter-spacing: 0.12em; text-transform: uppercase; color: #fff;\"\u003eShipping Destinations\u003c\/h3\u003e\n\u003c\/div\u003e\n\u003cdiv style=\"border: 1px solid #e4e8f0; border-top: none; padding: 12px 16px; font-family: 'Helvetica Neue', Helvetica, Arial, sans-serif; font-size: 0.95em;\"\u003e\u003cul style=\"margin: 0; padding: 0; list-style: none;\"\u003e\n\u003cli style=\"padding: 5px 0; border-bottom: 1px solid #f0f0f0;\"\u003e\n\u003cspan style=\"display: inline-block; width: 7px; height: 7px; background: #002147; border-radius: 50%; margin-right: 10px; vertical-align: middle;\"\u003e\u003c\/span\u003eEU \u0026amp; UK: Priority delivery, 2–5 business days.\u003c\/li\u003e\n\u003cli style=\"padding: 5px 0; border-bottom: 1px solid #f0f0f0;\"\u003e\n\u003cspan style=\"display: inline-block; width: 7px; height: 7px; background: #002147; border-radius: 50%; margin-right: 10px; vertical-align: middle;\"\u003e\u003c\/span\u003eUnited States (DDP): 3–7 business days, duties and taxes prepaid.\u003c\/li\u003e\n\u003cli style=\"padding: 5px 0; border-bottom: 1px solid #f0f0f0;\"\u003e\n\u003cspan style=\"display: inline-block; width: 7px; height: 7px; background: #002147; border-radius: 50%; margin-right: 10px; vertical-align: middle;\"\u003e\u003c\/span\u003eEFTA Countries (DDP): 3–7 business days, duties and taxes prepaid.\u003c\/li\u003e\n\u003cli style=\"padding: 5px 0; border-bottom: 1px solid #f0f0f0;\"\u003e\n\u003cspan style=\"display: inline-block; width: 7px; height: 7px; background: #002147; border-radius: 50%; margin-right: 10px; vertical-align: middle;\"\u003e\u003c\/span\u003eWorldwide: 7–14 business days, selected locations.\u003c\/li\u003e\n\u003c\/ul\u003e\u003c\/div\u003e\n\u003c\/div\u003e","brand":"NorrChemica™","offers":[{"title":"100 mg","offer_id":52699696496977,"sku":"NOR-958747-100mg","price":69.2,"currency_code":"EUR","in_stock":true},{"title":"250 mg","offer_id":52699696529745,"sku":"NOR-958747-250mg","price":129.25,"currency_code":"EUR","in_stock":true},{"title":"500 mg","offer_id":52699696562513,"sku":"NOR-958747-500mg","price":229.2,"currency_code":"EUR","in_stock":true},{"title":"1.0 g","offer_id":52699696595281,"sku":"NOR-958747-1g","price":398.2,"currency_code":"EUR","in_stock":true},{"title":"2.5 g","offer_id":53786292683089,"sku":"NOR-958747-2.5g","price":675.0,"currency_code":"EUR","in_stock":true},{"title":"5.0 g","offer_id":53786292715857,"sku":"NOR-958747-5g","price":1275.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0954\/6357\/1793\/files\/NorrChemica_3-Methylthymidine_N3-Methyl-dT.png?v=1782683270"},{"product_id":"3-5-di-o-pivaloylthymidine","title":"3',5'-Di-O-pivaloylthymidine | PubChem CID: 10873286 | ≥98%","description":"\u003cdiv style=\"margin-bottom: 28px;\"\u003e\n\u003cdiv style=\"background: #002147; padding: 10px 20px; margin-bottom: 0;\"\u003e\n\u003ch3 style=\"margin: 0; font-family: 'Helvetica Neue', Helvetica, Arial, sans-serif; font-size: 0.70em; font-weight: bold; letter-spacing: 0.12em; text-transform: uppercase; color: #fff;\"\u003eTechnical Specifications\u003c\/h3\u003e\n\u003c\/div\u003e\n\u003ctable style=\"width: 100%; border-collapse: collapse; font-size: 0.95em; border: 1px solid #e4e8f0; border-top: none; font-family: 'Helvetica Neue', Helvetica, Arial, sans-serif;\"\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eSMILES\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0; word-break: break-all;\"\u003eCC1=CN(C(=O)NC1=O)[C@H]2C[C@@H]([C@H](O2)COC(=O)C(C)(C)C)OC(=O)C(C)(C)C\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eInChI\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0; word-break: break-all;\"\u003eInChI=1S\/C20H30N2O7\/c1-11-9-22(18(26)21-15(11)23)14-8-12(29-17(25)20(5,6)7)13(28-14)10-27-16(24)19(2,3)4\/h9,12-14H,8,10H2,1-7H3,(H,21,23,26)\/t12-,13+,14+\/m0\/s1\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eInChIKey\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0; word-break: break-all;\"\u003eCDURWIFHJJVZIL-BFHYXJOUSA-N\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003ePubChem CID\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e10873286\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eMolecular Formula\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003eC₂₀H₃₀N₂O₇\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eMolecular Weight\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e410.46 g\/mol\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eSolubility\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003eSoluble in dichloromethane, chloroform, THF, and ethyl acetate; sparingly soluble in water.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003ePurity\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e≥98%\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003ePhysical Form\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003eWhite to off-white crystalline solid.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eHS Code\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e2934.99\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eShelf Life\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003eRetest period: 36 months from date of manufacture.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eStorage Conditions\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003eStore at room temperature in a tightly sealed container.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003c\/div\u003e\n\u003cdiv style=\"margin-bottom: 28px;\"\u003e\n\u003cdiv style=\"background: #002147; padding: 10px 20px; margin-bottom: 0;\"\u003e\n\u003ch3 style=\"margin: 0; font-family: 'Helvetica Neue', Helvetica, Arial, sans-serif; font-size: 0.70em; font-weight: bold; letter-spacing: 0.12em; text-transform: uppercase; color: #fff;\"\u003eProduct Description \u0026amp; Scientific Applications\u003c\/h3\u003e\n\u003c\/div\u003e\n\u003cdiv style=\"padding: 16px 20px; border: 1px solid #e4e8f0; border-top: none; font-family: Georgia, 'Times New Roman', serif; font-size: 0.95em; line-height: 1.65; color: #333;\"\u003e\n\u003cp\u003e\u003cstrong\u003e3′,5′-Di-O-pivaloylthymidine (3′,5′-di-O-trimethylacetylthymidine) \u003c\/strong\u003eis a thymidine derivative in which both 3′- and 5′-hydroxyls of the 2′-deoxyribose are esterified as pivaloyl esters, while the thymine nucleobase is unprotected. It is a white to off-white crystalline solid, handled as a hydrophobic protected-nucleoside intermediate. Pivaloyl is among the most sterically demanding acyl protecting groups for sugar hydroxyls: the \u003cem\u003etert\u003c\/em\u003e-butyl group adjacent to the carbonyl shields it from nucleophilic attack and slows nucleophilic acyl substitution relative to acetate, benzoate, and isobutyrate, giving the esters kinetic persistence under base hydrolysis, methanolysis, transesterification, and acyl-transfer conditions while remaining cleavable. The steric demand may also suppress acyl migration, though this is substrate- and condition-dependent. The group trades ease of removal for this persistence; compatibility with the nucleobase, phosphate, and final deprotection sequence must be established.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eOrthogonality window.\u003c\/strong\u003e Its cleavage logic differs from the ether alternatives: unlike benzyl ether, removal needs no hydrogenolysis, so it suits sequences where catalytic hydrogenation is precluded; unlike silyl ethers (TBS, TBDPS, TIPS), it carries no fluoride-triggered cleavage or acid\/moisture sensitivity. Double pivaloyl protection at both the 3′- and 5′-oxygens is an uncommon arrangement for thymidine, and this bulky-acyl pairing can underpin synthetic sequences not readily accessible with the more common sugar-protecting groups.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cdiv style=\"margin-bottom: 28px;\"\u003e\n\u003cdiv style=\"background: #002147; padding: 10px 20px; margin-bottom: 0;\"\u003e\n\u003ch3 style=\"margin: 0; font-family: 'Helvetica Neue', Helvetica, Arial, sans-serif; font-size: 0.70em; font-weight: bold; letter-spacing: 0.12em; text-transform: uppercase; color: #fff;\"\u003eShipping Destinations\u003c\/h3\u003e\n\u003c\/div\u003e\n\u003cdiv style=\"border: 1px solid #e4e8f0; border-top: none; padding: 12px 16px; font-family: 'Helvetica Neue', Helvetica, Arial, sans-serif; font-size: 0.95em;\"\u003e\n\u003cul style=\"margin: 0; padding: 0; list-style: none;\"\u003e\n\u003cli style=\"padding: 5px 0; border-bottom: 1px solid #f0f0f0;\"\u003e\n\u003cspan style=\"display: inline-block; width: 7px; height: 7px; background: #002147; border-radius: 50%; margin-right: 10px; vertical-align: middle;\"\u003e\u003c\/span\u003eEU \u0026amp; UK: Priority delivery, 2–5 business days.\u003c\/li\u003e\n\u003cli style=\"padding: 5px 0; border-bottom: 1px solid #f0f0f0;\"\u003e\n\u003cspan style=\"display: inline-block; width: 7px; height: 7px; background: #002147; border-radius: 50%; margin-right: 10px; vertical-align: middle;\"\u003e\u003c\/span\u003eUnited States (DDP): 3–7 business days, duties and taxes prepaid.\u003c\/li\u003e\n\u003cli style=\"padding: 5px 0; border-bottom: 1px solid #f0f0f0;\"\u003e\n\u003cspan style=\"display: inline-block; width: 7px; height: 7px; background: #002147; border-radius: 50%; margin-right: 10px; vertical-align: middle;\"\u003e\u003c\/span\u003eEFTA Countries (DDP): 3–7 business days, duties and taxes prepaid.\u003c\/li\u003e\n\u003cli style=\"padding: 5px 0; border-bottom: 1px solid #f0f0f0;\"\u003e\n\u003cspan style=\"display: inline-block; width: 7px; height: 7px; background: #002147; border-radius: 50%; margin-right: 10px; vertical-align: middle;\"\u003e\u003c\/span\u003eWorldwide: 7–14 business days, selected locations.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e","brand":"NorrChemica™","offers":[{"title":"500 mg","offer_id":52700070871377,"sku":"NOR-10873286-500mg","price":69.2,"currency_code":"EUR","in_stock":true},{"title":"1.0 g","offer_id":52700070904145,"sku":"NOR-10873286-1g","price":98.2,"currency_code":"EUR","in_stock":true},{"title":"2.0 g","offer_id":52700070936913,"sku":"NOR-10873286-2g","price":189.2,"currency_code":"EUR","in_stock":true},{"title":"5.0 g","offer_id":52700070969681,"sku":"NOR-10873286-5g","price":329.2,"currency_code":"EUR","in_stock":true},{"title":"10 g","offer_id":52700071002449,"sku":"NOR-10873286-10g","price":598.2,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0954\/6357\/1793\/files\/NorrChemica_3-5-Di-O-pivaloylthymidine.png?v=1782683270"},{"product_id":"n1-benzyl-n3-phenylthymine","title":"N1-Benzyl-N3-Phenylthymine | PubChem CID: 15867825 | ≥97%","description":"\u003cdiv style=\"margin-bottom: 28px;\"\u003e\n\u003cdiv style=\"background: #002147; padding: 10px 20px; margin-bottom: 0;\"\u003e  \u003ch3 style=\"margin: 0; font-family: 'Helvetica Neue', Helvetica, Arial, sans-serif; font-size: 0.70em; font-weight: 700; letter-spacing: 0.12em; text-transform: uppercase; color: #fff;\"\u003eTechnical Specifications\u003c\/h3\u003e\n\u003c\/div\u003e\n\u003ctable style=\"width: 100%; border-collapse: collapse; font-size: 0.95em; border: 1px solid #e4e8f0; border-top: none; font-family: 'Helvetica Neue', Helvetica, Arial, sans-serif;\"\u003e\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eSMILES\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0; word-break: break-all;\"\u003eC1=CC=C(C=C1)CN2C=CC(=O)N(C2=O)C3=CC=CC=C3\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eInChI\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0; word-break: break-all;\"\u003eInChI=1S\/C17H14N2O2\/c20-16-11-12-18(13-14-7-3-1-4-8-14)17(21)19(16)15-9-5-2-6-10-15\/h1-12H,13H2\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eInChIKey\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0; word-break: break-all;\"\u003eGLDGVXRTOLRHMM-UHFFFAOYSA-N\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003ePubChem CID\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e15867825\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eMolecular Formula\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003eC17H14N2O2\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eMolecular Weight\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e278.3 g\/mol\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eSolubility\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003eSoluble in chloroform, ethyl acetate, DMSO. Insoluble in water\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003ePurity\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e≥97%\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003ePhysical Form\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003eWhite solid\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eHS Code\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e2933.59\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eShelf Life\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003eRetest period: 36 months from date of manufacture\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eStorage Conditions\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003eStore in a cool, dry place in a tightly sealed container\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\u003c\/table\u003e\n\u003c\/div\u003e\u003cdiv style=\"margin-bottom: 28px;\"\u003e\n\u003cdiv style=\"background: #002147; padding: 10px 20px; margin-bottom: 0;\"\u003e  \u003ch3 style=\"margin: 0; font-family: 'Helvetica Neue', Helvetica, Arial, sans-serif; font-size: 0.70em; font-weight: 700; letter-spacing: 0.12em; text-transform: uppercase; color: #fff;\"\u003eProduct Description \u0026amp; Scientific Applications\u003c\/h3\u003e\n\u003c\/div\u003e\n\u003cdiv style=\"padding: 16px 20px; border: 1px solid #e4e8f0; border-top: none; font-family: Georgia, 'Times New Roman', serif; font-size: 0.95em; line-height: 1.65; color: #333;\"\u003e\n\u003cp\u003e\u003cstrong\u003eProposed building block for next-generation modified-nucleobase and oligonucleotide chemistry.\u003c\/strong\u003e As RNA and oligonucleotide technologies expand beyond canonical base modifications such as N1-methylpseudouridine, new nucleobase chemical spaces may help address emerging challenges in transcript stability, immunomodulation, base-pairing fidelity, and synthetic recognition. This doubly N-substituted thymine, featuring simultaneous N1 and N3 functionalisation, offers an underexplored structural module that may be evaluated as a precursor in modified-thymidine, antisense, aptamer, and non-natural base-pair research where deliberate disruption of canonical hydrogen bonding is part of the design strategy.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eReady-to-use N3-aryl thymine intermediate for downstream nucleoside chemistry.\u003c\/strong\u003e N3-functionalisation of pyrimidine-2,4-diones is a regioselectivity-sensitive target because the thymine ring contains two non-equivalent endocyclic nitrogens, with N1\/N3 isomer formation a recurring problem in nucleobase alkylation and glycosylation chemistry. This compound delivers the N3-aryl substitution preinstalled. After N1 debenzylation, the regenerated N1–H base can be evaluated for N-glycosylation with ribose or deoxyribose donors, opening a route to N3-aryl thymidine analogues that avoids performing N3-arylation in the presence of a sugar.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eProposed H-bond-ablated thymine analogue for non-natural base-pair research.\u003c\/strong\u003e Installation of the N3-phenyl group removes the Watson–Crick H-bond donor that contributes to natural A–T pairing in DNA and U–A pairing in RNA. The compound may serve as an exploratory probe or model base for hydrophobic and stacking-driven base-pair analogues, universal\/wobble base design, and supramolecular self-assembly of pyrimidine motifs where N3–H donation is intentionally absent.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003ePyrimidine-2,4-dione scaffold variant for medicinal chemistry and chemical biology.\u003c\/strong\u003e The pyrimidine-2,4-dione core is a recurrent medicinal-chemistry motif, including in antiviral and enzyme-inhibitor scaffold families. This compound is offered as a chemically defined, doubly N-substituted scaffold variant for SAR exploration where both ring nitrogens are deliberately blocked with distinct aryl and benzyl substituents.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\u003cdiv style=\"margin-bottom: 28px;\"\u003e\n\u003cdiv style=\"background: #002147; padding: 10px 20px; margin-bottom: 0;\"\u003e  \u003ch3 style=\"margin: 0; font-family: 'Helvetica Neue', Helvetica, Arial, sans-serif; font-size: 0.70em; font-weight: 700; letter-spacing: 0.12em; text-transform: uppercase; color: #fff;\"\u003eShipping Destinations\u003c\/h3\u003e\n\u003c\/div\u003e\n\u003cdiv style=\"border: 1px solid #e4e8f0; border-top: none; padding: 12px 16px; font-family: 'Helvetica Neue', Helvetica, Arial, sans-serif; font-size: 0.95em;\"\u003e\u003cul style=\"margin: 0; padding: 0; list-style: none;\"\u003e\n\u003cli style=\"padding: 5px 0; border-bottom: 1px solid #f0f0f0;\"\u003e\n\u003cspan style=\"display: inline-block; width: 7px; height: 7px; background: #002147; border-radius: 50%; margin-right: 10px; vertical-align: middle;\"\u003e\u003c\/span\u003eEU \u0026amp; UK: Priority delivery, 2–5 business days.\u003c\/li\u003e\n\u003cli style=\"padding: 5px 0; border-bottom: 1px solid #f0f0f0;\"\u003e\n\u003cspan style=\"display: inline-block; width: 7px; height: 7px; background: #002147; border-radius: 50%; margin-right: 10px; vertical-align: middle;\"\u003e\u003c\/span\u003eUnited States (DDP): 3–7 business days, duties and taxes prepaid.\u003c\/li\u003e\n\u003cli style=\"padding: 5px 0; border-bottom: 1px solid #f0f0f0;\"\u003e\n\u003cspan style=\"display: inline-block; width: 7px; height: 7px; background: #002147; border-radius: 50%; margin-right: 10px; vertical-align: middle;\"\u003e\u003c\/span\u003eEFTA Countries (DDP): 3–7 business days, duties and taxes prepaid.\u003c\/li\u003e\n\u003cli style=\"padding: 5px 0; border-bottom: 1px solid #f0f0f0;\"\u003e\n\u003cspan style=\"display: inline-block; width: 7px; height: 7px; background: #002147; border-radius: 50%; margin-right: 10px; vertical-align: middle;\"\u003e\u003c\/span\u003eWorldwide: 7–14 business days, selected locations.\u003c\/li\u003e\n\u003c\/ul\u003e\u003c\/div\u003e\n\u003c\/div\u003e","brand":"NorrChemica™","offers":[{"title":"50 mg","offer_id":53797929025873,"sku":"NOR-IK-1226131524-50mg","price":104.0,"currency_code":"EUR","in_stock":true},{"title":"100 mg","offer_id":53797929058641,"sku":"NOR-IK-1226131524-100mg","price":199.0,"currency_code":"EUR","in_stock":true},{"title":"250 mg","offer_id":53797929091409,"sku":"NOR-IK-1226131524-250mg","price":498.0,"currency_code":"EUR","in_stock":true},{"title":"500 mg","offer_id":53797929124177,"sku":"NOR-IK-1226131524-500mg","price":897.0,"currency_code":"EUR","in_stock":true},{"title":"1 g","offer_id":53797929156945,"sku":"NOR-IK-1226131524-1g","price":1663.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0954\/6357\/1793\/files\/NorrChemica_N1-Benzyl-N3-Phenylthymine.png?v=1782683270"},{"product_id":"n1-methyl-n3-benzylthymine","title":"N1-Methyl-N3-Benzylthymine | PubChem CID: 21627130 | ≥98%","description":"\u003cdiv style=\"margin-bottom: 28px;\"\u003e\n\u003cdiv style=\"background: #002147; padding: 10px 20px; margin-bottom: 0;\"\u003e  \u003ch3 style=\"margin: 0; font-family: 'Helvetica Neue', Helvetica, Arial, sans-serif; font-size: 0.70em; font-weight: 700; letter-spacing: 0.12em; text-transform: uppercase; color: #fff;\"\u003eTechnical Specifications\u003c\/h3\u003e\n\u003c\/div\u003e\n\u003ctable style=\"width: 100%; border-collapse: collapse; font-size: 0.95em; border: 1px solid #e4e8f0; border-top: none; font-family: 'Helvetica Neue', Helvetica, Arial, sans-serif;\"\u003e\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eSMILES\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0; word-break: break-all;\"\u003eCC1=CN(C(=O)N(C1=O)CC2=CC=CC=C2)C\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eInChI\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0; word-break: break-all;\"\u003eInChI=1S\/C13H14N2O2\/c1-10-8-14(2)13(17)15(12(10)16)9-11-6-4-3-5-7-11\/h3-8H,9H2,1-2H3\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eInChIKey\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0; word-break: break-all;\"\u003eRHBCQQYWSYVORA-UHFFFAOYSA-N\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003ePubChem CID\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e21627130\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eMolecular Formula\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003eC13H14N2O2\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eMolecular Weight\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e230.26 g\/mol\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eSolubility\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003eSoluble in chloroform, ethylacetate, DMF, DMSO.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003ePurity\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e≥98%\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003ePhysical Form\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003eWhite to off-white solid\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eHS Code\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e2933.59\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eShelf Life\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003eRetest period: 36 months from date of manufacture\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eStorage Conditions\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003eStore in a cool, dry place in a tightly sealed container\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\u003c\/table\u003e\n\u003c\/div\u003e\u003cdiv style=\"margin-bottom: 28px;\"\u003e\n\u003cdiv style=\"background: #002147; padding: 10px 20px; margin-bottom: 0;\"\u003e  \u003ch3 style=\"margin: 0; font-family: 'Helvetica Neue', Helvetica, Arial, sans-serif; font-size: 0.70em; font-weight: 700; letter-spacing: 0.12em; text-transform: uppercase; color: #fff;\"\u003eProduct Description \u0026amp; Scientific Applications\u003c\/h3\u003e\n\u003c\/div\u003e\n\u003cdiv style=\"padding: 16px 20px; border: 1px solid #e4e8f0; border-top: none; font-family: Georgia, 'Times New Roman', serif; font-size: 0.95em; line-height: 1.65; color: #333;\"\u003e\n\u003cp\u003e\u003cstrong\u003eProposed building block for next-generation modified-nucleobase and oligonucleotide chemistry.\u003c\/strong\u003e As RNA and oligonucleotide technologies expand beyond canonical base modifications such as pseudouridine and N1-methylpseudouridine, new nucleobase chemical spaces may help address emerging challenges in transcript stability, immunomodulation, base-pairing fidelity, and synthetic recognition. This doubly N-substituted thymine, with a permanent N1-methyl group and a removable N3-benzyl group, offers a structurally focused module on the N1-methylpyrimidinedione axis that may be evaluated as a precursor in modified-nucleobase, non-canonical nucleoside, antisense, aptamer, and non-natural base-pair research where deliberate disruption of canonical hydrogen bonding is part of the design strategy.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eProtected precursor to 1-methylthymine and non-canonical N3-nucleoside analogues.\u003c\/strong\u003e The regioselective functionalisation at N1 and\/or N3 remains a sensitive challenge in nucleobase alkylation chemistry. This compound contains a preinstalled methyl group at N1 which remains unaltered upon debenzylation conditions, yielding 1-methylthymine. Glycosidation reactions may then be conducted at N3 rather than at the usual — now blocked — N1 position, allowing access to unnatural \"reverse\" N3-glycosylated nucleoside analogues, a chemical space adjacent to the N1-methylpyrimidine logic explored in modified-mRNA chemistry which is otherwise unattainable from canonical thymine bases.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eProposed H-bond-ablated thymine analogue for non-natural base-pair research.\u003c\/strong\u003e Installation of the N3-benzyl group temporarily removes the Watson–Crick H-bond donor that contributes to natural A–T pairing in DNA and U–A pairing in RNA. While protected, the compound may serve as an exploratory probe or model base for hydrophobic and stacking-driven base-pair analogues, universal\/wobble base design, and supramolecular self-assembly of pyrimidine motifs where N3–H donation is intentionally absent.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003ePyrimidine-2,4-dione scaffold variant for medicinal chemistry and chemical biology.\u003c\/strong\u003e The pyrimidine-2,4-dione core is a recurrent medicinal-chemistry motif, including in antiviral and enzyme-inhibitor scaffold families. This compound is offered as a chemically defined, doubly N-substituted scaffold variant for SAR exploration.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\u003cdiv style=\"margin-bottom: 28px;\"\u003e\n\u003cdiv style=\"background: #002147; padding: 10px 20px; margin-bottom: 0;\"\u003e  \u003ch3 style=\"margin: 0; font-family: 'Helvetica Neue', Helvetica, Arial, sans-serif; font-size: 0.70em; font-weight: 700; letter-spacing: 0.12em; text-transform: uppercase; color: #fff;\"\u003eShipping Destinations\u003c\/h3\u003e\n\u003c\/div\u003e\n\u003cdiv style=\"border: 1px solid #e4e8f0; border-top: none; padding: 12px 16px; font-family: 'Helvetica Neue', Helvetica, Arial, sans-serif; font-size: 0.95em;\"\u003e\u003cul style=\"margin: 0; padding: 0; list-style: none;\"\u003e\n\u003cli style=\"padding: 5px 0; border-bottom: 1px solid #f0f0f0;\"\u003e\n\u003cspan style=\"display: inline-block; width: 7px; height: 7px; background: #002147; border-radius: 50%; margin-right: 10px; vertical-align: middle;\"\u003e\u003c\/span\u003eEU \u0026amp; UK: Priority delivery, 2–5 business days.\u003c\/li\u003e\n\u003cli style=\"padding: 5px 0; border-bottom: 1px solid #f0f0f0;\"\u003e\n\u003cspan style=\"display: inline-block; width: 7px; height: 7px; background: #002147; border-radius: 50%; margin-right: 10px; vertical-align: middle;\"\u003e\u003c\/span\u003eUnited States (DDP): 3–7 business days, duties and taxes prepaid.\u003c\/li\u003e\n\u003cli style=\"padding: 5px 0; border-bottom: 1px solid #f0f0f0;\"\u003e\n\u003cspan style=\"display: inline-block; width: 7px; height: 7px; background: #002147; border-radius: 50%; margin-right: 10px; vertical-align: middle;\"\u003e\u003c\/span\u003eEFTA Countries (DDP): 3–7 business days, duties and taxes prepaid.\u003c\/li\u003e\n\u003cli style=\"padding: 5px 0; border-bottom: 1px solid #f0f0f0;\"\u003e\n\u003cspan style=\"display: inline-block; width: 7px; height: 7px; background: #002147; border-radius: 50%; margin-right: 10px; vertical-align: middle;\"\u003e\u003c\/span\u003eWorldwide: 7–14 business days, selected locations.\u003c\/li\u003e\n\u003c\/ul\u003e\u003c\/div\u003e\n\u003c\/div\u003e","brand":"NorrChemica™","offers":[{"title":"50 mg","offer_id":53797976179025,"sku":"NOR-IK-1808020317-50mg","price":56.0,"currency_code":"EUR","in_stock":true},{"title":"100 mg","offer_id":53797976211793,"sku":"NOR-IK-1808020317-100mg","price":93.0,"currency_code":"EUR","in_stock":true},{"title":"250 mg","offer_id":53797976244561,"sku":"NOR-IK-1808020317-250mg","price":214.0,"currency_code":"EUR","in_stock":true},{"title":"500 mg","offer_id":53797976277329,"sku":"NOR-IK-1808020317-500mg","price":375.0,"currency_code":"EUR","in_stock":true},{"title":"1 g","offer_id":53797976310097,"sku":"NOR-IK-1808020317-1g","price":632.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0954\/6357\/1793\/files\/NorrChemica_N1-Methyl-N3-Benzylthymine.png?v=1782683270"},{"product_id":"n1-methylthymine","title":"N1-Methylthymine | CAS 4160-72-9 | ≥95%","description":"\u003cdiv style=\"margin-bottom: 28px;\"\u003e\n\u003cdiv style=\"background: #002147; padding: 10px 20px; margin-bottom: 0;\"\u003e  \u003ch3 style=\"margin: 0; font-family: 'Helvetica Neue', Helvetica, Arial, sans-serif; font-size: 0.70em; font-weight: 700; letter-spacing: 0.12em; text-transform: uppercase; color: #fff;\"\u003eTechnical Specifications\u003c\/h3\u003e\n\u003c\/div\u003e\n\u003ctable style=\"width: 100%; border-collapse: collapse; font-size: 0.95em; border: 1px solid #e4e8f0; border-top: none; font-family: 'Helvetica Neue', Helvetica, Arial, sans-serif;\"\u003e\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eCAS Number\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e4160-72-9\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eEC \/ EINECS Number\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e853-778-6\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eMDL Number\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003eMFCD00056055\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eSMILES\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0; word-break: break-all;\"\u003eCC1=CN(C(=O)NC1=O)C\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eInChI\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0; word-break: break-all;\"\u003eInChI=1S\/C6H8N2O2\/c1-4-3-8(2)6(10)7-5(4)9\/h3H,1-2H3,(H,7,9,10)\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eInChIKey\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0; word-break: break-all;\"\u003eGKMIDMKPBOUSBQ-UHFFFAOYSA-N\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003ePubChem CID\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e95961\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eMolecular Formula\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003eC6H8N2O2\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eMolecular Weight\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e140.14 g\/mol\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eMelting Point\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e292-293 °C\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eSolubility\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003eSoluble in DMSO, poorly soluble in water\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003ePurity\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e≥95%\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003ePhysical Form\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003eWhite to off-white solid\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eHS Code\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e2933.59\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eShelf Life\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003eRetest period: 36 months from date of manufacture\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eStorage Conditions\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003eStore in a cool, dry place in a tightly sealed container\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\u003c\/table\u003e\n\u003c\/div\u003e\u003cdiv style=\"margin-bottom: 28px;\"\u003e\n\u003cdiv style=\"background: #002147; padding: 10px 20px; margin-bottom: 0;\"\u003e  \u003ch3 style=\"margin: 0; font-family: 'Helvetica Neue', Helvetica, Arial, sans-serif; font-size: 0.70em; font-weight: 700; letter-spacing: 0.12em; text-transform: uppercase; color: #fff;\"\u003eProduct Description \u0026amp; Scientific Applications\u003c\/h3\u003e\n\u003c\/div\u003e\n\u003cdiv style=\"padding: 16px 20px; border: 1px solid #e4e8f0; border-top: none; font-family: Georgia, 'Times New Roman', serif; font-size: 0.95em; line-height: 1.65; color: #333;\"\u003e\n\u003cp\u003e\u003cstrong\u003eClean entry point to N3-functionalised thymine derivatives.\u003c\/strong\u003e N-functionalisation of thymine is regioselectivity-sensitive: the pyrimidine-2,4-dione ring carries two non-equivalent nitrogens (N1 and N3), so uncontrolled reactions give mixtures of N1-, N3-, and N1,N3-disubstituted products. In 1-methylthymine, N1 is permanently methylated, directing every subsequent N-functionalisation to N3 in a single step. This gives access to N3-substituted thymines — N3-alkyl, N3-aryl, N3-acyl, N3-glycosyl, and N3-PEG — including N1-Methyl-N3-Benzylthymine (also available from NorrChemica). It carries the same N1-methylpyrimidine motif used in modified-mRNA chemistry (N1-methylpseudouridine).\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eComplementary to N1-acetylthymine.\u003c\/strong\u003e Both 1-methylthymine and N1-acetylthymine (also available from NorrChemica) block N1, directing functionalisation to N3; the acetyl block is labile, the methyl permanent. This stability difference may serve dramatically different downstream applications.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eEstablished reference compound for thymine base-pair, photophysics, and tautomer studies.\u003c\/strong\u003e 1-Methylthymine is a model base for Watson–Crick A–T pairing, tautomeric equilibria of the pyrimidine-2,4-dione ring, electronic and vibrational spectroscopy of nucleobases, and photophysics of damaged DNA bases. The N1-methyl group mimics the N1-glycoside of natural thymidine while removing sugar-derived complexity from spectroscopic and crystallographic measurements, making it a widely used thymidine surrogate in physical-organic and biophysical nucleic-acid research.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\u003cdiv style=\"margin-bottom: 28px;\"\u003e\n\u003cdiv style=\"background: #002147; padding: 10px 20px; margin-bottom: 0;\"\u003e  \u003ch3 style=\"margin: 0; font-family: 'Helvetica Neue', Helvetica, Arial, sans-serif; font-size: 0.70em; font-weight: 700; letter-spacing: 0.12em; text-transform: uppercase; color: #fff;\"\u003eShipping Destinations\u003c\/h3\u003e\n\u003c\/div\u003e\n\u003cdiv style=\"border: 1px solid #e4e8f0; border-top: none; padding: 12px 16px; font-family: 'Helvetica Neue', Helvetica, Arial, sans-serif; font-size: 0.95em;\"\u003e\u003cul style=\"margin: 0; padding: 0; list-style: none;\"\u003e\n\u003cli style=\"padding: 5px 0; border-bottom: 1px solid #f0f0f0;\"\u003e\n\u003cspan style=\"display: inline-block; width: 7px; height: 7px; background: #002147; border-radius: 50%; margin-right: 10px; vertical-align: middle;\"\u003e\u003c\/span\u003eEU \u0026amp; UK: Priority delivery, 2–5 business days.\u003c\/li\u003e\n\u003cli style=\"padding: 5px 0; border-bottom: 1px solid #f0f0f0;\"\u003e\n\u003cspan style=\"display: inline-block; width: 7px; height: 7px; background: #002147; border-radius: 50%; margin-right: 10px; vertical-align: middle;\"\u003e\u003c\/span\u003eUnited States (DDP): 3–7 business days, duties and taxes prepaid.\u003c\/li\u003e\n\u003cli style=\"padding: 5px 0; border-bottom: 1px solid #f0f0f0;\"\u003e\n\u003cspan style=\"display: inline-block; width: 7px; height: 7px; background: #002147; border-radius: 50%; margin-right: 10px; vertical-align: middle;\"\u003e\u003c\/span\u003eEFTA Countries (DDP): 3–7 business days, duties and taxes prepaid.\u003c\/li\u003e\n\u003cli style=\"padding: 5px 0; border-bottom: 1px solid #f0f0f0;\"\u003e\n\u003cspan style=\"display: inline-block; width: 7px; height: 7px; background: #002147; border-radius: 50%; margin-right: 10px; vertical-align: middle;\"\u003e\u003c\/span\u003eWorldwide: 7–14 business days, selected locations.\u003c\/li\u003e\n\u003c\/ul\u003e\u003c\/div\u003e\n\u003c\/div\u003e","brand":"NorrChemica™","offers":[{"title":"50 mg","offer_id":53798119145809,"sku":"NOR-4160729-50mg","price":37.0,"currency_code":"EUR","in_stock":true},{"title":"100 mg","offer_id":53798119178577,"sku":"NOR-4160729-100mg","price":56.0,"currency_code":"EUR","in_stock":true},{"title":"250 mg","offer_id":53798119211345,"sku":"NOR-4160729-250mg","price":85.0,"currency_code":"EUR","in_stock":true},{"title":"500 mg","offer_id":53798119244113,"sku":"NOR-4160729-500mg","price":133.0,"currency_code":"EUR","in_stock":true},{"title":"1 g","offer_id":53798119276881,"sku":"NOR-4160729-1g","price":171.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0954\/6357\/1793\/files\/NorrChemica_N1-Methylthymine.png?v=1782683270"},{"product_id":"4-4-dimethoxytrityl-chloride-cas-40615-36-9","title":"4,4′-Dimethoxytrityl chloride | CAS 40615-36-9 | ≥98%","description":"\u003cdiv style=\"margin-bottom: 28px;\"\u003e\n\u003cdiv style=\"background: #002147; padding: 10px 20px; margin-bottom: 0;\"\u003e\u003ch3 style=\"margin: 0; font-family: 'Helvetica Neue', Helvetica, Arial, sans-serif; font-size: 0.70em; font-weight: bold; letter-spacing: 0.12em; text-transform: uppercase; color: #fff;\"\u003eTechnical Specifications\u003c\/h3\u003e\u003c\/div\u003e\n\u003ctable style=\"width: 100%; border-collapse: collapse; font-size: 0.95em; border: 1px solid #e4e8f0; border-top: none; font-family: 'Helvetica Neue', Helvetica, Arial, sans-serif;\"\u003e\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eCAS Number\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e40615-36-9\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eEC \/ EINECS Number\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e255-002-6\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eMDL Number\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003eMFCD00008409\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eSMILES\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0; word-break: break-all;\"\u003eCOC1=CC=C(C=C1)C(C2=CC=CC=C2)(C3=CC=C(C=C3)OC)Cl\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eInChI\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0; word-break: break-all;\"\u003eInChI=1S\/C21H19ClO2\/c1-23-19-12-8-17(9-13-19)21(22,16-6-4-3-5-7-16)18-10-14-20(24-2)15-11-18\/h3-15H,1-2H3\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eInChIKey\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0; word-break: break-all;\"\u003eJBWYRBLDOOOJEU-UHFFFAOYSA-N\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003ePubChem CID\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e96831\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eMolecular Formula\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003eC₂₁H₁₉ClO₂\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eMolecular Weight\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e338.8 g\/mol\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eMelting Point\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e119-123 °C (lit.)\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eSolubility\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003eSoluble in chloroform and methanol. Sparingly soluble in water.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003ePurity\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e≥98%\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003ePhysical Form\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003eSolid\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eHS Code\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e2909.30\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eShelf Life\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003eRetest period: 36 months from date of manufacture\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eStorage Conditions\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333;\"\u003eStore at ambient temperatures under nitrogen.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\u003c\/table\u003e\n\u003c\/div\u003e","brand":"NorrChemica™","offers":[{"title":"10 g","offer_id":55582522802513,"sku":"NOR-40615369-10g","price":39.2,"currency_code":"EUR","in_stock":true},{"title":"25 g","offer_id":55164430811473,"sku":"NOR-40615369-25g","price":59.2,"currency_code":"EUR","in_stock":true},{"title":"50 g","offer_id":55582522835281,"sku":"NOR-40615369-50g","price":74.2,"currency_code":"EUR","in_stock":true},{"title":"100 g","offer_id":55164430844241,"sku":"NOR-40615369-100g","price":84.2,"currency_code":"EUR","in_stock":true},{"title":"250 g","offer_id":55582522868049,"sku":"NOR-40615369-250g","price":119.2,"currency_code":"EUR","in_stock":true},{"title":"500 g","offer_id":55164430877009,"sku":"NOR-40615369-500g","price":209.8,"currency_code":"EUR","in_stock":true},{"title":"1 kg","offer_id":55164430909777,"sku":"NOR-40615369-1000g","price":389.2,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0954\/6357\/1793\/files\/NorrChemica_DMT_Chloride.png?v=1791046070"},{"product_id":"2-deoxyuridine-cas-951-78-0","title":"2′-Deoxyuridine | CAS 951-78-0 | ≥98%","description":"\u003cdiv style=\"margin-bottom: 28px;\"\u003e\n\u003cdiv style=\"background: #002147; padding: 10px 20px; margin-bottom: 0;\"\u003e\u003ch3 style=\"margin: 0; font-family: 'Helvetica Neue', Helvetica, Arial, sans-serif; font-size: 0.70em; font-weight: bold; letter-spacing: 0.12em; text-transform: uppercase; color: #fff;\"\u003eTechnical Specifications\u003c\/h3\u003e\u003c\/div\u003e\n\u003ctable style=\"width: 100%; border-collapse: collapse; font-size: 0.95em; border: 1px solid #e4e8f0; border-top: none; font-family: 'Helvetica Neue', Helvetica, Arial, sans-serif;\"\u003e\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eCAS Number\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e951-78-0\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eEC \/ EINECS Number\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e213-455-7\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eMDL Number\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003eMFCD00006527\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eRTECS Number\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003eYU7490000\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eSMILES\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0; word-break: break-all;\"\u003eC1[C@@H]([C@H](O[C@H]1N2C=CC(=O)NC2=O)CO)O\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eInChI\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0; word-break: break-all;\"\u003eInChI=1S\/C9H12N2O5\/c12-4-6-5(13)3-8(16-6)11-2-1-7(14)10-9(11)15\/h1-2,5-6,8,12-13H,3-4H2,(H,10,14,15)\/t5-,6+,8+\/m0\/s1\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eInChIKey\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0; word-break: break-all;\"\u003eMXHRCPNRJAMMIM-SHYZEUOFSA-N\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003ePubChem CID\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e13712\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eMolecular Formula\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003eC₉H₁₂N₂O₅\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eMolecular Weight\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e228.20 g\/mol\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eMelting Point\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e164–167 °C\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eSolubility\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003eSoluble in water (50 mg\/mL).\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eLog Pow\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e-1.51\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003ePurity\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e≥98%\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003ePhysical Form\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003eWhite to almost white powder or crystals\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eHS Code\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e2934.99\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eShelf Life\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003eRetest period: 36 months from date of manufacture\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eStorage Conditions\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333;\"\u003eStore in a cool, dry place in a tightly sealed container.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\u003c\/table\u003e\n\u003c\/div\u003e\n\u003cdiv style=\"margin-bottom: 28px;\"\u003e\n\u003cdiv style=\"background: #002147; padding: 10px 20px; margin-bottom: 0;\"\u003e\u003ch3 style=\"margin: 0; font-family: 'Helvetica Neue', Helvetica, Arial, sans-serif; font-size: 0.70em; font-weight: bold; letter-spacing: 0.12em; text-transform: uppercase; color: #fff;\"\u003eProduct Description \u0026amp; Scientific Applications\u003c\/h3\u003e\u003c\/div\u003e\n\u003cdiv style=\"padding: 16px 20px; border: 1px solid #e4e8f0; border-top: none; font-family: Georgia, 'Times New Roman', serif; font-size: 0.95em; line-height: 1.65; color: #333;\"\u003e\u003cdiv\u003e\n\u003cp\u003e\u003cstrong\u003e2′-Deoxyuridine\u003c\/strong\u003e (dUrd) is the 2′-deoxyribonucleoside of uracil: uracil bound through N1 to 2-deoxy-β-D-ribofuranose. Its 5′-monophosphate, dUMP, is the substrate of thymidylate synthase, which methylates it to dTMP; the methyl group comes from methylenetetrahydrofolate (CH₂H₄folate), which becomes dihydrofolate (H₂folate). dTMP is then converted to dTTP for DNA synthesis.\u003c\/p\u003e\n\u003cdiv style=\"margin:8px 0 18px 0;\"\u003e\n\u003cdiv style=\"display:flex;flex-wrap:wrap;align-items:center;justify-content:flex-start;gap:2px;\"\u003e\n\u003cdiv style=\"display:flex;align-items:center;\"\u003e\u003csvg role=\"img\" style=\"max-width:100%;height:auto;\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" fill=\"none\" stroke=\"#000\" stroke-width=\"1.6\" width=\"211px\" height=\"81px\" viewbox=\"0 0 211 81\"\u003e\u003cpath d=\"M 104.2,60.8 L 123.2,56.8\"\u003e\u003c\/path\u003e\u003cpath d=\"M 123.2,56.8 L 125.2,37.5\"\u003e\u003c\/path\u003e\u003cpath d=\"M 125.2,37.5 L 111.7,31.5\"\u003e\u003c\/path\u003e\u003cpath d=\"M 103.2,34.3 L 94.5,44.0\"\u003e\u003c\/path\u003e\u003cpath d=\"M 91.6,43.4 L 91.6,44.1\"\u003e\u003c\/path\u003e\u003cpath d=\"M 88.8,42.7 L 88.6,44.2\"\u003e\u003c\/path\u003e\u003cpath d=\"M 86.0,42.1 L 85.7,44.2\"\u003e\u003c\/path\u003e\u003cpath d=\"M 83.1,41.4 L 82.8,44.3\"\u003e\u003c\/path\u003e\u003cpath d=\"M 71.0,47.9 L 63.8,57.8\"\u003e\u003c\/path\u003e\u003cpath d=\"M 63.8,57.8 L 44.5,55.8\"\u003e\u003c\/path\u003e\u003cpath d=\"M 62.4,54.7 L 46.5,53.1\"\u003e\u003c\/path\u003e\u003cpath d=\"M 44.5,55.8 L 36.6,38.1\"\u003e\u003c\/path\u003e\u003cpath d=\"M 37.5,36.7 L 21.7,35.1\"\u003e\u003c\/path\u003e\u003cpath d=\"M 37.2,39.6 L 21.4,38.0\"\u003e\u003c\/path\u003e\u003cpath d=\"M 36.6,38.1 L 43.1,29.0\"\u003e\u003c\/path\u003e\u003cpath d=\"M 52.2,22.8 L 67.2,24.3\"\u003e\u003c\/path\u003e\u003cpath d=\"M 67.9,25.9 L 75.6,15.3\"\u003e\u003c\/path\u003e\u003cpath d=\"M 65.6,24.2 L 73.2,13.6\"\u003e\u003c\/path\u003e\u003cpath d=\"M 128.1,36.1 L 127.8,35.6\"\u003e\u003c\/path\u003e\u003cpath d=\"M 131.0,34.7 L 130.5,33.7\"\u003e\u003c\/path\u003e\u003cpath d=\"M 134.0,33.4 L 133.1,31.8\"\u003e\u003c\/path\u003e\u003cpath d=\"M 136.9,32.0 L 135.8,30.0\"\u003e\u003c\/path\u003e\u003cpath d=\"M 139.9,30.6 L 138.4,28.1\"\u003e\u003c\/path\u003e\u003cpath d=\"M 141.9,27.7 L 154.5,35.0\"\u003e\u003c\/path\u003e\u003cpath d=\"M 163.0,34.9 L 171.3,30.1\"\u003e\u003c\/path\u003e\u003cpath d=\"M 180.5,26.5 L 188.8,21.6\"\u003e\u003c\/path\u003e\u003cpath d=\"M 179.1,23.9 L 187.4,19.1\"\u003e\u003c\/path\u003e\u003cpath d=\"M 179.4,34.3 L 182.8,40.2\"\u003e\u003c\/path\u003e\u003cpath d=\"M 173.1,23.4 L 169.7,17.5\"\u003e\u003c\/path\u003e\u003cpath d=\"M 123.2,56.8 L 133.7,64.2 L 131.8,66.4 Z\"\u003e\u003c\/path\u003e\u003cpath d=\"M 94.5,44.0 L 104.2,60.8\"\u003e\u003c\/path\u003e\u003cpath d=\"M 67.2,24.3 L 73.3,37.8\"\u003e\u003c\/path\u003e\u003cpath d=\"M 105.2,60.6 L 104.2,60.8 L 103.7,60.0\"\u003e\u003c\/path\u003e\u003cpath d=\"M 122.2,57.0 L 123.2,56.8 L 123.3,55.8\"\u003e\u003c\/path\u003e\u003cpath d=\"M 125.1,38.4 L 125.2,37.5 L 124.5,37.2\"\u003e\u003c\/path\u003e\u003cpath d=\"M 94.9,43.6 L 94.5,44.0 L 94.9,44.9\"\u003e\u003c\/path\u003e\u003cpath d=\"M 64.2,57.3 L 63.8,57.8 L 62.8,57.7\"\u003e\u003c\/path\u003e\u003cpath d=\"M 45.5,55.9 L 44.5,55.8 L 44.1,54.9\"\u003e\u003c\/path\u003e\u003cpath d=\"M 37.0,38.9 L 36.6,38.1 L 36.9,37.6\"\u003e\u003c\/path\u003e\u003cpath d=\"M 66.5,24.2 L 67.2,24.3 L 67.6,25.0\"\u003e\u003c\/path\u003e\u003ctext x=\"103.8\" y=\"35.6\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eO\u003c\/text\u003e\u003ctext x=\"71.6\" y=\"48.1\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eN\u003c\/text\u003e\u003ctext x=\"13.7\" y=\"42.1\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eO\u003c\/text\u003e\u003ctext x=\"36.1\" y=\"28.4\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eH\u003c\/text\u003e\u003ctext x=\"44.4\" y=\"28.4\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eN\u003c\/text\u003e\u003ctext x=\"75.0\" y=\"14.6\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eO\u003c\/text\u003e\u003ctext x=\"155.2\" y=\"43.4\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eO\u003c\/text\u003e\u003ctext x=\"171.9\" y=\"33.7\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eP\u003c\/text\u003e\u003ctext x=\"188.7\" y=\"23.9\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eO\u003c\/text\u003e\u003ctext x=\"181.7\" y=\"50.4\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eO\u003c\/text\u003e\u003ctext x=\"190.0\" y=\"50.4\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eH\u003c\/text\u003e\u003ctext x=\"154.5\" y=\"16.9\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eH\u003c\/text\u003e\u003ctext x=\"162.2\" y=\"16.9\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eO\u003c\/text\u003e\u003ctext x=\"134.0\" y=\"75.7\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eO\u003c\/text\u003e\u003ctext x=\"142.3\" y=\"75.7\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eH\u003c\/text\u003e\u003c\/svg\u003e\u003c\/div\u003e\n\u003cdiv style=\"display:flex;align-items:center;\"\u003e\u003cdiv style=\"display:flex;flex-direction:column;align-items:center;justify-content:center;min-width:90px;max-width:150px;padding:0 4px;text-align:center;font-size:12px;line-height:1.3;\"\u003e\n\u003cdiv\u003ethymidylate synthase\u003c\/div\u003e\n\u003cdiv style=\"font-size:30px;line-height:1;\"\u003e⟶\u003c\/div\u003e\n\u003cdiv\u003eCH₂H₄folate → H₂folate\u003c\/div\u003e\n\u003c\/div\u003e\u003c\/div\u003e\n\u003cdiv style=\"display:flex;align-items:center;\"\u003e\u003csvg role=\"img\" style=\"max-width:100%;height:auto;\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" fill=\"none\" stroke=\"#000\" stroke-width=\"1.6\" width=\"211px\" height=\"81px\" viewbox=\"0 0 211 81\"\u003e\u003cpath d=\"M 33.2,71.8 L 44.5,56.0\"\u003e\u003c\/path\u003e\u003cpath d=\"M 44.5,56.0 L 63.8,57.9\"\u003e\u003c\/path\u003e\u003cpath d=\"M 46.5,53.3 L 62.5,54.9\"\u003e\u003c\/path\u003e\u003cpath d=\"M 63.8,57.9 L 70.9,48.1\"\u003e\u003c\/path\u003e\u003cpath d=\"M 73.2,37.9 L 67.2,24.5\"\u003e\u003c\/path\u003e\u003cpath d=\"M 67.9,26.0 L 75.4,15.5\"\u003e\u003c\/path\u003e\u003cpath d=\"M 65.5,24.3 L 73.1,13.8\"\u003e\u003c\/path\u003e\u003cpath d=\"M 67.2,24.5 L 52.1,23.0\"\u003e\u003c\/path\u003e\u003cpath d=\"M 43.1,29.2 L 36.6,38.3\"\u003e\u003c\/path\u003e\u003cpath d=\"M 37.5,37.0 L 21.6,35.4\"\u003e\u003c\/path\u003e\u003cpath d=\"M 37.3,39.9 L 21.3,38.3\"\u003e\u003c\/path\u003e\u003cpath d=\"M 91.7,43.5 L 91.6,44.2\"\u003e\u003c\/path\u003e\u003cpath d=\"M 88.8,42.8 L 88.7,44.2\"\u003e\u003c\/path\u003e\u003cpath d=\"M 86.0,42.2 L 85.7,44.3\"\u003e\u003c\/path\u003e\u003cpath d=\"M 83.1,41.5 L 82.8,44.4\"\u003e\u003c\/path\u003e\u003cpath d=\"M 94.5,44.1 L 104.3,60.9\"\u003e\u003c\/path\u003e\u003cpath d=\"M 104.3,60.9 L 123.3,56.7\"\u003e\u003c\/path\u003e\u003cpath d=\"M 123.3,56.7 L 125.2,37.4\"\u003e\u003c\/path\u003e\u003cpath d=\"M 125.2,37.4 L 111.6,31.5\"\u003e\u003c\/path\u003e\u003cpath d=\"M 128.1,36.0 L 127.8,35.5\"\u003e\u003c\/path\u003e\u003cpath d=\"M 131.1,34.6 L 130.5,33.6\"\u003e\u003c\/path\u003e\u003cpath d=\"M 134.0,33.3 L 133.1,31.7\"\u003e\u003c\/path\u003e\u003cpath d=\"M 136.9,31.9 L 135.8,29.9\"\u003e\u003c\/path\u003e\u003cpath d=\"M 139.9,30.5 L 138.4,28.0\"\u003e\u003c\/path\u003e\u003cpath d=\"M 141.9,27.6 L 154.5,34.8\"\u003e\u003c\/path\u003e\u003cpath d=\"M 163.0,34.8 L 171.3,29.9\"\u003e\u003c\/path\u003e\u003cpath d=\"M 180.5,26.2 L 188.8,21.4\"\u003e\u003c\/path\u003e\u003cpath d=\"M 179.0,23.7 L 187.3,18.9\"\u003e\u003c\/path\u003e\u003cpath d=\"M 179.4,34.1 L 182.8,40.0\"\u003e\u003c\/path\u003e\u003cpath d=\"M 173.1,23.2 L 169.6,17.3\"\u003e\u003c\/path\u003e\u003cpath d=\"M 123.3,56.7 L 133.9,64.2 L 131.9,66.3 Z\"\u003e\u003c\/path\u003e\u003cpath d=\"M 36.6,38.3 L 44.5,56.0\"\u003e\u003c\/path\u003e\u003cpath d=\"M 103.2,34.4 L 94.5,44.1\"\u003e\u003c\/path\u003e\u003cpath d=\"M 62.9,57.8 L 63.8,57.9 L 64.2,57.4\"\u003e\u003c\/path\u003e\u003cpath d=\"M 67.5,25.2 L 67.2,24.5 L 66.4,24.4\"\u003e\u003c\/path\u003e\u003cpath d=\"M 36.9,37.9 L 36.6,38.3 L 37.0,39.2\"\u003e\u003c\/path\u003e\u003cpath d=\"M 95.0,44.9 L 94.5,44.1 L 95.0,43.6\"\u003e\u003c\/path\u003e\u003cpath d=\"M 103.8,60.0 L 104.3,60.9 L 105.3,60.7\"\u003e\u003c\/path\u003e\u003cpath d=\"M 122.3,56.9 L 123.3,56.7 L 123.4,55.7\"\u003e\u003c\/path\u003e\u003cpath d=\"M 125.1,38.3 L 125.2,37.4 L 124.5,37.1\"\u003e\u003c\/path\u003e\u003ctext x=\"71.6\" y=\"48.2\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eN\u003c\/text\u003e\u003ctext x=\"74.9\" y=\"14.7\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eO\u003c\/text\u003e\u003ctext x=\"36.0\" y=\"28.6\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eH\u003c\/text\u003e\u003ctext x=\"44.3\" y=\"28.6\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eN\u003c\/text\u003e\u003ctext x=\"13.6\" y=\"42.4\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eO\u003c\/text\u003e\u003ctext x=\"103.8\" y=\"35.6\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eO\u003c\/text\u003e\u003ctext x=\"155.2\" y=\"43.2\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eO\u003c\/text\u003e\u003ctext x=\"171.9\" y=\"33.5\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eP\u003c\/text\u003e\u003ctext x=\"188.7\" y=\"23.7\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eO\u003c\/text\u003e\u003ctext x=\"181.7\" y=\"50.2\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eO\u003c\/text\u003e\u003ctext x=\"190.0\" y=\"50.2\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eH\u003c\/text\u003e\u003ctext x=\"154.5\" y=\"16.7\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eH\u003c\/text\u003e\u003ctext x=\"162.2\" y=\"16.7\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eO\u003c\/text\u003e\u003ctext x=\"134.2\" y=\"75.6\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eO\u003c\/text\u003e\u003ctext x=\"142.5\" y=\"75.6\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eH\u003c\/text\u003e\u003c\/svg\u003e\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cp style=\"font-size:12px;margin:4px 0 0 0;\"\u003e\u003cem\u003eReaction catalysed by thymidylate synthase: dUMP (left), the 5′-monophosphate of 2′-deoxyuridine, is methylated at C5 of uracil to give dTMP (right). Methylenetetrahydrofolate (CH₂H₄folate) is the methyl source and is converted to dihydrofolate (H₂folate).\u003c\/em\u003e\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cp\u003e\u003cstrong\u003eDeoxyuridine suppression test.\u003c\/strong\u003e The deoxyuridine suppression test measures how strongly exogenous deoxyuridine inhibits the incorporation of [³H]thymidine into DNA. In a series of marrow samples from one hospital, all abnormal results came from patients with vitamin B12 or folate deficiency. The test was of particular value in diagnosing these deficiencies in non-anaemic patients with macrocytosis and equivocal changes in marrow morphology, and in patients whose serum vitamin B12 or red cell folate levels were within the normal range. A later study found that it identified subtle cobalamin deficiency in patients without typical megaloblastic anaemia. A study in stimulated lymphocytes showed that the suppression is caused only in part by expansion of the cell's pools of non-radioactive dTMP and dTTP. Deoxyuridine also competitively inhibits thymidine kinase. The authors concluded that exogenous deoxyuridine has several effects on [³H]thymidine incorporation, and that these must be considered when the test results are interpreted.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eMarker of thymidylate synthase inhibition.\u003c\/strong\u003e A rise in plasma 2′-deoxyuridine is a surrogate marker of thymidylate synthase inhibition. It has been followed after administration of 5-fluorouracil and of specific thymidylate synthase inhibitors, with plasma deoxyuridine measured by reverse-phase HPLC. Inhibition of thymidylate synthase depletes dTTP and, at least in some cell lines, leads to accumulation of dUTP and misincorporation of uracil into DNA. How far the dUTP pool expands is largely determined by the expression of the pyrophosphatase dUTPase.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eThymidine phosphorylase deficiency.\u003c\/strong\u003e 2′-Deoxyuridine is a substrate of thymidine phosphorylase. Mutations in the thymidine phosphorylase gene cause mitochondrial neurogastrointestinal encephalomyopathy (MNGIE). In a study of patients with MNGIE, deoxyuridine accumulated in the circulation, but it was undetectable in mutation carriers and in controls. In a post-mortem study, thymidine and deoxyuridine were present in all tissues of MNGIE patients but absent from control tissues. This indicates that, without thymidine phosphorylase activity, tissues accumulate these nucleosides and excrete them into plasma.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eRelated thymidine analogues.\u003c\/strong\u003e Halogenated 2′-deoxyuridines are used as thymidine analogues in studies of DNA synthesis: 5-chloro-, 5-bromo- and 5-iodo-2′-deoxyuridine (CldU, BrdU and IdU) are used as labelling substrates. 5-Ethynyl-2′-deoxyuridine and 5-hydroxymethyl-2′-deoxyuridine are other analogues of 2′-deoxyuridine.\u003c\/p\u003e\n\u003c\/div\u003e\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cdiv style=\"margin-bottom: 28px;\"\u003e\n\u003cdiv style=\"background: #002147; padding: 10px 20px; margin-bottom: 0;\"\u003e\u003ch3 style=\"margin: 0; font-family: 'Helvetica Neue', Helvetica, Arial, sans-serif; font-size: 0.70em; font-weight: bold; letter-spacing: 0.12em; text-transform: uppercase; color: #fff;\"\u003eShipping Destinations\u003c\/h3\u003e\u003c\/div\u003e\n\u003cdiv style=\"border: 1px solid #e4e8f0; border-top: none; padding: 12px 16px; font-family: 'Helvetica Neue', Helvetica, Arial, sans-serif; font-size: 0.95em;\"\u003e\u003cul style=\"margin: 0; padding: 0; list-style: none;\"\u003e\n\u003cli style=\"padding: 5px 0; border-bottom: 1px solid #f0f0f0;\"\u003e\n\u003cspan style=\"display: inline-block; width: 7px; height: 7px; background: #002147; border-radius: 50%; margin-right: 10px; vertical-align: middle;\"\u003e\u003c\/span\u003eEU \u0026amp; UK: Priority delivery, 2–5 business days.\u003c\/li\u003e\n\u003cli style=\"padding: 5px 0; border-bottom: 1px solid #f0f0f0;\"\u003e\n\u003cspan style=\"display: inline-block; width: 7px; height: 7px; background: #002147; border-radius: 50%; margin-right: 10px; vertical-align: middle;\"\u003e\u003c\/span\u003eUnited States (DDP): 3–7 business days, duties and taxes prepaid.\u003c\/li\u003e\n\u003cli style=\"padding: 5px 0; border-bottom: 1px solid #f0f0f0;\"\u003e\n\u003cspan style=\"display: inline-block; width: 7px; height: 7px; background: #002147; border-radius: 50%; margin-right: 10px; vertical-align: middle;\"\u003e\u003c\/span\u003eEFTA Countries (DDP): 3–7 business days, duties and taxes prepaid.\u003c\/li\u003e\n\u003cli style=\"padding: 5px 0; border-bottom: 1px solid #f0f0f0;\"\u003e\n\u003cspan style=\"display: inline-block; width: 7px; height: 7px; background: #002147; border-radius: 50%; margin-right: 10px; vertical-align: middle;\"\u003e\u003c\/span\u003eWorldwide: 7–14 business days, selected locations.\u003c\/li\u003e\n\u003c\/ul\u003e\u003c\/div\u003e\n\u003c\/div\u003e","brand":"NorrChemica™","offers":[{"title":"5.0 g","offer_id":55354310033745,"sku":"NOR-951780-5g","price":59.2,"currency_code":"EUR","in_stock":true},{"title":"10 g","offer_id":55164431106385,"sku":"NOR-951780-10g","price":94.2,"currency_code":"EUR","in_stock":true},{"title":"25 g","offer_id":55164431139153,"sku":"NOR-951780-25g","price":149.2,"currency_code":"EUR","in_stock":true},{"title":"50 g","offer_id":55354317439313,"sku":"NOR-951780-50g","price":274.2,"currency_code":"EUR","in_stock":true},{"title":"100 g","offer_id":55164431171921,"sku":"NOR-951780-100g","price":479.2,"currency_code":"EUR","in_stock":true},{"title":"250 g","offer_id":55354310000977,"sku":"NOR-951780-250g","price":995.0,"currency_code":"EUR","in_stock":true},{"title":"500 g","offer_id":55164431204689,"sku":"NOR-951780-500g","price":1695.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0954\/6357\/1793\/files\/NorrChemica_2-Deoxyuridine.png?v=1791046176"},{"product_id":"5-bromo-2-deoxyuridine-cas-59-14-3","title":"5-Bromo-2′-deoxyuridine | CAS 59-14-3 | ≥98%","description":"\u003cdiv style=\"margin-bottom: 28px;\"\u003e\n\u003cdiv style=\"background: #002147; padding: 10px 20px; margin-bottom: 0;\"\u003e  \u003ch3 style=\"margin: 0; font-family: 'Helvetica Neue', Helvetica, Arial, sans-serif; font-size: 0.70em; font-weight: 700; letter-spacing: 0.12em; text-transform: uppercase; color: #fff;\"\u003eTechnical Specifications\u003c\/h3\u003e\n\u003c\/div\u003e\n\u003ctable style=\"width: 100%; border-collapse: collapse; font-size: 0.95em; border: 1px solid #e4e8f0; border-top: none; font-family: 'Helvetica Neue', Helvetica, Arial, sans-serif;\"\u003e\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eCAS Number\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e59-14-3\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eEC \/ EINECS Number\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e200-415-9\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eMDL Number\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003eMFCD00006529\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eRTECS Number\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003eYU7350000\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eSMILES\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0; word-break: break-all;\"\u003eC1[C@@H]([C@H](O[C@H]1N2C=C(C(=O)NC2=O)Br)CO)O\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eInChI\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0; word-break: break-all;\"\u003eInChI=1S\/C9H11BrN2O5\/c10-4-2-12(9(16)11-8(4)15)7-1-5(14)6(3-13)17-7\/h2,5-7,13-14H,1,3H2,(H,11,15,16)\/t5-,6+,7+\/m0\/s1\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eInChIKey\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0; word-break: break-all;\"\u003eWOVKYSAHUYNSMH-RRKCRQDMSA-N\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003ePubChem CID\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e6035\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eMolecular Formula\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003eC₉H₁₁BrN₂O₅\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eMolecular Weight\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e307.1 g\/mol\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eMelting Point\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e187-189 °C\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eSolubility\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003eSoluble in water (10 mg\/mL; 50–100 mg\/mL after heating); soluble in DMSO and DMF (50–100 mg\/mL)\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003ePurity\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e≥98%\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003ePhysical Form\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003eWhite to pale grey crystalline powder\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eHS Code\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e2934.99\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eShelf Life\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003eRetest period: 36 months from date of manufacture\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eStorage Conditions\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003eStore in cool place. Keep container tightly closed in a dry and well-ventilated place. Store away from strong oxidizing agents.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\u003c\/table\u003e\n\u003c\/div\u003e\u003cdiv style=\"margin-bottom: 28px;\"\u003e\n\u003cdiv style=\"background: #002147; padding: 10px 20px; margin-bottom: 0;\"\u003e  \u003ch3 style=\"margin: 0; font-family: 'Helvetica Neue', Helvetica, Arial, sans-serif; font-size: 0.70em; font-weight: 700; letter-spacing: 0.12em; text-transform: uppercase; color: #fff;\"\u003eProduct Description \u0026amp; Scientific Applications\u003c\/h3\u003e\n\u003c\/div\u003e\n\u003cdiv style=\"padding: 16px 20px; border: 1px solid #e4e8f0; border-top: none; font-family: Georgia, 'Times New Roman', serif; font-size: 0.95em; line-height: 1.65; color: #333;\"\u003e\n\u003cp\u003e\u003cstrong\u003e5-Bromo-2′-deoxyuridine\u003c\/strong\u003e (BrdU) is a synthetic halogenated pyrimidine analogue and a marker of DNA synthesis: as a thymidine analogue, it is incorporated into newly synthesised DNA. BrdU-substituted DNA stains much more weakly with Hoechst dye and Giemsa than unsubstituted DNA. Bromine at the C5 position of pyrimidines, as in BrdU, has been used to attach a heavy atom covalently when derivatising DNA or RNA.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eCell proliferation assays.\u003c\/strong\u003e The BrdU incorporation assay is the most commonly used method for assessing DNA replication and is typically read out by antibody immunostaining of the incorporated label. Because the C5 bromide is also a cross-coupling handle, BrdU incorporated in cells can instead be labelled directly with fluorescent boronic acid probes by Suzuki–Miyaura coupling, without antibody immunostaining.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eSister chromatid exchange.\u003c\/strong\u003e Once BrdU has been incorporated over two cell cycles, Hoechst\/Giemsa differential staining or anti-BrdU antibody detection reveals the newly synthesised DNA strand within each chromatid as harlequin chromosomes, which allows the exchanges to be analysed.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eCell-cycle kinetics.\u003c\/strong\u003e Flow-cytometric double staining gives bivariate BrdU\/DNA distributions, from which tumour S-phase duration and other cell-kinetic parameters are calculated.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eReplication timing.\u003c\/strong\u003e For genome-wide mapping, cells are pulse-labelled with BrdU, the early and late S-phase fractions are separated by flow sorting, and the labelled nascent DNA is immunoprecipitated and sequenced.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eNanopore sequencing.\u003c\/strong\u003e BrdU is detectable in DNA templates alongside other thymidine analogues, including CldU and IdU.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eRadiosensitisation.\u003c\/strong\u003e Halogenated pyrimidines such as BrdU sensitise cells to ionising radiation only after they have been incorporated into cellular DNA in place of thymidine.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003ePhoto-cross-linking.\u003c\/strong\u003e Site-specific substitution of BrdU into synthetic oligonucleotides greatly increases the yield of UV photo-cross-linking to bound proteins, which makes it a handle for mapping protein–DNA contacts.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eSynthetic oligonucleotides and DNA fragments.\u003c\/strong\u003e As its phosphoramidite, 5-bromo-2′-deoxyuridine is incorporated into synthetic oligodeoxynucleotides for structure–activity comparisons with other modified pyrimidines in serum stability, duplex binding affinity and RNase H-directed cleavage. An enzymatic polymerase\/ligase method places 5-bromo-2′-deoxyuridine at a predetermined site within double-stranded DNA fragments, enabling studies of the sequence dependence of sensitiser-induced DNA damage.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\u003cdiv style=\"margin-bottom: 28px;\"\u003e\n\u003cdiv style=\"background: #002147; padding: 10px 20px; margin-bottom: 0;\"\u003e  \u003ch3 style=\"margin: 0; font-family: 'Helvetica Neue', Helvetica, Arial, sans-serif; font-size: 0.70em; font-weight: 700; letter-spacing: 0.12em; text-transform: uppercase; color: #fff;\"\u003eShipping Destinations\u003c\/h3\u003e\n\u003c\/div\u003e\n\u003cdiv style=\"border: 1px solid #e4e8f0; border-top: none; padding: 12px 16px; font-family: 'Helvetica Neue', Helvetica, Arial, sans-serif; font-size: 0.95em;\"\u003e\u003cul style=\"margin: 0; padding: 0; list-style: none;\"\u003e\n\u003cli style=\"padding: 5px 0; border-bottom: 1px solid #f0f0f0;\"\u003e\n\u003cspan style=\"display: inline-block; width: 7px; height: 7px; background: #002147; border-radius: 50%; margin-right: 10px; vertical-align: middle;\"\u003e\u003c\/span\u003eEU \u0026amp; UK: Priority delivery, 3–5 business days.\u003c\/li\u003e\n\u003cli style=\"padding: 5px 0; border-bottom: 1px solid #f0f0f0;\"\u003e\n\u003cspan style=\"display: inline-block; width: 7px; height: 7px; background: #002147; border-radius: 50%; margin-right: 10px; vertical-align: middle;\"\u003e\u003c\/span\u003eUnited States (DDP): 3–7 business days, duties and taxes prepaid.\u003c\/li\u003e\n\u003cli style=\"padding: 5px 0; border-bottom: 1px solid #f0f0f0;\"\u003e\n\u003cspan style=\"display: inline-block; width: 7px; height: 7px; background: #002147; border-radius: 50%; margin-right: 10px; vertical-align: middle;\"\u003e\u003c\/span\u003eEFTA Countries (DDP): 3–7 business days, duties and taxes prepaid.\u003c\/li\u003e\n\u003cli style=\"padding: 5px 0; border-bottom: 1px solid #f0f0f0;\"\u003e\n\u003cspan style=\"display: inline-block; width: 7px; height: 7px; background: #002147; border-radius: 50%; margin-right: 10px; vertical-align: middle;\"\u003e\u003c\/span\u003eWorldwide: 7–14 business days, selected locations.\u003c\/li\u003e\n\u003c\/ul\u003e\u003c\/div\u003e\n\u003c\/div\u003e","brand":"NorrChemica™","offers":[{"title":"250 mg","offer_id":55164431237457,"sku":"NOR-59143-250mg","price":47.2,"currency_code":"EUR","in_stock":true},{"title":"1.0 g","offer_id":55164431270225,"sku":"NOR-59143-1g","price":69.2,"currency_code":"EUR","in_stock":true},{"title":"5.0 g","offer_id":55164431302993,"sku":"NOR-59143-5g","price":169.2,"currency_code":"EUR","in_stock":true},{"title":"10 g","offer_id":55164431335761,"sku":"NOR-59143-10g","price":274.2,"currency_code":"EUR","in_stock":true},{"title":"25 g","offer_id":55164431368529,"sku":"NOR-59143-25g","price":469.8,"currency_code":"EUR","in_stock":true},{"title":"50 g","offer_id":55177950789969,"sku":"NOR-59143-50g","price":898.0,"currency_code":"EUR","in_stock":true},{"title":"100 g","offer_id":55164431401297,"sku":"NOR-59143-100g","price":1425.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0954\/6357\/1793\/files\/NorrChemica_5-Bromo-2-deoxyuridine.png?v=1791046174"},{"product_id":"adenine-cas-73-24-5","title":"Adenine | CAS 73-24-5 | ≥98%","description":"\u003cdiv style=\"margin-bottom: 28px;\"\u003e\n\u003cdiv style=\"background: #002147; padding: 10px 20px; margin-bottom: 0;\"\u003e  \u003ch3 style=\"margin: 0; font-family: 'Helvetica Neue', Helvetica, Arial, sans-serif; font-size: 0.70em; font-weight: 700; letter-spacing: 0.12em; text-transform: uppercase; color: #fff;\"\u003eTechnical Specifications\u003c\/h3\u003e\n\u003c\/div\u003e\n\u003ctable style=\"width: 100%; border-collapse: collapse; font-size: 0.95em; border: 1px solid #e4e8f0; border-top: none; font-family: 'Helvetica Neue', Helvetica, Arial, sans-serif;\"\u003e\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eCAS Number\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e73-24-5\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eEC \/ EINECS Number\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e200-796-1\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eMDL Number\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003eMFCD00041790\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eRTECS Number\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003eAU6125000\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eSMILES\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0; word-break: break-all;\"\u003eC1=NC2=NC=NC(=C2N1)N\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eInChI\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0; word-break: break-all;\"\u003eInChI=1S\/C5H5N5\/c6-4-3-5(9-1-7-3)10-2-8-4\/h1-2H,(H3,6,7,8,9,10)\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eInChIKey\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0; word-break: break-all;\"\u003eGFFGJBXGBJISGV-UHFFFAOYSA-N\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003ePubChem CID\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e190\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eMolecular Formula\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003eC₅H₅N₅\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eMolecular Weight\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e135.13 g\/mol\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eMelting Point\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e360 °C (dec.)\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eSolubility\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003eSoluble in hot water, methanol and ethanol. Slightly soluble in cold water. Insoluble in diethyl ether\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003ePurity\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e≥98%\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003ePhysical Form\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003eWhite to off-white powder\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eHS Code\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e2933.59\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eShelf Life\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003eRetest period: 36 months from date of manufacture\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eStorage Conditions\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003eKeep containers tightly closed in a dry, cool and well-ventilated place\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\u003c\/table\u003e\n\u003c\/div\u003e\u003cdiv style=\"margin-bottom: 28px;\"\u003e\n\u003cdiv style=\"background: #002147; padding: 10px 20px; margin-bottom: 0;\"\u003e  \u003ch3 style=\"margin: 0; font-family: 'Helvetica Neue', Helvetica, Arial, sans-serif; font-size: 0.70em; font-weight: 700; letter-spacing: 0.12em; text-transform: uppercase; color: #fff;\"\u003eProduct Description \u0026amp; Scientific Applications\u003c\/h3\u003e\n\u003c\/div\u003e\n\u003cdiv style=\"padding: 16px 20px; border: 1px solid #e4e8f0; border-top: none; font-family: Georgia, 'Times New Roman', serif; font-size: 0.95em; line-height: 1.65; color: #333;\"\u003e\n\u003cp\u003e\u003cstrong\u003eAdenine\u003c\/strong\u003e is a purine nucleobase, one of the two purines in DNA and RNA, and pairs with thymine or uracil through Watson–Crick hydrogen bonding. Its rigid structure and strong metal-binding ability have been widely studied and support its use as a ligand in metal-based catalysis.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eN9 versus N3 alkylation.\u003c\/strong\u003e Under basic conditions, adenine is benzylated at N9 and N3: polar aprotic solvents such as DMSO, DMF and acetonitrile favour the N9 product, while polar protic solvents such as water favour the N3 isomer. With other electrophiles the minor isomer differs: the N7 isomer forms alongside the N9 product when adenine is alkylated with the iodide reagent of the adefovir synthesis, and the exocyclic amino group is alkylated as a by-product with (R)-4-methyl-1,3-dioxolan-2-one.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eAntiviral nucleotide analogues.\u003c\/strong\u003e Tenofovir disoproxil fumarate and tenofovir alafenamide are manufactured from adenine. Its alkylation with (R)-4-methyl-1,3-dioxolan-2-one gives (R)-9-(2-hydroxypropyl)adenine, which is then alkylated with a tosylated hydroxymethylphosphonate diester. In the synthesis of adefovir, alkylation of adenine with an iodide reagent gives the phosphonate directly.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eNucleoside synthesis.\u003c\/strong\u003e Glycosylation of adenine with peracylated sugar precursors gives nucleoside analogues, including trifluoromethyl- and dideoxy-substituted adenosine derivatives evaluated for antiviral activity.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eCoordination polymers.\u003c\/strong\u003e With silver ions, adenine forms coordination frameworks whose nuclearity depends on the N9 substituent, from dinuclear complexes to linear polymeric chains.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eCorrosion inhibition.\u003c\/strong\u003e Adenine is a natural inhibitor of mild-steel corrosion in NaCl solution when co-encapsulated with benzimidazole in a bio-metal–organic framework.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003ePeptide conjugates.\u003c\/strong\u003e Propargyladenine, coupled to homoazidoalanine by copper-catalysed azide–alkyne cycloaddition, gives nucleopeptide monomers for triazole-linked adenine peptides that recognise U-rich HIV RNA motifs.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eSupramolecular templating.\u003c\/strong\u003e Oligoadenine templates (dA20, dA40) direct thymine-substituted donor–acceptor π-conjugated monomers to self-assemble into tubular nanostructures through complementary adenine–thymine hydrogen bonding, an initial step towards DNA-templated polymerisation of synthetic DNA-mimetic polymers.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\u003cdiv style=\"margin-bottom: 28px;\"\u003e\n\u003cdiv style=\"background: #002147; padding: 10px 20px; margin-bottom: 0;\"\u003e  \u003ch3 style=\"margin: 0; font-family: 'Helvetica Neue', Helvetica, Arial, sans-serif; font-size: 0.70em; font-weight: 700; letter-spacing: 0.12em; text-transform: uppercase; color: #fff;\"\u003eShipping Destinations\u003c\/h3\u003e\n\u003c\/div\u003e\n\u003cdiv style=\"border: 1px solid #e4e8f0; border-top: none; padding: 12px 16px; font-family: 'Helvetica Neue', Helvetica, Arial, sans-serif; font-size: 0.95em;\"\u003e\u003cul style=\"margin: 0; padding: 0; list-style: none;\"\u003e\u003cli style=\"padding: 5px 0; border-bottom: 1px solid #f0f0f0;\"\u003e\n\u003cspan style=\"display: inline-block; width: 7px; height: 7px; background: #002147; border-radius: 50%; margin-right: 10px; vertical-align: middle;\"\u003e\u003c\/span\u003eEU \u0026amp; UK only: 3–7 business days.\u003c\/li\u003e\u003c\/ul\u003e\u003c\/div\u003e\n\u003c\/div\u003e","brand":"NorrChemica™","offers":[{"title":"5.0 g","offer_id":55164431434065,"sku":"NOR-73245-5g","price":69.2,"currency_code":"EUR","in_stock":true},{"title":"10 g","offer_id":55178182033745,"sku":"NOR-73245-10g","price":89.2,"currency_code":"EUR","in_stock":true},{"title":"25 g","offer_id":55178182066513,"sku":"NOR-73245-25g","price":129.2,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0954\/6357\/1793\/files\/NorrChemica_Adenine.png?v=1791041816"},{"product_id":"2-deoxyguanosine-monohydrate-cas-312693-72-4","title":"2′-Deoxyguanosine monohydrate | CAS 312693-72-4 | ≥97%","description":"\u003cdiv style=\"margin-bottom: 28px;\"\u003e\n\u003cdiv style=\"background: #002147; padding: 10px 20px; margin-bottom: 0;\"\u003e\u003ch3 style=\"margin: 0; font-family: 'Helvetica Neue', Helvetica, Arial, sans-serif; font-size: 0.70em; font-weight: bold; letter-spacing: 0.12em; text-transform: uppercase; color: #fff;\"\u003eTechnical Specifications\u003c\/h3\u003e\u003c\/div\u003e\n\u003ctable style=\"width: 100%; border-collapse: collapse; font-size: 0.95em; border: 1px solid #e4e8f0; border-top: none; font-family: 'Helvetica Neue', Helvetica, Arial, sans-serif;\"\u003e\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eCAS Number\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e312693-72-4\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eEC \/ EINECS Number\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e628-392-4\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eMDL Number\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003eMFCD00150760\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eRTECS Number\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003eMF8760000\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eSMILES\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0; word-break: break-all;\"\u003eC1[C@@H]([C@H](O[C@H]1N2C=NC3=C2N=C(NC3=O)N)CO)O.O\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eInChI\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0; word-break: break-all;\"\u003eInChI=1S\/C10H13N5O4.H2O\/c11-10-13-8-7(9(18)14-10)12-3-15(8)6-1-4(17)5(2-16)19-6;\/h3-6,16-17H,1-2H2,(H3,11,13,14,18);1H2\/t4-,5+,6+;\/m0.\/s1\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eInChIKey\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0; word-break: break-all;\"\u003eLZSCQUCOIRGCEJ-FPKZOZHISA-N\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003ePubChem CID\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e135445705\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eMolecular Formula\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003eC₁₀H₁₅N₅O₅\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eMolecular Weight\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e285.26 g\/mol\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eMelting Point\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e300 °C\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eSolubility\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003eSoluble in DMSO (10 mg\/mL), 0.1 M hydrochloric acid (10 mg\/mL) and 1 M aqueous ammonia (50 mg\/mL).\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003ePurity\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e≥97%\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003ePhysical Form\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003eWhite crystalline powder\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eHS Code\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e2934.99\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eShelf Life\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003eRetest period: 36 months from date of manufacture\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eStorage Conditions\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333;\"\u003eStore in a cool, dry place in a tightly sealed container.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\u003c\/table\u003e\n\u003c\/div\u003e\n\u003cdiv style=\"margin-bottom: 28px;\"\u003e\n\u003cdiv style=\"background: #002147; padding: 10px 20px; margin-bottom: 0;\"\u003e\u003ch3 style=\"margin: 0; font-family: 'Helvetica Neue', Helvetica, Arial, sans-serif; font-size: 0.70em; font-weight: bold; letter-spacing: 0.12em; text-transform: uppercase; color: #fff;\"\u003eProduct Description \u0026amp; Scientific Applications\u003c\/h3\u003e\u003c\/div\u003e\n\u003cdiv style=\"padding: 16px 20px; border: 1px solid #e4e8f0; border-top: none; font-family: Georgia, 'Times New Roman', serif; font-size: 0.95em; line-height: 1.65; color: #333;\"\u003e\u003cdiv\u003e\n\u003cp\u003e\u003cstrong\u003e2′-Deoxyguanosine\u003c\/strong\u003e (dG) is the 2′-deoxyribonucleoside of guanine and one of the four nucleosides of DNA. Kinases phosphorylate it in sequence to dGTP, which DNA polymerases and reverse transcriptases use to synthesise DNA. In mitochondria, deoxyguanosine kinase (dGK) phosphorylates it as the rate-limiting enzyme of the purine salvage pathway. The product is supplied as the monohydrate.\u003c\/p\u003e\n\u003cdiv style=\"margin:8px 0 18px 0;\"\u003e\n\u003cdiv style=\"display:flex;flex-wrap:wrap;align-items:center;justify-content:flex-start;gap:2px;\"\u003e\n\u003cdiv style=\"display:flex;align-items:center;\"\u003e\u003csvg role=\"img\" style=\"max-width:100%;height:auto;\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" fill=\"none\" stroke=\"#000\" stroke-width=\"1.6\" width=\"200px\" height=\"165px\" viewbox=\"0 0 200 165\"\u003e\u003cpath d=\"M 29.3,145.1 L 29.4,126.4\"\u003e\u003c\/path\u003e\u003cpath d=\"M 48.3,117.4 L 29.4,130.2 L 29.4,126.4 Z\" fill=\"#000\" stroke-width=\"0.4\"\u003e\u003c\/path\u003e\u003cpath d=\"M 48.3,117.4 L 50.1,100.8\"\u003e\u003c\/path\u003e\u003cpath d=\"M 55.3,94.7 L 72.1,91.2\"\u003e\u003c\/path\u003e\u003cpath d=\"M 72.1,91.2 L 77.0,76.3 L 80.0,77.7 Z\" fill=\"#000\" stroke-width=\"0.4\"\u003e\u003c\/path\u003e\u003cpath d=\"M 78.2,66.3 L 70.2,52.3\"\u003e\u003c\/path\u003e\u003cpath d=\"M 70.2,52.3 L 81.0,40.5\"\u003e\u003c\/path\u003e\u003cpath d=\"M 74.3,52.8 L 83.4,42.7\"\u003e\u003c\/path\u003e\u003cpath d=\"M 88.9,37.9 L 104.9,45.1\"\u003e\u003c\/path\u003e\u003cpath d=\"M 104.9,45.1 L 102.5,66.8\"\u003e\u003c\/path\u003e\u003cpath d=\"M 101.3,47.1 L 99.5,64.1\"\u003e\u003c\/path\u003e\u003cpath d=\"M 102.5,66.8 L 116.2,76.9\"\u003e\u003c\/path\u003e\u003cpath d=\"M 124.0,78.0 L 140.1,71.0\"\u003e\u003c\/path\u003e\u003cpath d=\"M 122.7,75.0 L 137.0,68.7\"\u003e\u003c\/path\u003e\u003cpath d=\"M 140.1,71.0 L 153.8,81.0\"\u003e\u003c\/path\u003e\u003cpath d=\"M 140.1,71.0 L 141.9,54.2\"\u003e\u003c\/path\u003e\u003cpath d=\"M 138.5,46.4 L 124.9,36.3\"\u003e\u003c\/path\u003e\u003cpath d=\"M 126.4,37.4 L 128.3,19.9\"\u003e\u003c\/path\u003e\u003cpath d=\"M 123.1,37.1 L 125.0,19.6\"\u003e\u003c\/path\u003e\u003cpath d=\"M 72.1,91.2 L 82.9,110.2\"\u003e\u003c\/path\u003e\u003cpath d=\"M 82.9,110.2 L 68.3,126.4\"\u003e\u003c\/path\u003e\u003cpath d=\"M 69.2,129.4 L 68.6,129.6\" stroke-width=\"0.8\"\u003e\u003c\/path\u003e\u003cpath d=\"M 70.2,132.5 L 68.9,132.7\" stroke-width=\"0.8\"\u003e\u003c\/path\u003e\u003cpath d=\"M 71.2,135.5 L 69.2,135.9\" stroke-width=\"0.8\"\u003e\u003c\/path\u003e\u003cpath d=\"M 72.1,138.6 L 69.6,139.1\" stroke-width=\"0.8\"\u003e\u003c\/path\u003e\u003cpath d=\"M 73.1,141.7 L 69.9,142.3\" stroke-width=\"0.8\"\u003e\u003c\/path\u003e\u003cpath d=\"M 68.3,126.4 L 48.3,117.4\"\u003e\u003c\/path\u003e\u003cpath d=\"M 102.5,66.8 L 85.0,70.5\"\u003e\u003c\/path\u003e\u003cpath d=\"M 124.9,36.3 L 104.9,45.1\"\u003e\u003c\/path\u003e\u003cpath d=\"M 48.4,116.5 L 48.3,117.4 L 49.3,117.8\"\u003e\u003c\/path\u003e\u003cpath d=\"M 71.3,91.4 L 72.1,91.2 L 72.6,92.2\"\u003e\u003c\/path\u003e\u003cpath d=\"M 70.6,53.0 L 70.2,52.3 L 70.8,51.7\"\u003e\u003c\/path\u003e\u003cpath d=\"M 125.5,36.8 L 124.9,36.3 L 123.9,36.8\"\u003e\u003c\/path\u003e\u003cpath d=\"M 82.4,109.2 L 82.9,110.2 L 82.2,111.0\"\u003e\u003c\/path\u003e\u003cpath d=\"M 69.0,125.5 L 68.3,126.4 L 67.3,125.9\"\u003e\u003c\/path\u003e\u003cg style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003e\u003ctext x=\"25.7\" y=\"154.3\" text-anchor=\"start\"\u003eOH\u003c\/text\u003e\u003ctext x=\"50.7\" y=\"99.9\" text-anchor=\"middle\"\u003eO\u003c\/text\u003e\u003ctext x=\"81.1\" y=\"75.5\" text-anchor=\"middle\"\u003eN\u003c\/text\u003e\u003ctext x=\"84.9\" y=\"40.3\" text-anchor=\"middle\"\u003eN\u003c\/text\u003e\u003ctext x=\"120.1\" y=\"84.0\" text-anchor=\"middle\"\u003eN\u003c\/text\u003e\u003ctext x=\"154.1\" y=\"88.1\" text-anchor=\"start\"\u003eNH₂\u003c\/text\u003e\u003ctext x=\"138.9\" y=\"53.4\" text-anchor=\"start\"\u003eNH\u003c\/text\u003e\u003ctext x=\"127.2\" y=\"18.8\" text-anchor=\"middle\"\u003eO\u003c\/text\u003e\u003ctext x=\"69.1\" y=\"151.9\" text-anchor=\"start\"\u003eOH\u003c\/text\u003e\u003c\/g\u003e\u003c\/svg\u003e\u003c\/div\u003e\n\u003cdiv style=\"display:flex;align-items:center;\"\u003e\u003cdiv style=\"display:flex;flex-direction:column;align-items:center;justify-content:center;min-width:90px;max-width:150px;padding:0 4px;text-align:center;font-size:12px;line-height:1.3;\"\u003e\n\u003cdiv\u003edGK\u003c\/div\u003e\n\u003cdiv style=\"font-size:30px;line-height:1;\"\u003e⟶\u003c\/div\u003e\n\u003cdiv\u003e(in mitochondria)\u003c\/div\u003e\n\u003c\/div\u003e\u003c\/div\u003e\n\u003cdiv style=\"display:flex;align-items:center;\"\u003e\u003csvg role=\"img\" style=\"max-width:100%;height:auto;\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" fill=\"none\" stroke=\"#000\" stroke-width=\"1.6\" width=\"200px\" height=\"165px\" viewbox=\"0 0 200 165\"\u003e\u003cpath d=\"M 28.9,140.5 L 37.4,135.7\"\u003e\u003c\/path\u003e\u003cpath d=\"M 30.2,142.9 L 38.7,138.1\"\u003e\u003c\/path\u003e\u003cpath d=\"M 38.6,130.6 L 34.8,124.0\"\u003e\u003c\/path\u003e\u003cpath d=\"M 43.7,139.6 L 47.6,146.3\"\u003e\u003c\/path\u003e\u003cpath d=\"M 44.2,133.4 L 52.8,128.5\"\u003e\u003c\/path\u003e\u003cpath d=\"M 57.0,121.6 L 57.0,106.5\"\u003e\u003c\/path\u003e\u003cpath d=\"M 72.8,99.0 L 57.0,109.6 L 57.0,106.5 Z\" fill=\"#000\" stroke-width=\"0.4\"\u003e\u003c\/path\u003e\u003cpath d=\"M 72.8,99.0 L 74.3,85.6\"\u003e\u003c\/path\u003e\u003cpath d=\"M 79.0,80.1 L 92.6,77.3\"\u003e\u003c\/path\u003e\u003cpath d=\"M 92.6,77.3 L 96.4,65.4 L 98.9,66.5 Z\" fill=\"#000\" stroke-width=\"0.4\"\u003e\u003c\/path\u003e\u003cpath d=\"M 97.4,56.4 L 91.0,45.1\"\u003e\u003c\/path\u003e\u003cpath d=\"M 91.0,45.1 L 99.6,35.6\"\u003e\u003c\/path\u003e\u003cpath d=\"M 94.3,45.5 L 101.7,37.4\"\u003e\u003c\/path\u003e\u003cpath d=\"M 106.7,33.3 L 119.7,39.1\"\u003e\u003c\/path\u003e\u003cpath d=\"M 119.7,39.1 L 117.8,57.2\"\u003e\u003c\/path\u003e\u003cpath d=\"M 116.8,40.8 L 115.3,54.9\"\u003e\u003c\/path\u003e\u003cpath d=\"M 117.8,57.2 L 128.8,65.3\"\u003e\u003c\/path\u003e\u003cpath d=\"M 135.9,66.3 L 148.9,60.6\"\u003e\u003c\/path\u003e\u003cpath d=\"M 134.8,63.9 L 146.4,58.7\"\u003e\u003c\/path\u003e\u003cpath d=\"M 148.9,60.6 L 160.0,68.7\"\u003e\u003c\/path\u003e\u003cpath d=\"M 148.9,60.6 L 150.5,47.1\"\u003e\u003c\/path\u003e\u003cpath d=\"M 147.4,40.0 L 136.3,31.9\"\u003e\u003c\/path\u003e\u003cpath d=\"M 137.6,32.8 L 139.2,18.6\"\u003e\u003c\/path\u003e\u003cpath d=\"M 134.9,32.5 L 136.5,18.3\"\u003e\u003c\/path\u003e\u003cpath d=\"M 92.6,77.3 L 101.6,93.1\"\u003e\u003c\/path\u003e\u003cpath d=\"M 101.6,93.1 L 89.3,106.5\"\u003e\u003c\/path\u003e\u003cpath d=\"M 90.3,109.6 L 89.6,109.7\" stroke-width=\"0.8\"\u003e\u003c\/path\u003e\u003cpath d=\"M 91.3,112.6 L 90.0,112.9\" stroke-width=\"0.8\"\u003e\u003c\/path\u003e\u003cpath d=\"M 92.3,115.7 L 90.3,116.2\" stroke-width=\"0.8\"\u003e\u003c\/path\u003e\u003cpath d=\"M 93.3,118.8 L 90.6,119.4\" stroke-width=\"0.8\"\u003e\u003c\/path\u003e\u003cpath d=\"M 89.3,106.5 L 72.8,99.0\"\u003e\u003c\/path\u003e\u003cpath d=\"M 117.8,57.2 L 103.5,60.1\"\u003e\u003c\/path\u003e\u003cpath d=\"M 136.3,31.9 L 119.7,39.1\"\u003e\u003c\/path\u003e\u003cpath d=\"M 72.9,98.3 L 72.8,99.0 L 73.6,99.4\"\u003e\u003c\/path\u003e\u003cpath d=\"M 91.9,77.4 L 92.6,77.3 L 93.0,78.1\"\u003e\u003c\/path\u003e\u003cpath d=\"M 91.3,45.7 L 91.0,45.1 L 91.4,44.6\"\u003e\u003c\/path\u003e\u003cpath d=\"M 136.9,32.3 L 136.3,31.9 L 135.5,32.2\"\u003e\u003c\/path\u003e\u003cpath d=\"M 101.1,92.3 L 101.6,93.1 L 100.9,93.7\"\u003e\u003c\/path\u003e\u003cpath d=\"M 89.9,105.8 L 89.3,106.5 L 88.5,106.1\"\u003e\u003c\/path\u003e\u003cg style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003e\u003ctext x=\"25.4\" y=\"148.3\" text-anchor=\"middle\"\u003eO\u003c\/text\u003e\u003ctext x=\"41.2\" y=\"139.3\" text-anchor=\"middle\"\u003eP\u003c\/text\u003e\u003ctext x=\"35.8\" y=\"123.6\" text-anchor=\"end\"\u003eHO\u003c\/text\u003e\u003ctext x=\"46.5\" y=\"155.1\" text-anchor=\"start\"\u003eOH\u003c\/text\u003e\u003ctext x=\"56.9\" y=\"130.3\" text-anchor=\"middle\"\u003eO\u003c\/text\u003e\u003ctext x=\"74.8\" y=\"85.2\" text-anchor=\"middle\"\u003eO\u003c\/text\u003e\u003ctext x=\"100.0\" y=\"65.1\" text-anchor=\"middle\"\u003eN\u003c\/text\u003e\u003ctext x=\"103.2\" y=\"35.9\" text-anchor=\"middle\"\u003eN\u003c\/text\u003e\u003ctext x=\"132.3\" y=\"72.1\" text-anchor=\"middle\"\u003eN\u003c\/text\u003e\u003ctext x=\"160.0\" y=\"75.5\" text-anchor=\"start\"\u003eNH₂\u003c\/text\u003e\u003ctext x=\"147.4\" y=\"46.8\" text-anchor=\"start\"\u003eNH\u003c\/text\u003e\u003ctext x=\"138.3\" y=\"18.0\" text-anchor=\"middle\"\u003eO\u003c\/text\u003e\u003ctext x=\"89.4\" y=\"128.4\" text-anchor=\"start\"\u003eOH\u003c\/text\u003e\u003c\/g\u003e\u003c\/svg\u003e\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cp style=\"font-size:12px;margin:4px 0 0 0;\"\u003e\u003cem\u003ePhosphorylation of 2′-deoxyguanosine (left) at the 5′-hydroxyl group gives dGMP (right). Further phosphorylation gives dGTP, the substrate of DNA polymerases.\u003c\/em\u003e\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cp\u003e\u003cstrong\u003eDeoxyguanosine kinase and mitochondrial DNA.\u003c\/strong\u003e Mutations in DGUOK, the gene that encodes dGK, cause depletion of mitochondrial DNA (mtDNA), mainly in the liver and brain. In cultured primary cells deficient in dGK, addition of deoxyguanosine prevented the fall in mtDNA copy number. In a zebrafish model lacking dguok, deoxyguanosine given alone lowered mtDNA copy number in juveniles, whereas supplementation with both purine nucleosides raised liver mtDNA in adult mutants. The authors suggested that the difference from the cell results may come from an imbalance in nucleotide pools.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eToxicity to T lymphoblasts.\u003c\/strong\u003e Deoxyguanosine is toxic to human lymphoid cells in culture and is linked to the immunodeficiency of purine nucleoside phosphorylase (PNP) deficiency. In human T lymphoblasts, deoxyguanosine raises dGTP, lowers dCTP and inhibits DNA synthesis, and the results support inhibition of ribonucleotide reductase as the cause. In mature T-cell and B-lymphoblastoid lines treated with a PNP inhibitor, growth inhibition by deoxyguanosine followed a rise in GTP instead, without an increase in dGTP.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eThymic organ culture.\u003c\/strong\u003e Deoxyguanosine is selectively toxic to haematopoietic cells. Embryonic mouse thymus lobes cultured in it therefore lose their own haematopoietic cells but keep the thymic stromal cells, including cortical and medullary epithelial cells. These alymphoid lobes are used to study how the thymic microenvironment supports T-cell development and selection. They are also recolonised in vitro with defined haematopoietic cells, transplanted into recipient mice, and used to build reaggregate thymus organ cultures.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eInnate immune sensing.\u003c\/strong\u003e Deoxyguanosine has been reported as an agonist of Toll-like receptor 7 (TLR7). It triggered cytokine production, including type I interferons, TNF and IL-6, in mouse bone-marrow-derived macrophages and plasmacytoid dendritic cells, and in human peripheral blood mononuclear cells.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eOxidative damage at C8.\u003c\/strong\u003e Of the four canonical DNA nucleosides, deoxyguanosine is the most electron-rich, and its nucleophilic sites are susceptible to oxidative damage. Ascorbic acid hydroxylates it at C8 in the presence of oxygen, and hydrogen peroxide strongly increases this reaction. The Udenfriend system (ascorbic acid, Fe(II), EDTA and O₂), other reducing agents and several metal–EDTA complexes act in the same way. Guanine residues in DNA are hydroxylated as well. The authors proposed a hydroxyl radical as the reactive species in most of these systems and discussed the reaction in relation to mutagenesis and carcinogenesis.\u003c\/p\u003e\n\u003cdiv style=\"margin:8px 0 18px 0;\"\u003e\n\u003cdiv style=\"display:flex;flex-wrap:wrap;align-items:center;justify-content:flex-start;gap:2px;\"\u003e\n\u003cdiv style=\"display:flex;align-items:center;\"\u003e\u003csvg role=\"img\" style=\"max-width:100%;height:auto;\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" fill=\"none\" stroke=\"#000\" stroke-width=\"1.6\" width=\"200px\" height=\"165px\" viewbox=\"0 0 200 165\"\u003e\u003cpath d=\"M 29.3,145.1 L 29.4,126.4\"\u003e\u003c\/path\u003e\u003cpath d=\"M 48.3,117.4 L 29.4,130.2 L 29.4,126.4 Z\" fill=\"#000\" stroke-width=\"0.4\"\u003e\u003c\/path\u003e\u003cpath d=\"M 48.3,117.4 L 50.1,100.8\"\u003e\u003c\/path\u003e\u003cpath d=\"M 55.3,94.7 L 72.1,91.2\"\u003e\u003c\/path\u003e\u003cpath d=\"M 72.1,91.2 L 77.0,76.3 L 80.0,77.7 Z\" fill=\"#000\" stroke-width=\"0.4\"\u003e\u003c\/path\u003e\u003cpath d=\"M 78.2,66.3 L 70.2,52.3\"\u003e\u003c\/path\u003e\u003cpath d=\"M 70.2,52.3 L 81.0,40.5\"\u003e\u003c\/path\u003e\u003cpath d=\"M 74.3,52.8 L 83.4,42.7\"\u003e\u003c\/path\u003e\u003cpath d=\"M 88.9,37.9 L 104.9,45.1\"\u003e\u003c\/path\u003e\u003cpath d=\"M 104.9,45.1 L 102.5,66.8\"\u003e\u003c\/path\u003e\u003cpath d=\"M 101.3,47.1 L 99.5,64.1\"\u003e\u003c\/path\u003e\u003cpath d=\"M 102.5,66.8 L 116.2,76.9\"\u003e\u003c\/path\u003e\u003cpath d=\"M 124.0,78.0 L 140.1,71.0\"\u003e\u003c\/path\u003e\u003cpath d=\"M 122.7,75.0 L 137.0,68.7\"\u003e\u003c\/path\u003e\u003cpath d=\"M 140.1,71.0 L 153.8,81.0\"\u003e\u003c\/path\u003e\u003cpath d=\"M 140.1,71.0 L 141.9,54.2\"\u003e\u003c\/path\u003e\u003cpath d=\"M 138.5,46.4 L 124.9,36.3\"\u003e\u003c\/path\u003e\u003cpath d=\"M 126.4,37.4 L 128.3,19.9\"\u003e\u003c\/path\u003e\u003cpath d=\"M 123.1,37.1 L 125.0,19.6\"\u003e\u003c\/path\u003e\u003cpath d=\"M 72.1,91.2 L 82.9,110.2\"\u003e\u003c\/path\u003e\u003cpath d=\"M 82.9,110.2 L 68.3,126.4\"\u003e\u003c\/path\u003e\u003cpath d=\"M 69.2,129.4 L 68.6,129.6\" stroke-width=\"0.8\"\u003e\u003c\/path\u003e\u003cpath d=\"M 70.2,132.5 L 68.9,132.7\" stroke-width=\"0.8\"\u003e\u003c\/path\u003e\u003cpath d=\"M 71.2,135.5 L 69.2,135.9\" stroke-width=\"0.8\"\u003e\u003c\/path\u003e\u003cpath d=\"M 72.1,138.6 L 69.6,139.1\" stroke-width=\"0.8\"\u003e\u003c\/path\u003e\u003cpath d=\"M 73.1,141.7 L 69.9,142.3\" stroke-width=\"0.8\"\u003e\u003c\/path\u003e\u003cpath d=\"M 68.3,126.4 L 48.3,117.4\"\u003e\u003c\/path\u003e\u003cpath d=\"M 102.5,66.8 L 85.0,70.5\"\u003e\u003c\/path\u003e\u003cpath d=\"M 124.9,36.3 L 104.9,45.1\"\u003e\u003c\/path\u003e\u003cpath d=\"M 48.4,116.5 L 48.3,117.4 L 49.3,117.8\"\u003e\u003c\/path\u003e\u003cpath d=\"M 71.3,91.4 L 72.1,91.2 L 72.6,92.2\"\u003e\u003c\/path\u003e\u003cpath d=\"M 70.6,53.0 L 70.2,52.3 L 70.8,51.7\"\u003e\u003c\/path\u003e\u003cpath d=\"M 125.5,36.8 L 124.9,36.3 L 123.9,36.8\"\u003e\u003c\/path\u003e\u003cpath d=\"M 82.4,109.2 L 82.9,110.2 L 82.2,111.0\"\u003e\u003c\/path\u003e\u003cpath d=\"M 69.0,125.5 L 68.3,126.4 L 67.3,125.9\"\u003e\u003c\/path\u003e\u003cg style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003e\u003ctext x=\"25.7\" y=\"154.3\" text-anchor=\"start\"\u003eOH\u003c\/text\u003e\u003ctext x=\"50.7\" y=\"99.9\" text-anchor=\"middle\"\u003eO\u003c\/text\u003e\u003ctext x=\"81.1\" y=\"75.5\" text-anchor=\"middle\"\u003eN\u003c\/text\u003e\u003ctext x=\"84.9\" y=\"40.3\" text-anchor=\"middle\"\u003eN\u003c\/text\u003e\u003ctext x=\"120.1\" y=\"84.0\" text-anchor=\"middle\"\u003eN\u003c\/text\u003e\u003ctext x=\"154.1\" y=\"88.1\" text-anchor=\"start\"\u003eNH₂\u003c\/text\u003e\u003ctext x=\"138.9\" y=\"53.4\" text-anchor=\"start\"\u003eNH\u003c\/text\u003e\u003ctext x=\"127.2\" y=\"18.8\" text-anchor=\"middle\"\u003eO\u003c\/text\u003e\u003ctext x=\"69.1\" y=\"151.9\" text-anchor=\"start\"\u003eOH\u003c\/text\u003e\u003c\/g\u003e\u003c\/svg\u003e\u003c\/div\u003e\n\u003cdiv style=\"display:flex;align-items:center;\"\u003e\u003cdiv style=\"display:flex;flex-direction:column;align-items:center;justify-content:center;min-width:90px;max-width:150px;padding:0 4px;text-align:center;font-size:12px;line-height:1.3;\"\u003e\n\u003cdiv\u003eascorbic acid, O₂\u003c\/div\u003e\n\u003cdiv style=\"font-size:30px;line-height:1;\"\u003e⟶\u003c\/div\u003e\n\u003cdiv\u003e(H₂O₂ enhances)\u003c\/div\u003e\n\u003c\/div\u003e\u003c\/div\u003e\n\u003cdiv style=\"display:flex;align-items:center;\"\u003e\u003csvg role=\"img\" style=\"max-width:100%;height:auto;\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" fill=\"none\" stroke=\"#000\" stroke-width=\"1.6\" width=\"200px\" height=\"165px\" viewbox=\"0 0 200 165\"\u003e\u003cpath d=\"M 53.3,50.3 L 70.4,52.2\"\u003e\u003c\/path\u003e\u003cpath d=\"M 70.4,52.2 L 81.2,40.4\"\u003e\u003c\/path\u003e\u003cpath d=\"M 74.4,52.7 L 83.6,42.6\"\u003e\u003c\/path\u003e\u003cpath d=\"M 89.0,37.9 L 105.0,45.1\"\u003e\u003c\/path\u003e\u003cpath d=\"M 105.0,45.1 L 125.0,36.3\"\u003e\u003c\/path\u003e\u003cpath d=\"M 126.5,37.4 L 128.5,19.9\"\u003e\u003c\/path\u003e\u003cpath d=\"M 123.3,37.1 L 125.2,19.6\"\u003e\u003c\/path\u003e\u003cpath d=\"M 125.0,36.3 L 138.7,46.4\"\u003e\u003c\/path\u003e\u003cpath d=\"M 142.0,54.2 L 140.2,71.0\"\u003e\u003c\/path\u003e\u003cpath d=\"M 140.2,71.0 L 153.8,81.0\"\u003e\u003c\/path\u003e\u003cpath d=\"M 140.2,71.0 L 124.1,78.0\"\u003e\u003c\/path\u003e\u003cpath d=\"M 137.1,68.7 L 122.8,75.0\"\u003e\u003c\/path\u003e\u003cpath d=\"M 116.2,76.8 L 102.6,66.8\"\u003e\u003c\/path\u003e\u003cpath d=\"M 102.6,66.8 L 85.1,70.4\"\u003e\u003c\/path\u003e\u003cpath d=\"M 72.2,91.1 L 77.1,76.2 L 80.1,77.6 Z\" fill=\"#000\" stroke-width=\"0.4\"\u003e\u003c\/path\u003e\u003cpath d=\"M 72.2,91.1 L 83.0,110.1\"\u003e\u003c\/path\u003e\u003cpath d=\"M 83.0,110.1 L 68.3,126.3\"\u003e\u003c\/path\u003e\u003cpath d=\"M 69.3,129.4 L 68.6,129.5\" stroke-width=\"0.8\"\u003e\u003c\/path\u003e\u003cpath d=\"M 70.2,132.5 L 69.0,132.8\" stroke-width=\"0.8\"\u003e\u003c\/path\u003e\u003cpath d=\"M 71.2,135.6 L 69.3,136.0\" stroke-width=\"0.8\"\u003e\u003c\/path\u003e\u003cpath d=\"M 72.2,138.6 L 69.6,139.2\" stroke-width=\"0.8\"\u003e\u003c\/path\u003e\u003cpath d=\"M 73.2,141.7 L 69.9,142.4\" stroke-width=\"0.8\"\u003e\u003c\/path\u003e\u003cpath d=\"M 68.3,126.3 L 48.3,117.3\"\u003e\u003c\/path\u003e\u003cpath d=\"M 48.3,117.3 L 29.3,130.1 L 29.3,126.3 Z\" fill=\"#000\" stroke-width=\"0.4\"\u003e\u003c\/path\u003e\u003cpath d=\"M 29.3,126.3 L 29.2,145.0\"\u003e\u003c\/path\u003e\u003cpath d=\"M 48.3,117.3 L 50.2,100.7\"\u003e\u003c\/path\u003e\u003cpath d=\"M 78.4,66.2 L 70.4,52.2\"\u003e\u003c\/path\u003e\u003cpath d=\"M 55.4,94.6 L 72.2,91.1\"\u003e\u003c\/path\u003e\u003cpath d=\"M 102.6,66.8 L 105.0,45.1\"\u003e\u003c\/path\u003e\u003cpath d=\"M 99.6,64.1 L 101.5,47.1\"\u003e\u003c\/path\u003e\u003cpath d=\"M 124.0,36.8 L 125.0,36.3 L 125.7,36.8\"\u003e\u003c\/path\u003e\u003cpath d=\"M 72.7,92.1 L 72.2,91.1 L 71.4,91.3\"\u003e\u003c\/path\u003e\u003cpath d=\"M 82.5,109.2 L 83.0,110.1 L 82.3,111.0\"\u003e\u003c\/path\u003e\u003cpath d=\"M 69.0,125.5 L 68.3,126.3 L 67.3,125.9\"\u003e\u003c\/path\u003e\u003cpath d=\"M 49.3,117.8 L 48.3,117.3 L 48.4,116.5\"\u003e\u003c\/path\u003e\u003cg style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003e\u003ctext x=\"52.3\" y=\"54.0\" text-anchor=\"end\"\u003eHO\u003c\/text\u003e\u003ctext x=\"85.1\" y=\"40.3\" text-anchor=\"middle\"\u003eN\u003c\/text\u003e\u003ctext x=\"127.4\" y=\"18.8\" text-anchor=\"middle\"\u003eO\u003c\/text\u003e\u003ctext x=\"139.0\" y=\"53.5\" text-anchor=\"start\"\u003eNH\u003c\/text\u003e\u003ctext x=\"154.2\" y=\"88.1\" text-anchor=\"start\"\u003eNH₂\u003c\/text\u003e\u003ctext x=\"120.2\" y=\"83.9\" text-anchor=\"middle\"\u003eN\u003c\/text\u003e\u003ctext x=\"81.2\" y=\"75.4\" text-anchor=\"middle\"\u003eN\u003c\/text\u003e\u003ctext x=\"69.1\" y=\"152.0\" text-anchor=\"start\"\u003eOH\u003c\/text\u003e\u003ctext x=\"25.6\" y=\"154.3\" text-anchor=\"start\"\u003eOH\u003c\/text\u003e\u003ctext x=\"50.8\" y=\"99.7\" text-anchor=\"middle\"\u003eO\u003c\/text\u003e\u003c\/g\u003e\u003c\/svg\u003e\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cp style=\"font-size:12px;margin:4px 0 0 0;\"\u003e\u003cem\u003eHydroxylation of 2′-deoxyguanosine (left) at C8 gives 8-hydroxy-2′-deoxyguanosine (right).\u003c\/em\u003e\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cp\u003e\u003cstrong\u003eC8-substituted derivatives.\u003c\/strong\u003e C8 is the main site at which food mutagens such as IQ react with deoxyguanosine. C8-substituted deoxyguanosines are made from 8-bromo-2′-deoxyguanosine by palladium-catalysed cross-coupling. Suzuki–Miyaura coupling with aryl- and heteroarylboronic acids and Stille coupling with organostannanes give 8-(hetero)aryl derivatives, and palladium-catalysed N-arylation, with the N2-amino group protected, gives C8–N arylamine adducts. In aqueous media, Suzuki coupling proceeds without protection of the sugar hydroxyl groups.\u003c\/p\u003e\n\u003cdiv style=\"margin:8px 0 18px 0;\"\u003e\n\u003cdiv style=\"display:flex;flex-wrap:wrap;align-items:center;justify-content:flex-start;gap:2px;\"\u003e\n\u003cdiv style=\"display:flex;align-items:center;\"\u003e\u003csvg role=\"img\" style=\"max-width:100%;height:auto;\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" fill=\"none\" stroke=\"#000\" stroke-width=\"1.6\" width=\"200px\" height=\"165px\" viewbox=\"0 0 200 165\"\u003e\u003cpath d=\"M 51.2,50.1 L 70.4,52.2\"\u003e\u003c\/path\u003e\u003cpath d=\"M 70.4,52.2 L 81.2,40.4\"\u003e\u003c\/path\u003e\u003cpath d=\"M 74.4,52.7 L 83.6,42.6\"\u003e\u003c\/path\u003e\u003cpath d=\"M 89.0,37.9 L 105.0,45.1\"\u003e\u003c\/path\u003e\u003cpath d=\"M 105.0,45.1 L 125.0,36.3\"\u003e\u003c\/path\u003e\u003cpath d=\"M 126.5,37.4 L 128.5,19.9\"\u003e\u003c\/path\u003e\u003cpath d=\"M 123.3,37.1 L 125.2,19.6\"\u003e\u003c\/path\u003e\u003cpath d=\"M 125.0,36.3 L 138.7,46.4\"\u003e\u003c\/path\u003e\u003cpath d=\"M 142.0,54.2 L 140.2,71.0\"\u003e\u003c\/path\u003e\u003cpath d=\"M 140.2,71.0 L 153.8,81.0\"\u003e\u003c\/path\u003e\u003cpath d=\"M 140.2,71.0 L 124.1,78.0\"\u003e\u003c\/path\u003e\u003cpath d=\"M 137.1,68.7 L 122.8,75.0\"\u003e\u003c\/path\u003e\u003cpath d=\"M 116.2,76.8 L 102.6,66.8\"\u003e\u003c\/path\u003e\u003cpath d=\"M 102.6,66.8 L 85.1,70.4\"\u003e\u003c\/path\u003e\u003cpath d=\"M 72.2,91.1 L 77.1,76.2 L 80.1,77.6 Z\" fill=\"#000\" stroke-width=\"0.4\"\u003e\u003c\/path\u003e\u003cpath d=\"M 72.2,91.1 L 83.0,110.1\"\u003e\u003c\/path\u003e\u003cpath d=\"M 83.0,110.1 L 68.3,126.3\"\u003e\u003c\/path\u003e\u003cpath d=\"M 69.3,129.4 L 68.6,129.5\" stroke-width=\"0.8\"\u003e\u003c\/path\u003e\u003cpath d=\"M 70.2,132.5 L 69.0,132.8\" stroke-width=\"0.8\"\u003e\u003c\/path\u003e\u003cpath d=\"M 71.2,135.6 L 69.3,136.0\" stroke-width=\"0.8\"\u003e\u003c\/path\u003e\u003cpath d=\"M 72.2,138.6 L 69.6,139.2\" stroke-width=\"0.8\"\u003e\u003c\/path\u003e\u003cpath d=\"M 73.2,141.7 L 69.9,142.4\" stroke-width=\"0.8\"\u003e\u003c\/path\u003e\u003cpath d=\"M 68.3,126.3 L 48.3,117.3\"\u003e\u003c\/path\u003e\u003cpath d=\"M 48.3,117.3 L 29.3,130.1 L 29.3,126.3 Z\" fill=\"#000\" stroke-width=\"0.4\"\u003e\u003c\/path\u003e\u003cpath d=\"M 29.3,126.3 L 29.2,145.0\"\u003e\u003c\/path\u003e\u003cpath d=\"M 48.3,117.3 L 50.2,100.7\"\u003e\u003c\/path\u003e\u003cpath d=\"M 78.4,66.2 L 70.4,52.2\"\u003e\u003c\/path\u003e\u003cpath d=\"M 55.4,94.6 L 72.2,91.1\"\u003e\u003c\/path\u003e\u003cpath d=\"M 102.6,66.8 L 105.0,45.1\"\u003e\u003c\/path\u003e\u003cpath d=\"M 99.6,64.1 L 101.5,47.1\"\u003e\u003c\/path\u003e\u003cpath d=\"M 124.0,36.8 L 125.0,36.3 L 125.7,36.8\"\u003e\u003c\/path\u003e\u003cpath d=\"M 72.7,92.1 L 72.2,91.1 L 71.4,91.3\"\u003e\u003c\/path\u003e\u003cpath d=\"M 82.5,109.2 L 83.0,110.1 L 82.3,111.0\"\u003e\u003c\/path\u003e\u003cpath d=\"M 69.0,125.5 L 68.3,126.3 L 67.3,125.9\"\u003e\u003c\/path\u003e\u003cpath d=\"M 49.3,117.8 L 48.3,117.3 L 48.4,116.5\"\u003e\u003c\/path\u003e\u003cg style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003e\u003ctext x=\"45.7\" y=\"54.0\" text-anchor=\"middle\"\u003eBr\u003c\/text\u003e\u003ctext x=\"85.1\" y=\"40.3\" text-anchor=\"middle\"\u003eN\u003c\/text\u003e\u003ctext x=\"127.4\" y=\"18.8\" text-anchor=\"middle\"\u003eO\u003c\/text\u003e\u003ctext x=\"139.0\" y=\"53.5\" text-anchor=\"start\"\u003eNH\u003c\/text\u003e\u003ctext x=\"154.2\" y=\"88.1\" text-anchor=\"start\"\u003eNH₂\u003c\/text\u003e\u003ctext x=\"120.2\" y=\"83.9\" text-anchor=\"middle\"\u003eN\u003c\/text\u003e\u003ctext x=\"81.2\" y=\"75.4\" text-anchor=\"middle\"\u003eN\u003c\/text\u003e\u003ctext x=\"69.1\" y=\"152.0\" text-anchor=\"start\"\u003eOH\u003c\/text\u003e\u003ctext x=\"25.6\" y=\"154.3\" text-anchor=\"start\"\u003eOH\u003c\/text\u003e\u003ctext x=\"50.8\" y=\"99.7\" text-anchor=\"middle\"\u003eO\u003c\/text\u003e\u003c\/g\u003e\u003c\/svg\u003e\u003c\/div\u003e\n\u003cdiv style=\"display:flex;align-items:center;\"\u003e\u003cdiv style=\"display:flex;flex-direction:column;align-items:center;justify-content:center;min-width:90px;max-width:150px;padding:0 4px;text-align:center;font-size:12px;line-height:1.3;\"\u003e\n\u003cdiv\u003eArB(OH)₂\u003c\/div\u003e\n\u003cdiv style=\"font-size:30px;line-height:1;\"\u003e⟶\u003c\/div\u003e\n\u003cdiv\u003ePd catalyst, aqueous\u003c\/div\u003e\n\u003c\/div\u003e\u003c\/div\u003e\n\u003cdiv style=\"display:flex;align-items:center;\"\u003e\u003csvg role=\"img\" style=\"max-width:100%;height:auto;\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" fill=\"none\" stroke=\"#000\" stroke-width=\"1.6\" width=\"200px\" height=\"165px\" viewbox=\"0 0 200 165\"\u003e\u003cpath d=\"M 51.2,50.1 L 70.4,52.2\"\u003e\u003c\/path\u003e\u003cpath d=\"M 70.4,52.2 L 81.2,40.4\"\u003e\u003c\/path\u003e\u003cpath d=\"M 74.4,52.7 L 83.6,42.6\"\u003e\u003c\/path\u003e\u003cpath d=\"M 89.0,37.9 L 105.0,45.1\"\u003e\u003c\/path\u003e\u003cpath d=\"M 105.0,45.1 L 125.0,36.3\"\u003e\u003c\/path\u003e\u003cpath d=\"M 126.5,37.4 L 128.5,19.9\"\u003e\u003c\/path\u003e\u003cpath d=\"M 123.3,37.1 L 125.2,19.6\"\u003e\u003c\/path\u003e\u003cpath d=\"M 125.0,36.3 L 138.7,46.4\"\u003e\u003c\/path\u003e\u003cpath d=\"M 142.0,54.2 L 140.2,71.0\"\u003e\u003c\/path\u003e\u003cpath d=\"M 140.2,71.0 L 153.8,81.0\"\u003e\u003c\/path\u003e\u003cpath d=\"M 140.2,71.0 L 124.1,78.0\"\u003e\u003c\/path\u003e\u003cpath d=\"M 137.1,68.7 L 122.8,75.0\"\u003e\u003c\/path\u003e\u003cpath d=\"M 116.2,76.8 L 102.6,66.8\"\u003e\u003c\/path\u003e\u003cpath d=\"M 102.6,66.8 L 85.1,70.4\"\u003e\u003c\/path\u003e\u003cpath d=\"M 72.2,91.1 L 77.1,76.2 L 80.1,77.6 Z\" fill=\"#000\" stroke-width=\"0.4\"\u003e\u003c\/path\u003e\u003cpath d=\"M 72.2,91.1 L 83.0,110.1\"\u003e\u003c\/path\u003e\u003cpath d=\"M 83.0,110.1 L 68.3,126.3\"\u003e\u003c\/path\u003e\u003cpath d=\"M 69.3,129.4 L 68.6,129.5\" stroke-width=\"0.8\"\u003e\u003c\/path\u003e\u003cpath d=\"M 70.2,132.5 L 69.0,132.8\" stroke-width=\"0.8\"\u003e\u003c\/path\u003e\u003cpath d=\"M 71.2,135.6 L 69.3,136.0\" stroke-width=\"0.8\"\u003e\u003c\/path\u003e\u003cpath d=\"M 72.2,138.6 L 69.6,139.2\" stroke-width=\"0.8\"\u003e\u003c\/path\u003e\u003cpath d=\"M 73.2,141.7 L 69.9,142.4\" stroke-width=\"0.8\"\u003e\u003c\/path\u003e\u003cpath d=\"M 68.3,126.3 L 48.3,117.3\"\u003e\u003c\/path\u003e\u003cpath d=\"M 48.3,117.3 L 29.3,130.1 L 29.3,126.3 Z\" fill=\"#000\" stroke-width=\"0.4\"\u003e\u003c\/path\u003e\u003cpath d=\"M 29.3,126.3 L 29.2,145.0\"\u003e\u003c\/path\u003e\u003cpath d=\"M 48.3,117.3 L 50.2,100.7\"\u003e\u003c\/path\u003e\u003cpath d=\"M 78.4,66.2 L 70.4,52.2\"\u003e\u003c\/path\u003e\u003cpath d=\"M 55.4,94.6 L 72.2,91.1\"\u003e\u003c\/path\u003e\u003cpath d=\"M 102.6,66.8 L 105.0,45.1\"\u003e\u003c\/path\u003e\u003cpath d=\"M 99.6,64.1 L 101.5,47.1\"\u003e\u003c\/path\u003e\u003cpath d=\"M 124.0,36.8 L 125.0,36.3 L 125.7,36.8\"\u003e\u003c\/path\u003e\u003cpath d=\"M 72.7,92.1 L 72.2,91.1 L 71.4,91.3\"\u003e\u003c\/path\u003e\u003cpath d=\"M 82.5,109.2 L 83.0,110.1 L 82.3,111.0\"\u003e\u003c\/path\u003e\u003cpath d=\"M 69.0,125.5 L 68.3,126.3 L 67.3,125.9\"\u003e\u003c\/path\u003e\u003cpath d=\"M 49.3,117.8 L 48.3,117.3 L 48.4,116.5\"\u003e\u003c\/path\u003e\u003cg style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003e\u003ctext x=\"45.7\" y=\"54.0\" text-anchor=\"middle\"\u003eAr\u003c\/text\u003e\u003ctext x=\"85.1\" y=\"40.3\" text-anchor=\"middle\"\u003eN\u003c\/text\u003e\u003ctext x=\"127.4\" y=\"18.8\" text-anchor=\"middle\"\u003eO\u003c\/text\u003e\u003ctext x=\"139.0\" y=\"53.5\" text-anchor=\"start\"\u003eNH\u003c\/text\u003e\u003ctext x=\"154.2\" y=\"88.1\" text-anchor=\"start\"\u003eNH₂\u003c\/text\u003e\u003ctext x=\"120.2\" y=\"83.9\" text-anchor=\"middle\"\u003eN\u003c\/text\u003e\u003ctext x=\"81.2\" y=\"75.4\" text-anchor=\"middle\"\u003eN\u003c\/text\u003e\u003ctext x=\"69.1\" y=\"152.0\" text-anchor=\"start\"\u003eOH\u003c\/text\u003e\u003ctext x=\"25.6\" y=\"154.3\" text-anchor=\"start\"\u003eOH\u003c\/text\u003e\u003ctext x=\"50.8\" y=\"99.7\" text-anchor=\"middle\"\u003eO\u003c\/text\u003e\u003c\/g\u003e\u003c\/svg\u003e\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cp style=\"font-size:12px;margin:4px 0 0 0;\"\u003e\u003cem\u003eSuzuki–Miyaura coupling of 8-bromo-2′-deoxyguanosine (left) with an arylboronic acid gives an 8-aryl-2′-deoxyguanosine (right); Ar = aryl or heteroaryl.\u003c\/em\u003e\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cp\u003e\u003cstrong\u003eBuilding blocks for modified oligonucleotides.\u003c\/strong\u003e C8-modified deoxyguanosines are used as building blocks for modified oligonucleotides and are of value as analytical standards. After C8 arylation the glycosidic bond is sensitive to acid, so the exocyclic amino group is protected as an N,N-dimethylformamidine before the nucleosides are converted to phosphoramidites and incorporated into synthetic oligonucleotides.\u003c\/p\u003e\n\u003c\/div\u003e\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cdiv style=\"margin-bottom: 28px;\"\u003e\n\u003cdiv style=\"background: #002147; padding: 10px 20px; margin-bottom: 0;\"\u003e\u003ch3 style=\"margin: 0; font-family: 'Helvetica Neue', Helvetica, Arial, sans-serif; font-size: 0.70em; font-weight: bold; letter-spacing: 0.12em; text-transform: uppercase; color: #fff;\"\u003eShipping Destinations\u003c\/h3\u003e\u003c\/div\u003e\n\u003cdiv style=\"border: 1px solid #e4e8f0; border-top: none; padding: 12px 16px; font-family: 'Helvetica Neue', Helvetica, Arial, sans-serif; font-size: 0.95em;\"\u003e\u003cul style=\"margin: 0; padding: 0; list-style: none;\"\u003e\n\u003cli style=\"padding: 5px 0; border-bottom: 1px solid #f0f0f0;\"\u003e\n\u003cspan style=\"display: inline-block; width: 7px; height: 7px; background: #002147; border-radius: 50%; margin-right: 10px; vertical-align: middle;\"\u003e\u003c\/span\u003eEU \u0026amp; UK: Priority delivery, 2–5 business days.\u003c\/li\u003e\n\u003cli style=\"padding: 5px 0; border-bottom: 1px solid #f0f0f0;\"\u003e\n\u003cspan style=\"display: inline-block; width: 7px; height: 7px; background: #002147; border-radius: 50%; margin-right: 10px; vertical-align: middle;\"\u003e\u003c\/span\u003eUnited States (DDP): 3–7 business days, duties and taxes prepaid.\u003c\/li\u003e\n\u003cli style=\"padding: 5px 0; border-bottom: 1px solid #f0f0f0;\"\u003e\n\u003cspan style=\"display: inline-block; width: 7px; height: 7px; background: #002147; border-radius: 50%; margin-right: 10px; vertical-align: middle;\"\u003e\u003c\/span\u003eEFTA Countries (DDP): 3–7 business days, duties and taxes prepaid.\u003c\/li\u003e\n\u003cli style=\"padding: 5px 0; border-bottom: 1px solid #f0f0f0;\"\u003e\n\u003cspan style=\"display: inline-block; width: 7px; height: 7px; background: #002147; border-radius: 50%; margin-right: 10px; vertical-align: middle;\"\u003e\u003c\/span\u003eWorldwide: 7–14 business days, selected locations.\u003c\/li\u003e\n\u003c\/ul\u003e\u003c\/div\u003e\n\u003c\/div\u003e","brand":"NorrChemica™","offers":[{"title":"1.0 g","offer_id":55166596284753,"sku":"NOR-312693724-1g","price":47.2,"currency_code":"EUR","in_stock":true},{"title":"2.0 g","offer_id":55361694466385,"sku":"NOR-312693724-2g","price":79.2,"currency_code":"EUR","in_stock":true},{"title":"5.0 g","offer_id":55166596317521,"sku":"NOR-312693724-5g","price":119.2,"currency_code":"EUR","in_stock":true},{"title":"10 g","offer_id":55166596350289,"sku":"NOR-312693724-10g","price":159.2,"currency_code":"EUR","in_stock":true},{"title":"25 g","offer_id":55166596383057,"sku":"NOR-312693724-25g","price":198.2,"currency_code":"EUR","in_stock":true},{"title":"50 g","offer_id":55361694499153,"sku":"NOR-312693724-50g","price":289.2,"currency_code":"EUR","in_stock":true},{"title":"100 g","offer_id":55166596415825,"sku":"NOR-312693724-100g","price":529.2,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0954\/6357\/1793\/files\/2-Deoxyguanosine_Monohydrate.png?v=1792272213"},{"product_id":"pseudouridine-cas-1445-07-4","title":"Pseudouridine | CAS 1445-07-4 | ≥98%","description":"\u003cdiv style=\"margin-bottom: 28px;\"\u003e\n\u003cdiv style=\"background: #002147; padding: 10px 20px; margin-bottom: 0;\"\u003e\u003ch3 style=\"margin: 0; font-family: 'Helvetica Neue', Helvetica, Arial, sans-serif; font-size: 0.70em; font-weight: bold; letter-spacing: 0.12em; text-transform: uppercase; color: #fff;\"\u003eTechnical Specifications\u003c\/h3\u003e\u003c\/div\u003e\n\u003ctable style=\"width: 100%; border-collapse: collapse; font-size: 0.95em; border: 1px solid #e4e8f0; border-top: none; font-family: 'Helvetica Neue', Helvetica, Arial, sans-serif;\"\u003e\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eCAS Number\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e1445-07-4\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eEC \/ EINECS Number\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e978-484-6\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eMDL Number\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003eMFCD00038458\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eSMILES\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0; word-break: break-all;\"\u003eC1=C(C(=O)NC(=O)N1)[C@H]2[C@@H]([C@@H]([C@H](O2)CO)O)O\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eInChI\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0; word-break: break-all;\"\u003eInChI=1S\/C9H12N2O6\/c12-2-4-5(13)6(14)7(17-4)3-1-10-9(16)11-8(3)15\/h1,4-7,12-14H,2H2,(H2,10,11,15,16)\/t4-,5-,6-,7+\/m1\/s1\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eInChIKey\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0; word-break: break-all;\"\u003ePTJWIQPHWPFNBW-GBNDHIKLSA-N\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003ePubChem CID\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e15047\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eMolecular Formula\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003eC₉H₁₂N₂O₆\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eMolecular Weight\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e244.20 g\/mol\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eMelting Point\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e231 °C (dec.)\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eSolubility\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003eSoluble in water.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003ePurity\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e≥98%\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003ePhysical Form\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003eWhite to off-white powder\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eHS Code\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e2934.99\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eShelf Life\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003eRetest period: 36 months from date of manufacture\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eStorage Conditions\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333;\"\u003eStore at 2–8 °C in a tightly sealed container.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\u003c\/table\u003e\n\u003c\/div\u003e\n\u003cdiv style=\"margin-bottom: 28px;\"\u003e\n\u003cdiv style=\"background: #002147; padding: 10px 20px; margin-bottom: 0;\"\u003e\u003ch3 style=\"margin: 0; font-family: 'Helvetica Neue', Helvetica, Arial, sans-serif; font-size: 0.70em; font-weight: bold; letter-spacing: 0.12em; text-transform: uppercase; color: #fff;\"\u003eProduct Description \u0026amp; Scientific Applications\u003c\/h3\u003e\u003c\/div\u003e\n\u003cdiv style=\"padding: 16px 20px; border: 1px solid #e4e8f0; border-top: none; font-family: Georgia, 'Times New Roman', serif; font-size: 0.95em; line-height: 1.65; color: #333;\"\u003e\u003cdiv\u003e\n\u003cp\u003e\u003cstrong\u003ePseudouridine\u003c\/strong\u003e (Ψ) is an isomer of the RNA nucleoside uridine in which the uracil base is connected to C1′ of the ribose through C5 instead of N1. It is the most common modified nucleoside in cellular RNA overall, partly because it is abundant in ribosomal and transfer RNAs.\u003c\/p\u003e\n\u003cdiv style=\"margin:8px 0 18px 0;\"\u003e\n\u003cdiv style=\"display:flex;flex-wrap:wrap;align-items:center;justify-content:flex-start;gap:2px;\"\u003e\n\u003cdiv style=\"display:flex;align-items:center;\"\u003e\u003csvg role=\"img\" style=\"max-width:100%;height:auto;\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" fill=\"none\" stroke=\"#000\" stroke-width=\"1.6\" width=\"152px\" height=\"117px\" viewbox=\"0 0 152 117\"\u003e\u003cpath d=\"M 29.9,50.3 L 46.8,60.0\"\u003e\u003c\/path\u003e\u003cpath d=\"M 32.9,48.6 L 46.8,56.6\"\u003e\u003c\/path\u003e\u003cpath d=\"M 46.8,60.0 L 59.3,52.7\"\u003e\u003c\/path\u003e\u003cpath d=\"M 63.5,46.0 L 63.5,30.9\"\u003e\u003c\/path\u003e\u003cpath d=\"M 63.5,32.6 L 76.8,24.9\"\u003e\u003c\/path\u003e\u003cpath d=\"M 62.1,30.0 L 75.4,22.4\"\u003e\u003c\/path\u003e\u003cpath d=\"M 63.5,30.9 L 51.0,23.6\"\u003e\u003c\/path\u003e\u003cpath d=\"M 42.5,23.6 L 29.9,30.9\"\u003e\u003c\/path\u003e\u003cpath d=\"M 31.4,30.1 L 18.1,22.4\"\u003e\u003c\/path\u003e\u003cpath d=\"M 29.9,32.6 L 16.6,24.9\"\u003e\u003c\/path\u003e\u003cpath d=\"M 80.4,60.0 L 67.7,54.4 L 69.2,51.8 Z\"\u003e\u003c\/path\u003e\u003cpath d=\"M 80.4,60.0 L 98.1,52.1\"\u003e\u003c\/path\u003e\u003cpath d=\"M 98.1,52.1 L 111.1,66.5\"\u003e\u003c\/path\u003e\u003cpath d=\"M 111.1,66.5 L 101.4,83.3\"\u003e\u003c\/path\u003e\u003cpath d=\"M 101.4,83.3 L 86.6,80.2\"\u003e\u003c\/path\u003e\u003cpath d=\"M 101.4,83.3 L 111.0,101.2 L 107.7,100.8 Z\"\u003e\u003c\/path\u003e\u003cpath d=\"M 107.7,100.8 L 124.3,102.6\"\u003e\u003c\/path\u003e\u003cpath d=\"M 113.9,65.9 L 114.0,66.5\"\u003e\u003c\/path\u003e\u003cpath d=\"M 116.8,65.3 L 116.9,66.4\"\u003e\u003c\/path\u003e\u003cpath d=\"M 119.6,64.7 L 119.8,66.4\"\u003e\u003c\/path\u003e\u003cpath d=\"M 122.5,64.1 L 122.7,66.4\"\u003e\u003c\/path\u003e\u003cpath d=\"M 125.3,63.5 L 125.6,66.4\"\u003e\u003c\/path\u003e\u003cpath d=\"M 98.3,49.1 L 99.0,49.2\"\u003e\u003c\/path\u003e\u003cpath d=\"M 98.6,46.1 L 100.0,46.4\"\u003e\u003c\/path\u003e\u003cpath d=\"M 98.9,43.1 L 101.0,43.5\"\u003e\u003c\/path\u003e\u003cpath d=\"M 99.1,40.1 L 102.0,40.7\"\u003e\u003c\/path\u003e\u003cpath d=\"M 29.9,30.9 L 29.9,50.3\"\u003e\u003c\/path\u003e\u003cpath d=\"M 82.0,75.0 L 80.4,60.0\"\u003e\u003c\/path\u003e\u003cpath d=\"M 30.8,50.8 L 29.9,50.3 L 29.9,49.3\"\u003e\u003c\/path\u003e\u003cpath d=\"M 45.9,59.5 L 46.8,60.0 L 47.4,59.6\"\u003e\u003c\/path\u003e\u003cpath d=\"M 63.5,31.6 L 63.5,30.9 L 62.9,30.5\"\u003e\u003c\/path\u003e\u003cpath d=\"M 30.6,30.5 L 29.9,30.9 L 29.9,31.9\"\u003e\u003c\/path\u003e\u003cpath d=\"M 81.2,59.6 L 80.4,60.0 L 80.4,60.7\"\u003e\u003c\/path\u003e\u003cpath d=\"M 97.2,52.5 L 98.1,52.1 L 98.7,52.8\"\u003e\u003c\/path\u003e\u003cpath d=\"M 110.4,65.7 L 111.1,66.5 L 110.6,67.3\"\u003e\u003c\/path\u003e\u003cpath d=\"M 101.9,82.4 L 101.4,83.3 L 100.6,83.1\"\u003e\u003c\/path\u003e\u003ctext x=\"59.9\" y=\"56.3\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eN\u003c\/text\u003e\u003ctext x=\"76.7\" y=\"27.2\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eO\u003c\/text\u003e\u003ctext x=\"43.1\" y=\"27.2\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eN\u003c\/text\u003e\u003ctext x=\"43.1\" y=\"16.6\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eH\u003c\/text\u003e\u003ctext x=\"9.5\" y=\"27.2\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eO\u003c\/text\u003e\u003ctext x=\"78.8\" y=\"85.3\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eO\u003c\/text\u003e\u003ctext x=\"125.0\" y=\"109.0\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eO\u003c\/text\u003e\u003ctext x=\"133.3\" y=\"109.0\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eH\u003c\/text\u003e\u003ctext x=\"126.8\" y=\"70.4\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eO\u003c\/text\u003e\u003ctext x=\"135.0\" y=\"70.4\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eH\u003c\/text\u003e\u003ctext x=\"98.5\" y=\"39.1\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eO\u003c\/text\u003e\u003ctext x=\"106.8\" y=\"39.1\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eH\u003c\/text\u003e\u003c\/svg\u003e\u003c\/div\u003e\n\u003cdiv style=\"display:flex;align-items:center;\"\u003e\u003cdiv style=\"display:flex;flex-direction:column;align-items:center;justify-content:center;min-width:90px;max-width:150px;padding:0 4px;text-align:center;font-size:12px;line-height:1.3;\"\u003e\n\u003cdiv\u003epseudouridine synthase\u003c\/div\u003e\n\u003cdiv style=\"font-size:30px;line-height:1;\"\u003e⟶\u003c\/div\u003e\n\u003cdiv\u003e(uridine residues in RNA)\u003c\/div\u003e\n\u003c\/div\u003e\u003c\/div\u003e\n\u003cdiv style=\"display:flex;align-items:center;\"\u003e\u003csvg role=\"img\" style=\"max-width:100%;height:auto;\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" fill=\"none\" stroke=\"#000\" stroke-width=\"1.6\" width=\"152px\" height=\"117px\" viewbox=\"0 0 152 117\"\u003e\u003cpath d=\"M 46.8,60.0 L 63.5,50.3\"\u003e\u003c\/path\u003e\u003cpath d=\"M 46.8,56.6 L 60.6,48.6\"\u003e\u003c\/path\u003e\u003cpath d=\"M 63.5,50.3 L 63.5,30.9\"\u003e\u003c\/path\u003e\u003cpath d=\"M 63.5,32.6 L 76.8,24.9\"\u003e\u003c\/path\u003e\u003cpath d=\"M 62.1,30.0 L 75.4,22.4\"\u003e\u003c\/path\u003e\u003cpath d=\"M 63.5,30.9 L 51.0,23.6\"\u003e\u003c\/path\u003e\u003cpath d=\"M 42.5,23.6 L 29.9,30.9\"\u003e\u003c\/path\u003e\u003cpath d=\"M 31.4,30.1 L 18.1,22.4\"\u003e\u003c\/path\u003e\u003cpath d=\"M 29.9,32.6 L 16.6,24.9\"\u003e\u003c\/path\u003e\u003cpath d=\"M 29.9,30.9 L 29.9,46.1\"\u003e\u003c\/path\u003e\u003cpath d=\"M 80.4,60.0 L 62.0,51.2 L 63.5,50.3 L 63.5,48.5 Z\"\u003e\u003c\/path\u003e\u003cpath d=\"M 80.4,60.0 L 98.1,52.1\"\u003e\u003c\/path\u003e\u003cpath d=\"M 98.1,52.1 L 111.1,66.5\"\u003e\u003c\/path\u003e\u003cpath d=\"M 111.1,66.5 L 101.4,83.3\"\u003e\u003c\/path\u003e\u003cpath d=\"M 101.4,83.3 L 86.6,80.2\"\u003e\u003c\/path\u003e\u003cpath d=\"M 101.4,83.3 L 111.0,101.2 L 107.7,100.8 Z\"\u003e\u003c\/path\u003e\u003cpath d=\"M 107.7,100.8 L 124.3,102.6\"\u003e\u003c\/path\u003e\u003cpath d=\"M 113.9,65.9 L 114.0,66.5\"\u003e\u003c\/path\u003e\u003cpath d=\"M 116.8,65.3 L 116.9,66.4\"\u003e\u003c\/path\u003e\u003cpath d=\"M 119.6,64.7 L 119.8,66.4\"\u003e\u003c\/path\u003e\u003cpath d=\"M 122.5,64.1 L 122.7,66.4\"\u003e\u003c\/path\u003e\u003cpath d=\"M 125.3,63.5 L 125.6,66.4\"\u003e\u003c\/path\u003e\u003cpath d=\"M 98.3,49.1 L 99.0,49.2\"\u003e\u003c\/path\u003e\u003cpath d=\"M 98.6,46.1 L 100.0,46.4\"\u003e\u003c\/path\u003e\u003cpath d=\"M 98.9,43.1 L 101.0,43.5\"\u003e\u003c\/path\u003e\u003cpath d=\"M 99.1,40.1 L 102.0,40.7\"\u003e\u003c\/path\u003e\u003cpath d=\"M 34.2,52.8 L 46.8,60.0\"\u003e\u003c\/path\u003e\u003cpath d=\"M 82.0,75.0 L 80.4,60.0\"\u003e\u003c\/path\u003e\u003cpath d=\"M 47.6,59.5 L 46.8,60.0 L 46.1,59.6\"\u003e\u003c\/path\u003e\u003cpath d=\"M 62.7,50.8 L 63.5,50.3 L 63.5,49.3\"\u003e\u003c\/path\u003e\u003cpath d=\"M 63.5,31.9 L 63.5,30.9 L 62.9,30.5\"\u003e\u003c\/path\u003e\u003cpath d=\"M 30.6,30.5 L 29.9,30.9 L 29.9,31.7\"\u003e\u003c\/path\u003e\u003cpath d=\"M 81.2,59.6 L 80.4,60.0 L 80.4,60.7\"\u003e\u003c\/path\u003e\u003cpath d=\"M 97.2,52.5 L 98.1,52.1 L 98.7,52.8\"\u003e\u003c\/path\u003e\u003cpath d=\"M 110.4,65.7 L 111.1,66.5 L 110.6,67.3\"\u003e\u003c\/path\u003e\u003cpath d=\"M 101.9,82.4 L 101.4,83.3 L 100.6,83.1\"\u003e\u003c\/path\u003e\u003ctext x=\"76.7\" y=\"27.2\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eO\u003c\/text\u003e\u003ctext x=\"43.1\" y=\"27.2\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eN\u003c\/text\u003e\u003ctext x=\"43.1\" y=\"16.6\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eH\u003c\/text\u003e\u003ctext x=\"9.5\" y=\"27.2\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eO\u003c\/text\u003e\u003ctext x=\"18.1\" y=\"56.3\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eH\u003c\/text\u003e\u003ctext x=\"26.3\" y=\"56.3\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eN\u003c\/text\u003e\u003ctext x=\"78.8\" y=\"85.3\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eO\u003c\/text\u003e\u003ctext x=\"125.0\" y=\"109.0\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eO\u003c\/text\u003e\u003ctext x=\"133.3\" y=\"109.0\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eH\u003c\/text\u003e\u003ctext x=\"126.8\" y=\"70.4\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eO\u003c\/text\u003e\u003ctext x=\"135.0\" y=\"70.4\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eH\u003c\/text\u003e\u003ctext x=\"98.5\" y=\"39.1\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eO\u003c\/text\u003e\u003ctext x=\"106.8\" y=\"39.1\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eH\u003c\/text\u003e\u003c\/svg\u003e\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cp style=\"font-size:12px;margin:4px 0 0 0;\"\u003e\u003cem\u003eUridine (left) and pseudouridine (right), drawn as the free nucleosides. In uridine the ribose is bound to N1 of uracil; in pseudouridine it is bound to C5. In cells, the isomerisation takes place on uridine residues within RNA strands.\u003c\/em\u003e\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cp\u003e\u003cstrong\u003eFormation in RNA.\u003c\/strong\u003e Pseudouridine is formed after transcription: enzymes called pseudouridine synthases isomerise selected uridine residues within RNA strands into pseudouridine. During the maturation of eukaryotic ribosomal RNA in the nucleolus, which uridines are modified depends on short ribosomal RNA sequences that are complementary to sequences in box H\/ACA small nucleolar RNAs, and genetic work in yeast showed that these small nucleolar RNAs act as guide RNAs. Pseudouridine is also present in messenger RNA. Transcriptome-wide mapping has found hundreds of pseudouridylated sites in yeast and human mRNAs, and the pseudouridylation of many of these sites is regulated in response to environmental signals, such as nutrient deprivation in yeast and serum starvation in human cells.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eEffect on RNA structure.\u003c\/strong\u003e Pseudouridine stabilises RNA structure, because its N1–H is available as an extra hydrogen-bond donor and because its base stacks slightly better than that of uridine. NMR measurements on model RNA oligonucleotides indicate that pseudouridine forms a more stable base-stacking arrangement than uridine, and that this effect spreads through the helix to stabilise the stacking of neighbouring purine nucleosides. The same study concluded that this conformational stabilisation is an intrinsic property of pseudouridine at the nucleotide level.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eModified mRNA.\u003c\/strong\u003e RNA activates the human innate immune receptors TLR3, TLR7 and TLR8, but RNA that contains pseudouridine, or one of several other modified nucleosides, does not. In vitro-transcribed mRNAs that contain pseudouridine were found to have a higher translational capacity than unmodified mRNAs, in mammalian cells and in mice. In the mouse experiments, only the unmodified mRNA was immunogenic and raised serum interferon-α to high levels. The mRNA vaccines used worldwide against SARS-CoV-2 have every uridine replaced by its N1-methyl derivative, N1-methylpseudouridine. This is done by replacing UTP with N1-methylpseudouridine triphosphate during in vitro transcription.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eMapping pseudouridine in RNA.\u003c\/strong\u003e In Pseudo-seq, RNA is treated with the carbodiimide CMC (N-cyclohexyl-N′-(2-morpholinoethyl)carbodiimide metho-p-toluenesulfonate), which selectively modifies pseudouridine. The adduct stops reverse transcriptase one nucleotide 3′ to the modified site, so sequencing the stop sites locates pseudouridine at single-nucleotide resolution. Bisulfite reacts with pseudouridine differently from the way it reacts with cytidine. Its two stable end products are aromatic adducts at C1′ in which the ribose ring has opened. The major product is the (R) O-adduct; a minor (S) S-adduct forms with excess bisulfite. The addition is irreversible. Reverse transcriptases bypass the adduct during cDNA synthesis and produce a characteristic deletion. In RBS-seq, this deletion signature after bisulfite treatment is used to locate pseudouridine.\u003c\/p\u003e\n\u003cdiv style=\"margin:8px 0 18px 0;\"\u003e\n\u003cdiv style=\"display:flex;flex-wrap:wrap;align-items:center;justify-content:flex-start;gap:2px;\"\u003e\n\u003cdiv style=\"display:flex;align-items:center;\"\u003e\u003csvg role=\"img\" style=\"max-width:100%;height:auto;\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" fill=\"none\" stroke=\"#000\" stroke-width=\"1.6\" width=\"152px\" height=\"117px\" viewbox=\"0 0 152 117\"\u003e\u003cpath d=\"M 46.8,60.0 L 63.5,50.3\"\u003e\u003c\/path\u003e\u003cpath d=\"M 46.8,56.6 L 60.6,48.6\"\u003e\u003c\/path\u003e\u003cpath d=\"M 63.5,50.3 L 63.5,30.9\"\u003e\u003c\/path\u003e\u003cpath d=\"M 63.5,32.6 L 76.8,24.9\"\u003e\u003c\/path\u003e\u003cpath d=\"M 62.1,30.0 L 75.4,22.4\"\u003e\u003c\/path\u003e\u003cpath d=\"M 63.5,30.9 L 51.0,23.6\"\u003e\u003c\/path\u003e\u003cpath d=\"M 42.5,23.6 L 29.9,30.9\"\u003e\u003c\/path\u003e\u003cpath d=\"M 31.4,30.1 L 18.1,22.4\"\u003e\u003c\/path\u003e\u003cpath d=\"M 29.9,32.6 L 16.6,24.9\"\u003e\u003c\/path\u003e\u003cpath d=\"M 29.9,30.9 L 29.9,46.1\"\u003e\u003c\/path\u003e\u003cpath d=\"M 80.4,60.0 L 62.0,51.2 L 63.5,50.3 L 63.5,48.5 Z\"\u003e\u003c\/path\u003e\u003cpath d=\"M 80.4,60.0 L 98.1,52.1\"\u003e\u003c\/path\u003e\u003cpath d=\"M 98.1,52.1 L 111.1,66.5\"\u003e\u003c\/path\u003e\u003cpath d=\"M 111.1,66.5 L 101.4,83.3\"\u003e\u003c\/path\u003e\u003cpath d=\"M 101.4,83.3 L 86.6,80.2\"\u003e\u003c\/path\u003e\u003cpath d=\"M 101.4,83.3 L 111.0,101.2 L 107.7,100.8 Z\"\u003e\u003c\/path\u003e\u003cpath d=\"M 107.7,100.8 L 124.3,102.6\"\u003e\u003c\/path\u003e\u003cpath d=\"M 113.9,65.9 L 114.0,66.5\"\u003e\u003c\/path\u003e\u003cpath d=\"M 116.8,65.3 L 116.9,66.4\"\u003e\u003c\/path\u003e\u003cpath d=\"M 119.6,64.7 L 119.8,66.4\"\u003e\u003c\/path\u003e\u003cpath d=\"M 122.5,64.1 L 122.7,66.4\"\u003e\u003c\/path\u003e\u003cpath d=\"M 125.3,63.5 L 125.6,66.4\"\u003e\u003c\/path\u003e\u003cpath d=\"M 98.3,49.1 L 99.0,49.2\"\u003e\u003c\/path\u003e\u003cpath d=\"M 98.6,46.1 L 100.0,46.4\"\u003e\u003c\/path\u003e\u003cpath d=\"M 98.9,43.1 L 101.0,43.5\"\u003e\u003c\/path\u003e\u003cpath d=\"M 99.1,40.1 L 102.0,40.7\"\u003e\u003c\/path\u003e\u003cpath d=\"M 34.2,52.8 L 46.8,60.0\"\u003e\u003c\/path\u003e\u003cpath d=\"M 82.0,75.0 L 80.4,60.0\"\u003e\u003c\/path\u003e\u003cpath d=\"M 47.6,59.5 L 46.8,60.0 L 46.1,59.6\"\u003e\u003c\/path\u003e\u003cpath d=\"M 62.7,50.8 L 63.5,50.3 L 63.5,49.3\"\u003e\u003c\/path\u003e\u003cpath d=\"M 63.5,31.9 L 63.5,30.9 L 62.9,30.5\"\u003e\u003c\/path\u003e\u003cpath d=\"M 30.6,30.5 L 29.9,30.9 L 29.9,31.7\"\u003e\u003c\/path\u003e\u003cpath d=\"M 81.2,59.6 L 80.4,60.0 L 80.4,60.7\"\u003e\u003c\/path\u003e\u003cpath d=\"M 97.2,52.5 L 98.1,52.1 L 98.7,52.8\"\u003e\u003c\/path\u003e\u003cpath d=\"M 110.4,65.7 L 111.1,66.5 L 110.6,67.3\"\u003e\u003c\/path\u003e\u003cpath d=\"M 101.9,82.4 L 101.4,83.3 L 100.6,83.1\"\u003e\u003c\/path\u003e\u003ctext x=\"76.7\" y=\"27.2\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eO\u003c\/text\u003e\u003ctext x=\"43.1\" y=\"27.2\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eN\u003c\/text\u003e\u003ctext x=\"43.1\" y=\"16.6\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eH\u003c\/text\u003e\u003ctext x=\"9.5\" y=\"27.2\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eO\u003c\/text\u003e\u003ctext x=\"18.1\" y=\"56.3\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eH\u003c\/text\u003e\u003ctext x=\"26.3\" y=\"56.3\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eN\u003c\/text\u003e\u003ctext x=\"78.8\" y=\"85.3\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eO\u003c\/text\u003e\u003ctext x=\"125.0\" y=\"109.0\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eO\u003c\/text\u003e\u003ctext x=\"133.3\" y=\"109.0\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eH\u003c\/text\u003e\u003ctext x=\"126.8\" y=\"70.4\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eO\u003c\/text\u003e\u003ctext x=\"135.0\" y=\"70.4\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eH\u003c\/text\u003e\u003ctext x=\"98.5\" y=\"39.1\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eO\u003c\/text\u003e\u003ctext x=\"106.8\" y=\"39.1\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eH\u003c\/text\u003e\u003c\/svg\u003e\u003c\/div\u003e\n\u003cdiv style=\"display:flex;align-items:center;\"\u003e\u003cdiv style=\"font-size:20px;padding:0 4px;align-self:center;\"\u003e+\u003c\/div\u003e\u003c\/div\u003e\n\u003cdiv style=\"display:flex;align-items:center;\"\u003e\u003cdiv style=\"font:13px sans-serif;padding:0 2px 0 0;margin-left:-2px;\"\u003eHSO₃⁻\u003c\/div\u003e\u003c\/div\u003e\n\u003cdiv style=\"display:flex;align-items:center;\"\u003e\u003cdiv style=\"display:flex;flex-direction:column;align-items:center;justify-content:center;min-width:90px;max-width:150px;padding:0 4px;text-align:center;font-size:12px;line-height:1.3;\"\u003e\n\u003cdiv\u003e\u003c\/div\u003e\n\u003cdiv style=\"font-size:30px;line-height:1;\"\u003e⟶\u003c\/div\u003e\n\u003cdiv\u003e\u003c\/div\u003e\n\u003c\/div\u003e\u003c\/div\u003e\n\u003cdiv style=\"display:flex;align-items:center;\"\u003e\u003csvg role=\"img\" style=\"max-width:100%;height:auto;\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" fill=\"none\" stroke=\"#000\" stroke-width=\"1.6\" width=\"124px\" height=\"124px\" viewbox=\"0 0 124 124\"\u003e\u003cpath d=\"M 75.1,26.0 L 61.9,33.7\"\u003e\u003c\/path\u003e\u003cpath d=\"M 73.7,23.5 L 60.4,31.2\"\u003e\u003c\/path\u003e\u003cpath d=\"M 61.9,32.0 L 49.3,24.8\"\u003e\u003c\/path\u003e\u003cpath d=\"M 40.8,24.8 L 28.3,32.0\"\u003e\u003c\/path\u003e\u003cpath d=\"M 29.7,31.2 L 16.4,23.5\"\u003e\u003c\/path\u003e\u003cpath d=\"M 28.3,33.7 L 15.0,26.0\"\u003e\u003c\/path\u003e\u003cpath d=\"M 28.3,32.0 L 28.3,47.2\"\u003e\u003c\/path\u003e\u003cpath d=\"M 32.5,53.9 L 45.1,61.1\"\u003e\u003c\/path\u003e\u003cpath d=\"M 45.1,61.1 L 61.9,51.4\"\u003e\u003c\/path\u003e\u003cpath d=\"M 45.1,57.8 L 58.9,49.8\"\u003e\u003c\/path\u003e\u003cpath d=\"M 61.9,51.4 L 78.7,61.2\"\u003e\u003c\/path\u003e\u003cpath d=\"M 78.7,61.2 L 91.3,53.9\"\u003e\u003c\/path\u003e\u003cpath d=\"M 78.7,61.2 L 78.8,76.4\"\u003e\u003c\/path\u003e\u003cpath d=\"M 83.0,83.0 L 91.4,87.9\"\u003e\u003c\/path\u003e\u003cpath d=\"M 100.6,89.1 L 108.9,84.3\"\u003e\u003c\/path\u003e\u003cpath d=\"M 99.1,86.6 L 107.4,81.8\"\u003e\u003c\/path\u003e\u003cpath d=\"M 95.6,96.9 L 95.6,105.5\"\u003e\u003c\/path\u003e\u003cpath d=\"M 61.9,51.4 L 61.9,32.0\"\u003e\u003c\/path\u003e\u003cpath d=\"M 61.2,31.7 L 61.9,32.0 L 61.9,33.0\"\u003e\u003c\/path\u003e\u003cpath d=\"M 28.9,31.7 L 28.3,32.0 L 28.3,32.8\"\u003e\u003c\/path\u003e\u003cpath d=\"M 44.4,60.8 L 45.1,61.1 L 45.9,60.7\"\u003e\u003c\/path\u003e\u003ctext x=\"75.1\" y=\"28.3\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eO\u003c\/text\u003e\u003ctext x=\"41.5\" y=\"28.3\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eN\u003c\/text\u003e\u003ctext x=\"41.5\" y=\"17.8\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eH\u003c\/text\u003e\u003ctext x=\"7.9\" y=\"28.3\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eO\u003c\/text\u003e\u003ctext x=\"16.4\" y=\"57.4\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eH\u003c\/text\u003e\u003ctext x=\"24.7\" y=\"57.4\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eN\u003c\/text\u003e\u003ctext x=\"91.9\" y=\"57.5\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eR\u003c\/text\u003e\u003ctext x=\"75.2\" y=\"86.6\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eO\u003c\/text\u003e\u003ctext x=\"92.0\" y=\"96.3\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eS\u003c\/text\u003e\u003ctext x=\"108.8\" y=\"86.6\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eO\u003c\/text\u003e\u003ctext x=\"92.0\" y=\"115.7\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eO\u003c\/text\u003e\u003ctext x=\"100.3\" y=\"110.9\" style=\"font:7px sans-serif;fill:#000;stroke:none\"\u003e-\u003c\/text\u003e\u003c\/svg\u003e\u003c\/div\u003e\n\u003cdiv style=\"display:flex;align-items:center;\"\u003e\u003cdiv style=\"font-size:20px;padding:0 4px;align-self:center;\"\u003e+\u003c\/div\u003e\u003c\/div\u003e\n\u003cdiv style=\"display:flex;align-items:center;\"\u003e\u003csvg role=\"img\" style=\"max-width:100%;height:auto;\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" fill=\"none\" stroke=\"#000\" stroke-width=\"1.6\" width=\"108px\" height=\"112px\" viewbox=\"0 0 108 112\"\u003e\u003cpath d=\"M 74.3,24.7 L 61.1,32.4\"\u003e\u003c\/path\u003e\u003cpath d=\"M 72.9,22.2 L 59.6,29.9\"\u003e\u003c\/path\u003e\u003cpath d=\"M 61.1,30.7 L 48.5,23.5\"\u003e\u003c\/path\u003e\u003cpath d=\"M 40.0,23.5 L 27.5,30.7\"\u003e\u003c\/path\u003e\u003cpath d=\"M 28.9,29.9 L 15.6,22.2\"\u003e\u003c\/path\u003e\u003cpath d=\"M 27.5,32.4 L 14.2,24.7\"\u003e\u003c\/path\u003e\u003cpath d=\"M 27.5,30.7 L 27.5,45.9\"\u003e\u003c\/path\u003e\u003cpath d=\"M 31.7,52.6 L 44.3,59.8\"\u003e\u003c\/path\u003e\u003cpath d=\"M 44.3,59.8 L 61.1,50.1\"\u003e\u003c\/path\u003e\u003cpath d=\"M 44.3,56.5 L 58.2,48.4\"\u003e\u003c\/path\u003e\u003cpath d=\"M 61.1,50.1 L 77.9,59.8\"\u003e\u003c\/path\u003e\u003cpath d=\"M 77.9,59.8 L 90.4,52.5\"\u003e\u003c\/path\u003e\u003cpath d=\"M 77.9,59.8 L 77.9,74.9\"\u003e\u003c\/path\u003e\u003cpath d=\"M 73.7,77.7 L 62.7,77.7\"\u003e\u003c\/path\u003e\u003cpath d=\"M 73.7,80.6 L 62.7,80.7\"\u003e\u003c\/path\u003e\u003cpath d=\"M 82.1,80.6 L 93.1,80.6\"\u003e\u003c\/path\u003e\u003cpath d=\"M 82.1,77.7 L 93.1,77.7\"\u003e\u003c\/path\u003e\u003cpath d=\"M 77.9,85.8 L 77.9,94.3\"\u003e\u003c\/path\u003e\u003cpath d=\"M 61.1,50.1 L 61.1,30.7\"\u003e\u003c\/path\u003e\u003cpath d=\"M 60.4,30.3 L 61.1,30.7 L 61.1,31.7\"\u003e\u003c\/path\u003e\u003cpath d=\"M 28.1,30.4 L 27.5,30.7 L 27.5,31.5\"\u003e\u003c\/path\u003e\u003cpath d=\"M 43.7,59.5 L 44.3,59.8 L 45.1,59.3\"\u003e\u003c\/path\u003e\u003ctext x=\"74.3\" y=\"27.0\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eO\u003c\/text\u003e\u003ctext x=\"40.7\" y=\"27.0\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eN\u003c\/text\u003e\u003ctext x=\"40.7\" y=\"16.5\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eH\u003c\/text\u003e\u003ctext x=\"7.1\" y=\"27.0\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eO\u003c\/text\u003e\u003ctext x=\"15.6\" y=\"56.1\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eH\u003c\/text\u003e\u003ctext x=\"23.9\" y=\"56.1\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eN\u003c\/text\u003e\u003ctext x=\"91.1\" y=\"56.1\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eR\u003c\/text\u003e\u003ctext x=\"74.3\" y=\"85.2\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eS\u003c\/text\u003e\u003ctext x=\"54.9\" y=\"85.2\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eO\u003c\/text\u003e\u003ctext x=\"93.7\" y=\"85.2\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eO\u003c\/text\u003e\u003ctext x=\"74.3\" y=\"104.6\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eO\u003c\/text\u003e\u003ctext x=\"82.6\" y=\"99.8\" style=\"font:7px sans-serif;fill:#000;stroke:none\"\u003e-\u003c\/text\u003e\u003c\/svg\u003e\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cp style=\"font-size:12px;margin:4px 0 0 0;\"\u003e\u003cem\u003eReaction of pseudouridine with bisulfite. Both stable end products are adducts at C1′ with the ribose ring opened; R = the open sugar chain, CH(OH)–CH(OH)–CH(OH)–CH₂OH. The O-adduct (left, R configuration at C1′) is the major product; the S-adduct (right, S configuration at C1′) is a minor product formed with excess bisulfite. The configuration at C1′ is not drawn.\u003c\/em\u003e\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cp\u003e\u003cstrong\u003eMarker of kidney function.\u003c\/strong\u003e Free pseudouridine accumulates in the serum of patients with renal failure, because its excretion by the kidney is impaired. Non-targeted metabolomics identified pseudouridine as a non-traditional marker of kidney function, and it has since been quantified in blood and urine by targeted liquid chromatography–mass spectrometry with stable isotope-labelled internal standards. Plasma pseudouridine has also been reported to predict the progression of type 2 diabetic kidney disease to end-stage renal disease.\u003c\/p\u003e\n\u003c\/div\u003e\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cdiv style=\"margin-bottom: 28px;\"\u003e\n\u003cdiv style=\"background: #002147; padding: 10px 20px; margin-bottom: 0;\"\u003e\u003ch3 style=\"margin: 0; font-family: 'Helvetica Neue', Helvetica, Arial, sans-serif; font-size: 0.70em; font-weight: bold; letter-spacing: 0.12em; text-transform: uppercase; color: #fff;\"\u003eShipping Destinations\u003c\/h3\u003e\u003c\/div\u003e\n\u003cdiv style=\"border: 1px solid #e4e8f0; border-top: none; padding: 12px 16px; font-family: 'Helvetica Neue', Helvetica, Arial, sans-serif; font-size: 0.95em;\"\u003e\u003cul style=\"margin: 0; padding: 0; list-style: none;\"\u003e\n\u003cli style=\"padding: 5px 0; border-bottom: 1px solid #f0f0f0;\"\u003e\n\u003cspan style=\"display: inline-block; width: 7px; height: 7px; background: #002147; border-radius: 50%; margin-right: 10px; vertical-align: middle;\"\u003e\u003c\/span\u003eEU \u0026amp; UK: Priority delivery, 2–5 business days.\u003c\/li\u003e\n\u003cli style=\"padding: 5px 0; border-bottom: 1px solid #f0f0f0;\"\u003e\n\u003cspan style=\"display: inline-block; width: 7px; height: 7px; background: #002147; border-radius: 50%; margin-right: 10px; vertical-align: middle;\"\u003e\u003c\/span\u003eUnited States (DDP): 3–7 business days, duties and taxes prepaid.\u003c\/li\u003e\n\u003cli style=\"padding: 5px 0; border-bottom: 1px solid #f0f0f0;\"\u003e\n\u003cspan style=\"display: inline-block; width: 7px; height: 7px; background: #002147; border-radius: 50%; margin-right: 10px; vertical-align: middle;\"\u003e\u003c\/span\u003eEFTA Countries (DDP): 3–7 business days, duties and taxes prepaid.\u003c\/li\u003e\n\u003cli style=\"padding: 5px 0; border-bottom: 1px solid #f0f0f0;\"\u003e\n\u003cspan style=\"display: inline-block; width: 7px; height: 7px; background: #002147; border-radius: 50%; margin-right: 10px; vertical-align: middle;\"\u003e\u003c\/span\u003eWorldwide: 7–14 business days, selected locations.\u003c\/li\u003e\n\u003c\/ul\u003e\u003c\/div\u003e\n\u003c\/div\u003e","brand":"NorrChemica™","offers":[{"title":"100 mg","offer_id":55166596514129,"sku":"NOR-1445074-100mg","price":69.2,"currency_code":"EUR","in_stock":true},{"title":"250 mg","offer_id":55166596546897,"sku":"NOR-1445074-250mg","price":98.2,"currency_code":"EUR","in_stock":true},{"title":"1.0 g","offer_id":55166596579665,"sku":"NOR-1445074-1g","price":189.2,"currency_code":"EUR","in_stock":true},{"title":"5.0 g","offer_id":55166596612433,"sku":"NOR-1445074-5g","price":549.2,"currency_code":"EUR","in_stock":true},{"title":"10 g","offer_id":55354005946705,"sku":"NOR-1445074-10g","price":998.2,"currency_code":"EUR","in_stock":true},{"title":"25 g","offer_id":55166596645201,"sku":"NOR-1445074-25g","price":1698.2,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0954\/6357\/1793\/files\/Pseudouridine.png?v=1792270352"},{"product_id":"n1-methylpseudouridine-cas-13860-38-3","title":"N1-Methylpseudouridine | CAS 13860-38-3 | ≥97%","description":"\u003cdiv style=\"margin-bottom: 28px;\"\u003e\n\u003cdiv style=\"background: #002147; padding: 10px 20px; margin-bottom: 0;\"\u003e\u003ch3 style=\"margin: 0; font-family: 'Helvetica Neue', Helvetica, Arial, sans-serif; font-size: 0.70em; font-weight: bold; letter-spacing: 0.12em; text-transform: uppercase; color: #fff;\"\u003eTechnical Specifications\u003c\/h3\u003e\u003c\/div\u003e\n\u003ctable style=\"width: 100%; border-collapse: collapse; font-size: 0.95em; border: 1px solid #e4e8f0; border-top: none; font-family: 'Helvetica Neue', Helvetica, Arial, sans-serif;\"\u003e\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eCAS Number\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e13860-38-3\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eEC \/ EINECS Number\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e974-126-8\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eMDL Number\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003eMFCD10687017\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eSMILES\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0; word-break: break-all;\"\u003eCN1C=C(C(=O)NC1=O)[C@H]2[C@@H]([C@@H]([C@H](O2)CO)O)O\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eInChI\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0; word-break: break-all;\"\u003eInChI=1S\/C10H14N2O6\/c1-12-2-4(9(16)11-10(12)17)8-7(15)6(14)5(3-13)18-8\/h2,5-8,13-15H,3H2,1H3,(H,11,16,17)\/t5-,6-,7-,8+\/m1\/s1\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eInChIKey\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0; word-break: break-all;\"\u003eUVBYMVOUBXYSFV-XUTVFYLZSA-N\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003ePubChem CID\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e99543\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eMolecular Formula\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003eC₁₀H₁₄N₂O₆\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eMolecular Weight\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e258.23 g\/mol\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eMelting Point\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e187–191 °C\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003ePurity\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e≥97%\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003ePhysical Form\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003eWhite to light yellow powder or crystals\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eHS Code\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e2934.99\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eShelf Life\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003eRetest period: 36 months from date of manufacture\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eStorage Conditions\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333;\"\u003eStore at 2–8 °C in a tightly sealed container.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\u003c\/table\u003e\n\u003c\/div\u003e\n\u003cdiv style=\"margin-bottom: 28px;\"\u003e\n\u003cdiv style=\"background: #002147; padding: 10px 20px; margin-bottom: 0;\"\u003e\u003ch3 style=\"margin: 0; font-family: 'Helvetica Neue', Helvetica, Arial, sans-serif; font-size: 0.70em; font-weight: bold; letter-spacing: 0.12em; text-transform: uppercase; color: #fff;\"\u003eProduct Description \u0026amp; Scientific Applications\u003c\/h3\u003e\u003c\/div\u003e\n\u003cdiv style=\"padding: 16px 20px; border: 1px solid #e4e8f0; border-top: none; font-family: Georgia, 'Times New Roman', serif; font-size: 0.95em; line-height: 1.65; color: #333;\"\u003e\u003cdiv\u003e\n\u003cp\u003e\u003cstrong\u003eN1-Methylpseudouridine\u003c\/strong\u003e (m1Ψ) is pseudouridine carrying a methyl group on N1 of the uracil ring. In nature it occurs in the transfer RNA of many archaea, where it is found at position 54 in the TΨC loop in place of ribothymidine.\u003c\/p\u003e\n\u003cdiv style=\"margin:8px 0 18px 0;\"\u003e\n\u003cdiv style=\"display:flex;flex-wrap:wrap;align-items:center;justify-content:flex-start;gap:2px;\"\u003e\n\u003cdiv style=\"display:flex;align-items:center;\"\u003e\u003csvg role=\"img\" style=\"max-width:100%;height:auto;\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" fill=\"none\" stroke=\"#000\" stroke-width=\"1.6\" width=\"152px\" height=\"117px\" viewbox=\"0 0 152 117\"\u003e\u003cpath d=\"M 46.8,60.0 L 63.5,50.3\"\u003e\u003c\/path\u003e\u003cpath d=\"M 46.8,56.6 L 60.6,48.6\"\u003e\u003c\/path\u003e\u003cpath d=\"M 63.5,50.3 L 63.5,30.9\"\u003e\u003c\/path\u003e\u003cpath d=\"M 63.5,32.6 L 76.8,24.9\"\u003e\u003c\/path\u003e\u003cpath d=\"M 62.1,30.0 L 75.4,22.4\"\u003e\u003c\/path\u003e\u003cpath d=\"M 63.5,30.9 L 51.0,23.6\"\u003e\u003c\/path\u003e\u003cpath d=\"M 42.5,23.6 L 29.9,30.9\"\u003e\u003c\/path\u003e\u003cpath d=\"M 31.4,30.1 L 18.1,22.4\"\u003e\u003c\/path\u003e\u003cpath d=\"M 29.9,32.6 L 16.6,24.9\"\u003e\u003c\/path\u003e\u003cpath d=\"M 29.9,30.9 L 29.9,46.1\"\u003e\u003c\/path\u003e\u003cpath d=\"M 80.4,60.0 L 62.0,51.2 L 63.5,50.3 L 63.5,48.5 Z\"\u003e\u003c\/path\u003e\u003cpath d=\"M 80.4,60.0 L 98.1,52.1\"\u003e\u003c\/path\u003e\u003cpath d=\"M 98.1,52.1 L 111.1,66.5\"\u003e\u003c\/path\u003e\u003cpath d=\"M 111.1,66.5 L 101.4,83.3\"\u003e\u003c\/path\u003e\u003cpath d=\"M 101.4,83.3 L 86.6,80.2\"\u003e\u003c\/path\u003e\u003cpath d=\"M 101.4,83.3 L 111.0,101.2 L 107.7,100.8 Z\"\u003e\u003c\/path\u003e\u003cpath d=\"M 107.7,100.8 L 124.3,102.6\"\u003e\u003c\/path\u003e\u003cpath d=\"M 113.9,65.9 L 114.0,66.5\"\u003e\u003c\/path\u003e\u003cpath d=\"M 116.8,65.3 L 116.9,66.4\"\u003e\u003c\/path\u003e\u003cpath d=\"M 119.6,64.7 L 119.8,66.4\"\u003e\u003c\/path\u003e\u003cpath d=\"M 122.5,64.1 L 122.7,66.4\"\u003e\u003c\/path\u003e\u003cpath d=\"M 125.3,63.5 L 125.6,66.4\"\u003e\u003c\/path\u003e\u003cpath d=\"M 98.3,49.1 L 99.0,49.2\"\u003e\u003c\/path\u003e\u003cpath d=\"M 98.6,46.1 L 100.0,46.4\"\u003e\u003c\/path\u003e\u003cpath d=\"M 98.9,43.1 L 101.0,43.5\"\u003e\u003c\/path\u003e\u003cpath d=\"M 99.1,40.1 L 102.0,40.7\"\u003e\u003c\/path\u003e\u003cpath d=\"M 34.2,52.8 L 46.8,60.0\"\u003e\u003c\/path\u003e\u003cpath d=\"M 82.0,75.0 L 80.4,60.0\"\u003e\u003c\/path\u003e\u003cpath d=\"M 47.6,59.5 L 46.8,60.0 L 46.1,59.6\"\u003e\u003c\/path\u003e\u003cpath d=\"M 62.7,50.8 L 63.5,50.3 L 63.5,49.3\"\u003e\u003c\/path\u003e\u003cpath d=\"M 63.5,31.9 L 63.5,30.9 L 62.9,30.5\"\u003e\u003c\/path\u003e\u003cpath d=\"M 30.6,30.5 L 29.9,30.9 L 29.9,31.7\"\u003e\u003c\/path\u003e\u003cpath d=\"M 81.2,59.6 L 80.4,60.0 L 80.4,60.7\"\u003e\u003c\/path\u003e\u003cpath d=\"M 97.2,52.5 L 98.1,52.1 L 98.7,52.8\"\u003e\u003c\/path\u003e\u003cpath d=\"M 110.4,65.7 L 111.1,66.5 L 110.6,67.3\"\u003e\u003c\/path\u003e\u003cpath d=\"M 101.9,82.4 L 101.4,83.3 L 100.6,83.1\"\u003e\u003c\/path\u003e\u003ctext x=\"76.7\" y=\"27.2\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eO\u003c\/text\u003e\u003ctext x=\"43.1\" y=\"27.2\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eN\u003c\/text\u003e\u003ctext x=\"43.1\" y=\"16.6\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eH\u003c\/text\u003e\u003ctext x=\"9.5\" y=\"27.2\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eO\u003c\/text\u003e\u003ctext x=\"18.1\" y=\"56.3\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eH\u003c\/text\u003e\u003ctext x=\"26.3\" y=\"56.3\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eN\u003c\/text\u003e\u003ctext x=\"78.8\" y=\"85.3\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eO\u003c\/text\u003e\u003ctext x=\"125.0\" y=\"109.0\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eO\u003c\/text\u003e\u003ctext x=\"133.3\" y=\"109.0\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eH\u003c\/text\u003e\u003ctext x=\"126.8\" y=\"70.4\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eO\u003c\/text\u003e\u003ctext x=\"135.0\" y=\"70.4\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eH\u003c\/text\u003e\u003ctext x=\"98.5\" y=\"39.1\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eO\u003c\/text\u003e\u003ctext x=\"106.8\" y=\"39.1\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eH\u003c\/text\u003e\u003c\/svg\u003e\u003c\/div\u003e\n\u003cdiv style=\"display:flex;align-items:center;\"\u003e\u003cdiv style=\"display:flex;flex-direction:column;align-items:center;justify-content:center;min-width:90px;max-width:150px;padding:0 4px;text-align:center;font-size:12px;line-height:1.3;\"\u003e\n\u003cdiv\u003eN1-methyltransferase\u003c\/div\u003e\n\u003cdiv style=\"font-size:30px;line-height:1;\"\u003e⟶\u003c\/div\u003e\n\u003cdiv\u003e(pseudouridine residues in RNA)\u003c\/div\u003e\n\u003c\/div\u003e\u003c\/div\u003e\n\u003cdiv style=\"display:flex;align-items:center;\"\u003e\u003csvg role=\"img\" style=\"max-width:100%;height:auto;\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" fill=\"none\" stroke=\"#000\" stroke-width=\"1.6\" width=\"153px\" height=\"118px\" viewbox=\"0 0 153 118\"\u003e\u003cpath d=\"M 13.5,60.6 L 26.2,53.3\"\u003e\u003c\/path\u003e\u003cpath d=\"M 34.6,53.3 L 47.3,60.6\"\u003e\u003c\/path\u003e\u003cpath d=\"M 47.3,60.6 L 64.2,50.9\"\u003e\u003c\/path\u003e\u003cpath d=\"M 47.3,57.3 L 61.3,49.2\"\u003e\u003c\/path\u003e\u003cpath d=\"M 64.2,50.9 L 64.2,31.4\"\u003e\u003c\/path\u003e\u003cpath d=\"M 64.2,33.0 L 77.6,25.3\"\u003e\u003c\/path\u003e\u003cpath d=\"M 62.7,30.5 L 76.1,22.8\"\u003e\u003c\/path\u003e\u003cpath d=\"M 64.2,31.4 L 51.5,24.1\"\u003e\u003c\/path\u003e\u003cpath d=\"M 43.1,24.1 L 30.4,31.4\"\u003e\u003c\/path\u003e\u003cpath d=\"M 31.9,30.5 L 18.5,22.8\"\u003e\u003c\/path\u003e\u003cpath d=\"M 30.4,33.0 L 17.0,25.3\"\u003e\u003c\/path\u003e\u003cpath d=\"M 81.1,60.6 L 62.7,51.8 L 64.2,50.9 L 64.2,49.1 Z\"\u003e\u003c\/path\u003e\u003cpath d=\"M 81.1,60.6 L 98.8,52.7\"\u003e\u003c\/path\u003e\u003cpath d=\"M 98.8,52.7 L 111.8,67.2\"\u003e\u003c\/path\u003e\u003cpath d=\"M 111.8,67.2 L 102.1,84.0\"\u003e\u003c\/path\u003e\u003cpath d=\"M 102.1,84.0 L 87.4,80.8\"\u003e\u003c\/path\u003e\u003cpath d=\"M 102.1,84.0 L 111.7,101.9 L 108.4,101.5 Z\"\u003e\u003c\/path\u003e\u003cpath d=\"M 108.4,101.5 L 125.0,103.3\"\u003e\u003c\/path\u003e\u003cpath d=\"M 114.6,66.6 L 114.7,67.1\"\u003e\u003c\/path\u003e\u003cpath d=\"M 117.5,66.0 L 117.6,67.1\"\u003e\u003c\/path\u003e\u003cpath d=\"M 120.4,65.4 L 120.5,67.1\"\u003e\u003c\/path\u003e\u003cpath d=\"M 123.2,64.8 L 123.4,67.1\"\u003e\u003c\/path\u003e\u003cpath d=\"M 126.1,64.2 L 126.4,67.1\"\u003e\u003c\/path\u003e\u003cpath d=\"M 99.1,49.7 L 99.8,49.9\"\u003e\u003c\/path\u003e\u003cpath d=\"M 99.3,46.7 L 100.8,47.0\"\u003e\u003c\/path\u003e\u003cpath d=\"M 99.6,43.7 L 101.8,44.2\"\u003e\u003c\/path\u003e\u003cpath d=\"M 99.9,40.7 L 102.7,41.4\"\u003e\u003c\/path\u003e\u003cpath d=\"M 30.4,31.4 L 30.4,46.6\"\u003e\u003c\/path\u003e\u003cpath d=\"M 82.7,75.7 L 81.1,60.6\"\u003e\u003c\/path\u003e\u003cpath d=\"M 46.7,60.3 L 47.3,60.6 L 48.1,60.1\"\u003e\u003c\/path\u003e\u003cpath d=\"M 63.4,51.4 L 64.2,50.9 L 64.2,49.9\"\u003e\u003c\/path\u003e\u003cpath d=\"M 64.2,32.3 L 64.2,31.4 L 63.6,31.0\"\u003e\u003c\/path\u003e\u003cpath d=\"M 31.0,31.0 L 30.4,31.4 L 30.4,32.1\"\u003e\u003c\/path\u003e\u003cpath d=\"M 82.0,60.2 L 81.1,60.6 L 81.2,61.4\"\u003e\u003c\/path\u003e\u003cpath d=\"M 97.9,53.1 L 98.8,52.7 L 99.5,53.5\"\u003e\u003c\/path\u003e\u003cpath d=\"M 111.1,66.4 L 111.8,67.2 L 111.3,68.0\"\u003e\u003c\/path\u003e\u003cpath d=\"M 102.6,83.1 L 102.1,84.0 L 101.4,83.8\"\u003e\u003c\/path\u003e\u003ctext x=\"26.8\" y=\"56.9\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eN\u003c\/text\u003e\u003ctext x=\"77.5\" y=\"27.6\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eO\u003c\/text\u003e\u003ctext x=\"43.7\" y=\"27.6\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eN\u003c\/text\u003e\u003ctext x=\"43.7\" y=\"17.0\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eH\u003c\/text\u003e\u003ctext x=\"9.9\" y=\"27.6\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eO\u003c\/text\u003e\u003ctext x=\"79.5\" y=\"85.9\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eO\u003c\/text\u003e\u003ctext x=\"125.7\" y=\"109.7\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eO\u003c\/text\u003e\u003ctext x=\"134.0\" y=\"109.7\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eH\u003c\/text\u003e\u003ctext x=\"127.5\" y=\"71.1\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eO\u003c\/text\u003e\u003ctext x=\"135.8\" y=\"71.1\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eH\u003c\/text\u003e\u003ctext x=\"99.3\" y=\"39.8\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eO\u003c\/text\u003e\u003ctext x=\"107.5\" y=\"39.8\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eH\u003c\/text\u003e\u003c\/svg\u003e\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cp style=\"font-size:12px;margin:4px 0 0 0;\"\u003e\u003cem\u003ePseudouridine (left) and N1-methylpseudouridine (right), drawn as the free nucleosides. In cells, the methyl group is added to N1 of pseudouridine residues within RNA, for example by TrmY at position 54 of archaeal tRNA, in a reaction that depends on S-adenosylmethionine. Nep1 also methylates N1 of pseudouridine in RNA, and is proposed to do so in eukaryotic 18S ribosomal RNA, where the modified nucleoside is m1acp3Ψ.\u003c\/em\u003e\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cp\u003e\u003cstrong\u003eFormation in RNA.\u003c\/strong\u003e In archaea, m1Ψ is formed on the tRNA in two steps: the pseudouridine synthase Pus10 forms pseudouridine at position 54, and the methyltransferase TrmY then methylates it. The methylation depends on S-adenosylmethionine. The ribosome assembly factor Nep1 is a methyltransferase specific for N1 of pseudouridine. Its activity is conserved in human Nep1, and Nep1 is proposed to install the N1-methyl group of the hypermodified nucleoside m1acp3Ψ in eukaryotic 18S ribosomal RNA. A mutation in human Nep1 causes Bowen–Conradi syndrome.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eModified mRNA.\u003c\/strong\u003e mRNAs that contain m1Ψ gave higher reporter protein expression than pseudouridine-modified mRNAs in cell lines and in mice, and lower innate immunogenicity in transfected cells. The authors suggest that the higher protein expression may be due, at least in part, to the mRNA being better at avoiding activation of the endosomal Toll-like receptor TLR3. In another study, m1Ψ outperformed several other nucleoside modifications, and combinations of them, in translation capacity. Work in cell-free translation systems showed that m1Ψ in the mRNA switches off the inhibition of translation that is linked to the immune response and to eIF2α phosphorylation, and that it also increases ribosome pausing and ribosome density on the mRNA. The COVID-19 mRNA vaccines of Pfizer-BioNTech (BNT162b2) and Moderna (mRNA-1273) use m1Ψ, and in BNT162b2 every uridine in the mRNA is replaced by m1Ψ. Such mRNAs are made by in vitro transcription with T7 RNA polymerase, with m1Ψ triphosphate in place of UTP. In a study with T7 RNA polymerase and a mixture of UTP and m1Ψ triphosphate, the ratio in which the two were inserted depended strongly on the neighbouring sequence, and UTP was inserted more often in every sequence context tested.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eFidelity of transcription and translation.\u003c\/strong\u003e During in vitro transcription, m1Ψ is incorporated with higher fidelity than pseudouridine. In a reconstituted translation system, m1Ψ did not significantly alter decoding accuracy, and, compared with unmodified mRNA, no increase in miscoded peptides was detected when m1Ψ-containing mRNA was translated in cell culture. However, m1Ψ in mRNA has been shown to cause +1 ribosomal frameshifting in vitro, at slippery sequences, probably because it makes ribosomes stall. Synonymous changes to these slippery sequences reduce the frameshifted products.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eReaction with bisulfite.\u003c\/strong\u003e Like pseudouridine, m1Ψ reacts with bisulfite to give ribose adducts: two constitutional isomers in which bisulfite is bound through oxygen (O-adduct) or sulfur (S-adduct) to C1′ of a ring-opened ribose, with the O-adduct as the main product. At neutral pH, bisulfite did not react with cytidine or 5-methylcytidine, while uridine, 5-methyluridine, pseudouridine and m1Ψ all reacted. The authors report that at this pH bisulfite reacts specifically with pseudouridine and m1Ψ to give stable end products.\u003c\/p\u003e\n\u003cdiv style=\"margin:8px 0 18px 0;\"\u003e\n\u003cdiv style=\"display:flex;flex-wrap:wrap;align-items:center;justify-content:flex-start;gap:2px;\"\u003e\n\u003cdiv style=\"display:flex;align-items:center;\"\u003e\u003csvg role=\"img\" style=\"max-width:100%;height:auto;\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" fill=\"none\" stroke=\"#000\" stroke-width=\"1.6\" width=\"153px\" height=\"118px\" viewbox=\"0 0 153 118\"\u003e\u003cpath d=\"M 13.5,60.6 L 26.2,53.3\"\u003e\u003c\/path\u003e\u003cpath d=\"M 34.6,53.3 L 47.3,60.6\"\u003e\u003c\/path\u003e\u003cpath d=\"M 47.3,60.6 L 64.2,50.9\"\u003e\u003c\/path\u003e\u003cpath d=\"M 47.3,57.3 L 61.3,49.2\"\u003e\u003c\/path\u003e\u003cpath d=\"M 64.2,50.9 L 64.2,31.4\"\u003e\u003c\/path\u003e\u003cpath d=\"M 64.2,33.0 L 77.6,25.3\"\u003e\u003c\/path\u003e\u003cpath d=\"M 62.7,30.5 L 76.1,22.8\"\u003e\u003c\/path\u003e\u003cpath d=\"M 64.2,31.4 L 51.5,24.1\"\u003e\u003c\/path\u003e\u003cpath d=\"M 43.1,24.1 L 30.4,31.4\"\u003e\u003c\/path\u003e\u003cpath d=\"M 31.9,30.5 L 18.5,22.8\"\u003e\u003c\/path\u003e\u003cpath d=\"M 30.4,33.0 L 17.0,25.3\"\u003e\u003c\/path\u003e\u003cpath d=\"M 81.1,60.6 L 62.7,51.8 L 64.2,50.9 L 64.2,49.1 Z\"\u003e\u003c\/path\u003e\u003cpath d=\"M 81.1,60.6 L 98.8,52.7\"\u003e\u003c\/path\u003e\u003cpath d=\"M 98.8,52.7 L 111.8,67.2\"\u003e\u003c\/path\u003e\u003cpath d=\"M 111.8,67.2 L 102.1,84.0\"\u003e\u003c\/path\u003e\u003cpath d=\"M 102.1,84.0 L 87.4,80.8\"\u003e\u003c\/path\u003e\u003cpath d=\"M 102.1,84.0 L 111.7,101.9 L 108.4,101.5 Z\"\u003e\u003c\/path\u003e\u003cpath d=\"M 108.4,101.5 L 125.0,103.3\"\u003e\u003c\/path\u003e\u003cpath d=\"M 114.6,66.6 L 114.7,67.1\"\u003e\u003c\/path\u003e\u003cpath d=\"M 117.5,66.0 L 117.6,67.1\"\u003e\u003c\/path\u003e\u003cpath d=\"M 120.4,65.4 L 120.5,67.1\"\u003e\u003c\/path\u003e\u003cpath d=\"M 123.2,64.8 L 123.4,67.1\"\u003e\u003c\/path\u003e\u003cpath d=\"M 126.1,64.2 L 126.4,67.1\"\u003e\u003c\/path\u003e\u003cpath d=\"M 99.1,49.7 L 99.8,49.9\"\u003e\u003c\/path\u003e\u003cpath d=\"M 99.3,46.7 L 100.8,47.0\"\u003e\u003c\/path\u003e\u003cpath d=\"M 99.6,43.7 L 101.8,44.2\"\u003e\u003c\/path\u003e\u003cpath d=\"M 99.9,40.7 L 102.7,41.4\"\u003e\u003c\/path\u003e\u003cpath d=\"M 30.4,31.4 L 30.4,46.6\"\u003e\u003c\/path\u003e\u003cpath d=\"M 82.7,75.7 L 81.1,60.6\"\u003e\u003c\/path\u003e\u003cpath d=\"M 46.7,60.3 L 47.3,60.6 L 48.1,60.1\"\u003e\u003c\/path\u003e\u003cpath d=\"M 63.4,51.4 L 64.2,50.9 L 64.2,49.9\"\u003e\u003c\/path\u003e\u003cpath d=\"M 64.2,32.3 L 64.2,31.4 L 63.6,31.0\"\u003e\u003c\/path\u003e\u003cpath d=\"M 31.0,31.0 L 30.4,31.4 L 30.4,32.1\"\u003e\u003c\/path\u003e\u003cpath d=\"M 82.0,60.2 L 81.1,60.6 L 81.2,61.4\"\u003e\u003c\/path\u003e\u003cpath d=\"M 97.9,53.1 L 98.8,52.7 L 99.5,53.5\"\u003e\u003c\/path\u003e\u003cpath d=\"M 111.1,66.4 L 111.8,67.2 L 111.3,68.0\"\u003e\u003c\/path\u003e\u003cpath d=\"M 102.6,83.1 L 102.1,84.0 L 101.4,83.8\"\u003e\u003c\/path\u003e\u003ctext x=\"26.8\" y=\"56.9\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eN\u003c\/text\u003e\u003ctext x=\"77.5\" y=\"27.6\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eO\u003c\/text\u003e\u003ctext x=\"43.7\" y=\"27.6\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eN\u003c\/text\u003e\u003ctext x=\"43.7\" y=\"17.0\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eH\u003c\/text\u003e\u003ctext x=\"9.9\" y=\"27.6\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eO\u003c\/text\u003e\u003ctext x=\"79.5\" y=\"85.9\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eO\u003c\/text\u003e\u003ctext x=\"125.7\" y=\"109.7\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eO\u003c\/text\u003e\u003ctext x=\"134.0\" y=\"109.7\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eH\u003c\/text\u003e\u003ctext x=\"127.5\" y=\"71.1\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eO\u003c\/text\u003e\u003ctext x=\"135.8\" y=\"71.1\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eH\u003c\/text\u003e\u003ctext x=\"99.3\" y=\"39.8\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eO\u003c\/text\u003e\u003ctext x=\"107.5\" y=\"39.8\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eH\u003c\/text\u003e\u003c\/svg\u003e\u003c\/div\u003e\n\u003cdiv style=\"display:flex;align-items:center;\"\u003e\u003cdiv style=\"font-size:20px;padding:0 4px;align-self:center;\"\u003e+\u003c\/div\u003e\u003c\/div\u003e\n\u003cdiv style=\"display:flex;align-items:center;\"\u003e\u003cdiv style=\"font:13px sans-serif;padding:0 2px 0 0;margin-left:-2px;\"\u003eHSO₃⁻\u003c\/div\u003e\u003c\/div\u003e\n\u003cdiv style=\"display:flex;align-items:center;\"\u003e\u003cdiv style=\"display:flex;flex-direction:column;align-items:center;justify-content:center;min-width:90px;max-width:150px;padding:0 4px;text-align:center;font-size:12px;line-height:1.3;\"\u003e\n\u003cdiv\u003e\u003c\/div\u003e\n\u003cdiv style=\"font-size:30px;line-height:1;\"\u003e⟶\u003c\/div\u003e\n\u003cdiv\u003e\u003c\/div\u003e\n\u003c\/div\u003e\u003c\/div\u003e\n\u003cdiv style=\"display:flex;align-items:center;\"\u003e\u003csvg role=\"img\" style=\"max-width:100%;height:auto;\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" fill=\"none\" stroke=\"#000\" stroke-width=\"1.6\" width=\"124px\" height=\"124px\" viewbox=\"0 0 124 124\"\u003e\u003cpath d=\"M 75.2,26.1 L 61.9,33.7\"\u003e\u003c\/path\u003e\u003cpath d=\"M 73.8,23.6 L 60.5,31.2\"\u003e\u003c\/path\u003e\u003cpath d=\"M 61.9,32.1 L 49.4,24.8\"\u003e\u003c\/path\u003e\u003cpath d=\"M 40.9,24.8 L 28.3,32.1\"\u003e\u003c\/path\u003e\u003cpath d=\"M 29.8,31.2 L 16.5,23.6\"\u003e\u003c\/path\u003e\u003cpath d=\"M 28.3,33.7 L 15.1,26.1\"\u003e\u003c\/path\u003e\u003cpath d=\"M 28.3,32.1 L 28.3,47.2\"\u003e\u003c\/path\u003e\u003cpath d=\"M 24.1,53.9 L 11.5,61.2\"\u003e\u003c\/path\u003e\u003cpath d=\"M 32.6,53.9 L 45.1,61.2\"\u003e\u003c\/path\u003e\u003cpath d=\"M 45.1,61.2 L 61.9,51.5\"\u003e\u003c\/path\u003e\u003cpath d=\"M 45.1,57.8 L 59.0,49.8\"\u003e\u003c\/path\u003e\u003cpath d=\"M 61.9,51.5 L 78.7,61.2\"\u003e\u003c\/path\u003e\u003cpath d=\"M 78.7,61.2 L 91.3,53.9\"\u003e\u003c\/path\u003e\u003cpath d=\"M 78.7,61.2 L 78.7,76.3\"\u003e\u003c\/path\u003e\u003cpath d=\"M 83.0,83.0 L 91.3,87.8\"\u003e\u003c\/path\u003e\u003cpath d=\"M 100.5,89.1 L 108.8,84.3\"\u003e\u003c\/path\u003e\u003cpath d=\"M 99.1,86.6 L 107.4,81.8\"\u003e\u003c\/path\u003e\u003cpath d=\"M 95.5,96.9 L 95.5,105.4\"\u003e\u003c\/path\u003e\u003cpath d=\"M 61.9,51.5 L 61.9,32.1\"\u003e\u003c\/path\u003e\u003cpath d=\"M 61.3,31.7 L 61.9,32.1 L 61.9,33.0\"\u003e\u003c\/path\u003e\u003cpath d=\"M 29.0,31.7 L 28.3,32.1 L 28.3,32.8\"\u003e\u003c\/path\u003e\u003cpath d=\"M 44.5,60.8 L 45.1,61.2 L 46.0,60.7\"\u003e\u003c\/path\u003e\u003ctext x=\"75.1\" y=\"28.4\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eO\u003c\/text\u003e\u003ctext x=\"41.5\" y=\"28.4\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eN\u003c\/text\u003e\u003ctext x=\"41.5\" y=\"17.8\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eH\u003c\/text\u003e\u003ctext x=\"7.9\" y=\"28.4\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eO\u003c\/text\u003e\u003ctext x=\"24.7\" y=\"57.5\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eN\u003c\/text\u003e\u003ctext x=\"91.9\" y=\"57.5\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eR\u003c\/text\u003e\u003ctext x=\"75.1\" y=\"86.6\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eO\u003c\/text\u003e\u003ctext x=\"91.9\" y=\"96.3\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eS\u003c\/text\u003e\u003ctext x=\"108.7\" y=\"86.6\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eO\u003c\/text\u003e\u003ctext x=\"91.9\" y=\"115.7\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eO\u003c\/text\u003e\u003ctext x=\"100.2\" y=\"110.9\" style=\"font:7px sans-serif;fill:#000;stroke:none\"\u003e-\u003c\/text\u003e\u003c\/svg\u003e\u003c\/div\u003e\n\u003cdiv style=\"display:flex;align-items:center;\"\u003e\u003cdiv style=\"font-size:20px;padding:0 4px;align-self:center;\"\u003e+\u003c\/div\u003e\u003c\/div\u003e\n\u003cdiv style=\"display:flex;align-items:center;\"\u003e\u003csvg role=\"img\" style=\"max-width:100%;height:auto;\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" fill=\"none\" stroke=\"#000\" stroke-width=\"1.6\" width=\"108px\" height=\"112px\" viewbox=\"0 0 108 112\"\u003e\u003cpath d=\"M 74.3,24.7 L 61.1,32.4\"\u003e\u003c\/path\u003e\u003cpath d=\"M 72.9,22.2 L 59.6,29.9\"\u003e\u003c\/path\u003e\u003cpath d=\"M 61.1,30.7 L 48.5,23.5\"\u003e\u003c\/path\u003e\u003cpath d=\"M 40.0,23.5 L 27.5,30.7\"\u003e\u003c\/path\u003e\u003cpath d=\"M 28.9,29.9 L 15.6,22.2\"\u003e\u003c\/path\u003e\u003cpath d=\"M 27.5,32.4 L 14.2,24.7\"\u003e\u003c\/path\u003e\u003cpath d=\"M 27.5,30.7 L 27.5,45.9\"\u003e\u003c\/path\u003e\u003cpath d=\"M 23.2,52.6 L 10.7,59.8\"\u003e\u003c\/path\u003e\u003cpath d=\"M 31.7,52.6 L 44.3,59.8\"\u003e\u003c\/path\u003e\u003cpath d=\"M 44.3,59.8 L 61.1,50.1\"\u003e\u003c\/path\u003e\u003cpath d=\"M 44.3,56.5 L 58.2,48.4\"\u003e\u003c\/path\u003e\u003cpath d=\"M 61.1,50.1 L 77.9,59.8\"\u003e\u003c\/path\u003e\u003cpath d=\"M 77.9,59.8 L 90.4,52.5\"\u003e\u003c\/path\u003e\u003cpath d=\"M 77.9,59.8 L 77.9,74.9\"\u003e\u003c\/path\u003e\u003cpath d=\"M 82.1,80.6 L 93.1,80.6\"\u003e\u003c\/path\u003e\u003cpath d=\"M 82.1,77.7 L 93.1,77.7\"\u003e\u003c\/path\u003e\u003cpath d=\"M 73.7,77.7 L 62.7,77.7\"\u003e\u003c\/path\u003e\u003cpath d=\"M 73.7,80.6 L 62.7,80.7\"\u003e\u003c\/path\u003e\u003cpath d=\"M 77.9,85.8 L 77.9,94.3\"\u003e\u003c\/path\u003e\u003cpath d=\"M 61.1,50.1 L 61.1,30.7\"\u003e\u003c\/path\u003e\u003cpath d=\"M 60.4,30.3 L 61.1,30.7 L 61.1,31.7\"\u003e\u003c\/path\u003e\u003cpath d=\"M 28.1,30.4 L 27.5,30.7 L 27.5,31.5\"\u003e\u003c\/path\u003e\u003cpath d=\"M 43.7,59.5 L 44.3,59.8 L 45.1,59.3\"\u003e\u003c\/path\u003e\u003ctext x=\"74.3\" y=\"27.0\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eO\u003c\/text\u003e\u003ctext x=\"40.7\" y=\"27.0\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eN\u003c\/text\u003e\u003ctext x=\"40.7\" y=\"16.5\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eH\u003c\/text\u003e\u003ctext x=\"7.1\" y=\"27.0\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eO\u003c\/text\u003e\u003ctext x=\"23.9\" y=\"56.1\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eN\u003c\/text\u003e\u003ctext x=\"91.1\" y=\"56.1\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eR\u003c\/text\u003e\u003ctext x=\"74.3\" y=\"85.2\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eS\u003c\/text\u003e\u003ctext x=\"93.7\" y=\"85.2\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eO\u003c\/text\u003e\u003ctext x=\"54.9\" y=\"85.2\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eO\u003c\/text\u003e\u003ctext x=\"74.3\" y=\"104.6\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eO\u003c\/text\u003e\u003ctext x=\"82.6\" y=\"99.8\" style=\"font:7px sans-serif;fill:#000;stroke:none\"\u003e-\u003c\/text\u003e\u003c\/svg\u003e\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cp style=\"font-size:12px;margin:4px 0 0 0;\"\u003e\u003cem\u003eReaction of N1-methylpseudouridine with bisulfite. Both end products are adducts at C1′ with the ribose ring opened; R = the open sugar chain, CH(OH)–CH(OH)–CH(OH)–CH₂OH. The O-adduct (left) is the main product and the S-adduct (right) the minor one. The adducts are drawn as the N1-methyl analogues of the pseudouridine adducts, with which they were assigned.\u003c\/em\u003e\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cdiv style=\"margin-bottom: 28px;\"\u003e\n\u003cdiv style=\"background: #002147; padding: 10px 20px; margin-bottom: 0;\"\u003e\u003ch3 style=\"margin: 0; font-family: 'Helvetica Neue', Helvetica, Arial, sans-serif; font-size: 0.70em; font-weight: bold; letter-spacing: 0.12em; text-transform: uppercase; color: #fff;\"\u003eShipping Destinations\u003c\/h3\u003e\u003c\/div\u003e\n\u003cdiv style=\"border: 1px solid #e4e8f0; border-top: none; padding: 12px 16px; font-family: 'Helvetica Neue', Helvetica, Arial, sans-serif; font-size: 0.95em;\"\u003e\u003cul style=\"margin: 0; padding: 0; list-style: none;\"\u003e\n\u003cli style=\"padding: 5px 0; border-bottom: 1px solid #f0f0f0;\"\u003e\n\u003cspan style=\"display: inline-block; width: 7px; height: 7px; background: #002147; border-radius: 50%; margin-right: 10px; vertical-align: middle;\"\u003e\u003c\/span\u003eEU \u0026amp; UK: Priority delivery, 2–5 business days.\u003c\/li\u003e\n\u003cli style=\"padding: 5px 0; border-bottom: 1px solid #f0f0f0;\"\u003e\n\u003cspan style=\"display: inline-block; width: 7px; height: 7px; background: #002147; border-radius: 50%; margin-right: 10px; vertical-align: middle;\"\u003e\u003c\/span\u003eUnited States (DDP): 3–7 business days, duties and taxes prepaid.\u003c\/li\u003e\n\u003cli style=\"padding: 5px 0; border-bottom: 1px solid #f0f0f0;\"\u003e\n\u003cspan style=\"display: inline-block; width: 7px; height: 7px; background: #002147; border-radius: 50%; margin-right: 10px; vertical-align: middle;\"\u003e\u003c\/span\u003eEFTA Countries (DDP): 3–7 business days, duties and taxes prepaid.\u003c\/li\u003e\n\u003cli style=\"padding: 5px 0; border-bottom: 1px solid #f0f0f0;\"\u003e\n\u003cspan style=\"display: inline-block; width: 7px; height: 7px; background: #002147; border-radius: 50%; margin-right: 10px; vertical-align: middle;\"\u003e\u003c\/span\u003eWorldwide: 7–14 business days, selected locations.\u003c\/li\u003e\n\u003c\/ul\u003e\u003c\/div\u003e\n\u003c\/div\u003e","brand":"NorrChemica™","offers":[{"title":"50 mg","offer_id":55166596677969,"sku":"NOR-13860383-50mg","price":45.2,"currency_code":"EUR","in_stock":true},{"title":"100 mg","offer_id":55166596710737,"sku":"NOR-13860383-100mg","price":64.2,"currency_code":"EUR","in_stock":true},{"title":"250 mg","offer_id":55166596743505,"sku":"NOR-13860383-250mg","price":79.2,"currency_code":"EUR","in_stock":true},{"title":"1.0 g","offer_id":55354037961041,"sku":"NOR-13860383-1g","price":129.2,"currency_code":"EUR","in_stock":true},{"title":"2.0 g","offer_id":55354037993809,"sku":"NOR-13860383-2g","price":229.2,"currency_code":"EUR","in_stock":true},{"title":"5.0 g","offer_id":55166596776273,"sku":"NOR-13860383-5g","price":429.2,"currency_code":"EUR","in_stock":true},{"title":"10 g","offer_id":55354038026577,"sku":"NOR-13860383-10g","price":809.2,"currency_code":"EUR","in_stock":true},{"title":"25 g","offer_id":55166596809041,"sku":"NOR-13860383-25g","price":1895.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0954\/6357\/1793\/files\/N1-Methylpseudouridine.png?v=1792269305"},{"product_id":"n6-methyladenosine-cas-1867-73-8","title":"N6-Methyladenosine | CAS 1867-73-8 | ≥97%","description":"\u003cdiv style=\"margin-bottom: 28px;\"\u003e\n\u003cdiv style=\"background: #002147; padding: 10px 20px; margin-bottom: 0;\"\u003e\u003ch3 style=\"margin: 0; font-family: 'Helvetica Neue', Helvetica, Arial, sans-serif; font-size: 0.70em; font-weight: bold; letter-spacing: 0.12em; text-transform: uppercase; color: #fff;\"\u003eTechnical Specifications\u003c\/h3\u003e\u003c\/div\u003e\n\u003ctable style=\"width: 100%; border-collapse: collapse; font-size: 0.95em; border: 1px solid #e4e8f0; border-top: none; font-family: 'Helvetica Neue', Helvetica, Arial, sans-serif;\"\u003e\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eCAS Number\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e1867-73-8\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eMDL Number\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003eMFCD00005739\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eSMILES\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0; word-break: break-all;\"\u003eCNC1=C2C(=NC=N1)N(C=N2)[C@H]3[C@@H]([C@@H]([C@H](O3)CO)O)O\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eInChI\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0; word-break: break-all;\"\u003eInChI=1S\/C11H15N5O4\/c1-12-9-6-10(14-3-13-9)16(4-15-6)11-8(19)7(18)5(2-17)20-11\/h3-5,7-8,11,17-19H,2H2,1H3,(H,12,13,14)\/t5-,7-,8-,11-\/m1\/s1\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eInChIKey\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0; word-break: break-all;\"\u003eVQAYFKKCNSOZKM-IOSLPCCCSA-N\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003ePubChem CID\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e102175\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eMolecular Formula\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003eC₁₁H₁₅N₅O₄\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eMolecular Weight\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e281.27 g\/mol\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003ePurity\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e≥97%\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003ePhysical Form\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003eSolid\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eHS Code\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e2934.99\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eShelf Life\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003eRetest period: 36 months from date of manufacture\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eStorage Conditions\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333;\"\u003eStore at 2–8 °C in a tightly sealed container.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\u003c\/table\u003e\n\u003c\/div\u003e\n\u003cdiv style=\"margin-bottom: 28px;\"\u003e\n\u003cdiv style=\"background: #002147; padding: 10px 20px; margin-bottom: 0;\"\u003e\u003ch3 style=\"margin: 0; font-family: 'Helvetica Neue', Helvetica, Arial, sans-serif; font-size: 0.70em; font-weight: bold; letter-spacing: 0.12em; text-transform: uppercase; color: #fff;\"\u003eProduct Description \u0026amp; Scientific Applications\u003c\/h3\u003e\u003c\/div\u003e\n\u003cdiv style=\"padding: 16px 20px; border: 1px solid #e4e8f0; border-top: none; font-family: Georgia, 'Times New Roman', serif; font-size: 0.95em; line-height: 1.65; color: #333;\"\u003e\u003cdiv\u003e\n\u003cp\u003e\u003cstrong\u003eN6-Methyladenosine\u003c\/strong\u003e (m\u003csup\u003e6\u003c\/sup\u003eA) is adenosine with a methyl group on the 6-amino group of the adenine base. It is the most prevalent internal modification of mRNA in higher eukaryotes. An early study looked at mRNA from hepatoma cells and found that the nucleosides methylated on the base were mainly N6-methyladenosine. Two transcriptome-wide methods, m\u003csup\u003e6\u003c\/sup\u003eA-seq and MeRIP-seq, combine antibody capture of methylated RNA with high-throughput sequencing. They found m\u003csup\u003e6\u003c\/sup\u003eA in the mRNAs of thousands of human and mouse genes, with sites concentrated near stop codons.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eFormation in RNA.\u003c\/strong\u003e In mammalian cells, m\u003csup\u003e6\u003c\/sup\u003eA is added to nuclear RNAs by a methyltransferase complex whose core is a stable heterodimer of METTL3 and METTL14. The methyl group comes from S-adenosylmethionine (SAM). Crystal structures of the METTL3–METTL14 methyltransferase domains show SAM bound in the catalytic site. In one study, the enzymes were given SAM whose methyl group was labelled with deuterium, and the m\u003csup\u003e6\u003c\/sup\u003eA they formed carried the label. In mammalian mRNA, methylation takes place within the consensus sequence Pu[G\u0026gt;A]m\u003csup\u003e6\u003c\/sup\u003eAC[A\/C\/U] (Pu = purine), although only some of the sequences that match this pattern carry m\u003csup\u003e6\u003c\/sup\u003eA.\u003c\/p\u003e\n\u003cdiv style=\"margin:8px 0 18px 0;\"\u003e\n\u003cdiv style=\"display:flex;flex-wrap:wrap;align-items:center;justify-content:flex-start;gap:2px;\"\u003e\n\u003cdiv style=\"display:flex;align-items:center;\"\u003e\u003csvg role=\"img\" style=\"max-width:100%;height:auto;\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" fill=\"none\" stroke=\"#000\" stroke-width=\"1.6\" width=\"112px\" height=\"160px\" viewbox=\"0 0 112 160\"\u003e\u003cpath d=\"M 100.9,62.4 L 100.9,49.6\"\u003e\u003c\/path\u003e\u003cpath d=\"M 98.0,60.7 L 98.0,49.6\"\u003e\u003c\/path\u003e\u003cpath d=\"M 96.7,40.5 L 84.1,33.2\"\u003e\u003c\/path\u003e\u003cpath d=\"M 84.1,33.2 L 67.2,43.0\"\u003e\u003c\/path\u003e\u003cpath d=\"M 84.1,36.6 L 70.1,44.6\"\u003e\u003c\/path\u003e\u003cpath d=\"M 67.2,43.0 L 67.2,62.4\"\u003e\u003c\/path\u003e\u003cpath d=\"M 67.2,62.4 L 79.8,69.7\"\u003e\u003c\/path\u003e\u003cpath d=\"M 70.1,60.7 L 81.3,67.2\"\u003e\u003c\/path\u003e\u003cpath d=\"M 67.2,62.4 L 52.9,67.1\"\u003e\u003c\/path\u003e\u003cpath d=\"M 45.6,64.2 L 37.2,52.7\"\u003e\u003c\/path\u003e\u003cpath d=\"M 37.2,52.7 L 44.4,42.8\"\u003e\u003c\/path\u003e\u003cpath d=\"M 40.8,52.7 L 46.8,44.5\"\u003e\u003c\/path\u003e\u003cpath d=\"M 42.6,87.0 L 44.9,75.3 L 47.7,76.2 Z\"\u003e\u003c\/path\u003e\u003cpath d=\"M 42.6,87.0 L 54.0,102.7\"\u003e\u003c\/path\u003e\u003cpath d=\"M 54.0,102.7 L 42.6,118.4\"\u003e\u003c\/path\u003e\u003cpath d=\"M 42.6,118.4 L 24.2,112.4\"\u003e\u003c\/path\u003e\u003cpath d=\"M 24.2,112.4 L 24.2,99.6\"\u003e\u003c\/path\u003e\u003cpath d=\"M 24.2,112.4 L 8.7,125.5 L 8.3,122.2 Z\"\u003e\u003c\/path\u003e\u003cpath d=\"M 8.3,122.2 L 10.1,138.8\"\u003e\u003c\/path\u003e\u003cpath d=\"M 43.8,121.0 L 43.2,121.2\"\u003e\u003c\/path\u003e\u003cpath d=\"M 44.9,123.6 L 43.8,124.0\"\u003e\u003c\/path\u003e\u003cpath d=\"M 46.1,126.2 L 44.4,126.8\"\u003e\u003c\/path\u003e\u003cpath d=\"M 47.3,128.9 L 45.0,129.6\"\u003e\u003c\/path\u003e\u003cpath d=\"M 48.4,131.5 L 45.7,132.4\"\u003e\u003c\/path\u003e\u003cpath d=\"M 56.9,102.4 L 56.9,103.0\"\u003e\u003c\/path\u003e\u003cpath d=\"M 59.8,102.1 L 59.8,103.3\"\u003e\u003c\/path\u003e\u003cpath d=\"M 62.7,101.8 L 62.7,103.6\"\u003e\u003c\/path\u003e\u003cpath d=\"M 65.6,101.5 L 65.6,103.8\"\u003e\u003c\/path\u003e\u003cpath d=\"M 68.6,101.2 L 68.6,104.1\"\u003e\u003c\/path\u003e\u003cpath d=\"M 84.1,33.2 L 84.1,20.4\"\u003e\u003c\/path\u003e\u003cpath d=\"M 88.3,69.7 L 100.9,62.4\"\u003e\u003c\/path\u003e\u003cpath d=\"M 52.9,38.3 L 67.2,43.0\"\u003e\u003c\/path\u003e\u003cpath d=\"M 28.4,91.6 L 42.6,87.0\"\u003e\u003c\/path\u003e\u003cpath d=\"M 100.9,61.8 L 100.9,62.4 L 100.3,62.8\"\u003e\u003c\/path\u003e\u003cpath d=\"M 37.6,53.3 L 37.2,52.7 L 37.6,52.2\"\u003e\u003c\/path\u003e\u003cpath d=\"M 43.2,87.8 L 42.6,87.0 L 41.9,87.2\"\u003e\u003c\/path\u003e\u003cpath d=\"M 53.5,101.9 L 54.0,102.7 L 53.5,103.5\"\u003e\u003c\/path\u003e\u003cpath d=\"M 43.2,117.6 L 42.6,118.4 L 41.7,118.1\"\u003e\u003c\/path\u003e\u003cpath d=\"M 25.1,112.7 L 24.2,112.4 L 24.2,111.7\"\u003e\u003c\/path\u003e\u003ctext x=\"97.3\" y=\"49.0\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eN\u003c\/text\u003e\u003ctext x=\"80.5\" y=\"78.2\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eN\u003c\/text\u003e\u003ctext x=\"45.1\" y=\"74.5\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eN\u003c\/text\u003e\u003ctext x=\"45.1\" y=\"42.9\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eN\u003c\/text\u003e\u003ctext x=\"20.6\" y=\"99.0\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eO\u003c\/text\u003e\u003ctext x=\"6.9\" y=\"149.1\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eO\u003c\/text\u003e\u003ctext x=\"15.2\" y=\"149.1\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eH\u003c\/text\u003e\u003ctext x=\"45.0\" y=\"142.8\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eO\u003c\/text\u003e\u003ctext x=\"53.3\" y=\"142.8\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eH\u003c\/text\u003e\u003ctext x=\"69.8\" y=\"108.7\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eO\u003c\/text\u003e\u003ctext x=\"78.1\" y=\"108.7\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eH\u003c\/text\u003e\u003ctext x=\"80.5\" y=\"19.7\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eN\u003c\/text\u003e\u003ctext x=\"88.7\" y=\"19.7\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eH\u003c\/text\u003e\u003ctext x=\"97.0\" y=\"24.5\" style=\"font:7px sans-serif;fill:#000;stroke:none\"\u003e2\u003c\/text\u003e\u003c\/svg\u003e\u003c\/div\u003e\n\u003cdiv style=\"display:flex;align-items:center;\"\u003e\u003cdiv style=\"display:flex;flex-direction:column;align-items:center;justify-content:center;min-width:90px;max-width:150px;padding:0 4px;text-align:center;font-size:12px;line-height:1.3;\"\u003e\n\u003cdiv\u003eMETTL3–METTL14\u003c\/div\u003e\n\u003cdiv style=\"font-size:30px;line-height:1;\"\u003e⟶\u003c\/div\u003e\n\u003cdiv\u003eSAM (methyl donor)\u003c\/div\u003e\n\u003c\/div\u003e\u003c\/div\u003e\n\u003cdiv style=\"display:flex;align-items:center;\"\u003e\u003csvg role=\"img\" style=\"max-width:100%;height:auto;\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" fill=\"none\" stroke=\"#000\" stroke-width=\"1.6\" width=\"112px\" height=\"167px\" viewbox=\"0 0 112 167\"\u003e\u003cpath d=\"M 67.3,10.5 L 79.8,17.8\"\u003e\u003c\/path\u003e\u003cpath d=\"M 84.1,26.8 L 84.1,39.7\"\u003e\u003c\/path\u003e\u003cpath d=\"M 84.1,39.7 L 67.2,49.4\"\u003e\u003c\/path\u003e\u003cpath d=\"M 84.1,43.1 L 70.1,51.1\"\u003e\u003c\/path\u003e\u003cpath d=\"M 67.2,49.4 L 67.2,68.9\"\u003e\u003c\/path\u003e\u003cpath d=\"M 67.2,68.9 L 79.8,76.2\"\u003e\u003c\/path\u003e\u003cpath d=\"M 70.1,67.2 L 81.3,73.7\"\u003e\u003c\/path\u003e\u003cpath d=\"M 88.3,76.2 L 100.9,68.9\"\u003e\u003c\/path\u003e\u003cpath d=\"M 100.9,68.9 L 100.9,56.1\"\u003e\u003c\/path\u003e\u003cpath d=\"M 98.0,67.2 L 98.0,56.1\"\u003e\u003c\/path\u003e\u003cpath d=\"M 67.2,68.9 L 52.9,73.5\"\u003e\u003c\/path\u003e\u003cpath d=\"M 45.6,70.7 L 37.2,59.2\"\u003e\u003c\/path\u003e\u003cpath d=\"M 37.2,59.2 L 44.4,49.2\"\u003e\u003c\/path\u003e\u003cpath d=\"M 40.8,59.2 L 46.8,51.0\"\u003e\u003c\/path\u003e\u003cpath d=\"M 42.6,93.5 L 44.9,81.8 L 47.7,82.7 Z\"\u003e\u003c\/path\u003e\u003cpath d=\"M 42.6,93.5 L 54.0,109.1\"\u003e\u003c\/path\u003e\u003cpath d=\"M 54.0,109.1 L 42.6,124.8\"\u003e\u003c\/path\u003e\u003cpath d=\"M 42.6,124.8 L 24.2,118.8\"\u003e\u003c\/path\u003e\u003cpath d=\"M 24.2,118.8 L 24.2,106.1\"\u003e\u003c\/path\u003e\u003cpath d=\"M 24.2,118.8 L 8.7,132.0 L 8.3,128.6 Z\"\u003e\u003c\/path\u003e\u003cpath d=\"M 8.3,128.6 L 10.1,145.3\"\u003e\u003c\/path\u003e\u003cpath d=\"M 43.8,127.5 L 43.2,127.6\"\u003e\u003c\/path\u003e\u003cpath d=\"M 44.9,130.1 L 43.8,130.4\"\u003e\u003c\/path\u003e\u003cpath d=\"M 46.1,132.7 L 44.4,133.3\"\u003e\u003c\/path\u003e\u003cpath d=\"M 47.3,135.3 L 45.0,136.1\"\u003e\u003c\/path\u003e\u003cpath d=\"M 48.4,138.0 L 45.7,138.9\"\u003e\u003c\/path\u003e\u003cpath d=\"M 56.9,108.9 L 56.9,109.4\"\u003e\u003c\/path\u003e\u003cpath d=\"M 59.8,108.6 L 59.8,109.7\"\u003e\u003c\/path\u003e\u003cpath d=\"M 62.7,108.3 L 62.7,110.0\"\u003e\u003c\/path\u003e\u003cpath d=\"M 65.6,108.0 L 65.6,110.3\"\u003e\u003c\/path\u003e\u003cpath d=\"M 68.6,107.7 L 68.6,110.6\"\u003e\u003c\/path\u003e\u003cpath d=\"M 96.7,47.0 L 84.1,39.7\"\u003e\u003c\/path\u003e\u003cpath d=\"M 52.9,44.8 L 67.2,49.4\"\u003e\u003c\/path\u003e\u003cpath d=\"M 28.4,98.1 L 42.6,93.5\"\u003e\u003c\/path\u003e\u003cpath d=\"M 100.3,69.3 L 100.9,68.9 L 100.9,68.3\"\u003e\u003c\/path\u003e\u003cpath d=\"M 37.6,59.7 L 37.2,59.2 L 37.6,58.7\"\u003e\u003c\/path\u003e\u003cpath d=\"M 43.2,94.2 L 42.6,93.5 L 41.9,93.7\"\u003e\u003c\/path\u003e\u003cpath d=\"M 53.5,108.4 L 54.0,109.1 L 53.5,109.9\"\u003e\u003c\/path\u003e\u003cpath d=\"M 43.2,124.1 L 42.6,124.8 L 41.7,124.5\"\u003e\u003c\/path\u003e\u003cpath d=\"M 25.1,119.1 L 24.2,118.8 L 24.2,118.2\"\u003e\u003c\/path\u003e\u003ctext x=\"80.5\" y=\"26.2\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eN\u003c\/text\u003e\u003ctext x=\"88.7\" y=\"26.2\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eH\u003c\/text\u003e\u003ctext x=\"80.5\" y=\"84.6\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eN\u003c\/text\u003e\u003ctext x=\"97.3\" y=\"55.4\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eN\u003c\/text\u003e\u003ctext x=\"45.1\" y=\"80.9\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eN\u003c\/text\u003e\u003ctext x=\"45.1\" y=\"49.4\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eN\u003c\/text\u003e\u003ctext x=\"20.6\" y=\"105.4\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eO\u003c\/text\u003e\u003ctext x=\"6.9\" y=\"155.5\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eO\u003c\/text\u003e\u003ctext x=\"15.2\" y=\"155.5\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eH\u003c\/text\u003e\u003ctext x=\"45.0\" y=\"149.3\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eO\u003c\/text\u003e\u003ctext x=\"53.3\" y=\"149.3\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eH\u003c\/text\u003e\u003ctext x=\"69.8\" y=\"115.2\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eO\u003c\/text\u003e\u003ctext x=\"78.1\" y=\"115.2\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eH\u003c\/text\u003e\u003c\/svg\u003e\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cp style=\"font-size:12px;margin:4px 0 0 0;\"\u003e\u003cem\u003eFormation of N6-methyladenosine (m\u003csup\u003e6\u003c\/sup\u003eA, right) from adenosine (left) by the METTL3–METTL14 methyltransferase complex, with S-adenosylmethionine (SAM) as the methyl donor. In RNA the reaction takes place on adenosine residues; the structures are drawn as nucleosides.\u003c\/em\u003e\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cp\u003e\u003cstrong\u003eRemoval by oxidative demethylation.\u003c\/strong\u003e The modification is reversible. In one study, the enzyme FTO removed the methyl group from m\u003csup\u003e6\u003c\/sup\u003eA in RNA by oxidation in vitro. In the same study, lowering FTO levels in human cells raised the amount of m\u003csup\u003e6\u003c\/sup\u003eA in mRNA, and overexpressing FTO lowered it. A later study reported a second mammalian demethylase, ALKBH5, which removes the methyl group from m\u003csup\u003e6\u003c\/sup\u003eA in mRNA by oxidation, both in vitro and in vivo. One study showed that FTO, an Fe(II)- and α-ketoglutarate-dependent enzyme, oxidises m\u003csup\u003e6\u003c\/sup\u003eA first to N6-hydroxymethyladenosine and then to N6-formyladenosine, and that both break down to adenosine in water. The same study found both modifications in mRNA isolated from human cells and mouse tissues.\u003c\/p\u003e\n\u003cdiv style=\"margin:8px 0 18px 0;\"\u003e\n\u003cdiv style=\"display:flex;flex-wrap:wrap;align-items:center;justify-content:flex-start;gap:2px;\"\u003e\n\u003cdiv style=\"display:flex;align-items:center;\"\u003e\u003csvg role=\"img\" style=\"max-width:100%;height:auto;\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" fill=\"none\" stroke=\"#000\" stroke-width=\"1.6\" width=\"112px\" height=\"167px\" viewbox=\"0 0 112 167\"\u003e\u003cpath d=\"M 67.3,10.5 L 79.8,17.8\"\u003e\u003c\/path\u003e\u003cpath d=\"M 84.1,26.8 L 84.1,39.7\"\u003e\u003c\/path\u003e\u003cpath d=\"M 84.1,39.7 L 67.2,49.4\"\u003e\u003c\/path\u003e\u003cpath d=\"M 84.1,43.1 L 70.1,51.1\"\u003e\u003c\/path\u003e\u003cpath d=\"M 67.2,49.4 L 67.2,68.9\"\u003e\u003c\/path\u003e\u003cpath d=\"M 67.2,68.9 L 79.8,76.2\"\u003e\u003c\/path\u003e\u003cpath d=\"M 70.1,67.2 L 81.3,73.7\"\u003e\u003c\/path\u003e\u003cpath d=\"M 88.3,76.2 L 100.9,68.9\"\u003e\u003c\/path\u003e\u003cpath d=\"M 100.9,68.9 L 100.9,56.1\"\u003e\u003c\/path\u003e\u003cpath d=\"M 98.0,67.2 L 98.0,56.1\"\u003e\u003c\/path\u003e\u003cpath d=\"M 67.2,68.9 L 52.9,73.5\"\u003e\u003c\/path\u003e\u003cpath d=\"M 45.6,70.7 L 37.2,59.2\"\u003e\u003c\/path\u003e\u003cpath d=\"M 37.2,59.2 L 44.4,49.2\"\u003e\u003c\/path\u003e\u003cpath d=\"M 40.8,59.2 L 46.8,51.0\"\u003e\u003c\/path\u003e\u003cpath d=\"M 42.6,93.5 L 44.9,81.8 L 47.7,82.7 Z\"\u003e\u003c\/path\u003e\u003cpath d=\"M 42.6,93.5 L 54.0,109.1\"\u003e\u003c\/path\u003e\u003cpath d=\"M 54.0,109.1 L 42.6,124.8\"\u003e\u003c\/path\u003e\u003cpath d=\"M 42.6,124.8 L 24.2,118.8\"\u003e\u003c\/path\u003e\u003cpath d=\"M 24.2,118.8 L 24.2,106.1\"\u003e\u003c\/path\u003e\u003cpath d=\"M 24.2,118.8 L 8.7,132.0 L 8.3,128.6 Z\"\u003e\u003c\/path\u003e\u003cpath d=\"M 8.3,128.6 L 10.1,145.3\"\u003e\u003c\/path\u003e\u003cpath d=\"M 43.8,127.5 L 43.2,127.6\"\u003e\u003c\/path\u003e\u003cpath d=\"M 44.9,130.1 L 43.8,130.4\"\u003e\u003c\/path\u003e\u003cpath d=\"M 46.1,132.7 L 44.4,133.3\"\u003e\u003c\/path\u003e\u003cpath d=\"M 47.3,135.3 L 45.0,136.1\"\u003e\u003c\/path\u003e\u003cpath d=\"M 48.4,138.0 L 45.7,138.9\"\u003e\u003c\/path\u003e\u003cpath d=\"M 56.9,108.9 L 56.9,109.4\"\u003e\u003c\/path\u003e\u003cpath d=\"M 59.8,108.6 L 59.8,109.7\"\u003e\u003c\/path\u003e\u003cpath d=\"M 62.7,108.3 L 62.7,110.0\"\u003e\u003c\/path\u003e\u003cpath d=\"M 65.6,108.0 L 65.6,110.3\"\u003e\u003c\/path\u003e\u003cpath d=\"M 68.6,107.7 L 68.6,110.6\"\u003e\u003c\/path\u003e\u003cpath d=\"M 96.7,47.0 L 84.1,39.7\"\u003e\u003c\/path\u003e\u003cpath d=\"M 52.9,44.8 L 67.2,49.4\"\u003e\u003c\/path\u003e\u003cpath d=\"M 28.4,98.1 L 42.6,93.5\"\u003e\u003c\/path\u003e\u003cpath d=\"M 100.3,69.3 L 100.9,68.9 L 100.9,68.3\"\u003e\u003c\/path\u003e\u003cpath d=\"M 37.6,59.7 L 37.2,59.2 L 37.6,58.7\"\u003e\u003c\/path\u003e\u003cpath d=\"M 43.2,94.2 L 42.6,93.5 L 41.9,93.7\"\u003e\u003c\/path\u003e\u003cpath d=\"M 53.5,108.4 L 54.0,109.1 L 53.5,109.9\"\u003e\u003c\/path\u003e\u003cpath d=\"M 43.2,124.1 L 42.6,124.8 L 41.7,124.5\"\u003e\u003c\/path\u003e\u003cpath d=\"M 25.1,119.1 L 24.2,118.8 L 24.2,118.2\"\u003e\u003c\/path\u003e\u003ctext x=\"80.5\" y=\"26.2\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eN\u003c\/text\u003e\u003ctext x=\"88.7\" y=\"26.2\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eH\u003c\/text\u003e\u003ctext x=\"80.5\" y=\"84.6\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eN\u003c\/text\u003e\u003ctext x=\"97.3\" y=\"55.4\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eN\u003c\/text\u003e\u003ctext x=\"45.1\" y=\"80.9\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eN\u003c\/text\u003e\u003ctext x=\"45.1\" y=\"49.4\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eN\u003c\/text\u003e\u003ctext x=\"20.6\" y=\"105.4\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eO\u003c\/text\u003e\u003ctext x=\"6.9\" y=\"155.5\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eO\u003c\/text\u003e\u003ctext x=\"15.2\" y=\"155.5\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eH\u003c\/text\u003e\u003ctext x=\"45.0\" y=\"149.3\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eO\u003c\/text\u003e\u003ctext x=\"53.3\" y=\"149.3\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eH\u003c\/text\u003e\u003ctext x=\"69.8\" y=\"115.2\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eO\u003c\/text\u003e\u003ctext x=\"78.1\" y=\"115.2\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eH\u003c\/text\u003e\u003c\/svg\u003e\u003c\/div\u003e\n\u003cdiv style=\"display:flex;align-items:center;\"\u003e\u003cdiv style=\"display:flex;flex-direction:column;align-items:center;justify-content:center;min-width:90px;max-width:150px;padding:0 4px;text-align:center;font-size:12px;line-height:1.3;\"\u003e\n\u003cdiv\u003eFTO\u003c\/div\u003e\n\u003cdiv style=\"font-size:30px;line-height:1;\"\u003e⟶\u003c\/div\u003e\n\u003cdiv\u003eFe(II), α-KG\u003c\/div\u003e\n\u003c\/div\u003e\u003c\/div\u003e\n\u003cdiv style=\"display:flex;align-items:center;\"\u003e\u003csvg role=\"img\" style=\"max-width:100%;height:auto;\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" fill=\"none\" stroke=\"#000\" stroke-width=\"1.6\" width=\"112px\" height=\"193px\" viewbox=\"0 0 112 193\"\u003e\u003cpath d=\"M 100.9,93.4 L 100.9,80.7\"\u003e\u003c\/path\u003e\u003cpath d=\"M 98.0,91.8 L 98.0,80.7\"\u003e\u003c\/path\u003e\u003cpath d=\"M 96.6,71.6 L 84.1,64.3\"\u003e\u003c\/path\u003e\u003cpath d=\"M 84.1,64.3 L 67.2,74.0\"\u003e\u003c\/path\u003e\u003cpath d=\"M 84.1,67.6 L 70.1,75.7\"\u003e\u003c\/path\u003e\u003cpath d=\"M 67.2,74.0 L 67.3,93.4\"\u003e\u003c\/path\u003e\u003cpath d=\"M 67.3,93.4 L 79.8,100.7\"\u003e\u003c\/path\u003e\u003cpath d=\"M 70.2,91.7 L 81.3,98.2\"\u003e\u003c\/path\u003e\u003cpath d=\"M 67.3,93.4 L 53.0,98.0\"\u003e\u003c\/path\u003e\u003cpath d=\"M 45.7,95.2 L 37.4,83.7\"\u003e\u003c\/path\u003e\u003cpath d=\"M 37.4,83.7 L 44.6,73.8\"\u003e\u003c\/path\u003e\u003cpath d=\"M 41.0,83.7 L 46.9,75.5\"\u003e\u003c\/path\u003e\u003cpath d=\"M 42.7,118.0 L 45.0,106.2 L 47.8,107.1 Z\"\u003e\u003c\/path\u003e\u003cpath d=\"M 42.7,118.0 L 54.1,133.7\"\u003e\u003c\/path\u003e\u003cpath d=\"M 54.1,133.7 L 42.7,149.4\"\u003e\u003c\/path\u003e\u003cpath d=\"M 42.7,149.4 L 24.2,143.4\"\u003e\u003c\/path\u003e\u003cpath d=\"M 24.2,143.4 L 24.2,130.6\"\u003e\u003c\/path\u003e\u003cpath d=\"M 24.2,143.4 L 8.7,156.5 L 8.4,153.2 Z\"\u003e\u003c\/path\u003e\u003cpath d=\"M 8.4,153.2 L 10.1,169.8\"\u003e\u003c\/path\u003e\u003cpath d=\"M 43.8,152.0 L 43.3,152.2\"\u003e\u003c\/path\u003e\u003cpath d=\"M 45.0,154.6 L 43.9,155.0\"\u003e\u003c\/path\u003e\u003cpath d=\"M 46.1,157.2 L 44.5,157.8\"\u003e\u003c\/path\u003e\u003cpath d=\"M 47.3,159.9 L 45.1,160.6\"\u003e\u003c\/path\u003e\u003cpath d=\"M 48.5,162.5 L 45.7,163.4\"\u003e\u003c\/path\u003e\u003cpath d=\"M 57.0,133.4 L 57.0,134.0\"\u003e\u003c\/path\u003e\u003cpath d=\"M 59.9,133.1 L 59.9,134.3\"\u003e\u003c\/path\u003e\u003cpath d=\"M 62.8,132.8 L 62.8,134.6\"\u003e\u003c\/path\u003e\u003cpath d=\"M 65.7,132.5 L 65.7,134.9\"\u003e\u003c\/path\u003e\u003cpath d=\"M 68.6,132.2 L 68.6,135.1\"\u003e\u003c\/path\u003e\u003cpath d=\"M 84.1,64.3 L 84.1,51.5\"\u003e\u003c\/path\u003e\u003cpath d=\"M 79.9,42.4 L 67.3,35.1\"\u003e\u003c\/path\u003e\u003cpath d=\"M 67.3,35.1 L 67.3,22.4\"\u003e\u003c\/path\u003e\u003cpath d=\"M 88.3,100.7 L 100.9,93.4\"\u003e\u003c\/path\u003e\u003cpath d=\"M 53.0,69.4 L 67.2,74.0\"\u003e\u003c\/path\u003e\u003cpath d=\"M 28.5,122.6 L 42.7,118.0\"\u003e\u003c\/path\u003e\u003cpath d=\"M 100.9,92.8 L 100.9,93.4 L 100.3,93.8\"\u003e\u003c\/path\u003e\u003cpath d=\"M 37.8,84.3 L 37.4,83.7 L 37.7,83.2\"\u003e\u003c\/path\u003e\u003cpath d=\"M 43.3,118.8 L 42.7,118.0 L 42.0,118.2\"\u003e\u003c\/path\u003e\u003cpath d=\"M 53.5,132.9 L 54.1,133.7 L 53.5,134.5\"\u003e\u003c\/path\u003e\u003cpath d=\"M 43.2,148.6 L 42.7,149.4 L 41.7,149.1\"\u003e\u003c\/path\u003e\u003cpath d=\"M 25.2,143.7 L 24.2,143.4 L 24.2,142.7\"\u003e\u003c\/path\u003e\u003cpath d=\"M 68.0,35.5 L 67.3,35.1 L 67.3,34.5\"\u003e\u003c\/path\u003e\u003ctext x=\"97.3\" y=\"80.0\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eN\u003c\/text\u003e\u003ctext x=\"80.5\" y=\"109.1\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eN\u003c\/text\u003e\u003ctext x=\"45.2\" y=\"105.4\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eN\u003c\/text\u003e\u003ctext x=\"45.2\" y=\"74.0\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eN\u003c\/text\u003e\u003ctext x=\"20.6\" y=\"129.9\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eO\u003c\/text\u003e\u003ctext x=\"7.0\" y=\"180.0\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eO\u003c\/text\u003e\u003ctext x=\"15.2\" y=\"180.0\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eH\u003c\/text\u003e\u003ctext x=\"45.1\" y=\"173.8\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eO\u003c\/text\u003e\u003ctext x=\"53.3\" y=\"173.8\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eH\u003c\/text\u003e\u003ctext x=\"69.9\" y=\"139.7\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eO\u003c\/text\u003e\u003ctext x=\"78.2\" y=\"139.7\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eH\u003c\/text\u003e\u003ctext x=\"80.5\" y=\"50.9\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eN\u003c\/text\u003e\u003ctext x=\"88.8\" y=\"50.9\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eH\u003c\/text\u003e\u003ctext x=\"63.8\" y=\"21.7\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eO\u003c\/text\u003e\u003ctext x=\"72.0\" y=\"21.7\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eH\u003c\/text\u003e\u003c\/svg\u003e\u003c\/div\u003e\n\u003cdiv style=\"display:flex;align-items:center;\"\u003e\u003cdiv style=\"display:flex;flex-direction:column;align-items:center;justify-content:center;min-width:90px;max-width:150px;padding:0 4px;text-align:center;font-size:12px;line-height:1.3;\"\u003e\n\u003cdiv\u003eFTO\u003c\/div\u003e\n\u003cdiv style=\"font-size:30px;line-height:1;\"\u003e⟶\u003c\/div\u003e\n\u003cdiv\u003e\u003c\/div\u003e\n\u003c\/div\u003e\u003c\/div\u003e\n\u003cdiv style=\"display:flex;align-items:center;\"\u003e\u003csvg role=\"img\" style=\"max-width:100%;height:auto;\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" fill=\"none\" stroke=\"#000\" stroke-width=\"1.6\" width=\"112px\" height=\"193px\" viewbox=\"0 0 112 193\"\u003e\u003cpath d=\"M 100.9,93.4 L 100.9,80.7\"\u003e\u003c\/path\u003e\u003cpath d=\"M 98.0,91.8 L 98.0,80.7\"\u003e\u003c\/path\u003e\u003cpath d=\"M 96.6,71.6 L 84.1,64.3\"\u003e\u003c\/path\u003e\u003cpath d=\"M 84.1,64.3 L 67.2,74.0\"\u003e\u003c\/path\u003e\u003cpath d=\"M 84.1,67.6 L 70.1,75.7\"\u003e\u003c\/path\u003e\u003cpath d=\"M 67.2,74.0 L 67.3,93.4\"\u003e\u003c\/path\u003e\u003cpath d=\"M 67.3,93.4 L 79.8,100.7\"\u003e\u003c\/path\u003e\u003cpath d=\"M 70.2,91.7 L 81.3,98.2\"\u003e\u003c\/path\u003e\u003cpath d=\"M 67.3,93.4 L 53.0,98.0\"\u003e\u003c\/path\u003e\u003cpath d=\"M 45.7,95.2 L 37.4,83.7\"\u003e\u003c\/path\u003e\u003cpath d=\"M 37.4,83.7 L 44.6,73.8\"\u003e\u003c\/path\u003e\u003cpath d=\"M 41.0,83.7 L 46.9,75.5\"\u003e\u003c\/path\u003e\u003cpath d=\"M 42.7,118.0 L 45.0,106.2 L 47.8,107.1 Z\"\u003e\u003c\/path\u003e\u003cpath d=\"M 42.7,118.0 L 54.1,133.7\"\u003e\u003c\/path\u003e\u003cpath d=\"M 54.1,133.7 L 42.7,149.4\"\u003e\u003c\/path\u003e\u003cpath d=\"M 42.7,149.4 L 24.2,143.4\"\u003e\u003c\/path\u003e\u003cpath d=\"M 24.2,143.4 L 24.2,130.6\"\u003e\u003c\/path\u003e\u003cpath d=\"M 24.2,143.4 L 8.7,156.5 L 8.4,153.1 Z\"\u003e\u003c\/path\u003e\u003cpath d=\"M 8.4,153.1 L 10.1,169.8\"\u003e\u003c\/path\u003e\u003cpath d=\"M 43.8,152.0 L 43.3,152.2\"\u003e\u003c\/path\u003e\u003cpath d=\"M 45.0,154.6 L 43.9,155.0\"\u003e\u003c\/path\u003e\u003cpath d=\"M 46.1,157.2 L 44.5,157.8\"\u003e\u003c\/path\u003e\u003cpath d=\"M 47.3,159.9 L 45.1,160.6\"\u003e\u003c\/path\u003e\u003cpath d=\"M 48.5,162.5 L 45.7,163.4\"\u003e\u003c\/path\u003e\u003cpath d=\"M 57.0,133.4 L 57.0,134.0\"\u003e\u003c\/path\u003e\u003cpath d=\"M 59.9,133.1 L 59.9,134.3\"\u003e\u003c\/path\u003e\u003cpath d=\"M 62.8,132.8 L 62.8,134.6\"\u003e\u003c\/path\u003e\u003cpath d=\"M 65.7,132.5 L 65.7,134.9\"\u003e\u003c\/path\u003e\u003cpath d=\"M 68.6,132.2 L 68.6,135.1\"\u003e\u003c\/path\u003e\u003cpath d=\"M 84.1,64.3 L 84.1,51.5\"\u003e\u003c\/path\u003e\u003cpath d=\"M 79.9,42.4 L 67.3,35.1\"\u003e\u003c\/path\u003e\u003cpath d=\"M 67.3,35.1 L 67.3,22.4\"\u003e\u003c\/path\u003e\u003cpath d=\"M 70.2,33.4 L 70.3,22.4\"\u003e\u003c\/path\u003e\u003cpath d=\"M 88.3,100.7 L 100.9,93.4\"\u003e\u003c\/path\u003e\u003cpath d=\"M 53.0,69.4 L 67.2,74.0\"\u003e\u003c\/path\u003e\u003cpath d=\"M 28.5,122.6 L 42.7,118.0\"\u003e\u003c\/path\u003e\u003cpath d=\"M 100.9,92.8 L 100.9,93.4 L 100.3,93.8\"\u003e\u003c\/path\u003e\u003cpath d=\"M 37.8,84.3 L 37.4,83.7 L 37.7,83.2\"\u003e\u003c\/path\u003e\u003cpath d=\"M 43.3,118.8 L 42.7,118.0 L 42.0,118.2\"\u003e\u003c\/path\u003e\u003cpath d=\"M 53.5,132.9 L 54.1,133.7 L 53.5,134.5\"\u003e\u003c\/path\u003e\u003cpath d=\"M 43.2,148.6 L 42.7,149.4 L 41.7,149.1\"\u003e\u003c\/path\u003e\u003cpath d=\"M 25.2,143.7 L 24.2,143.4 L 24.2,142.7\"\u003e\u003c\/path\u003e\u003cpath d=\"M 68.0,35.5 L 67.3,35.1 L 67.3,34.5\"\u003e\u003c\/path\u003e\u003ctext x=\"97.3\" y=\"80.0\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eN\u003c\/text\u003e\u003ctext x=\"80.5\" y=\"109.1\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eN\u003c\/text\u003e\u003ctext x=\"45.2\" y=\"105.4\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eN\u003c\/text\u003e\u003ctext x=\"45.2\" y=\"74.0\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eN\u003c\/text\u003e\u003ctext x=\"20.6\" y=\"129.9\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eO\u003c\/text\u003e\u003ctext x=\"7.0\" y=\"180.0\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eO\u003c\/text\u003e\u003ctext x=\"15.2\" y=\"180.0\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eH\u003c\/text\u003e\u003ctext x=\"45.1\" y=\"173.8\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eO\u003c\/text\u003e\u003ctext x=\"53.3\" y=\"173.8\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eH\u003c\/text\u003e\u003ctext x=\"69.9\" y=\"139.7\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eO\u003c\/text\u003e\u003ctext x=\"78.2\" y=\"139.7\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eH\u003c\/text\u003e\u003ctext x=\"80.5\" y=\"50.9\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eN\u003c\/text\u003e\u003ctext x=\"88.8\" y=\"50.9\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eH\u003c\/text\u003e\u003ctext x=\"65.2\" y=\"21.7\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eO\u003c\/text\u003e\u003c\/svg\u003e\u003c\/div\u003e\n\u003cdiv style=\"display:flex;align-items:center;\"\u003e\u003cdiv style=\"display:flex;flex-direction:column;align-items:center;justify-content:center;min-width:90px;max-width:150px;padding:0 4px;text-align:center;font-size:12px;line-height:1.3;\"\u003e\n\u003cdiv\u003ewater\u003c\/div\u003e\n\u003cdiv style=\"font-size:30px;line-height:1;\"\u003e⟶\u003c\/div\u003e\n\u003cdiv\u003e(hydrolysis)\u003c\/div\u003e\n\u003c\/div\u003e\u003c\/div\u003e\n\u003cdiv style=\"display:flex;align-items:center;\"\u003e\u003csvg role=\"img\" style=\"max-width:100%;height:auto;\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" fill=\"none\" stroke=\"#000\" stroke-width=\"1.6\" width=\"112px\" height=\"160px\" viewbox=\"0 0 112 160\"\u003e\u003cpath d=\"M 100.9,62.4 L 100.9,49.6\"\u003e\u003c\/path\u003e\u003cpath d=\"M 98.0,60.7 L 98.0,49.6\"\u003e\u003c\/path\u003e\u003cpath d=\"M 96.7,40.5 L 84.1,33.2\"\u003e\u003c\/path\u003e\u003cpath d=\"M 84.1,33.2 L 67.2,43.0\"\u003e\u003c\/path\u003e\u003cpath d=\"M 84.1,36.6 L 70.1,44.6\"\u003e\u003c\/path\u003e\u003cpath d=\"M 67.2,43.0 L 67.2,62.4\"\u003e\u003c\/path\u003e\u003cpath d=\"M 67.2,62.4 L 79.8,69.7\"\u003e\u003c\/path\u003e\u003cpath d=\"M 70.1,60.7 L 81.3,67.2\"\u003e\u003c\/path\u003e\u003cpath d=\"M 67.2,62.4 L 52.9,67.1\"\u003e\u003c\/path\u003e\u003cpath d=\"M 45.6,64.2 L 37.2,52.7\"\u003e\u003c\/path\u003e\u003cpath d=\"M 37.2,52.7 L 44.4,42.8\"\u003e\u003c\/path\u003e\u003cpath d=\"M 40.8,52.7 L 46.8,44.5\"\u003e\u003c\/path\u003e\u003cpath d=\"M 42.6,87.0 L 44.9,75.3 L 47.7,76.2 Z\"\u003e\u003c\/path\u003e\u003cpath d=\"M 42.6,87.0 L 54.0,102.7\"\u003e\u003c\/path\u003e\u003cpath d=\"M 54.0,102.7 L 42.6,118.4\"\u003e\u003c\/path\u003e\u003cpath d=\"M 42.6,118.4 L 24.2,112.4\"\u003e\u003c\/path\u003e\u003cpath d=\"M 24.2,112.4 L 24.2,99.6\"\u003e\u003c\/path\u003e\u003cpath d=\"M 24.2,112.4 L 8.7,125.5 L 8.3,122.2 Z\"\u003e\u003c\/path\u003e\u003cpath d=\"M 8.3,122.2 L 10.1,138.8\"\u003e\u003c\/path\u003e\u003cpath d=\"M 43.8,121.0 L 43.2,121.2\"\u003e\u003c\/path\u003e\u003cpath d=\"M 44.9,123.6 L 43.8,124.0\"\u003e\u003c\/path\u003e\u003cpath d=\"M 46.1,126.2 L 44.4,126.8\"\u003e\u003c\/path\u003e\u003cpath d=\"M 47.3,128.9 L 45.0,129.6\"\u003e\u003c\/path\u003e\u003cpath d=\"M 48.4,131.5 L 45.7,132.4\"\u003e\u003c\/path\u003e\u003cpath d=\"M 56.9,102.4 L 56.9,103.0\"\u003e\u003c\/path\u003e\u003cpath d=\"M 59.8,102.1 L 59.8,103.3\"\u003e\u003c\/path\u003e\u003cpath d=\"M 62.7,101.8 L 62.7,103.6\"\u003e\u003c\/path\u003e\u003cpath d=\"M 65.6,101.5 L 65.6,103.8\"\u003e\u003c\/path\u003e\u003cpath d=\"M 68.6,101.2 L 68.6,104.1\"\u003e\u003c\/path\u003e\u003cpath d=\"M 84.1,33.2 L 84.1,20.4\"\u003e\u003c\/path\u003e\u003cpath d=\"M 88.3,69.7 L 100.9,62.4\"\u003e\u003c\/path\u003e\u003cpath d=\"M 52.9,38.3 L 67.2,43.0\"\u003e\u003c\/path\u003e\u003cpath d=\"M 28.4,91.6 L 42.6,87.0\"\u003e\u003c\/path\u003e\u003cpath d=\"M 100.9,61.8 L 100.9,62.4 L 100.3,62.8\"\u003e\u003c\/path\u003e\u003cpath d=\"M 37.6,53.3 L 37.2,52.7 L 37.6,52.2\"\u003e\u003c\/path\u003e\u003cpath d=\"M 43.2,87.8 L 42.6,87.0 L 41.9,87.2\"\u003e\u003c\/path\u003e\u003cpath d=\"M 53.5,101.9 L 54.0,102.7 L 53.5,103.5\"\u003e\u003c\/path\u003e\u003cpath d=\"M 43.2,117.6 L 42.6,118.4 L 41.7,118.1\"\u003e\u003c\/path\u003e\u003cpath d=\"M 25.1,112.7 L 24.2,112.4 L 24.2,111.7\"\u003e\u003c\/path\u003e\u003ctext x=\"97.3\" y=\"49.0\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eN\u003c\/text\u003e\u003ctext x=\"80.5\" y=\"78.2\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eN\u003c\/text\u003e\u003ctext x=\"45.1\" y=\"74.5\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eN\u003c\/text\u003e\u003ctext x=\"45.1\" y=\"42.9\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eN\u003c\/text\u003e\u003ctext x=\"20.6\" y=\"99.0\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eO\u003c\/text\u003e\u003ctext x=\"6.9\" y=\"149.1\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eO\u003c\/text\u003e\u003ctext x=\"15.2\" y=\"149.1\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eH\u003c\/text\u003e\u003ctext x=\"45.0\" y=\"142.8\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eO\u003c\/text\u003e\u003ctext x=\"53.3\" y=\"142.8\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eH\u003c\/text\u003e\u003ctext x=\"69.8\" y=\"108.7\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eO\u003c\/text\u003e\u003ctext x=\"78.1\" y=\"108.7\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eH\u003c\/text\u003e\u003ctext x=\"80.5\" y=\"19.7\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eN\u003c\/text\u003e\u003ctext x=\"88.7\" y=\"19.7\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eH\u003c\/text\u003e\u003ctext x=\"97.0\" y=\"24.5\" style=\"font:7px sans-serif;fill:#000;stroke:none\"\u003e2\u003c\/text\u003e\u003c\/svg\u003e\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cp style=\"font-size:12px;margin:4px 0 0 0;\"\u003e\u003cem\u003eIn one study, FTO, an Fe(II)- and α-ketoglutarate (α-KG)-dependent enzyme, oxidised N6-methyladenosine to N6-hydroxymethyladenosine and then to N6-formyladenosine. Both products break down to adenosine in water; the last arrow shows this for N6-formyladenosine. In RNA the reactions take place on m\u003csup\u003e6\u003c\/sup\u003eA residues; the structures are drawn as nucleosides.\u003c\/em\u003e\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cp\u003e\u003cstrong\u003eReader proteins.\u003c\/strong\u003e In one study, the human reader protein YTHDF2 bound m\u003csup\u003e6\u003c\/sup\u003eA-containing mRNA through its C-terminal domain. Its N-terminal domain took the bound mRNA from the pool available for translation to sites of mRNA decay, such as processing bodies. m\u003csup\u003e6\u003c\/sup\u003eA has been reported to affect the localisation, stability, translation and splicing of mRNA.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eDimroth rearrangement.\u003c\/strong\u003e Under alkaline conditions at elevated temperatures, 1-methyladenosine (m\u003csup\u003e1\u003c\/sup\u003eA) rearranges to N6-methyladenosine. Because of this, m\u003csup\u003e1\u003c\/sup\u003eA in RNA may be converted to m\u003csup\u003e6\u003c\/sup\u003eA during purification and measurement, which can add noise to m\u003csup\u003e6\u003c\/sup\u003eA measurements. One study that mapped m\u003csup\u003e1\u003c\/sup\u003eA in mRNA used the rearrangement on purpose. m\u003csup\u003e1\u003c\/sup\u003eA often causes errors during reverse transcription, but m\u003csup\u003e6\u003c\/sup\u003eA rarely does, so converting m\u003csup\u003e1\u003c\/sup\u003eA to m\u003csup\u003e6\u003c\/sup\u003eA with alkali helped the authors confirm where m\u003csup\u003e1\u003c\/sup\u003eA sits.\u003c\/p\u003e\n\u003cdiv style=\"margin:8px 0 18px 0;\"\u003e\n\u003cdiv style=\"display:flex;flex-wrap:wrap;align-items:center;justify-content:flex-start;gap:2px;\"\u003e\n\u003cdiv style=\"display:flex;align-items:center;\"\u003e\u003csvg role=\"img\" style=\"max-width:100%;height:auto;\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" fill=\"none\" stroke=\"#000\" stroke-width=\"1.6\" width=\"128px\" height=\"160px\" viewbox=\"0 0 128 160\"\u003e\u003cpath d=\"M 119.1,33.2 L 106.5,40.5\"\u003e\u003c\/path\u003e\u003cpath d=\"M 102.2,49.6 L 102.2,62.4\"\u003e\u003c\/path\u003e\u003cpath d=\"M 102.2,62.4 L 89.6,69.7\"\u003e\u003c\/path\u003e\u003cpath d=\"M 99.3,60.7 L 88.2,67.2\"\u003e\u003c\/path\u003e\u003cpath d=\"M 81.1,69.7 L 68.5,62.4\"\u003e\u003c\/path\u003e\u003cpath d=\"M 68.5,62.4 L 68.5,43.0\"\u003e\u003c\/path\u003e\u003cpath d=\"M 65.6,60.3 L 65.6,45.1\"\u003e\u003c\/path\u003e\u003cpath d=\"M 68.5,43.0 L 85.4,33.2\"\u003e\u003c\/path\u003e\u003cpath d=\"M 86.8,34.1 L 86.8,20.4\"\u003e\u003c\/path\u003e\u003cpath d=\"M 83.9,34.1 L 83.9,20.4\"\u003e\u003c\/path\u003e\u003cpath d=\"M 68.5,43.0 L 54.2,38.3\"\u003e\u003c\/path\u003e\u003cpath d=\"M 45.7,42.8 L 38.5,52.7\"\u003e\u003c\/path\u003e\u003cpath d=\"M 48.1,44.5 L 42.1,52.7\"\u003e\u003c\/path\u003e\u003cpath d=\"M 38.5,52.7 L 46.9,64.2\"\u003e\u003c\/path\u003e\u003cpath d=\"M 44.0,87.0 L 46.2,75.3 L 49.0,76.2 Z\"\u003e\u003c\/path\u003e\u003cpath d=\"M 44.0,87.0 L 55.4,102.7\"\u003e\u003c\/path\u003e\u003cpath d=\"M 55.4,102.7 L 44.0,118.4\"\u003e\u003c\/path\u003e\u003cpath d=\"M 44.0,118.4 L 25.5,112.4\"\u003e\u003c\/path\u003e\u003cpath d=\"M 25.5,112.4 L 25.5,99.6\"\u003e\u003c\/path\u003e\u003cpath d=\"M 25.5,112.4 L 10.0,125.5 L 9.6,122.2 Z\"\u003e\u003c\/path\u003e\u003cpath d=\"M 9.6,122.2 L 11.4,138.8\"\u003e\u003c\/path\u003e\u003cpath d=\"M 45.1,121.0 L 44.6,121.2\"\u003e\u003c\/path\u003e\u003cpath d=\"M 46.3,123.6 L 45.2,124.0\"\u003e\u003c\/path\u003e\u003cpath d=\"M 47.4,126.2 L 45.8,126.8\"\u003e\u003c\/path\u003e\u003cpath d=\"M 48.6,128.9 L 46.4,129.6\"\u003e\u003c\/path\u003e\u003cpath d=\"M 49.8,131.5 L 47.0,132.4\"\u003e\u003c\/path\u003e\u003cpath d=\"M 58.3,102.4 L 58.3,103.0\"\u003e\u003c\/path\u003e\u003cpath d=\"M 61.2,102.1 L 61.2,103.3\"\u003e\u003c\/path\u003e\u003cpath d=\"M 64.1,101.8 L 64.1,103.5\"\u003e\u003c\/path\u003e\u003cpath d=\"M 67.0,101.5 L 67.0,103.8\"\u003e\u003c\/path\u003e\u003cpath d=\"M 69.9,101.2 L 69.9,104.1\"\u003e\u003c\/path\u003e\u003cpath d=\"M 85.4,33.2 L 98.0,40.5\"\u003e\u003c\/path\u003e\u003cpath d=\"M 54.2,67.1 L 68.5,62.4\"\u003e\u003c\/path\u003e\u003cpath d=\"M 29.7,91.6 L 44.0,87.0\"\u003e\u003c\/path\u003e\u003cpath d=\"M 102.2,61.8 L 102.2,62.4 L 101.6,62.8\"\u003e\u003c\/path\u003e\u003cpath d=\"M 84.5,33.7 L 85.4,33.2 L 86.0,33.6\"\u003e\u003c\/path\u003e\u003cpath d=\"M 38.9,52.2 L 38.5,52.7 L 38.9,53.3\"\u003e\u003c\/path\u003e\u003cpath d=\"M 44.5,87.8 L 44.0,87.0 L 43.2,87.2\"\u003e\u003c\/path\u003e\u003cpath d=\"M 54.8,101.9 L 55.4,102.7 L 54.8,103.5\"\u003e\u003c\/path\u003e\u003cpath d=\"M 44.5,117.6 L 44.0,118.4 L 43.0,118.1\"\u003e\u003c\/path\u003e\u003cpath d=\"M 26.4,112.7 L 25.5,112.4 L 25.5,111.7\"\u003e\u003c\/path\u003e\u003ctext x=\"98.6\" y=\"49.0\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eN\u003c\/text\u003e\u003ctext x=\"81.8\" y=\"78.2\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eN\u003c\/text\u003e\u003ctext x=\"81.8\" y=\"19.7\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eN\u003c\/text\u003e\u003ctext x=\"90.0\" y=\"19.7\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eH\u003c\/text\u003e\u003ctext x=\"46.4\" y=\"42.9\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eN\u003c\/text\u003e\u003ctext x=\"46.4\" y=\"74.5\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eN\u003c\/text\u003e\u003ctext x=\"21.9\" y=\"99.0\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eO\u003c\/text\u003e\u003ctext x=\"8.2\" y=\"149.1\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eO\u003c\/text\u003e\u003ctext x=\"16.5\" y=\"149.1\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eH\u003c\/text\u003e\u003ctext x=\"46.4\" y=\"142.8\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eO\u003c\/text\u003e\u003ctext x=\"54.6\" y=\"142.8\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eH\u003c\/text\u003e\u003ctext x=\"71.2\" y=\"108.7\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eO\u003c\/text\u003e\u003ctext x=\"79.4\" y=\"108.7\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eH\u003c\/text\u003e\u003c\/svg\u003e\u003c\/div\u003e\n\u003cdiv style=\"display:flex;align-items:center;\"\u003e\u003cdiv style=\"display:flex;flex-direction:column;align-items:center;justify-content:center;min-width:90px;max-width:150px;padding:0 4px;text-align:center;font-size:12px;line-height:1.3;\"\u003e\n\u003cdiv\u003ealkaline pH, heat\u003c\/div\u003e\n\u003cdiv style=\"font-size:30px;line-height:1;\"\u003e⟶\u003c\/div\u003e\n\u003cdiv\u003eDimroth rearrangement\u003c\/div\u003e\n\u003c\/div\u003e\u003c\/div\u003e\n\u003cdiv style=\"display:flex;align-items:center;\"\u003e\u003csvg role=\"img\" style=\"max-width:100%;height:auto;\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" fill=\"none\" stroke=\"#000\" stroke-width=\"1.6\" width=\"112px\" height=\"167px\" viewbox=\"0 0 112 167\"\u003e\u003cpath d=\"M 67.3,10.5 L 79.8,17.8\"\u003e\u003c\/path\u003e\u003cpath d=\"M 84.1,26.8 L 84.1,39.7\"\u003e\u003c\/path\u003e\u003cpath d=\"M 84.1,39.7 L 67.2,49.4\"\u003e\u003c\/path\u003e\u003cpath d=\"M 84.1,43.1 L 70.1,51.1\"\u003e\u003c\/path\u003e\u003cpath d=\"M 67.2,49.4 L 67.2,68.9\"\u003e\u003c\/path\u003e\u003cpath d=\"M 67.2,68.9 L 79.8,76.2\"\u003e\u003c\/path\u003e\u003cpath d=\"M 70.1,67.2 L 81.3,73.7\"\u003e\u003c\/path\u003e\u003cpath d=\"M 88.3,76.2 L 100.9,68.9\"\u003e\u003c\/path\u003e\u003cpath d=\"M 100.9,68.9 L 100.9,56.1\"\u003e\u003c\/path\u003e\u003cpath d=\"M 98.0,67.2 L 98.0,56.1\"\u003e\u003c\/path\u003e\u003cpath d=\"M 67.2,68.9 L 52.9,73.5\"\u003e\u003c\/path\u003e\u003cpath d=\"M 45.6,70.7 L 37.2,59.2\"\u003e\u003c\/path\u003e\u003cpath d=\"M 37.2,59.2 L 44.4,49.2\"\u003e\u003c\/path\u003e\u003cpath d=\"M 40.8,59.2 L 46.8,51.0\"\u003e\u003c\/path\u003e\u003cpath d=\"M 42.6,93.5 L 44.9,81.8 L 47.7,82.7 Z\"\u003e\u003c\/path\u003e\u003cpath d=\"M 42.6,93.5 L 54.0,109.1\"\u003e\u003c\/path\u003e\u003cpath d=\"M 54.0,109.1 L 42.6,124.8\"\u003e\u003c\/path\u003e\u003cpath d=\"M 42.6,124.8 L 24.2,118.8\"\u003e\u003c\/path\u003e\u003cpath d=\"M 24.2,118.8 L 24.2,106.1\"\u003e\u003c\/path\u003e\u003cpath d=\"M 24.2,118.8 L 8.7,132.0 L 8.3,128.6 Z\"\u003e\u003c\/path\u003e\u003cpath d=\"M 8.3,128.6 L 10.1,145.3\"\u003e\u003c\/path\u003e\u003cpath d=\"M 43.8,127.5 L 43.2,127.6\"\u003e\u003c\/path\u003e\u003cpath d=\"M 44.9,130.1 L 43.8,130.4\"\u003e\u003c\/path\u003e\u003cpath d=\"M 46.1,132.7 L 44.4,133.3\"\u003e\u003c\/path\u003e\u003cpath d=\"M 47.3,135.3 L 45.0,136.1\"\u003e\u003c\/path\u003e\u003cpath d=\"M 48.4,138.0 L 45.7,138.9\"\u003e\u003c\/path\u003e\u003cpath d=\"M 56.9,108.9 L 56.9,109.4\"\u003e\u003c\/path\u003e\u003cpath d=\"M 59.8,108.6 L 59.8,109.7\"\u003e\u003c\/path\u003e\u003cpath d=\"M 62.7,108.3 L 62.7,110.0\"\u003e\u003c\/path\u003e\u003cpath d=\"M 65.6,108.0 L 65.6,110.3\"\u003e\u003c\/path\u003e\u003cpath d=\"M 68.6,107.7 L 68.6,110.6\"\u003e\u003c\/path\u003e\u003cpath d=\"M 96.7,47.0 L 84.1,39.7\"\u003e\u003c\/path\u003e\u003cpath d=\"M 52.9,44.8 L 67.2,49.4\"\u003e\u003c\/path\u003e\u003cpath d=\"M 28.4,98.1 L 42.6,93.5\"\u003e\u003c\/path\u003e\u003cpath d=\"M 100.3,69.3 L 100.9,68.9 L 100.9,68.3\"\u003e\u003c\/path\u003e\u003cpath d=\"M 37.6,59.7 L 37.2,59.2 L 37.6,58.7\"\u003e\u003c\/path\u003e\u003cpath d=\"M 43.2,94.2 L 42.6,93.5 L 41.9,93.7\"\u003e\u003c\/path\u003e\u003cpath d=\"M 53.5,108.4 L 54.0,109.1 L 53.5,109.9\"\u003e\u003c\/path\u003e\u003cpath d=\"M 43.2,124.1 L 42.6,124.8 L 41.7,124.5\"\u003e\u003c\/path\u003e\u003cpath d=\"M 25.1,119.1 L 24.2,118.8 L 24.2,118.2\"\u003e\u003c\/path\u003e\u003ctext x=\"80.5\" y=\"26.2\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eN\u003c\/text\u003e\u003ctext x=\"88.7\" y=\"26.2\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eH\u003c\/text\u003e\u003ctext x=\"80.5\" y=\"84.6\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eN\u003c\/text\u003e\u003ctext x=\"97.3\" y=\"55.4\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eN\u003c\/text\u003e\u003ctext x=\"45.1\" y=\"80.9\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eN\u003c\/text\u003e\u003ctext x=\"45.1\" y=\"49.4\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eN\u003c\/text\u003e\u003ctext x=\"20.6\" y=\"105.4\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eO\u003c\/text\u003e\u003ctext x=\"6.9\" y=\"155.5\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eO\u003c\/text\u003e\u003ctext x=\"15.2\" y=\"155.5\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eH\u003c\/text\u003e\u003ctext x=\"45.0\" y=\"149.3\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eO\u003c\/text\u003e\u003ctext x=\"53.3\" y=\"149.3\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eH\u003c\/text\u003e\u003ctext x=\"69.8\" y=\"115.2\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eO\u003c\/text\u003e\u003ctext x=\"78.1\" y=\"115.2\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eH\u003c\/text\u003e\u003c\/svg\u003e\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cp style=\"font-size:12px;margin:4px 0 0 0;\"\u003e\u003cem\u003eDimroth rearrangement of 1-methyladenosine (m\u003csup\u003e1\u003c\/sup\u003eA, left) to N6-methyladenosine (m\u003csup\u003e6\u003c\/sup\u003eA, right) under alkaline conditions at elevated temperatures. m\u003csup\u003e1\u003c\/sup\u003eA is drawn as the imino form given by PubChem.\u003c\/em\u003e\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cp\u003e\u003cstrong\u003eModified RNA and immune sensors.\u003c\/strong\u003e In one study, RNA containing m\u003csup\u003e6\u003c\/sup\u003eA, made by in vitro transcription, was less able to stimulate the RNA sensor TLR3 and did not stimulate TLR7 or TLR8. These tests used cultured cells engineered to express each human receptor. In the same study, however, RNA containing m\u003csup\u003e6\u003c\/sup\u003eA still activated primary dendritic cells from blood as strongly as unmodified RNA. Of the modifications tested, only those on uridine stopped this activation.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eAnalytical standard.\u003c\/strong\u003e Pure m\u003csup\u003e6\u003c\/sup\u003eA has been used, together with pure adenosine, to build standard curves for measuring the m\u003csup\u003e6\u003c\/sup\u003eA\/A ratio in mRNA by LC-MS\/MS.\u003c\/p\u003e\n\u003c\/div\u003e\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cdiv style=\"margin-bottom: 28px;\"\u003e\n\u003cdiv style=\"background: #002147; padding: 10px 20px; margin-bottom: 0;\"\u003e\u003ch3 style=\"margin: 0; font-family: 'Helvetica Neue', Helvetica, Arial, sans-serif; font-size: 0.70em; font-weight: bold; letter-spacing: 0.12em; text-transform: uppercase; color: #fff;\"\u003eShipping Destinations\u003c\/h3\u003e\u003c\/div\u003e\n\u003cdiv style=\"border: 1px solid #e4e8f0; border-top: none; padding: 12px 16px; font-family: 'Helvetica Neue', Helvetica, Arial, sans-serif; font-size: 0.95em;\"\u003e\u003cul style=\"margin: 0; padding: 0; list-style: none;\"\u003e\n\u003cli style=\"padding: 5px 0; border-bottom: 1px solid #f0f0f0;\"\u003e\n\u003cspan style=\"display: inline-block; width: 7px; height: 7px; background: #002147; border-radius: 50%; margin-right: 10px; vertical-align: middle;\"\u003e\u003c\/span\u003eEU \u0026amp; UK: Priority delivery, 2–5 business days.\u003c\/li\u003e\n\u003cli style=\"padding: 5px 0; border-bottom: 1px solid #f0f0f0;\"\u003e\n\u003cspan style=\"display: inline-block; width: 7px; height: 7px; background: #002147; border-radius: 50%; margin-right: 10px; vertical-align: middle;\"\u003e\u003c\/span\u003eUnited States (DDP): 3–7 business days, duties and taxes prepaid.\u003c\/li\u003e\n\u003cli style=\"padding: 5px 0; border-bottom: 1px solid #f0f0f0;\"\u003e\n\u003cspan style=\"display: inline-block; width: 7px; height: 7px; background: #002147; border-radius: 50%; margin-right: 10px; vertical-align: middle;\"\u003e\u003c\/span\u003eEFTA Countries (DDP): 3–7 business days, duties and taxes prepaid.\u003c\/li\u003e\n\u003cli style=\"padding: 5px 0; border-bottom: 1px solid #f0f0f0;\"\u003e\n\u003cspan style=\"display: inline-block; width: 7px; height: 7px; background: #002147; border-radius: 50%; margin-right: 10px; vertical-align: middle;\"\u003e\u003c\/span\u003eWorldwide: 7–14 business days, selected locations.\u003c\/li\u003e\n\u003c\/ul\u003e\u003c\/div\u003e\n\u003c\/div\u003e","brand":"NorrChemica™","offers":[{"title":"250 mg","offer_id":55166596874577,"sku":"NOR-1867738-250mg","price":49.2,"currency_code":"EUR","in_stock":true},{"title":"1.0 g","offer_id":55361943109969,"sku":"NOR-1867738-1g","price":98.2,"currency_code":"EUR","in_stock":true},{"title":"5.0 g","offer_id":55166596907345,"sku":"NOR-1867738-5g","price":329.2,"currency_code":"EUR","in_stock":true},{"title":"10 g","offer_id":55361950908753,"sku":"NOR-1867738-10g","price":598.2,"currency_code":"EUR","in_stock":false},{"title":"25 g","offer_id":55166596940113,"sku":"NOR-1867738-25g","price":1089.2,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0954\/6357\/1793\/files\/N6-Methyladenosine.png?v=1792268659"},{"product_id":"5-methylcytidine-cas-2140-61-6","title":"5-Methylcytidine | CAS 2140-61-6 | ≥97%","description":"\u003cdiv style=\"margin-bottom: 28px;\"\u003e\n\u003cdiv style=\"background: #002147; padding: 10px 20px; margin-bottom: 0;\"\u003e\u003ch3 style=\"margin: 0; font-family: 'Helvetica Neue', Helvetica, Arial, sans-serif; font-size: 0.70em; font-weight: bold; letter-spacing: 0.12em; text-transform: uppercase; color: #fff;\"\u003eTechnical Specifications\u003c\/h3\u003e\u003c\/div\u003e\n\u003ctable style=\"width: 100%; border-collapse: collapse; font-size: 0.95em; border: 1px solid #e4e8f0; border-top: none; font-family: 'Helvetica Neue', Helvetica, Arial, sans-serif;\"\u003e\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eCAS Number\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e2140-61-6\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eEC \/ EINECS Number\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e218-390-8\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eMDL Number\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003eMFCD00006548\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eSMILES\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0; word-break: break-all;\"\u003eCC1=CN(C(=O)N=C1N)[C@H]2[C@@H]([C@@H]([C@H](O2)CO)O)O\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eInChI\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0; word-break: break-all;\"\u003eInChI=1S\/C10H15N3O5\/c1-4-2-13(10(17)12-8(4)11)9-7(16)6(15)5(3-14)18-9\/h2,5-7,9,14-16H,3H2,1H3,(H2,11,12,17)\/t5-,6-,7-,9-\/m1\/s1\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eInChIKey\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0; word-break: break-all;\"\u003eZAYHVCMSTBRABG-JXOAFFINSA-N\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003ePubChem CID\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e92918\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eMolecular Formula\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003eC₁₀H₁₅N₃O₅\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eMolecular Weight\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e257.24 g\/mol\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eMelting Point\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e212–215 °C (dec.)\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eSolubility\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003eSoluble in water, DMSO, DMF and phosphate-buffered saline (pH 7.2).\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eLog Pow\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e-2.01\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003ePurity\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e≥97%\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003ePhysical Form\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003eWhite to almost white powder or crystals\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eHS Code\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e2934.99\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eShelf Life\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003eRetest period: 36 months from date of manufacture\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eStorage Conditions\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333;\"\u003eStore in a cool, dry place in a tightly sealed container.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\u003c\/table\u003e\n\u003c\/div\u003e\n\u003cdiv style=\"margin-bottom: 28px;\"\u003e\n\u003cdiv style=\"background: #002147; padding: 10px 20px; margin-bottom: 0;\"\u003e\u003ch3 style=\"margin: 0; font-family: 'Helvetica Neue', Helvetica, Arial, sans-serif; font-size: 0.70em; font-weight: bold; letter-spacing: 0.12em; text-transform: uppercase; color: #fff;\"\u003eProduct Description \u0026amp; Scientific Applications\u003c\/h3\u003e\u003c\/div\u003e\n\u003cdiv style=\"padding: 16px 20px; border: 1px solid #e4e8f0; border-top: none; font-family: Georgia, 'Times New Roman', serif; font-size: 0.95em; line-height: 1.65; color: #333;\"\u003e\u003cdiv\u003e\n\u003cp\u003e\u003cstrong\u003e5-Methylcytidine\u003c\/strong\u003e (m\u003csup\u003e5\u003c\/sup\u003eC) is cytidine with a methyl group at C5 of the cytosine ring. It occurs naturally in RNA, and it has long been known to occur in the tRNA and rRNA of a wide variety of organisms. Transcriptome-wide mapping has also reported m\u003csup\u003e5\u003c\/sup\u003eC sites in the mRNAs of an archaeon and, in one study of human cells, candidate sites in mRNAs and in non-coding RNAs.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eFormation in RNA.\u003c\/strong\u003e In RNA, m\u003csup\u003e5\u003c\/sup\u003eC is formed by m\u003csup\u003e5\u003c\/sup\u003eC RNA methyltransferases, which transfer a methyl group from S-adenosyl-L-methionine (SAM) to C5 of a cytidine residue. A cysteine of the enzyme first adds to C6. This makes C5 nucleophilic, so it takes the methyl group from SAM, and β-elimination of the cysteine and the C5 hydrogen then releases the enzyme. In animals, the methyltransferase NSUN2 is known to modify specific tRNAs. One study of human RNA found further NSUN2 targets: another tRNA, the RPPH1 subunit of RNase P and two mRNAs. Another study found that human DNMT2, which closely resembles DNA cytosine methyltransferases, did not methylate DNA but methylated cytosine 38 in the anticodon loop of tRNA\u003csup\u003eAsp\u003c\/sup\u003e.\u003c\/p\u003e\n\u003cdiv style=\"margin:8px 0 18px 0;\"\u003e\n\u003cdiv style=\"display:flex;flex-wrap:wrap;align-items:center;justify-content:flex-start;gap:2px;\"\u003e\n\u003cdiv style=\"display:flex;align-items:center;\"\u003e\u003csvg role=\"img\" style=\"max-width:100%;height:auto;\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" fill=\"none\" stroke=\"#000\" stroke-width=\"1.6\" width=\"166px\" height=\"105px\" viewbox=\"0 0 166 105\"\u003e\u003cpath d=\"M 43.3,39.3 L 60.2,49.0\"\u003e\u003c\/path\u003e\u003cpath d=\"M 46.3,37.6 L 60.2,45.6\"\u003e\u003c\/path\u003e\u003cpath d=\"M 60.2,49.0 L 72.7,41.7\"\u003e\u003c\/path\u003e\u003cpath d=\"M 76.9,35.1 L 76.9,19.9\"\u003e\u003c\/path\u003e\u003cpath d=\"M 76.9,21.6 L 90.2,13.9\"\u003e\u003c\/path\u003e\u003cpath d=\"M 75.5,19.1 L 88.8,11.4\"\u003e\u003c\/path\u003e\u003cpath d=\"M 76.9,19.9 L 64.4,12.7\"\u003e\u003c\/path\u003e\u003cpath d=\"M 55.9,12.7 L 43.3,19.9\"\u003e\u003c\/path\u003e\u003cpath d=\"M 57.3,15.2 L 46.2,21.6\"\u003e\u003c\/path\u003e\u003cpath d=\"M 43.3,19.9 L 30.8,12.7\"\u003e\u003c\/path\u003e\u003cpath d=\"M 93.8,49.0 L 81.1,43.4 L 82.6,40.8 Z\"\u003e\u003c\/path\u003e\u003cpath d=\"M 93.8,49.0 L 111.5,41.1\"\u003e\u003c\/path\u003e\u003cpath d=\"M 111.5,41.1 L 124.5,55.5\"\u003e\u003c\/path\u003e\u003cpath d=\"M 124.5,55.5 L 114.8,72.3\"\u003e\u003c\/path\u003e\u003cpath d=\"M 114.8,72.3 L 100.0,69.2\"\u003e\u003c\/path\u003e\u003cpath d=\"M 114.8,72.3 L 124.4,90.2 L 121.1,89.8 Z\"\u003e\u003c\/path\u003e\u003cpath d=\"M 121.1,89.8 L 137.7,91.6\"\u003e\u003c\/path\u003e\u003cpath d=\"M 127.3,54.9 L 127.4,55.5\"\u003e\u003c\/path\u003e\u003cpath d=\"M 130.2,54.3 L 130.3,55.5\"\u003e\u003c\/path\u003e\u003cpath d=\"M 133.0,53.7 L 133.2,55.4\"\u003e\u003c\/path\u003e\u003cpath d=\"M 135.9,53.1 L 136.1,55.4\"\u003e\u003c\/path\u003e\u003cpath d=\"M 138.7,52.5 L 139.0,55.4\"\u003e\u003c\/path\u003e\u003cpath d=\"M 111.7,38.1 L 112.5,38.2\"\u003e\u003c\/path\u003e\u003cpath d=\"M 112.0,35.1 L 113.4,35.4\"\u003e\u003c\/path\u003e\u003cpath d=\"M 112.3,32.1 L 114.4,32.5\"\u003e\u003c\/path\u003e\u003cpath d=\"M 112.5,29.1 L 115.4,29.7\"\u003e\u003c\/path\u003e\u003cpath d=\"M 43.3,19.9 L 43.3,39.3\"\u003e\u003c\/path\u003e\u003cpath d=\"M 95.4,64.0 L 93.8,49.0\"\u003e\u003c\/path\u003e\u003cpath d=\"M 44.2,39.8 L 43.3,39.3 L 43.3,38.4\"\u003e\u003c\/path\u003e\u003cpath d=\"M 59.3,48.5 L 60.2,49.0 L 60.8,48.6\"\u003e\u003c\/path\u003e\u003cpath d=\"M 76.9,20.7 L 76.9,19.9 L 76.3,19.5\"\u003e\u003c\/path\u003e\u003cpath d=\"M 94.6,48.6 L 93.8,49.0 L 93.8,49.7\"\u003e\u003c\/path\u003e\u003cpath d=\"M 110.6,41.5 L 111.5,41.1 L 112.1,41.8\"\u003e\u003c\/path\u003e\u003cpath d=\"M 123.8,54.8 L 124.5,55.5 L 124.0,56.3\"\u003e\u003c\/path\u003e\u003cpath d=\"M 115.3,71.5 L 114.8,72.3 L 114.0,72.1\"\u003e\u003c\/path\u003e\u003ctext x=\"73.3\" y=\"45.3\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eN\u003c\/text\u003e\u003ctext x=\"90.1\" y=\"16.2\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eO\u003c\/text\u003e\u003ctext x=\"56.5\" y=\"16.2\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eN\u003c\/text\u003e\u003ctext x=\"10.8\" y=\"16.2\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eH\u003c\/text\u003e\u003ctext x=\"19.1\" y=\"21.0\" style=\"font:7px sans-serif;fill:#000;stroke:none\"\u003e2\u003c\/text\u003e\u003ctext x=\"22.9\" y=\"16.2\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eN\u003c\/text\u003e\u003ctext x=\"92.2\" y=\"74.3\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eO\u003c\/text\u003e\u003ctext x=\"138.4\" y=\"98.0\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eO\u003c\/text\u003e\u003ctext x=\"146.7\" y=\"98.0\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eH\u003c\/text\u003e\u003ctext x=\"140.2\" y=\"59.4\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eO\u003c\/text\u003e\u003ctext x=\"148.4\" y=\"59.4\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eH\u003c\/text\u003e\u003ctext x=\"111.9\" y=\"28.1\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eO\u003c\/text\u003e\u003ctext x=\"120.2\" y=\"28.1\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eH\u003c\/text\u003e\u003c\/svg\u003e\u003c\/div\u003e\n\u003cdiv style=\"display:flex;align-items:center;\"\u003e\u003cdiv style=\"display:flex;flex-direction:column;align-items:center;justify-content:center;min-width:90px;max-width:150px;padding:0 4px;text-align:center;font-size:12px;line-height:1.3;\"\u003e\n\u003cdiv\u003em\u003csup\u003e5\u003c\/sup\u003eC RNA methyltransferase\u003c\/div\u003e\n\u003cdiv style=\"font-size:30px;line-height:1;\"\u003e⟶\u003c\/div\u003e\n\u003cdiv\u003eSAM (methyl donor)\u003c\/div\u003e\n\u003c\/div\u003e\u003c\/div\u003e\n\u003cdiv style=\"display:flex;align-items:center;\"\u003e\u003csvg role=\"img\" style=\"max-width:100%;height:auto;\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" fill=\"none\" stroke=\"#000\" stroke-width=\"1.6\" width=\"167px\" height=\"105px\" viewbox=\"0 0 167 105\"\u003e\u003cpath d=\"M 26.4,49.1 L 43.3,39.3\"\u003e\u003c\/path\u003e\u003cpath d=\"M 43.3,39.3 L 60.2,49.1\"\u003e\u003c\/path\u003e\u003cpath d=\"M 46.2,37.6 L 60.2,45.7\"\u003e\u003c\/path\u003e\u003cpath d=\"M 60.2,49.1 L 72.9,41.8\"\u003e\u003c\/path\u003e\u003cpath d=\"M 77.1,35.1 L 77.1,19.8\"\u003e\u003c\/path\u003e\u003cpath d=\"M 77.1,21.5 L 90.5,13.8\"\u003e\u003c\/path\u003e\u003cpath d=\"M 75.6,19.0 L 89.0,11.2\"\u003e\u003c\/path\u003e\u003cpath d=\"M 77.1,19.8 L 64.4,12.5\"\u003e\u003c\/path\u003e\u003cpath d=\"M 56.0,12.5 L 43.3,19.8\"\u003e\u003c\/path\u003e\u003cpath d=\"M 57.4,15.0 L 46.2,21.5\"\u003e\u003c\/path\u003e\u003cpath d=\"M 43.3,19.8 L 30.7,12.5\"\u003e\u003c\/path\u003e\u003cpath d=\"M 94.0,49.1 L 81.3,43.4 L 82.7,40.9 Z\"\u003e\u003c\/path\u003e\u003cpath d=\"M 94.0,49.1 L 111.7,41.2\"\u003e\u003c\/path\u003e\u003cpath d=\"M 111.7,41.2 L 124.7,55.6\"\u003e\u003c\/path\u003e\u003cpath d=\"M 124.7,55.6 L 115.0,72.4\"\u003e\u003c\/path\u003e\u003cpath d=\"M 115.0,72.4 L 100.3,69.3\"\u003e\u003c\/path\u003e\u003cpath d=\"M 115.0,72.4 L 124.6,90.3 L 121.3,90.0 Z\"\u003e\u003c\/path\u003e\u003cpath d=\"M 121.3,90.0 L 137.9,91.7\"\u003e\u003c\/path\u003e\u003cpath d=\"M 127.5,55.0 L 127.6,55.6\"\u003e\u003c\/path\u003e\u003cpath d=\"M 130.4,54.4 L 130.5,55.6\"\u003e\u003c\/path\u003e\u003cpath d=\"M 133.3,53.8 L 133.4,55.6\"\u003e\u003c\/path\u003e\u003cpath d=\"M 136.1,53.2 L 136.3,55.5\"\u003e\u003c\/path\u003e\u003cpath d=\"M 139.0,52.6 L 139.3,55.5\"\u003e\u003c\/path\u003e\u003cpath d=\"M 112.0,38.2 L 112.7,38.3\"\u003e\u003c\/path\u003e\u003cpath d=\"M 112.2,35.2 L 113.7,35.5\"\u003e\u003c\/path\u003e\u003cpath d=\"M 112.5,32.2 L 114.7,32.6\"\u003e\u003c\/path\u003e\u003cpath d=\"M 112.8,29.2 L 115.6,29.8\"\u003e\u003c\/path\u003e\u003cpath d=\"M 43.3,19.8 L 43.3,39.3\"\u003e\u003c\/path\u003e\u003cpath d=\"M 95.6,64.1 L 94.0,49.1\"\u003e\u003c\/path\u003e\u003cpath d=\"M 59.4,48.6 L 60.2,49.1 L 60.8,48.7\"\u003e\u003c\/path\u003e\u003cpath d=\"M 77.1,20.6 L 77.1,19.8 L 76.5,19.4\"\u003e\u003c\/path\u003e\u003cpath d=\"M 94.9,48.7 L 94.0,49.1 L 94.1,49.8\"\u003e\u003c\/path\u003e\u003cpath d=\"M 110.8,41.6 L 111.7,41.2 L 112.4,41.9\"\u003e\u003c\/path\u003e\u003cpath d=\"M 124.0,54.9 L 124.7,55.6 L 124.2,56.4\"\u003e\u003c\/path\u003e\u003cpath d=\"M 115.5,71.6 L 115.0,72.4 L 114.3,72.2\"\u003e\u003c\/path\u003e\u003ctext x=\"73.5\" y=\"45.3\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eN\u003c\/text\u003e\u003ctext x=\"90.4\" y=\"16.0\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eO\u003c\/text\u003e\u003ctext x=\"56.6\" y=\"16.0\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eN\u003c\/text\u003e\u003ctext x=\"10.7\" y=\"16.0\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eH\u003c\/text\u003e\u003ctext x=\"19.0\" y=\"20.8\" style=\"font:7px sans-serif;fill:#000;stroke:none\"\u003e2\u003c\/text\u003e\u003ctext x=\"22.8\" y=\"16.0\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eN\u003c\/text\u003e\u003ctext x=\"92.4\" y=\"74.4\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eO\u003c\/text\u003e\u003ctext x=\"138.6\" y=\"98.2\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eO\u003c\/text\u003e\u003ctext x=\"146.9\" y=\"98.2\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eH\u003c\/text\u003e\u003ctext x=\"140.4\" y=\"59.6\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eO\u003c\/text\u003e\u003ctext x=\"148.7\" y=\"59.6\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eH\u003c\/text\u003e\u003ctext x=\"112.2\" y=\"28.2\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eO\u003c\/text\u003e\u003ctext x=\"120.4\" y=\"28.2\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eH\u003c\/text\u003e\u003c\/svg\u003e\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cp style=\"font-size:12px;margin:4px 0 0 0;\"\u003e\u003cem\u003eFormation of 5-methylcytidine (m\u003csup\u003e5\u003c\/sup\u003eC, right) from cytidine (left) by an m\u003csup\u003e5\u003c\/sup\u003eC RNA methyltransferase, with S-adenosyl-L-methionine (SAM) as the methyl donor. In RNA the reaction takes place on cytidine residues; the structures are drawn as nucleosides.\u003c\/em\u003e\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cp\u003e\u003cstrong\u003eDetection by bisulfite sequencing.\u003c\/strong\u003e Sodium bisulfite converts cytosine residues in single-stranded DNA to uracil. At acidic pH, bisulfite adds to C6, with protonation at C5, to give a 5,6-dihydrocytosine-6-sulfonate. This is deaminated to 5,6-dihydrouracil-6-sulfonate. Treatment under basic conditions then restores the 5,6-double bond by β-elimination, which gives uracil. The reaction is selective for cytosine over 5-methylcytosine, the base of 5-methylcytidine. This selectivity is the basis of bisulfite sequencing, which locates m\u003csup\u003e5\u003c\/sup\u003eC sites. One study adapted the method to RNA and detected cytosine methylation in tRNAs and rRNAs reproducibly and quantitatively.\u003c\/p\u003e\n\u003cdiv style=\"margin:8px 0 18px 0;\"\u003e\n\u003cdiv style=\"display:flex;flex-wrap:wrap;align-items:center;justify-content:flex-start;gap:2px;\"\u003e\n\u003cdiv style=\"display:flex;align-items:center;\"\u003e\u003csvg role=\"img\" style=\"max-width:100%;height:auto;\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" fill=\"none\" stroke=\"#000\" stroke-width=\"1.6\" width=\"110px\" height=\"58px\" viewbox=\"0 0 110 58\"\u003e\u003cpath d=\"M 14.6,43.5 L 25.0,41.1\"\u003e\u003c\/path\u003e\u003cpath d=\"M 33.4,44.6 L 42.5,54.2\"\u003e\u003c\/path\u003e\u003cpath d=\"M 42.5,54.2 L 61.4,49.8\"\u003e\u003c\/path\u003e\u003cpath d=\"M 43.4,51.0 L 59.1,47.3\"\u003e\u003c\/path\u003e\u003cpath d=\"M 61.4,49.8 L 67.0,31.2\"\u003e\u003c\/path\u003e\u003cpath d=\"M 67.0,31.2 L 81.6,27.8\"\u003e\u003c\/path\u003e\u003cpath d=\"M 67.0,31.2 L 57.9,21.6\"\u003e\u003c\/path\u003e\u003cpath d=\"M 63.7,32.0 L 55.8,23.6\"\u003e\u003c\/path\u003e\u003cpath d=\"M 49.5,18.1 L 34.8,21.5\"\u003e\u003c\/path\u003e\u003cpath d=\"M 36.5,21.1 L 26.8,10.9\"\u003e\u003c\/path\u003e\u003cpath d=\"M 34.3,23.1 L 24.7,12.9\"\u003e\u003c\/path\u003e\u003cpath d=\"M 34.8,21.5 L 30.5,35.8\"\u003e\u003c\/path\u003e\u003cpath d=\"M 42.0,53.7 L 42.5,54.2 L 43.4,54.0\"\u003e\u003c\/path\u003e\u003cpath d=\"M 60.4,50.0 L 61.4,49.8 L 61.6,48.9\"\u003e\u003c\/path\u003e\u003cpath d=\"M 35.6,21.3 L 34.8,21.5 L 34.6,22.2\"\u003e\u003c\/path\u003e\u003ctext x=\"6.7\" y=\"50.5\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eR\u003c\/text\u003e\u003ctext x=\"25.6\" y=\"46.1\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eN\u003c\/text\u003e\u003ctext x=\"82.3\" y=\"32.8\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eN\u003c\/text\u003e\u003ctext x=\"90.6\" y=\"32.8\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eH\u003c\/text\u003e\u003ctext x=\"98.8\" y=\"37.6\" style=\"font:7px sans-serif;fill:#000;stroke:none\"\u003e2\u003c\/text\u003e\u003ctext x=\"50.1\" y=\"23.1\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eN\u003c\/text\u003e\u003ctext x=\"17.9\" y=\"13.3\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eO\u003c\/text\u003e\u003c\/svg\u003e\u003c\/div\u003e\n\u003cdiv style=\"display:flex;align-items:center;\"\u003e\u003cdiv style=\"display:flex;flex-direction:column;align-items:center;justify-content:center;min-width:90px;max-width:150px;padding:0 4px;text-align:center;font-size:12px;line-height:1.3;\"\u003e\n\u003cdiv\u003eHSO₃⁻, H⁺\u003c\/div\u003e\n\u003cdiv style=\"font-size:30px;line-height:1;\"\u003e⟶\u003c\/div\u003e\n\u003cdiv\u003e\u003c\/div\u003e\n\u003c\/div\u003e\u003c\/div\u003e\n\u003cdiv style=\"display:flex;align-items:center;\"\u003e\u003csvg role=\"img\" style=\"max-width:100%;height:auto;\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" fill=\"none\" stroke=\"#000\" stroke-width=\"1.6\" width=\"110px\" height=\"108px\" viewbox=\"0 0 110 108\"\u003e\u003cpath d=\"M 14.6,46.9 L 25.0,44.5\"\u003e\u003c\/path\u003e\u003cpath d=\"M 33.4,48.0 L 42.5,57.6\"\u003e\u003c\/path\u003e\u003cpath d=\"M 42.5,57.6 L 38.1,72.0\"\u003e\u003c\/path\u003e\u003cpath d=\"M 40.7,78.9 L 50.8,81.9\"\u003e\u003c\/path\u003e\u003cpath d=\"M 41.5,76.1 L 51.6,79.2\"\u003e\u003c\/path\u003e\u003cpath d=\"M 33.0,73.5 L 22.9,70.5\"\u003e\u003c\/path\u003e\u003cpath d=\"M 32.2,76.3 L 22.1,73.3\"\u003e\u003c\/path\u003e\u003cpath d=\"M 34.8,82.9 L 32.5,90.5\"\u003e\u003c\/path\u003e\u003cpath d=\"M 42.5,57.6 L 61.4,53.2\"\u003e\u003c\/path\u003e\u003cpath d=\"M 61.4,53.2 L 67.0,34.7\"\u003e\u003c\/path\u003e\u003cpath d=\"M 67.0,34.7 L 81.6,31.2\"\u003e\u003c\/path\u003e\u003cpath d=\"M 67.0,34.7 L 57.9,25.0\"\u003e\u003c\/path\u003e\u003cpath d=\"M 63.7,35.4 L 55.8,27.0\"\u003e\u003c\/path\u003e\u003cpath d=\"M 49.5,21.5 L 34.8,24.9\"\u003e\u003c\/path\u003e\u003cpath d=\"M 36.5,24.5 L 26.8,14.3\"\u003e\u003c\/path\u003e\u003cpath d=\"M 34.3,26.5 L 24.7,16.3\"\u003e\u003c\/path\u003e\u003cpath d=\"M 34.8,24.9 L 30.5,39.3\"\u003e\u003c\/path\u003e\u003cpath d=\"M 60.4,53.4 L 61.4,53.2 L 61.6,52.3\"\u003e\u003c\/path\u003e\u003cpath d=\"M 35.6,24.8 L 34.8,24.9 L 34.6,25.6\"\u003e\u003c\/path\u003e\u003ctext x=\"6.7\" y=\"53.9\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eR\u003c\/text\u003e\u003ctext x=\"25.6\" y=\"49.5\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eN\u003c\/text\u003e\u003ctext x=\"33.3\" y=\"82.2\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eS\u003c\/text\u003e\u003ctext x=\"51.8\" y=\"87.8\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eO\u003c\/text\u003e\u003ctext x=\"14.7\" y=\"76.6\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eO\u003c\/text\u003e\u003ctext x=\"27.6\" y=\"100.8\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eO\u003c\/text\u003e\u003ctext x=\"35.9\" y=\"96.0\" style=\"font:7px sans-serif;fill:#000;stroke:none\"\u003e-\u003c\/text\u003e\u003ctext x=\"82.3\" y=\"36.2\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eN\u003c\/text\u003e\u003ctext x=\"90.6\" y=\"36.2\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eH\u003c\/text\u003e\u003ctext x=\"98.8\" y=\"41.0\" style=\"font:7px sans-serif;fill:#000;stroke:none\"\u003e2\u003c\/text\u003e\u003ctext x=\"50.1\" y=\"26.5\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eN\u003c\/text\u003e\u003ctext x=\"17.9\" y=\"16.8\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eO\u003c\/text\u003e\u003c\/svg\u003e\u003c\/div\u003e\n\u003cdiv style=\"display:flex;align-items:center;\"\u003e\u003cdiv style=\"display:flex;flex-direction:column;align-items:center;justify-content:center;min-width:90px;max-width:150px;padding:0 4px;text-align:center;font-size:12px;line-height:1.3;\"\u003e\n\u003cdiv\u003edeamination\u003c\/div\u003e\n\u003cdiv style=\"font-size:30px;line-height:1;\"\u003e⟶\u003c\/div\u003e\n\u003cdiv\u003e\u003c\/div\u003e\n\u003c\/div\u003e\u003c\/div\u003e\n\u003cdiv style=\"display:flex;align-items:center;\"\u003e\u003csvg role=\"img\" style=\"max-width:100%;height:auto;\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" fill=\"none\" stroke=\"#000\" stroke-width=\"1.6\" width=\"95px\" height=\"109px\" viewbox=\"0 0 95 109\"\u003e\u003cpath d=\"M 13.7,47.4 L 24.1,45.0\"\u003e\u003c\/path\u003e\u003cpath d=\"M 32.6,48.5 L 41.6,58.1\"\u003e\u003c\/path\u003e\u003cpath d=\"M 41.6,58.1 L 37.2,72.4\"\u003e\u003c\/path\u003e\u003cpath d=\"M 39.8,79.4 L 49.9,82.4\"\u003e\u003c\/path\u003e\u003cpath d=\"M 40.6,76.6 L 50.7,79.6\"\u003e\u003c\/path\u003e\u003cpath d=\"M 32.1,74.0 L 22.1,71.0\"\u003e\u003c\/path\u003e\u003cpath d=\"M 31.3,76.8 L 21.2,73.7\"\u003e\u003c\/path\u003e\u003cpath d=\"M 34.0,83.3 L 31.6,91.0\"\u003e\u003c\/path\u003e\u003cpath d=\"M 41.6,58.1 L 60.5,53.7\"\u003e\u003c\/path\u003e\u003cpath d=\"M 60.5,53.7 L 66.1,35.1\"\u003e\u003c\/path\u003e\u003cpath d=\"M 65.6,36.7 L 81.1,33.1\"\u003e\u003c\/path\u003e\u003cpath d=\"M 64.9,33.9 L 80.4,30.3\"\u003e\u003c\/path\u003e\u003cpath d=\"M 66.1,35.1 L 57.1,25.5\"\u003e\u003c\/path\u003e\u003cpath d=\"M 48.6,22.0 L 33.9,25.4\"\u003e\u003c\/path\u003e\u003cpath d=\"M 35.6,25.0 L 26.0,14.8\"\u003e\u003c\/path\u003e\u003cpath d=\"M 33.4,27.0 L 23.8,16.8\"\u003e\u003c\/path\u003e\u003cpath d=\"M 33.9,25.4 L 29.6,39.7\"\u003e\u003c\/path\u003e\u003cpath d=\"M 59.5,53.9 L 60.5,53.7 L 60.8,52.8\"\u003e\u003c\/path\u003e\u003cpath d=\"M 65.8,36.1 L 66.1,35.1 L 65.6,34.7\"\u003e\u003c\/path\u003e\u003cpath d=\"M 34.7,25.2 L 33.9,25.4 L 33.7,26.1\"\u003e\u003c\/path\u003e\u003ctext x=\"5.8\" y=\"54.4\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eR\u003c\/text\u003e\u003ctext x=\"24.7\" y=\"50.0\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eN\u003c\/text\u003e\u003ctext x=\"32.4\" y=\"82.7\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eS\u003c\/text\u003e\u003ctext x=\"50.9\" y=\"88.3\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eO\u003c\/text\u003e\u003ctext x=\"13.8\" y=\"77.1\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eO\u003c\/text\u003e\u003ctext x=\"26.7\" y=\"101.3\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eO\u003c\/text\u003e\u003ctext x=\"35.0\" y=\"96.5\" style=\"font:7px sans-serif;fill:#000;stroke:none\"\u003e-\u003c\/text\u003e\u003ctext x=\"81.4\" y=\"36.7\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eO\u003c\/text\u003e\u003ctext x=\"49.2\" y=\"27.0\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eN\u003c\/text\u003e\u003ctext x=\"49.2\" y=\"16.4\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eH\u003c\/text\u003e\u003ctext x=\"17.1\" y=\"17.3\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eO\u003c\/text\u003e\u003c\/svg\u003e\u003c\/div\u003e\n\u003cdiv style=\"display:flex;align-items:center;\"\u003e\u003cdiv style=\"display:flex;flex-direction:column;align-items:center;justify-content:center;min-width:90px;max-width:150px;padding:0 4px;text-align:center;font-size:12px;line-height:1.3;\"\u003e\n\u003cdiv\u003ebase\u003c\/div\u003e\n\u003cdiv style=\"font-size:30px;line-height:1;\"\u003e⟶\u003c\/div\u003e\n\u003cdiv\u003eβ-elimination\u003c\/div\u003e\n\u003c\/div\u003e\u003c\/div\u003e\n\u003cdiv style=\"display:flex;align-items:center;\"\u003e\u003csvg role=\"img\" style=\"max-width:100%;height:auto;\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" fill=\"none\" stroke=\"#000\" stroke-width=\"1.6\" width=\"95px\" height=\"59px\" viewbox=\"0 0 95 59\"\u003e\u003cpath d=\"M 13.9,43.9 L 24.2,41.5\"\u003e\u003c\/path\u003e\u003cpath d=\"M 32.7,45.0 L 41.6,54.6\"\u003e\u003c\/path\u003e\u003cpath d=\"M 41.6,54.6 L 60.4,50.2\"\u003e\u003c\/path\u003e\u003cpath d=\"M 42.6,51.4 L 58.1,47.8\"\u003e\u003c\/path\u003e\u003cpath d=\"M 60.4,50.2 L 66.0,31.7\"\u003e\u003c\/path\u003e\u003cpath d=\"M 65.5,33.3 L 80.9,29.7\"\u003e\u003c\/path\u003e\u003cpath d=\"M 64.8,30.5 L 80.2,26.9\"\u003e\u003c\/path\u003e\u003cpath d=\"M 66.0,31.7 L 57.0,22.2\"\u003e\u003c\/path\u003e\u003cpath d=\"M 48.5,18.6 L 34.0,22.1\"\u003e\u003c\/path\u003e\u003cpath d=\"M 35.6,21.7 L 26.1,11.5\"\u003e\u003c\/path\u003e\u003cpath d=\"M 33.5,23.7 L 24.0,13.5\"\u003e\u003c\/path\u003e\u003cpath d=\"M 34.0,22.1 L 29.7,36.3\"\u003e\u003c\/path\u003e\u003cpath d=\"M 41.2,54.1 L 41.6,54.6 L 42.6,54.4\"\u003e\u003c\/path\u003e\u003cpath d=\"M 59.5,50.4 L 60.4,50.2 L 60.7,49.3\"\u003e\u003c\/path\u003e\u003cpath d=\"M 65.7,32.7 L 66.0,31.7 L 65.5,31.2\"\u003e\u003c\/path\u003e\u003cpath d=\"M 34.7,21.9 L 34.0,22.1 L 33.8,22.8\"\u003e\u003c\/path\u003e\u003ctext x=\"6.0\" y=\"50.9\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eR\u003c\/text\u003e\u003ctext x=\"24.8\" y=\"46.5\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eN\u003c\/text\u003e\u003ctext x=\"81.2\" y=\"33.3\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eO\u003c\/text\u003e\u003ctext x=\"49.2\" y=\"23.7\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eN\u003c\/text\u003e\u003ctext x=\"49.2\" y=\"13.1\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eH\u003c\/text\u003e\u003ctext x=\"17.2\" y=\"14.0\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eO\u003c\/text\u003e\u003c\/svg\u003e\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cp style=\"font-size:12px;margin:4px 0 0 0;\"\u003e\u003cem\u003eBisulfite-mediated deamination of a cytidine residue to a uridine residue (R = ribose of the RNA). At acidic pH, bisulfite adds at C6 to give 5,6-dihydrocytosine-6-sulfonate, deamination gives 5,6-dihydrouracil-6-sulfonate, and β-elimination under basic conditions restores the 5,6-double bond. The reaction is selective for cytidine over 5-methylcytidine.\u003c\/em\u003e\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cp\u003e\u003cstrong\u003eOxidation to 5-hydroxymethylcytidine.\u003c\/strong\u003e In one study, the catalytic domain of Tet1, one of the Tet enzymes that oxidise 5-methylcytosine in DNA, converted 5-methylcytidine in a single-stranded RNA to 5-hydroxymethylcytidine in vitro. Overexpressing the catalytic domains of the three Tet enzymes in human cells raised the level of 5-hydroxymethylcytidine in their RNA. In another study, isotope-tracing experiments showed that 5-methylcytidine is oxidised in mammals to 5-hydroxymethylcytidine and 5-formylcytidine. The same study found 5-hydroxymethylcytidine in total RNA from bacteria, archaea and eukaryotes.\u003c\/p\u003e\n\u003cdiv style=\"margin:8px 0 18px 0;\"\u003e\n\u003cdiv style=\"display:flex;flex-wrap:wrap;align-items:center;justify-content:flex-start;gap:2px;\"\u003e\n\u003cdiv style=\"display:flex;align-items:center;\"\u003e\u003csvg role=\"img\" style=\"max-width:100%;height:auto;\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" fill=\"none\" stroke=\"#000\" stroke-width=\"1.6\" width=\"167px\" height=\"105px\" viewbox=\"0 0 167 105\"\u003e\u003cpath d=\"M 26.4,49.1 L 43.3,39.3\"\u003e\u003c\/path\u003e\u003cpath d=\"M 43.3,39.3 L 60.2,49.1\"\u003e\u003c\/path\u003e\u003cpath d=\"M 46.2,37.6 L 60.2,45.7\"\u003e\u003c\/path\u003e\u003cpath d=\"M 60.2,49.1 L 72.9,41.8\"\u003e\u003c\/path\u003e\u003cpath d=\"M 77.1,35.1 L 77.1,19.8\"\u003e\u003c\/path\u003e\u003cpath d=\"M 77.1,21.5 L 90.5,13.8\"\u003e\u003c\/path\u003e\u003cpath d=\"M 75.6,19.0 L 89.0,11.2\"\u003e\u003c\/path\u003e\u003cpath d=\"M 77.1,19.8 L 64.4,12.5\"\u003e\u003c\/path\u003e\u003cpath d=\"M 56.0,12.5 L 43.3,19.8\"\u003e\u003c\/path\u003e\u003cpath d=\"M 57.4,15.0 L 46.2,21.5\"\u003e\u003c\/path\u003e\u003cpath d=\"M 43.3,19.8 L 30.7,12.5\"\u003e\u003c\/path\u003e\u003cpath d=\"M 94.0,49.1 L 81.3,43.4 L 82.7,40.9 Z\"\u003e\u003c\/path\u003e\u003cpath d=\"M 94.0,49.1 L 111.7,41.2\"\u003e\u003c\/path\u003e\u003cpath d=\"M 111.7,41.2 L 124.7,55.6\"\u003e\u003c\/path\u003e\u003cpath d=\"M 124.7,55.6 L 115.0,72.4\"\u003e\u003c\/path\u003e\u003cpath d=\"M 115.0,72.4 L 100.3,69.3\"\u003e\u003c\/path\u003e\u003cpath d=\"M 115.0,72.4 L 124.6,90.3 L 121.3,90.0 Z\"\u003e\u003c\/path\u003e\u003cpath d=\"M 121.3,90.0 L 137.9,91.7\"\u003e\u003c\/path\u003e\u003cpath d=\"M 127.5,55.0 L 127.6,55.6\"\u003e\u003c\/path\u003e\u003cpath d=\"M 130.4,54.4 L 130.5,55.6\"\u003e\u003c\/path\u003e\u003cpath d=\"M 133.3,53.8 L 133.4,55.6\"\u003e\u003c\/path\u003e\u003cpath d=\"M 136.1,53.2 L 136.3,55.5\"\u003e\u003c\/path\u003e\u003cpath d=\"M 139.0,52.6 L 139.3,55.5\"\u003e\u003c\/path\u003e\u003cpath d=\"M 112.0,38.2 L 112.7,38.3\"\u003e\u003c\/path\u003e\u003cpath d=\"M 112.2,35.2 L 113.7,35.5\"\u003e\u003c\/path\u003e\u003cpath d=\"M 112.5,32.2 L 114.7,32.6\"\u003e\u003c\/path\u003e\u003cpath d=\"M 112.8,29.2 L 115.6,29.8\"\u003e\u003c\/path\u003e\u003cpath d=\"M 43.3,19.8 L 43.3,39.3\"\u003e\u003c\/path\u003e\u003cpath d=\"M 95.6,64.1 L 94.0,49.1\"\u003e\u003c\/path\u003e\u003cpath d=\"M 59.4,48.6 L 60.2,49.1 L 60.8,48.7\"\u003e\u003c\/path\u003e\u003cpath d=\"M 77.1,20.6 L 77.1,19.8 L 76.5,19.4\"\u003e\u003c\/path\u003e\u003cpath d=\"M 94.9,48.7 L 94.0,49.1 L 94.1,49.8\"\u003e\u003c\/path\u003e\u003cpath d=\"M 110.8,41.6 L 111.7,41.2 L 112.4,41.9\"\u003e\u003c\/path\u003e\u003cpath d=\"M 124.0,54.9 L 124.7,55.6 L 124.2,56.4\"\u003e\u003c\/path\u003e\u003cpath d=\"M 115.5,71.6 L 115.0,72.4 L 114.3,72.2\"\u003e\u003c\/path\u003e\u003ctext x=\"73.5\" y=\"45.3\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eN\u003c\/text\u003e\u003ctext x=\"90.4\" y=\"16.0\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eO\u003c\/text\u003e\u003ctext x=\"56.6\" y=\"16.0\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eN\u003c\/text\u003e\u003ctext x=\"10.7\" y=\"16.0\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eH\u003c\/text\u003e\u003ctext x=\"19.0\" y=\"20.8\" style=\"font:7px sans-serif;fill:#000;stroke:none\"\u003e2\u003c\/text\u003e\u003ctext x=\"22.8\" y=\"16.0\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eN\u003c\/text\u003e\u003ctext x=\"92.4\" y=\"74.4\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eO\u003c\/text\u003e\u003ctext x=\"138.6\" y=\"98.2\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eO\u003c\/text\u003e\u003ctext x=\"146.9\" y=\"98.2\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eH\u003c\/text\u003e\u003ctext x=\"140.4\" y=\"59.6\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eO\u003c\/text\u003e\u003ctext x=\"148.7\" y=\"59.6\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eH\u003c\/text\u003e\u003ctext x=\"112.2\" y=\"28.2\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eO\u003c\/text\u003e\u003ctext x=\"120.4\" y=\"28.2\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eH\u003c\/text\u003e\u003c\/svg\u003e\u003c\/div\u003e\n\u003cdiv style=\"display:flex;align-items:center;\"\u003e\u003cdiv style=\"display:flex;flex-direction:column;align-items:center;justify-content:center;min-width:90px;max-width:150px;padding:0 4px;text-align:center;font-size:12px;line-height:1.3;\"\u003e\n\u003cdiv\u003eTet1 catalytic domain\u003c\/div\u003e\n\u003cdiv style=\"font-size:30px;line-height:1;\"\u003e⟶\u003c\/div\u003e\n\u003cdiv\u003e(in RNA, in vitro)\u003c\/div\u003e\n\u003c\/div\u003e\u003c\/div\u003e\n\u003cdiv style=\"display:flex;align-items:center;\"\u003e\u003csvg role=\"img\" style=\"max-width:100%;height:auto;\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" fill=\"none\" stroke=\"#000\" stroke-width=\"1.6\" width=\"181px\" height=\"105px\" viewbox=\"0 0 181 105\"\u003e\u003cpath d=\"M 73.7,49.1 L 56.8,39.3\"\u003e\u003c\/path\u003e\u003cpath d=\"M 73.7,45.7 L 59.7,37.6\"\u003e\u003c\/path\u003e\u003cpath d=\"M 56.8,39.3 L 56.8,19.8\"\u003e\u003c\/path\u003e\u003cpath d=\"M 56.8,19.8 L 69.5,12.5\"\u003e\u003c\/path\u003e\u003cpath d=\"M 59.7,21.5 L 70.9,15.0\"\u003e\u003c\/path\u003e\u003cpath d=\"M 78.0,12.5 L 90.6,19.8\"\u003e\u003c\/path\u003e\u003cpath d=\"M 90.6,21.5 L 104.0,13.8\"\u003e\u003c\/path\u003e\u003cpath d=\"M 89.2,19.0 L 102.5,11.2\"\u003e\u003c\/path\u003e\u003cpath d=\"M 90.6,19.8 L 90.6,35.1\"\u003e\u003c\/path\u003e\u003cpath d=\"M 107.5,49.1 L 94.8,43.4 L 96.2,40.9 Z\"\u003e\u003c\/path\u003e\u003cpath d=\"M 107.5,49.1 L 125.2,41.2\"\u003e\u003c\/path\u003e\u003cpath d=\"M 125.2,41.2 L 138.2,55.6\"\u003e\u003c\/path\u003e\u003cpath d=\"M 138.2,55.6 L 128.5,72.4\"\u003e\u003c\/path\u003e\u003cpath d=\"M 128.5,72.4 L 113.8,69.3\"\u003e\u003c\/path\u003e\u003cpath d=\"M 128.5,72.4 L 138.2,90.3 L 134.8,90.0 Z\"\u003e\u003c\/path\u003e\u003cpath d=\"M 134.8,90.0 L 151.5,91.7\"\u003e\u003c\/path\u003e\u003cpath d=\"M 141.1,55.0 L 141.1,55.6\"\u003e\u003c\/path\u003e\u003cpath d=\"M 143.9,54.4 L 144.0,55.6\"\u003e\u003c\/path\u003e\u003cpath d=\"M 146.8,53.8 L 147.0,55.6\"\u003e\u003c\/path\u003e\u003cpath d=\"M 149.6,53.2 L 149.9,55.5\"\u003e\u003c\/path\u003e\u003cpath d=\"M 152.5,52.6 L 152.8,55.5\"\u003e\u003c\/path\u003e\u003cpath d=\"M 125.5,38.2 L 126.2,38.3\"\u003e\u003c\/path\u003e\u003cpath d=\"M 125.8,35.2 L 127.2,35.5\"\u003e\u003c\/path\u003e\u003cpath d=\"M 126.0,32.2 L 128.2,32.6\"\u003e\u003c\/path\u003e\u003cpath d=\"M 126.3,29.2 L 129.2,29.8\"\u003e\u003c\/path\u003e\u003cpath d=\"M 56.8,19.8 L 44.2,12.5\"\u003e\u003c\/path\u003e\u003cpath d=\"M 56.8,39.3 L 39.9,49.1\"\u003e\u003c\/path\u003e\u003cpath d=\"M 39.9,49.1 L 27.4,41.8\"\u003e\u003c\/path\u003e\u003cpath d=\"M 86.4,41.8 L 73.7,49.1\"\u003e\u003c\/path\u003e\u003cpath d=\"M 109.1,64.1 L 107.5,49.1\"\u003e\u003c\/path\u003e\u003cpath d=\"M 72.9,48.6 L 73.7,49.1 L 74.4,48.7\"\u003e\u003c\/path\u003e\u003cpath d=\"M 90.0,19.4 L 90.6,19.8 L 90.6,20.6\"\u003e\u003c\/path\u003e\u003cpath d=\"M 108.4,48.7 L 107.5,49.1 L 107.6,49.8\"\u003e\u003c\/path\u003e\u003cpath d=\"M 124.4,41.6 L 125.2,41.2 L 125.9,41.9\"\u003e\u003c\/path\u003e\u003cpath d=\"M 137.6,54.9 L 138.2,55.6 L 137.7,56.4\"\u003e\u003c\/path\u003e\u003cpath d=\"M 129.0,71.6 L 128.5,72.4 L 127.8,72.2\"\u003e\u003c\/path\u003e\u003cpath d=\"M 40.8,48.6 L 39.9,49.1 L 39.3,48.7\"\u003e\u003c\/path\u003e\u003ctext x=\"70.1\" y=\"16.0\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eN\u003c\/text\u003e\u003ctext x=\"103.9\" y=\"16.0\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eO\u003c\/text\u003e\u003ctext x=\"87.0\" y=\"45.3\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eN\u003c\/text\u003e\u003ctext x=\"105.9\" y=\"74.4\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eO\u003c\/text\u003e\u003ctext x=\"152.1\" y=\"98.2\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eO\u003c\/text\u003e\u003ctext x=\"160.4\" y=\"98.2\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eH\u003c\/text\u003e\u003ctext x=\"153.9\" y=\"59.6\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eO\u003c\/text\u003e\u003ctext x=\"162.2\" y=\"59.6\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eH\u003c\/text\u003e\u003ctext x=\"125.7\" y=\"28.2\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eO\u003c\/text\u003e\u003ctext x=\"134.0\" y=\"28.2\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eH\u003c\/text\u003e\u003ctext x=\"24.2\" y=\"16.0\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eH\u003c\/text\u003e\u003ctext x=\"32.5\" y=\"20.8\" style=\"font:7px sans-serif;fill:#000;stroke:none\"\u003e2\u003c\/text\u003e\u003ctext x=\"36.3\" y=\"16.0\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eN\u003c\/text\u003e\u003ctext x=\"11.8\" y=\"45.4\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eH\u003c\/text\u003e\u003ctext x=\"19.5\" y=\"45.4\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eO\u003c\/text\u003e\u003c\/svg\u003e\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cp style=\"font-size:12px;margin:4px 0 0 0;\"\u003e\u003cem\u003eOxidation of a 5-methylcytidine residue (m\u003csup\u003e5\u003c\/sup\u003eC, left) to a 5-hydroxymethylcytidine residue (right) in RNA, shown in one study with the catalytic domain of Tet1 in vitro. The structures are drawn as nucleosides.\u003c\/em\u003e\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cp\u003e\u003cstrong\u003eModified mRNA.\u003c\/strong\u003e In one study, RNA made by in vitro transcription with 5-methylcytidine no longer stimulated the RNA sensors TLR7 and TLR8 in cell lines that express these receptors. For TLR3, the suppression was less marked than with some other modifications, or absent. This RNA still activated primary dendritic cells from blood as strongly as unmodified RNA. In work on reprogramming human cells with synthetic mRNA, complete replacement of cytidine by 5-methylcytidine in GFP-encoding transcripts improved cell viability and increased protein expression. The largest improvement came when 5-methylcytidine was combined with pseudouridine in place of uridine. These transcripts were made with 5-methylcytidine triphosphate. In a later study, mRNA carrying 5-methylcytidine together with N1-methylpseudouridine, another replacement for uridine, gave higher reporter protein expression than mRNA carrying 5-methylcytidine with pseudouridine. In transfected cells, this mRNA also caused less innate immune activation and gave better cell viability.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eAnalytical standard.\u003c\/strong\u003e Synthetic 5-methylcytidine has been used, together with other nucleosides, to prepare calibration solutions for the quantification of RNA modifications by LC-MS\/MS.\u003c\/p\u003e\n\u003c\/div\u003e\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cdiv style=\"margin-bottom: 28px;\"\u003e\n\u003cdiv style=\"background: #002147; padding: 10px 20px; margin-bottom: 0;\"\u003e\u003ch3 style=\"margin: 0; font-family: 'Helvetica Neue', Helvetica, Arial, sans-serif; font-size: 0.70em; font-weight: bold; letter-spacing: 0.12em; text-transform: uppercase; color: #fff;\"\u003eShipping Destinations\u003c\/h3\u003e\u003c\/div\u003e\n\u003cdiv style=\"border: 1px solid #e4e8f0; border-top: none; padding: 12px 16px; font-family: 'Helvetica Neue', Helvetica, Arial, sans-serif; font-size: 0.95em;\"\u003e\u003cul style=\"margin: 0; padding: 0; list-style: none;\"\u003e\n\u003cli style=\"padding: 5px 0; border-bottom: 1px solid #f0f0f0;\"\u003e\n\u003cspan style=\"display: inline-block; width: 7px; height: 7px; background: #002147; border-radius: 50%; margin-right: 10px; vertical-align: middle;\"\u003e\u003c\/span\u003eEU \u0026amp; UK: Priority delivery, 2–5 business days.\u003c\/li\u003e\n\u003cli style=\"padding: 5px 0; border-bottom: 1px solid #f0f0f0;\"\u003e\n\u003cspan style=\"display: inline-block; width: 7px; height: 7px; background: #002147; border-radius: 50%; margin-right: 10px; vertical-align: middle;\"\u003e\u003c\/span\u003eUnited States (DDP): 3–7 business days, duties and taxes prepaid.\u003c\/li\u003e\n\u003cli style=\"padding: 5px 0; border-bottom: 1px solid #f0f0f0;\"\u003e\n\u003cspan style=\"display: inline-block; width: 7px; height: 7px; background: #002147; border-radius: 50%; margin-right: 10px; vertical-align: middle;\"\u003e\u003c\/span\u003eEFTA Countries (DDP): 3–7 business days, duties and taxes prepaid.\u003c\/li\u003e\n\u003cli style=\"padding: 5px 0; border-bottom: 1px solid #f0f0f0;\"\u003e\n\u003cspan style=\"display: inline-block; width: 7px; height: 7px; background: #002147; border-radius: 50%; margin-right: 10px; vertical-align: middle;\"\u003e\u003c\/span\u003eWorldwide: 7–14 business days, selected locations.\u003c\/li\u003e\n\u003c\/ul\u003e\u003c\/div\u003e\n\u003c\/div\u003e","brand":"NorrChemica™","offers":[{"title":"1.0 g","offer_id":55166998741329,"sku":"NOR-2140616-1g","price":57.2,"currency_code":"EUR","in_stock":true},{"title":"2.0 g","offer_id":55358036050257,"sku":"NOR-2140616-2g","price":98.2,"currency_code":"EUR","in_stock":true},{"title":"5.0 g","offer_id":55259039007057,"sku":"NOR-2140616-5g","price":169.2,"currency_code":"EUR","in_stock":true},{"title":"10 g","offer_id":55166998774097,"sku":"NOR-2140616-10g","price":279.2,"currency_code":"EUR","in_stock":true},{"title":"25 g","offer_id":55166998806865,"sku":"NOR-2140616-25g","price":629.2,"currency_code":"EUR","in_stock":true},{"title":"50 g","offer_id":55259039039825,"sku":"NOR-2140616-50g","price":1149.0,"currency_code":"EUR","in_stock":true},{"title":"100 g","offer_id":55166998839633,"sku":"NOR-2140616-100g","price":1895.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0954\/6357\/1793\/files\/5-Methylcytidine.png?v=1791725125"},{"product_id":"2-thiouracil-cas-141-90-2","title":"2-Thiouracil | CAS 141-90-2 | ≥97%","description":"\u003cdiv style=\"margin-bottom: 28px;\"\u003e\n\u003cdiv style=\"background: #002147; padding: 10px 20px; margin-bottom: 0;\"\u003e\n\u003ch3 style=\"margin: 0; font-family: 'Helvetica Neue', Helvetica, Arial, sans-serif; font-size: 0.70em; font-weight: bold; letter-spacing: 0.12em; text-transform: uppercase; color: #fff;\"\u003eTechnical Specifications\u003c\/h3\u003e\n\u003c\/div\u003e\n\u003ctable style=\"width: 100%; border-collapse: collapse; font-size: 0.95em; border: 1px solid #e4e8f0; border-top: none; font-family: 'Helvetica Neue', Helvetica, Arial, sans-serif;\"\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eCAS Number\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e141-90-2\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eEC \/ EINECS Number\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e205-508-8\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eMDL Number\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003eMFCD00006039\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eRTECS Number\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003eYR1575000\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eSMILES\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0; word-break: break-all;\"\u003eC1=CNC(=S)NC1=O\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eInChI\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0; word-break: break-all;\"\u003eInChI=1S\/C4H4N2OS\/c7-3-1-2-5-4(8)6-3\/h1-2H,(H2,5,6,7,8)\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eInChIKey\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0; word-break: break-all;\"\u003eZEMGGZBWXRYJHK-UHFFFAOYSA-N\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003ePubChem CID\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e1269845\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eMolecular Formula\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003eC₄H₄N₂OS\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eMolecular Weight\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e128.15 g\/mol\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eMelting Point\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e\u0026gt;300 °C (dec.)\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eSolubility\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003eSoluble in aqueous alkaline solutions, including 1 M sodium hydroxide. Sparingly soluble in water and alcohol. Insoluble in ether and acids\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003ePurity\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e≥97%\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003ePhysical Form\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003eWhite to light yellow crystalline powder\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eHS Code\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e2933.59\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eShelf Life\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003eRetest period: 36 months from date of manufacture\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eStorage Conditions\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333;\"\u003eStore at room temperature in a tightly sealed container, protected from light and moisture\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003c\/div\u003e\n\u003cdiv style=\"margin-bottom: 28px;\"\u003e\n\u003cdiv style=\"background: #002147; padding: 10px 20px; margin-bottom: 0;\"\u003e\n\u003ch3 style=\"margin: 0; font-family: 'Helvetica Neue', Helvetica, Arial, sans-serif; font-size: 0.70em; font-weight: bold; letter-spacing: 0.12em; text-transform: uppercase; color: #fff;\"\u003eProduct Description \u0026amp; Scientific Applications\u003c\/h3\u003e\n\u003c\/div\u003e\n\u003cdiv style=\"padding: 16px 20px; border: 1px solid #e4e8f0; border-top: none; font-family: Georgia, 'Times New Roman', serif; font-size: 0.95em; line-height: 1.65; color: #333;\"\u003e\n\u003cdiv\u003e\n\u003cp\u003e\n\u003cstrong\u003e2-Thiouracil\u003c\/strong\u003e is a thio-derivative of uracil, a pyrimidine nucleobase. It is an established antithyroid drug and melanoma seeker.\u003c\/p\u003e\n\u003cp\u003e\n\u003cstrong\u003eThyroid peroxidase.\u003c\/strong\u003e In vitro, thiouracil irreversibly inactivated thyroid peroxidase when it was preincubated with the enzyme and hydrogen peroxide without iodide or another oxidisable substrate. Iodide or thiocyanate prevented this inactivation.\u003c\/p\u003e\n\u003cp\u003e\n\u003cstrong\u003eNeuronal nitric oxide synthase.\u003c\/strong\u003e In vitro, 2-thiouracil was found to inhibit neuronal nitric oxide synthase selectively and competitively, and it was inactive on the other NOS isoforms. It apparently interfered with substrate and tetrahydrobiopterin binding, and it antagonised tetrahydrobiopterin-induced dimerisation of the enzyme.\u003c\/p\u003e\n\u003cp\u003e\n\u003cstrong\u003eMelanin research.\u003c\/strong\u003e 2-Thiouracil is generally recognised as a highly specific melanoma seeker because it is selectively accumulated into active melanin-producing tissues. In vitro, it reacts with dopaquinone, an early intermediate in melanin biosynthesis, to give the addition product 6-\u003cem\u003eS\u003c\/em\u003e-thiouracildopa.\u003c\/p\u003e\n\u003cdiv style=\"margin:8px 0 18px 0;\"\u003e\n\u003cdiv style=\"display:flex;flex-wrap:wrap;align-items:center;justify-content:flex-start;gap:2px;\"\u003e\n\u003cdiv style=\"display:flex;align-items:center;\"\u003e\n\u003csvg fill=\"none\" stroke=\"#000\" stroke-width=\"1.6\" role=\"img\" style=\"max-width:100%;height:auto;\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"130px\" height=\"120px\" viewbox=\"0 0 130 120\"\u003e\n\u003cpath d=\"M 35.6,87.1 L 50.8,78.4\"\u003e\u003c\/path\u003e\n\u003cpath d=\"M 37.3,90 L 52.5,81.2\"\u003e\u003c\/path\u003e\n\u003cpath d=\"M 50.8,80.3 L 69.9,91.3\"\u003e\u003c\/path\u003e\n\u003cpath d=\"M 69.9,91.3 L 88.9,80.3\"\u003e\u003c\/path\u003e\n\u003cpath d=\"M 69.9,87.5 L 85.6,78.4\"\u003e\u003c\/path\u003e\n\u003cpath d=\"M 88.9,80.3 L 88.9,65.6\"\u003e\u003c\/path\u003e\n\u003cpath d=\"M 84.3,55.6 L 69.9,47.3\"\u003e\u003c\/path\u003e\n\u003cpath d=\"M 71.5,48.2 L 71.6,32.6\"\u003e\u003c\/path\u003e\n\u003cpath d=\"M 68.2,48.2 L 68.3,32.6\"\u003e\u003c\/path\u003e\n\u003cpath d=\"M 69.9,47.3 L 55.5,55.6\"\u003e\u003c\/path\u003e\n\u003cpath d=\"M 50.8,65.6 L 50.8,80.3\"\u003e\u003c\/path\u003e\n\u003cpath d=\"M 51.8,80.8 L 50.8,80.3 L 50.8,79.5\" stroke-miterlimit=\"10\"\u003e\u003c\/path\u003e\n\u003cpath d=\"M 68.9,90.7 L 69.9,91.3 L 70.8,90.7\" stroke-miterlimit=\"10\"\u003e\u003c\/path\u003e\n\u003cpath d=\"M 88,80.9 L 88.9,80.3 L 88.9,79.6\" stroke-miterlimit=\"10\"\u003e\u003c\/path\u003e\n\u003cpath d=\"M 70.6,47.7 L 69.9,47.3 L 69.2,47.7\" stroke-miterlimit=\"10\"\u003e\u003c\/path\u003e\n\u003ctext x=\"27.8\" y=\"97.9\" style=\"font:13px sans-serif\" stroke=\"none\" fill=\"#000\"\u003eO\u003c\/text\u003e\n\u003ctext x=\"85\" y=\"64.9\" style=\"font:13px sans-serif\" stroke=\"none\" fill=\"#000\"\u003eN\u003c\/text\u003e\n\u003ctext x=\"94.1\" y=\"64.9\" style=\"font:13px sans-serif\" stroke=\"none\" fill=\"#000\"\u003eH\u003c\/text\u003e\n\u003ctext x=\"66\" y=\"31.9\" style=\"font:13px sans-serif\" stroke=\"none\" fill=\"#000\"\u003eS\u003c\/text\u003e\n\u003ctext x=\"37.8\" y=\"64.9\" style=\"font:13px sans-serif\" stroke=\"none\" fill=\"#000\"\u003eH\u003c\/text\u003e\n\u003ctext x=\"46.9\" y=\"64.9\" style=\"font:13px sans-serif\" stroke=\"none\" fill=\"#000\"\u003eN\u003c\/text\u003e\n\u003c\/svg\u003e\n\u003c\/div\u003e\n\u003cdiv style=\"display:flex;align-items:center;\"\u003e\n\u003cdiv style=\"font-size:20px;padding:0 4px;align-self:center;\"\u003e+\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cdiv style=\"display:flex;align-items:center;\"\u003e\n\u003csvg fill=\"none\" stroke=\"#000\" stroke-width=\"1.6\" role=\"img\" style=\"max-width:100%;height:auto;\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"190px\" height=\"150px\" viewbox=\"0 0 190 150\"\u003e\n\u003cpath d=\"M 99.2,108 L 113,100.1\"\u003e\u003c\/path\u003e\n\u003cpath d=\"M 113,100.1 L 113,79\"\u003e\u003c\/path\u003e\n\u003cpath d=\"M 113,79 L 94.7,68.5\"\u003e\u003c\/path\u003e\n\u003cpath d=\"M 94.7,68.5 L 94.7,47.4\"\u003e\u003c\/path\u003e\n\u003cpath d=\"M 91.5,66.7 L 91.5,49.2\"\u003e\u003c\/path\u003e\n\u003cpath d=\"M 94.7,47.4 L 76.4,36.9\"\u003e\u003c\/path\u003e\n\u003cpath d=\"M 78,37.8 L 78,22.8\"\u003e\u003c\/path\u003e\n\u003cpath d=\"M 74.8,37.8 L 74.8,22.8\"\u003e\u003c\/path\u003e\n\u003cpath d=\"M 76.4,36.9 L 58.2,47.4\"\u003e\u003c\/path\u003e\n\u003cpath d=\"M 59.8,46.5 L 45.2,38.1\"\u003e\u003c\/path\u003e\n\u003cpath d=\"M 58.2,49.3 L 43.6,40.9\"\u003e\u003c\/path\u003e\n\u003cpath d=\"M 58.2,47.4 L 58.2,68.5\"\u003e\u003c\/path\u003e\n\u003cpath d=\"M 58.2,68.5 L 76.5,79\"\u003e\u003c\/path\u003e\n\u003cpath d=\"M 61.4,66.7 L 76.5,75.4\"\u003e\u003c\/path\u003e\n\u003cpath d=\"M 113,100.1 L 131.2,110.6\"\u003e\u003c\/path\u003e\n\u003cpath d=\"M 131.2,112.4 L 145.8,104\"\u003e\u003c\/path\u003e\n\u003cpath d=\"M 129.7,109.7 L 144.2,101.3\"\u003e\u003c\/path\u003e\n\u003cpath d=\"M 131.2,110.6 L 131.3,127.2\"\u003e\u003c\/path\u003e\n\u003cpath d=\"M 76.5,79 L 94.7,68.5\"\u003e\u003c\/path\u003e\n\u003cpath d=\"M 113,80.1 L 113,79 L 112,78.5\" stroke-miterlimit=\"10\"\u003e\u003c\/path\u003e\n\u003cpath d=\"M 94.7,48.5 L 94.7,47.4 L 93.8,46.9\" stroke-miterlimit=\"10\"\u003e\u003c\/path\u003e\n\u003cpath d=\"M 77.3,37.4 L 76.4,36.9 L 75.5,37.4\" stroke-miterlimit=\"10\"\u003e\u003c\/path\u003e\n\u003cpath d=\"M 59.1,46.9 L 58.2,47.4 L 58.2,48.5\" stroke-miterlimit=\"10\"\u003e\u003c\/path\u003e\n\u003cpath d=\"M 58.2,67.5 L 58.2,68.5 L 59.1,69\" stroke-miterlimit=\"10\"\u003e\u003c\/path\u003e\n\u003cpath d=\"M 75.5,78.5 L 76.5,79 L 77.4,78.5\" stroke-miterlimit=\"10\"\u003e\u003c\/path\u003e\n\u003cpath d=\"M 130.3,110.1 L 131.2,110.6 L 131.2,111.4\" stroke-miterlimit=\"10\"\u003e\u003c\/path\u003e\n\u003ctext x=\"78.2\" y=\"117\" style=\"font:12px sans-serif\" stroke=\"none\" fill=\"#000\"\u003eH\u003c\/text\u003e\n\u003ctext x=\"86.9\" y=\"122\" style=\"font:8px sans-serif\" stroke=\"none\" fill=\"#000\"\u003e2\u003c\/text\u003e\n\u003ctext x=\"90.9\" y=\"117\" style=\"font:12px sans-serif\" stroke=\"none\" fill=\"#000\"\u003eN\u003c\/text\u003e\n\u003ctext x=\"72.6\" y=\"22.1\" style=\"font:12px sans-serif\" stroke=\"none\" fill=\"#000\"\u003eO\u003c\/text\u003e\n\u003ctext x=\"36.1\" y=\"43.2\" style=\"font:12px sans-serif\" stroke=\"none\" fill=\"#000\"\u003eO\u003c\/text\u003e\n\u003ctext x=\"145.7\" y=\"106.4\" style=\"font:12px sans-serif\" stroke=\"none\" fill=\"#000\"\u003eO\u003c\/text\u003e\n\u003ctext x=\"127.5\" y=\"138\" style=\"font:12px sans-serif\" stroke=\"none\" fill=\"#000\"\u003eO\u003c\/text\u003e\n\u003ctext x=\"136.2\" y=\"138\" style=\"font:12px sans-serif\" stroke=\"none\" fill=\"#000\"\u003eH\u003c\/text\u003e\n\u003c\/svg\u003e\n\u003c\/div\u003e\n\u003cdiv style=\"display:flex;align-items:center;\"\u003e\n\u003cdiv style=\"display:flex;flex-direction:column;align-items:center;justify-content:center;min-width:90px;max-width:150px;padding:0 4px;text-align:center;font-size:12px;line-height:1.3;\"\u003e\n\u003cdiv\u003eaddition\u003c\/div\u003e\n\u003cdiv style=\"font-size:30px;line-height:1;\"\u003e⟶\u003c\/div\u003e\n\u003cdiv\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cdiv style=\"display:flex;align-items:center;\"\u003e\n\u003csvg fill=\"none\" stroke=\"#000\" stroke-width=\"1.6\" role=\"img\" style=\"max-width:100%;height:auto;\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"230px\" height=\"160px\" viewbox=\"0 0 230 160\"\u003e\n\u003cpath d=\"M 138.3,111.7 L 152.5,103.6\"\u003e\u003c\/path\u003e\n\u003cpath d=\"M 152.5,103.6 L 152.5,81.9\"\u003e\u003c\/path\u003e\n\u003cpath d=\"M 152.5,81.9 L 133.8,71\"\u003e\u003c\/path\u003e\n\u003cpath d=\"M 133.8,71 L 133.8,49.3\"\u003e\u003c\/path\u003e\n\u003cpath d=\"M 133.8,49.3 L 115,38.4\"\u003e\u003c\/path\u003e\n\u003cpath d=\"M 130.5,51.2 L 115,42.2\"\u003e\u003c\/path\u003e\n\u003cpath d=\"M 115,38.4 L 115.1,23.9\"\u003e\u003c\/path\u003e\n\u003cpath d=\"M 115,38.4 L 96.2,49.2\"\u003e\u003c\/path\u003e\n\u003cpath d=\"M 96.2,49.2 L 82.1,41\"\u003e\u003c\/path\u003e\n\u003cpath d=\"M 96.2,49.2 L 96.2,70.9\"\u003e\u003c\/path\u003e\n\u003cpath d=\"M 99.5,51.1 L 99.4,69\"\u003e\u003c\/path\u003e\n\u003cpath d=\"M 96.2,70.9 L 114.9,81.8\"\u003e\u003c\/path\u003e\n\u003cpath d=\"M 114.9,81.8 L 114.9,98.9\"\u003e\u003c\/path\u003e\n\u003cpath d=\"M 110.3,106.1 L 96.1,114.3\"\u003e\u003c\/path\u003e\n\u003cpath d=\"M 96.1,114.3 L 96.1,131.4\"\u003e\u003c\/path\u003e\n\u003cpath d=\"M 92.8,116.2 L 92.8,131.4\"\u003e\u003c\/path\u003e\n\u003cpath d=\"M 91.4,138.6 L 77.2,146.8\"\u003e\u003c\/path\u003e\n\u003cpath d=\"M 77.2,146.8 L 58.5,135.9\"\u003e\u003c\/path\u003e\n\u003cpath d=\"M 77.2,143 L 61.7,134\"\u003e\u003c\/path\u003e\n\u003cpath d=\"M 58.5,135.9 L 58.5,114.2\"\u003e\u003c\/path\u003e\n\u003cpath d=\"M 60.1,113.3 L 45.2,104.6\"\u003e\u003c\/path\u003e\n\u003cpath d=\"M 58.5,116.1 L 43.5,107.4\"\u003e\u003c\/path\u003e\n\u003cpath d=\"M 58.5,114.2 L 72.7,106.1\"\u003e\u003c\/path\u003e\n\u003cpath d=\"M 152.5,103.6 L 171.2,114.4\"\u003e\u003c\/path\u003e\n\u003cpath d=\"M 171.2,116.3 L 186.2,107.7\"\u003e\u003c\/path\u003e\n\u003cpath d=\"M 169.6,113.5 L 184.6,104.9\"\u003e\u003c\/path\u003e\n\u003cpath d=\"M 171.2,114.4 L 171.2,131.5\"\u003e\u003c\/path\u003e\n\u003cpath d=\"M 114.9,81.8 L 133.8,71\"\u003e\u003c\/path\u003e\n\u003cpath d=\"M 115,78 L 130.5,69.1\"\u003e\u003c\/path\u003e\n\u003cpath d=\"M 81.9,106.1 L 96.1,114.3\"\u003e\u003c\/path\u003e\n\u003cpath d=\"M 152.5,83 L 152.5,81.9 L 151.6,81.3\" stroke-miterlimit=\"10\"\u003e\u003c\/path\u003e\n\u003cpath d=\"M 133.8,50.4 L 133.8,49.3 L 132.9,48.7\" stroke-miterlimit=\"10\"\u003e\u003c\/path\u003e\n\u003cpath d=\"M 96.2,69.8 L 96.2,70.9 L 97.1,71.4\" stroke-miterlimit=\"10\"\u003e\u003c\/path\u003e\n\u003cpath d=\"M 77.9,146.4 L 77.2,146.8 L 76.3,146.3\" stroke-miterlimit=\"10\"\u003e\u003c\/path\u003e\n\u003cpath d=\"M 59.4,136.5 L 58.5,135.9 L 58.5,134.8\" stroke-miterlimit=\"10\"\u003e\u003c\/path\u003e\n\u003cpath d=\"M 58.5,115.3 L 58.5,114.2 L 59.2,113.8\" stroke-miterlimit=\"10\"\u003e\u003c\/path\u003e\n\u003cpath d=\"M 170.3,113.9 L 171.2,114.4 L 171.2,115.3\" stroke-miterlimit=\"10\"\u003e\u003c\/path\u003e\n\u003ctext x=\"116.6\" y=\"120.9\" style=\"font:13px sans-serif\" stroke=\"none\" fill=\"#000\"\u003eH\u003c\/text\u003e\n\u003ctext x=\"125.6\" y=\"126.1\" style=\"font:8px sans-serif\" stroke=\"none\" fill=\"#000\"\u003e2\u003c\/text\u003e\n\u003ctext x=\"129.8\" y=\"120.9\" style=\"font:13px sans-serif\" stroke=\"none\" fill=\"#000\"\u003eN\u003c\/text\u003e\n\u003ctext x=\"111.2\" y=\"23.2\" style=\"font:13px sans-serif\" stroke=\"none\" fill=\"#000\"\u003eO\u003c\/text\u003e\n\u003ctext x=\"120.2\" y=\"23.2\" style=\"font:13px sans-serif\" stroke=\"none\" fill=\"#000\"\u003eH\u003c\/text\u003e\n\u003ctext x=\"65.2\" y=\"44.8\" style=\"font:13px sans-serif\" stroke=\"none\" fill=\"#000\"\u003eH\u003c\/text\u003e\n\u003ctext x=\"73.6\" y=\"44.8\" style=\"font:13px sans-serif\" stroke=\"none\" fill=\"#000\"\u003eO\u003c\/text\u003e\n\u003ctext x=\"111\" y=\"110\" style=\"font:13px sans-serif\" stroke=\"none\" fill=\"#000\"\u003eS\u003c\/text\u003e\n\u003ctext x=\"92.1\" y=\"142.5\" style=\"font:13px sans-serif\" stroke=\"none\" fill=\"#000\"\u003eN\u003c\/text\u003e\n\u003ctext x=\"35.8\" y=\"109.8\" style=\"font:13px sans-serif\" stroke=\"none\" fill=\"#000\"\u003eO\u003c\/text\u003e\n\u003ctext x=\"73.4\" y=\"109.9\" style=\"font:13px sans-serif\" stroke=\"none\" fill=\"#000\"\u003eN\u003c\/text\u003e\n\u003ctext x=\"73.4\" y=\"98.5\" style=\"font:13px sans-serif\" stroke=\"none\" fill=\"#000\"\u003eH\u003c\/text\u003e\n\u003ctext x=\"186.2\" y=\"110.1\" style=\"font:13px sans-serif\" stroke=\"none\" fill=\"#000\"\u003eO\u003c\/text\u003e\n\u003ctext x=\"167.3\" y=\"142.6\" style=\"font:13px sans-serif\" stroke=\"none\" fill=\"#000\"\u003eO\u003c\/text\u003e\n\u003ctext x=\"176.3\" y=\"142.6\" style=\"font:13px sans-serif\" stroke=\"none\" fill=\"#000\"\u003eH\u003c\/text\u003e\n\u003c\/svg\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cp style=\"font-size:12px;margin:4px 0 0 0;\"\u003e\n\u003cem\u003eReaction (in vitro): 2-thiouracil + dopaquinone → 6-S-thiouracildopa.\u003c\/em\u003e\n\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cp\u003eIts proposed route into growing melanin is nucleophilic attack of the thioureylene group on quinonoid intermediates of the melanin pathway, chiefly dopaquinone and 5,6-indolequinones.\u003c\/p\u003e\n\u003cp\u003e\n\u003cstrong\u003eExcited-state dynamics.\u003c\/strong\u003e The ultrafast internal conversion and intersystem crossing dynamics of 2-thiouracil have been studied by time-resolved photoelectron spectroscopy. Like other thiobases, it populates the triplet manifold with high quantum yields through the lowest singlet excited state.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cdiv style=\"margin-bottom: 28px;\"\u003e\n\u003cdiv style=\"background: #002147; padding: 10px 20px; margin-bottom: 0;\"\u003e\n\u003ch3 style=\"margin: 0; font-family: 'Helvetica Neue', Helvetica, Arial, sans-serif; font-size: 0.70em; font-weight: bold; letter-spacing: 0.12em; text-transform: uppercase; color: #fff;\"\u003eShipping Destinations\u003c\/h3\u003e\n\u003c\/div\u003e\n\u003cdiv style=\"border: 1px solid #e4e8f0; border-top: none; padding: 12px 16px; font-family: 'Helvetica Neue', Helvetica, Arial, sans-serif; font-size: 0.95em;\"\u003e\n\u003cul style=\"margin: 0; padding: 0; list-style: none;\"\u003e\n\u003cli style=\"padding: 5px 0; border-bottom: 1px solid #f0f0f0;\"\u003e\n\u003cspan style=\"display: inline-block; width: 7px; height: 7px; background: #002147; border-radius: 50%; margin-right: 10px; vertical-align: middle;\"\u003e\n\u003c\/span\u003eEU \u0026amp; UK: Priority delivery, 2–5 business days.\u003c\/li\u003e\n\u003cli style=\"padding: 5px 0; border-bottom: 1px solid #f0f0f0;\"\u003e\n\u003cspan style=\"display: inline-block; width: 7px; height: 7px; background: #002147; border-radius: 50%; margin-right: 10px; vertical-align: middle;\"\u003e\n\u003c\/span\u003eUnited States (DDP): 3–7 business days, duties and taxes prepaid.\u003c\/li\u003e\n\u003cli style=\"padding: 5px 0; border-bottom: 1px solid #f0f0f0;\"\u003e\n\u003cspan style=\"display: inline-block; width: 7px; height: 7px; background: #002147; border-radius: 50%; margin-right: 10px; vertical-align: middle;\"\u003e\n\u003c\/span\u003eEFTA Countries (DDP): 3–7 business days, duties and taxes prepaid.\u003c\/li\u003e\n\u003cli style=\"padding: 5px 0; border-bottom: 1px solid #f0f0f0;\"\u003e\n\u003cspan style=\"display: inline-block; width: 7px; height: 7px; background: #002147; border-radius: 50%; margin-right: 10px; vertical-align: middle;\"\u003e\n\u003c\/span\u003eWorldwide: 7–14 business days, selected locations.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e","brand":"NorrChemica™","offers":[{"title":"5.0 g","offer_id":55257352175953,"sku":"NOR-141902-5g","price":39.9,"currency_code":"EUR","in_stock":true},{"title":"10 g","offer_id":55257352208721,"sku":"NOR-141902-10g","price":49.2,"currency_code":"EUR","in_stock":true},{"title":"25 g","offer_id":55186338709841,"sku":"NOR-141902-25g","price":64.2,"currency_code":"EUR","in_stock":true},{"title":"50 g","offer_id":55257397854545,"sku":"NOR-141902-50g","price":84.2,"currency_code":"EUR","in_stock":true},{"title":"100 g","offer_id":55186338742609,"sku":"NOR-141902-100g","price":109.2,"currency_code":"EUR","in_stock":true},{"title":"250 g","offer_id":55257373540689,"sku":"NOR-141902-250g","price":149.2,"currency_code":"EUR","in_stock":true},{"title":"500 g","offer_id":55186338775377,"sku":"NOR-141902-500g","price":198.2,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0954\/6357\/1793\/files\/2-Thiouracil.png?v=1791717807"},{"product_id":"5-fluorouridine-cas-316-46-1","title":"5-Fluorouridine | CAS 316-46-1 | ≥97%","description":"\u003cdiv style=\"margin-bottom: 28px;\"\u003e\n\u003cdiv style=\"background: #002147; padding: 10px 20px; margin-bottom: 0;\"\u003e\u003ch3 style=\"margin: 0; font-family: 'Helvetica Neue', Helvetica, Arial, sans-serif; font-size: 0.70em; font-weight: bold; letter-spacing: 0.12em; text-transform: uppercase; color: #fff;\"\u003eTechnical Specifications\u003c\/h3\u003e\u003c\/div\u003e\n\u003ctable style=\"width: 100%; border-collapse: collapse; font-size: 0.95em; border: 1px solid #e4e8f0; border-top: none; font-family: 'Helvetica Neue', Helvetica, Arial, sans-serif;\"\u003e\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eCAS Number\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e316-46-1\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eEC \/ EINECS Number\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e206-260-3\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eMDL Number\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003eMFCD00036832\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eRTECS Number\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003eYU8050000\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eSMILES\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0; word-break: break-all;\"\u003eC1=C(C(=O)NC(=O)N1[C@H]2[C@@H]([C@@H]([C@H](O2)CO)O)O)F\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eInChI\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0; word-break: break-all;\"\u003eInChI=1S\/C9H11FN2O6\/c10-3-1-12(9(17)11-7(3)16)8-6(15)5(14)4(2-13)18-8\/h1,4-6,8,13-15H,2H2,(H,11,16,17)\/t4-,5-,6-,8-\/m1\/s1\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eInChIKey\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0; word-break: break-all;\"\u003eFHIDNBAQOFJWCA-UAKXSSHOSA-N\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003ePubChem CID\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e9427\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eMolecular Formula\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003eC₉H₁₁FN₂O₆\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eMolecular Weight\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e262.19 g\/mol\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eMelting Point\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e182 °C\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eSolubility\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003eSoluble in water and DMSO. Slightly soluble in methanol.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003ePurity\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e≥97%\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003ePhysical Form\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003eWhite powder\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eHS Code\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e2934.99\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eShelf Life\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003eRetest period: 36 months from date of manufacture\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eStorage Conditions\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333;\"\u003eStore in a cool, dry place in a tightly sealed container.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\u003c\/table\u003e\n\u003c\/div\u003e\n\u003cdiv style=\"margin-bottom: 28px;\"\u003e\n\u003cdiv style=\"background: #002147; padding: 10px 20px; margin-bottom: 0;\"\u003e\u003ch3 style=\"margin: 0; font-family: 'Helvetica Neue', Helvetica, Arial, sans-serif; font-size: 0.70em; font-weight: bold; letter-spacing: 0.12em; text-transform: uppercase; color: #fff;\"\u003eProduct Description \u0026amp; Scientific Applications\u003c\/h3\u003e\u003c\/div\u003e\n\u003cdiv style=\"padding: 16px 20px; border: 1px solid #e4e8f0; border-top: none; font-family: Georgia, 'Times New Roman', serif; font-size: 0.95em; line-height: 1.65; color: #333;\"\u003e\u003cdiv\u003e\n\u003cp\u003e\u003cstrong\u003e5-Fluorouridine\u003c\/strong\u003e (FUrd) is a fluoropyrimidine nucleoside analogue: uridine with a fluorine atom at C-5 of the base. It is a cell-permeable, modified RNA precursor.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eInside the cell.\u003c\/strong\u003e Uridine–cytidine kinase converts 5-fluorouridine to 5-fluorouridine monophosphate (FUMP). Further phosphorylation gives the diphosphate (FUDP) and the triphosphate (FUTP), which is incorporated into RNA. Through ribonucleotide reductase, part of the FUDP is converted to 5-fluoro-2′-deoxyuridine monophosphate (FdUMP), an inhibitor of thymidylate synthase.\u003c\/p\u003e\n\u003cdiv style=\"margin:8px 0 18px 0;\"\u003e\n\u003cdiv style=\"display:flex;flex-wrap:wrap;align-items:center;justify-content:flex-start;gap:2px;\"\u003e\n\u003cdiv style=\"display:flex;align-items:center;\"\u003e\u003csvg role=\"img\" style=\"max-width:100%;height:auto;\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" fill=\"none\" stroke=\"#000\" stroke-width=\"1.6\" width=\"185px\" height=\"160px\" viewbox=\"0 0 185 160\"\u003e\u003cpath d=\"M 125.9,89.9 L 145.3,83.5\"\u003e\u003c\/path\u003e\u003cpath d=\"M 126.6,86.4 L 142.7,81.2\"\u003e\u003c\/path\u003e\u003cpath d=\"M 145.3,83.5 L 149.6,63.6\"\u003e\u003c\/path\u003e\u003cpath d=\"M 149.2,65.3 L 164.9,60.2\"\u003e\u003c\/path\u003e\u003cpath d=\"M 148.3,62.4 L 164.0,57.3\"\u003e\u003c\/path\u003e\u003cpath d=\"M 149.6,63.6 L 138.3,53.4\"\u003e\u003c\/path\u003e\u003cpath d=\"M 130.5,51.1 L 115.0,56.2\"\u003e\u003c\/path\u003e\u003cpath d=\"M 116.6,55.6 L 105.4,45.5\"\u003e\u003c\/path\u003e\u003cpath d=\"M 114.6,57.9 L 103.3,47.8\"\u003e\u003c\/path\u003e\u003cpath d=\"M 115.0,56.2 L 111.8,71.3\"\u003e\u003c\/path\u003e\u003cpath d=\"M 91.3,82.5 L 105.7,76.2 L 106.6,79.1 Z\" fill=\"#000\" stroke-width=\"0.4\"\u003e\u003c\/path\u003e\u003cpath d=\"M 91.3,82.5 L 85.0,101.9\"\u003e\u003c\/path\u003e\u003cpath d=\"M 85.0,101.9 L 64.5,101.9\"\u003e\u003c\/path\u003e\u003cpath d=\"M 64.5,101.9 L 58.2,82.5\"\u003e\u003c\/path\u003e\u003cpath d=\"M 58.2,82.5 L 70.2,73.8\"\u003e\u003c\/path\u003e\u003cpath d=\"M 58.2,82.5 L 37.4,77.4 L 40.0,75.1 Z\" fill=\"#000\" stroke-width=\"0.4\"\u003e\u003c\/path\u003e\u003cpath d=\"M 40.0,75.1 L 28.1,85.8\"\u003e\u003c\/path\u003e\u003cpath d=\"M 62.9,104.9 L 62.2,104.4\" stroke-width=\"0.8\"\u003e\u003c\/path\u003e\u003cpath d=\"M 61.2,107.8 L 59.9,106.9\" stroke-width=\"0.8\"\u003e\u003c\/path\u003e\u003cpath d=\"M 59.5,110.8 L 57.7,109.4\" stroke-width=\"0.8\"\u003e\u003c\/path\u003e\u003cpath d=\"M 57.8,113.7 L 55.4,111.9\" stroke-width=\"0.8\"\u003e\u003c\/path\u003e\u003cpath d=\"M 87.2,104.4 L 86.6,104.9\" stroke-width=\"0.8\"\u003e\u003c\/path\u003e\u003cpath d=\"M 89.5,106.9 L 88.3,107.8\" stroke-width=\"0.8\"\u003e\u003c\/path\u003e\u003cpath d=\"M 91.8,109.4 L 90.0,110.8\" stroke-width=\"0.8\"\u003e\u003c\/path\u003e\u003cpath d=\"M 94.1,111.9 L 91.6,113.7\" stroke-width=\"0.8\"\u003e\u003c\/path\u003e\u003cpath d=\"M 145.3,83.5 L 157.3,94.3\"\u003e\u003c\/path\u003e\u003cpath d=\"M 114.6,79.7 L 125.9,89.9\"\u003e\u003c\/path\u003e\u003cpath d=\"M 79.3,73.8 L 91.3,82.5\"\u003e\u003c\/path\u003e\u003cpath d=\"M 126.9,89.5 L 125.9,89.9 L 125.3,89.4\"\u003e\u003c\/path\u003e\u003cpath d=\"M 149.4,64.6 L 149.6,63.6 L 149.0,63.0\"\u003e\u003c\/path\u003e\u003cpath d=\"M 115.7,55.9 L 115.0,56.2 L 114.8,56.9\"\u003e\u003c\/path\u003e\u003cpath d=\"M 91.0,83.5 L 91.3,82.5 L 90.7,82.1\"\u003e\u003c\/path\u003e\u003cpath d=\"M 85.3,101.0 L 85.0,101.9 L 83.9,101.9\"\u003e\u003c\/path\u003e\u003cpath d=\"M 65.5,101.9 L 64.5,101.9 L 64.2,101.0\"\u003e\u003c\/path\u003e\u003cpath d=\"M 58.5,83.5 L 58.2,82.5 L 58.8,82.1\"\u003e\u003c\/path\u003e\u003cg style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003e\u003ctext x=\"169.0\" y=\"61.4\" text-anchor=\"middle\"\u003eO\u003c\/text\u003e\u003ctext x=\"130.8\" y=\"54.1\" text-anchor=\"start\"\u003eNH\u003c\/text\u003e\u003ctext x=\"99.8\" y=\"46.7\" text-anchor=\"middle\"\u003eO\u003c\/text\u003e\u003ctext x=\"110.7\" y=\"80.4\" text-anchor=\"middle\"\u003eN\u003c\/text\u003e\u003ctext x=\"74.7\" y=\"74.7\" text-anchor=\"middle\"\u003eO\u003c\/text\u003e\u003ctext x=\"27.2\" y=\"94.1\" text-anchor=\"end\"\u003eHO\u003c\/text\u003e\u003ctext x=\"56.1\" y=\"122.7\" text-anchor=\"end\"\u003eHO\u003c\/text\u003e\u003ctext x=\"93.4\" y=\"122.7\" text-anchor=\"start\"\u003eOH\u003c\/text\u003e\u003ctext x=\"160.5\" y=\"101.4\" text-anchor=\"middle\"\u003eF\u003c\/text\u003e\u003c\/g\u003e\u003c\/svg\u003e\u003c\/div\u003e\n\u003cdiv style=\"display:flex;align-items:center;\"\u003e\u003cdiv style=\"display:flex;flex-direction:column;align-items:center;justify-content:center;min-width:80px;max-width:108px;padding:0 4px;text-align:center;font-size:12px;line-height:1.3;\"\u003e\n\u003cdiv\u003ephosphorylation\u003c\/div\u003e\n\u003cdiv style=\"font-size:30px;line-height:1;\"\u003e⟶\u003c\/div\u003e\n\u003cdiv\u003euridine–cytidine kinase\u003c\/div\u003e\n\u003c\/div\u003e\u003c\/div\u003e\n\u003cdiv style=\"display:flex;align-items:center;\"\u003e\u003csvg role=\"img\" style=\"max-width:100%;height:auto;\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" fill=\"none\" stroke=\"#000\" stroke-width=\"1.6\" width=\"185px\" height=\"160px\" viewbox=\"0 0 185 160\"\u003e\u003cpath d=\"M 133.4,88.6 L 149.8,83.3\"\u003e\u003c\/path\u003e\u003cpath d=\"M 134.0,85.7 L 147.6,81.3\"\u003e\u003c\/path\u003e\u003cpath d=\"M 149.8,83.3 L 153.4,66.4\"\u003e\u003c\/path\u003e\u003cpath d=\"M 153.1,67.9 L 166.0,63.7\"\u003e\u003c\/path\u003e\u003cpath d=\"M 152.3,65.4 L 165.2,61.3\"\u003e\u003c\/path\u003e\u003cpath d=\"M 153.4,66.4 L 144.1,58.1\"\u003e\u003c\/path\u003e\u003cpath d=\"M 137.1,56.1 L 124.2,60.2\"\u003e\u003c\/path\u003e\u003cpath d=\"M 125.6,59.7 L 116.4,51.5\"\u003e\u003c\/path\u003e\u003cpath d=\"M 123.9,61.7 L 114.7,53.4\"\u003e\u003c\/path\u003e\u003cpath d=\"M 124.2,60.2 L 121.5,72.6\"\u003e\u003c\/path\u003e\u003cpath d=\"M 104.2,82.4 L 116.1,77.2 L 116.9,79.6 Z\" fill=\"#000\" stroke-width=\"0.4\"\u003e\u003c\/path\u003e\u003cpath d=\"M 104.2,82.4 L 98.9,98.7\"\u003e\u003c\/path\u003e\u003cpath d=\"M 98.9,98.7 L 81.7,98.7\"\u003e\u003c\/path\u003e\u003cpath d=\"M 81.7,98.7 L 76.4,82.3\"\u003e\u003c\/path\u003e\u003cpath d=\"M 76.4,82.3 L 86.2,75.2\"\u003e\u003c\/path\u003e\u003cpath d=\"M 76.4,82.3 L 58.8,78.0 L 61.1,76.0 Z\" fill=\"#000\" stroke-width=\"0.4\"\u003e\u003c\/path\u003e\u003cpath d=\"M 61.1,76.0 L 51.3,84.8\"\u003e\u003c\/path\u003e\u003cpath d=\"M 43.0,87.1 L 33.9,84.2\"\u003e\u003c\/path\u003e\u003cpath d=\"M 28.2,80.9 L 19.0,77.9\"\u003e\u003c\/path\u003e\u003cpath d=\"M 27.4,83.4 L 18.2,80.4\"\u003e\u003c\/path\u003e\u003cpath d=\"M 29.4,87.6 L 27.0,95.0\"\u003e\u003c\/path\u003e\u003cpath d=\"M 32.3,78.7 L 34.7,71.4\"\u003e\u003c\/path\u003e\u003cpath d=\"M 79.9,101.9 L 79.2,101.4\" stroke-width=\"0.8\"\u003e\u003c\/path\u003e\u003cpath d=\"M 78.1,105.1 L 76.7,104.1\" stroke-width=\"0.8\"\u003e\u003c\/path\u003e\u003cpath d=\"M 76.3,108.3 L 74.2,106.8\" stroke-width=\"0.8\"\u003e\u003c\/path\u003e\u003cpath d=\"M 101.4,101.4 L 100.7,101.9\" stroke-width=\"0.8\"\u003e\u003c\/path\u003e\u003cpath d=\"M 103.9,104.1 L 102.5,105.1\" stroke-width=\"0.8\"\u003e\u003c\/path\u003e\u003cpath d=\"M 106.4,106.8 L 104.3,108.4\" stroke-width=\"0.8\"\u003e\u003c\/path\u003e\u003cpath d=\"M 149.8,83.3 L 159.7,92.2\"\u003e\u003c\/path\u003e\u003cpath d=\"M 124.1,80.2 L 133.4,88.6\"\u003e\u003c\/path\u003e\u003cpath d=\"M 94.4,75.2 L 104.2,82.4\"\u003e\u003c\/path\u003e\u003cpath d=\"M 134.2,88.3 L 133.4,88.6 L 132.9,88.2\"\u003e\u003c\/path\u003e\u003cpath d=\"M 153.2,67.3 L 153.4,66.4 L 152.9,66.0\"\u003e\u003c\/path\u003e\u003cpath d=\"M 124.8,60.0 L 124.2,60.2 L 124.1,60.8\"\u003e\u003c\/path\u003e\u003cpath d=\"M 104.0,83.2 L 104.2,82.4 L 103.7,82.0\"\u003e\u003c\/path\u003e\u003cpath d=\"M 99.1,97.9 L 98.9,98.7 L 98.0,98.7\"\u003e\u003c\/path\u003e\u003cpath d=\"M 82.5,98.7 L 81.7,98.7 L 81.4,97.9\"\u003e\u003c\/path\u003e\u003cpath d=\"M 76.6,83.1 L 76.4,82.3 L 76.9,82.0\"\u003e\u003c\/path\u003e\u003cg style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003e\u003ctext x=\"169.7\" y=\"65.3\" text-anchor=\"middle\"\u003eO\u003c\/text\u003e\u003ctext x=\"137.0\" y=\"59.1\" text-anchor=\"start\"\u003eNH\u003c\/text\u003e\u003ctext x=\"111.4\" y=\"52.9\" text-anchor=\"middle\"\u003eO\u003c\/text\u003e\u003ctext x=\"120.6\" y=\"81.3\" text-anchor=\"middle\"\u003eN\u003c\/text\u003e\u003ctext x=\"90.3\" y=\"76.4\" text-anchor=\"middle\"\u003eO\u003c\/text\u003e\u003ctext x=\"47.2\" y=\"92.7\" text-anchor=\"middle\"\u003eO\u003c\/text\u003e\u003ctext x=\"30.8\" y=\"87.4\" text-anchor=\"middle\"\u003eP\u003c\/text\u003e\u003ctext x=\"14.5\" y=\"82.0\" text-anchor=\"middle\"\u003eO\u003c\/text\u003e\u003ctext x=\"29.1\" y=\"103.7\" text-anchor=\"end\"\u003eHO\u003c\/text\u003e\u003ctext x=\"32.6\" y=\"71.0\" text-anchor=\"start\"\u003eOH\u003c\/text\u003e\u003ctext x=\"75.1\" y=\"116.8\" text-anchor=\"end\"\u003eHO\u003c\/text\u003e\u003ctext x=\"105.4\" y=\"116.9\" text-anchor=\"start\"\u003eOH\u003c\/text\u003e\u003ctext x=\"162.5\" y=\"99.0\" text-anchor=\"middle\"\u003eF\u003c\/text\u003e\u003c\/g\u003e\u003c\/svg\u003e\u003c\/div\u003e\n\u003cdiv style=\"display:flex;align-items:center;\"\u003e\u003cdiv style=\"display:flex;flex-direction:column;align-items:center;justify-content:center;min-width:80px;max-width:108px;padding:0 4px;text-align:center;font-size:12px;line-height:1.3;\"\u003e\n\u003cdiv\u003ephosphorylation\u003c\/div\u003e\n\u003cdiv style=\"font-size:30px;line-height:1;\"\u003e⟶\u003c\/div\u003e\n\u003cdiv\u003evia FUDP\u003c\/div\u003e\n\u003c\/div\u003e\u003c\/div\u003e\n\u003cdiv style=\"display:flex;align-items:center;font-size:14px;padding:0 4px;\"\u003eFUTP\u003c\/div\u003e\n\u003cdiv style=\"display:flex;align-items:center;\"\u003e\u003cdiv style=\"display:flex;flex-direction:column;align-items:center;justify-content:center;min-width:80px;max-width:108px;padding:0 4px;text-align:center;font-size:12px;line-height:1.3;\"\u003e\n\u003cdiv\u003eincorporation\u003c\/div\u003e\n\u003cdiv style=\"font-size:30px;line-height:1;\"\u003e⟶\u003c\/div\u003e\n\u003cdiv\u003e\u003c\/div\u003e\n\u003c\/div\u003e\u003c\/div\u003e\n\u003cdiv style=\"display:flex;align-items:center;font-size:14px;padding:0 4px;\"\u003eRNA\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cp style=\"font-size:12px;margin:4px 0 0 0;\"\u003e\u003cem\u003eUridine–cytidine kinase converts 5-fluorouridine (left) to FUMP (centre). Further phosphorylation through FUDP gives FUTP, which is incorporated into RNA.\u003c\/em\u003e\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cp\u003e\u003cstrong\u003eAntiproliferative activity.\u003c\/strong\u003e 5-Fluorouridine is antiproliferative towards cancer cells and is used in comparison studies with 5-fluorouracil and related fluoropyrimidines. In human colorectal (SW480) and cervical (HeLa) cancer cells, uridine and uridine monophosphate reversed its effect, but thymidine did not. It inhibited thymidylate synthase about 100 times less strongly than 5-fluoro-2′-deoxyuridine (FdUrd). Its effect therefore arises mainly through RNA, that of FdUrd mainly through DNA.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eLabelling active transcription sites.\u003c\/strong\u003e Porcine fetal fibroblasts were incubated with 2.5 mM 5-fluorouridine for 30 minutes, fixed and stained with an antibody against 5-bromo-2′-deoxyuridine (anti-BrdU), which detects the incorporated label. The label appeared as dots throughout the nucleus and in the nucleolus. Flavopiridol, an inhibitor of transcription by RNA polymerase II, abolished the signal.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eImmunocytochemistry in human cell lines.\u003c\/strong\u003e A 5-minute pulse of 100 µM 5-fluorouridine, detected with anti-BrdU, labels transcription in the nucleoli. The nucleolar signal correlated with the amounts of RNA polymerase I and of fibrillarin, a nucleolar protein. Actinomycin D (0.05 µg\/mL for 10 minutes) blocked the incorporation.\u003c\/p\u003e\n\u003c\/div\u003e\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cdiv style=\"margin-bottom: 28px;\"\u003e\n\u003cdiv style=\"background: #002147; padding: 10px 20px; margin-bottom: 0;\"\u003e\u003ch3 style=\"margin: 0; font-family: 'Helvetica Neue', Helvetica, Arial, sans-serif; font-size: 0.70em; font-weight: bold; letter-spacing: 0.12em; text-transform: uppercase; color: #fff;\"\u003eShipping Destinations\u003c\/h3\u003e\u003c\/div\u003e\n\u003cdiv style=\"border: 1px solid #e4e8f0; border-top: none; padding: 12px 16px; font-family: 'Helvetica Neue', Helvetica, Arial, sans-serif; font-size: 0.95em;\"\u003e\u003cul style=\"margin: 0; padding: 0; list-style: none;\"\u003e\n\u003cli style=\"padding: 5px 0; border-bottom: 1px solid #f0f0f0;\"\u003e\n\u003cspan style=\"display: inline-block; width: 7px; height: 7px; background: #002147; border-radius: 50%; margin-right: 10px; vertical-align: middle;\"\u003e\u003c\/span\u003eEU \u0026amp; UK: Priority delivery, 2–5 business days.\u003c\/li\u003e\n\u003cli style=\"padding: 5px 0; border-bottom: 1px solid #f0f0f0;\"\u003e\n\u003cspan style=\"display: inline-block; width: 7px; height: 7px; background: #002147; border-radius: 50%; margin-right: 10px; vertical-align: middle;\"\u003e\u003c\/span\u003eUnited States (DDP): 3–7 business days, duties and taxes prepaid.\u003c\/li\u003e\n\u003cli style=\"padding: 5px 0; border-bottom: 1px solid #f0f0f0;\"\u003e\n\u003cspan style=\"display: inline-block; width: 7px; height: 7px; background: #002147; border-radius: 50%; margin-right: 10px; vertical-align: middle;\"\u003e\u003c\/span\u003eEFTA Countries (DDP): 3–7 business days, duties and taxes prepaid.\u003c\/li\u003e\n\u003cli style=\"padding: 5px 0; border-bottom: 1px solid #f0f0f0;\"\u003e\n\u003cspan style=\"display: inline-block; width: 7px; height: 7px; background: #002147; border-radius: 50%; margin-right: 10px; vertical-align: middle;\"\u003e\u003c\/span\u003eWorldwide: 7–14 business days, selected locations.\u003c\/li\u003e\n\u003c\/ul\u003e\u003c\/div\u003e\n\u003c\/div\u003e","brand":"NorrChemica™","offers":[{"title":"1.0 g","offer_id":55186377802065,"sku":"NOR-316461-1g","price":64.2,"currency_code":"EUR","in_stock":true},{"title":"2.0 g","offer_id":55379588645201,"sku":"NOR-316461-2g","price":89.2,"currency_code":"EUR","in_stock":true},{"title":"5.0 g","offer_id":55186377834833,"sku":"NOR-316461-5g","price":119.2,"currency_code":"EUR","in_stock":true},{"title":"10 g","offer_id":55379588677969,"sku":"NOR-316461-10g","price":189.2,"currency_code":"EUR","in_stock":true},{"title":"25 g","offer_id":55186377867601,"sku":"NOR-316461-25g","price":349.0,"currency_code":"EUR","in_stock":true},{"title":"50 g","offer_id":55379588710737,"sku":"NOR-316461-50g","price":589.2,"currency_code":"EUR","in_stock":true},{"title":"100 g","offer_id":55186377900369,"sku":"NOR-316461-100g","price":995.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0954\/6357\/1793\/files\/5-Fluorouridine.png?v=1792184826"},{"product_id":"2-3-dideoxyadenosine-cas-4097-22-7","title":"2′,3′-Dideoxyadenosine | CAS 4097-22-7 | ≥98%","description":"\u003cdiv style=\"margin-bottom: 28px;\"\u003e\n\u003cdiv style=\"background: #002147; padding: 10px 20px; margin-bottom: 0;\"\u003e\u003ch3 style=\"margin: 0; font-family: 'Helvetica Neue', Helvetica, Arial, sans-serif; font-size: 0.70em; font-weight: bold; letter-spacing: 0.12em; text-transform: uppercase; color: #fff;\"\u003eTechnical Specifications\u003c\/h3\u003e\u003c\/div\u003e\n\u003ctable style=\"width: 100%; border-collapse: collapse; font-size: 0.95em; border: 1px solid #e4e8f0; border-top: none; font-family: 'Helvetica Neue', Helvetica, Arial, sans-serif;\"\u003e\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eCAS Number\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e4097-22-7\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eEC \/ EINECS Number\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e223-853-2\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eMDL Number\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003eMFCD00010534\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eRTECS Number\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003eAU7358900\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eSMILES\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0; word-break: break-all;\"\u003eC1C[C@@H](O[C@@H]1CO)N2C=NC3=C(N=CN=C32)N\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eInChI\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0; word-break: break-all;\"\u003eInChI=1S\/C10H13N5O2\/c11-9-8-10(13-4-12-9)15(5-14-8)7-2-1-6(3-16)17-7\/h4-7,16H,1-3H2,(H2,11,12,13)\/t6-,7+\/m0\/s1\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eInChIKey\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0; word-break: break-all;\"\u003eWVXRAFOPTSTNLL-NKWVEPMBSA-N\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003ePubChem CID\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e20039\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eMolecular Formula\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003eC₁₀H₁₃N₅O₂\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eMolecular Weight\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e235.24 g\/mol\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eMelting Point\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e181–184 °C\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003ePurity\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e≥98%\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003ePhysical Form\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003eOff-white powder\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eHS Code\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e2934.99\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eShelf Life\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003eRetest period: 36 months from date of manufacture\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eStorage Conditions\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333;\"\u003eStore at 2–8 °C in a tightly sealed container.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\u003c\/table\u003e\n\u003c\/div\u003e","brand":"NorrChemica™","offers":[{"title":"250 mg","offer_id":55555701506385,"sku":"NOR-4097227-250mg","price":149.2,"currency_code":"EUR","in_stock":true},{"title":"1.0 g","offer_id":55555701539153,"sku":"NOR-4097227-1g","price":369.2,"currency_code":"EUR","in_stock":true},{"title":"5.0 g","offer_id":55555701571921,"sku":"NOR-4097227-5g","price":1479.2,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0954\/6357\/1793\/files\/2-3-Dideoxyadenosine.png?v=1793361209"},{"product_id":"8-bromoguanosine-cas-4016-63-1","title":"8-Bromoguanosine | CAS 4016-63-1 | ≥95%","description":"\u003cdiv style=\"margin-bottom: 28px;\"\u003e\n\u003cdiv style=\"background: #002147; padding: 10px 20px; margin-bottom: 0;\"\u003e\u003ch3 style=\"margin: 0; font-family: 'Helvetica Neue', Helvetica, Arial, sans-serif; font-size: 0.70em; font-weight: bold; letter-spacing: 0.12em; text-transform: uppercase; color: #fff;\"\u003eTechnical Specifications\u003c\/h3\u003e\u003c\/div\u003e\n\u003ctable style=\"width: 100%; border-collapse: collapse; font-size: 0.95em; border: 1px solid #e4e8f0; border-top: none; font-family: 'Helvetica Neue', Helvetica, Arial, sans-serif;\"\u003e\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eCAS Number\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e4016-63-1\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eEC \/ EINECS Number\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e223-677-6\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eMDL Number\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003eMFCD00037985\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eSMILES\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0; word-break: break-all;\"\u003eC([C@@H]1[C@H]([C@H]([C@@H](O1)N2C3=C(C(=O)NC(=N3)N)N=C2Br)O)O)O\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eInChI\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0; word-break: break-all;\"\u003eInChI=1S\/C10H12BrN5O5\/c11-9-13-3-6(14-10(12)15-7(3)20)16(9)8-5(19)4(18)2(1-17)21-8\/h2,4-5,8,17-19H,1H2,(H3,12,14,15,20)\/t2-,4-,5-,8-\/m1\/s1\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eInChIKey\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0; word-break: break-all;\"\u003eASUCSHXLTWZYBA-UMMCILCDSA-N\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003ePubChem CID\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e135465599\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eMolecular Formula\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003eC₁₀H₁₂BrN₅O₅\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eMolecular Weight\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e362.14 g\/mol\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003ePurity\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e≥95%\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003ePhysical Form\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003eWhite powder\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eShelf Life\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003eRetest period: 36 months from date of manufacture\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eStorage Conditions\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333;\"\u003eStore at −20 °C in a tightly sealed container.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\u003c\/table\u003e\n\u003c\/div\u003e","brand":"NorrChemica™","offers":[{"title":"1.0 g","offer_id":55555710484817,"sku":"NOR-4016631-1g","price":49.2,"currency_code":"EUR","in_stock":true},{"title":"5.0 g","offer_id":55555710517585,"sku":"NOR-4016631-5g","price":69.2,"currency_code":"EUR","in_stock":true},{"title":"10 g","offer_id":55595195531601,"sku":"NOR-4016631-10g","price":89.2,"currency_code":"EUR","in_stock":true},{"title":"25 g","offer_id":55555710550353,"sku":"NOR-4016631-25g","price":123.2,"currency_code":"EUR","in_stock":true},{"title":"100 g","offer_id":55555710583121,"sku":"NOR-4016631-100g","price":349.2,"currency_code":"EUR","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0954\/6357\/1793\/files\/8-Bromoguanosine.png?v=1793361348"},{"product_id":"cladribine-cas-4291-63-8","title":"Cladribine | CAS 4291-63-8 | ≥99%","description":"\u003cdiv style=\"margin-bottom: 28px;\"\u003e\n\u003cdiv style=\"background: #002147; padding: 10px 20px; margin-bottom: 0;\"\u003e\u003ch3 style=\"margin: 0; font-family: 'Helvetica Neue', Helvetica, Arial, sans-serif; font-size: 0.70em; font-weight: bold; letter-spacing: 0.12em; text-transform: uppercase; color: #fff;\"\u003eTechnical Specifications\u003c\/h3\u003e\u003c\/div\u003e\n\u003ctable style=\"width: 100%; border-collapse: collapse; font-size: 0.95em; border: 1px solid #e4e8f0; border-top: none; font-family: 'Helvetica Neue', Helvetica, Arial, sans-serif;\"\u003e\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eCAS Number\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e4291-63-8\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eMDL Number\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003eMFCD00153939\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eRTECS Number\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003eAU7357560\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eSMILES\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0; word-break: break-all;\"\u003eC1[C@@H]([C@H](O[C@H]1N2C=NC3=C(N=C(N=C32)Cl)N)CO)O\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eInChI\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0; word-break: break-all;\"\u003eInChI=1S\/C10H12ClN5O3\/c11-10-14-8(12)7-9(15-10)16(3-13-7)6-1-4(18)5(2-17)19-6\/h3-6,17-18H,1-2H2,(H2,12,14,15)\/t4-,5+,6+\/m0\/s1\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eInChIKey\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0; word-break: break-all;\"\u003ePTOAARAWEBMLNO-KVQBGUIXSA-N\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003ePubChem CID\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e20279\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eMolecular Formula\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003eC₁₀H₁₂ClN₅O₃\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eMolecular Weight\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e285.69 g\/mol\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eMelting Point\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e220 °C (softens)\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eLog Pow\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e0.03\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003ePurity\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e≥99%\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003ePhysical Form\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003ePowder or crystals\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eHS Code\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e2934.99\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eShelf Life\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003eRetest period: 36 months from date of manufacture\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eStorage Conditions\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333;\"\u003eStore at 2–8 °C in a tightly sealed container.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\u003c\/table\u003e\n\u003c\/div\u003e","brand":"NorrChemica™","offers":[{"title":"50 mg","offer_id":55555740795217,"sku":"NOR-4291638-50mg","price":109.2,"currency_code":"EUR","in_stock":true},{"title":"100 mg","offer_id":55555740827985,"sku":"NOR-4291638-100mg","price":149.2,"currency_code":"EUR","in_stock":true},{"title":"250 mg","offer_id":55555740860753,"sku":"NOR-4291638-250mg","price":189.2,"currency_code":"EUR","in_stock":true},{"title":"1.0 g","offer_id":55555740893521,"sku":"NOR-4291638-1g","price":239.2,"currency_code":"EUR","in_stock":false},{"title":"5.0 g","offer_id":55555740926289,"sku":"NOR-4291638-5g","price":1345.0,"currency_code":"EUR","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0954\/6357\/1793\/files\/Cladribine.png?v=1793361453"},{"product_id":"locked-nucleic-acid-thymidine-lna-t-cas-206055-67-6","title":"Locked Nucleic Acid Thymidine (LNA-T) | CAS 206055-67-6 | ≥99%","description":"\u003cdiv style=\"margin-bottom: 28px;\"\u003e\n\u003cdiv style=\"background: #002147; padding: 10px 20px; margin-bottom: 0;\"\u003e\u003ch3 style=\"margin: 0; font-family: 'Helvetica Neue', Helvetica, Arial, sans-serif; font-size: 0.70em; font-weight: bold; letter-spacing: 0.12em; text-transform: uppercase; color: #fff;\"\u003eTechnical Specifications\u003c\/h3\u003e\u003c\/div\u003e\n\u003ctable style=\"width: 100%; border-collapse: collapse; font-size: 0.95em; border: 1px solid #e4e8f0; border-top: none; font-family: 'Helvetica Neue', Helvetica, Arial, sans-serif;\"\u003e\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eCAS Number\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e206055-67-6\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eMDL Number\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003eMFCD12911819\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eSMILES\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0; word-break: break-all;\"\u003eCC1=CN(C(=O)NC1=O)[C@H]2[C@H]3[C@@H]([C@@](O2)(CO3)CO)O\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eInChI\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0; word-break: break-all;\"\u003eInChI=1S\/C11H14N2O6\/c1-5-2-13(10(17)12-8(5)16)9-6-7(15)11(3-14,19-9)4-18-6\/h2,6-7,9,14-15H,3-4H2,1H3,(H,12,16,17)\/t6-,7+,9-,11+\/m1\/s1\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eInChIKey\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0; word-break: break-all;\"\u003eTYYUAZVXLRMUMN-SZVQBCOZSA-N\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003ePubChem CID\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e10221080\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eMolecular Formula\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003eC₁₁H₁₄N₂O₆\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eMolecular Weight\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e270.24 g\/mol\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003ePurity\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e≥99%\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eShelf Life\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003eRetest period: 36 months from date of manufacture\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eStorage Conditions\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333;\"\u003eStore in a cool, dry place in a tightly sealed container.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\u003c\/table\u003e\n\u003c\/div\u003e","brand":"NorrChemica™","offers":[{"title":"250 mg","offer_id":55555776610641,"sku":"NOR-206055676-250mg","price":149.2,"currency_code":"EUR","in_stock":true},{"title":"1.0 g","offer_id":55555776643409,"sku":"NOR-206055676-1g","price":349.2,"currency_code":"EUR","in_stock":true},{"title":"5.0 g","offer_id":55555776676177,"sku":"NOR-206055676-5g","price":0.0,"currency_code":"EUR","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0954\/6357\/1793\/files\/LNA-T.png?v=1793362383"},{"product_id":"3-o-tert-butyldimethylsilyl-thymidine-cas-40733-27-5","title":"3′-O-(tert-Butyldimethylsilyl)thymidine | CAS 40733-27-5 | ≥97%","description":"\u003cdiv style=\"margin-bottom: 28px;\"\u003e\n\u003cdiv style=\"background: #002147; padding: 10px 20px; margin-bottom: 0;\"\u003e\u003ch3 style=\"margin: 0; font-family: 'Helvetica Neue', Helvetica, Arial, sans-serif; font-size: 0.70em; font-weight: bold; letter-spacing: 0.12em; text-transform: uppercase; color: #fff;\"\u003eTechnical Specifications\u003c\/h3\u003e\u003c\/div\u003e\n\u003ctable style=\"width: 100%; border-collapse: collapse; font-size: 0.95em; border: 1px solid #e4e8f0; border-top: none; font-family: 'Helvetica Neue', Helvetica, Arial, sans-serif;\"\u003e\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eCAS Number\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e40733-27-5\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eMDL Number\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003eMFCD01631040\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eSMILES\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0; word-break: break-all;\"\u003eCC1=CN(C(=O)NC1=O)[C@H]2C[C@@H]([C@H](O2)CO)O[Si](C)(C)C(C)(C)C\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eInChI\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0; word-break: break-all;\"\u003eInChI=1S\/C16H28N2O5Si\/c1-10-8-18(15(21)17-14(10)20)13-7-11(12(9-19)22-13)23-24(5,6)16(2,3)4\/h8,11-13,19H,7,9H2,1-6H3,(H,17,20,21)\/t11-,12+,13+\/m0\/s1\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eInChIKey\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0; word-break: break-all;\"\u003eQAPSNMNOIOSXSQ-YNEHKIRRSA-N\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003ePubChem CID\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e453844\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eMolecular Formula\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003eC₁₆H₂₈N₂O₅Si\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eMolecular Weight\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e356.49 g\/mol\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003ePurity\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e≥97%\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003ePhysical Form\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003eWhite to light yellow powder to crystal\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eHS Code\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e2934.99\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eShelf Life\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003eRetest period: 36 months from date of manufacture\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eStorage Conditions\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333;\"\u003eStore refrigerated (0–10 °C) under inert gas in a tightly sealed container.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\u003c\/table\u003e\n\u003c\/div\u003e","brand":"NorrChemica™","offers":[{"title":"100 mg","offer_id":55555870720337,"sku":"NOR-40733275-100mg","price":89.2,"currency_code":"EUR","in_stock":true},{"title":"250 mg","offer_id":55555870753105,"sku":"NOR-40733275-250mg","price":149.2,"currency_code":"EUR","in_stock":true},{"title":"1.0 g","offer_id":55555870785873,"sku":"NOR-40733275-1g","price":189.0,"currency_code":"EUR","in_stock":false},{"title":"5.0 g","offer_id":55555870818641,"sku":"NOR-40733275-5g","price":549.2,"currency_code":"EUR","in_stock":false},{"title":"25 g","offer_id":55555870851409,"sku":"NOR-40733275-25g","price":1898.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0954\/6357\/1793\/files\/3-O-TBS-Thymidine.png?v=1793364219"},{"product_id":"3-5-bis-o-tbs-2-deoxy-d-ribonolactone-cas-83159-91-5","title":"3,5-Bis-O-TBS-2-deoxy-D-ribonolactone | CAS 83159-91-5 | ≥98%","description":"\u003cdiv style=\"margin-bottom: 28px;\"\u003e\n\u003cdiv style=\"background: #002147; padding: 10px 20px; margin-bottom: 0;\"\u003e\u003ch3 style=\"margin: 0; font-family: 'Helvetica Neue', Helvetica, Arial, sans-serif; font-size: 0.70em; font-weight: bold; letter-spacing: 0.12em; text-transform: uppercase; color: #fff;\"\u003eTechnical Specifications\u003c\/h3\u003e\u003c\/div\u003e\n\u003ctable style=\"width: 100%; border-collapse: collapse; font-size: 0.95em; border: 1px solid #e4e8f0; border-top: none; font-family: 'Helvetica Neue', Helvetica, Arial, sans-serif;\"\u003e\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eCAS Number\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e83159-91-5\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eMDL Number\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003eMFCD01630917\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eSMILES\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0; word-break: break-all;\"\u003eCC(C)(C)[Si](C)(C)OC[C@@H]1[C@H](CC(=O)O1)O[Si](C)(C)C(C)(C)C\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eInChI\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0; word-break: break-all;\"\u003eInChI=1S\/C17H36O4Si2\/c1-16(2,3)22(7,8)19-12-14-13(11-15(18)20-14)21-23(9,10)17(4,5)6\/h13-14H,11-12H2,1-10H3\/t13-,14+\/m0\/s1\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eInChIKey\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0; word-break: break-all;\"\u003eDCFHRVSQGCDCMH-UONOGXRCSA-N\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003ePubChem CID\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e10761020\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eMolecular Formula\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003eC₁₇H₃₆O₄Si₂\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eMolecular Weight\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e360.6 g\/mol\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003ePurity\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e≥98%\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eShelf Life\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003eRetest period: 36 months from date of manufacture\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eStorage Conditions\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333;\"\u003eStore in a cool, dry place in a tightly sealed container.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\u003c\/table\u003e\n\u003c\/div\u003e","brand":"NorrChemica™","offers":[{"title":"250 mg","offer_id":55555890184529,"sku":"NOR-83159915-250mg","price":74.2,"currency_code":"EUR","in_stock":true},{"title":"1.0 g","offer_id":55555890217297,"sku":"NOR-83159915-1g","price":109.2,"currency_code":"EUR","in_stock":true},{"title":"5.0 g","offer_id":55555890250065,"sku":"NOR-83159915-5g","price":398.2,"currency_code":"EUR","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0954\/6357\/1793\/files\/3-5-Bis-O-TBS-2-deoxy-D-ribonolactone.png?v=1793364365"},{"product_id":"3-5-o-di-tert-butylsilanediyl-uridine-cas-97219-04-0","title":"3′,5′-O-(Di-tert-butylsilanediyl)uridine | CAS 97219-04-0 | ≥98%","description":"\u003cdiv style=\"margin-bottom: 28px;\"\u003e\n\u003cdiv style=\"background: #002147; padding: 10px 20px; margin-bottom: 0;\"\u003e\u003ch3 style=\"margin: 0; font-family: 'Helvetica Neue', Helvetica, Arial, sans-serif; font-size: 0.70em; font-weight: bold; letter-spacing: 0.12em; text-transform: uppercase; color: #fff;\"\u003eTechnical Specifications\u003c\/h3\u003e\u003c\/div\u003e\n\u003ctable style=\"width: 100%; border-collapse: collapse; font-size: 0.95em; border: 1px solid #e4e8f0; border-top: none; font-family: 'Helvetica Neue', Helvetica, Arial, sans-serif;\"\u003e\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eCAS Number\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e97219-04-0\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eSMILES\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0; word-break: break-all;\"\u003eCC(C)(C)[Si]1(OC[C@@H]2[C@@H](O1)[C@H]([C@@H](O2)N3C=CC(=O)NC3=O)O)C(C)(C)C\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eInChI\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0; word-break: break-all;\"\u003eInChI=1S\/C17H28N2O6Si\/c1-16(2,3)26(17(4,5)6)23-9-10-13(25-26)12(21)14(24-10)19-8-7-11(20)18-15(19)22\/h7-8,10,12-14,21H,9H2,1-6H3,(H,18,20,22)\/t10-,12-,13-,14-\/m1\/s1\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eInChIKey\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0; word-break: break-all;\"\u003eGRBQGEFUMJONLP-FMKGYKFTSA-N\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003ePubChem CID\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e14506381\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eMolecular Formula\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003eC₁₇H₂₈N₂O₆Si\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eMolecular Weight\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e384.5 g\/mol\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003ePurity\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e≥98%\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eShelf Life\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003eRetest period: 36 months from date of manufacture\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eStorage Conditions\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333;\"\u003eStore in a cool, dry place in a tightly sealed container.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\u003c\/table\u003e\n\u003c\/div\u003e","brand":"NorrChemica™","offers":[{"title":"250 mg","offer_id":55556039639377,"sku":"NOR-97219040-250mg","price":47.2,"currency_code":"EUR","in_stock":true},{"title":"1.0 g","offer_id":55556039672145,"sku":"NOR-97219040-1g","price":109.2,"currency_code":"EUR","in_stock":true},{"title":"5.0 g","offer_id":55556039704913,"sku":"NOR-97219040-5g","price":329.2,"currency_code":"EUR","in_stock":true},{"title":"10 g","offer_id":55556039737681,"sku":"NOR-97219040-10g","price":498.2,"currency_code":"EUR","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0954\/6357\/1793\/files\/3-5-O-Di-tert-butylsilanediyl_Uridine.png?v=1793364955"},{"product_id":"3-o-tbdms-2-o-methyluridine-cas-171268-84-1","title":"3′-O-TBDMS-2′-O-methyluridine | CAS 171268-84-1 | ≥99%","description":"\u003cdiv style=\"margin-bottom: 28px;\"\u003e\n\u003cdiv style=\"background: #002147; padding: 10px 20px; margin-bottom: 0;\"\u003e\u003ch3 style=\"margin: 0; font-family: 'Helvetica Neue', Helvetica, Arial, sans-serif; font-size: 0.70em; font-weight: bold; letter-spacing: 0.12em; text-transform: uppercase; color: #fff;\"\u003eTechnical Specifications\u003c\/h3\u003e\u003c\/div\u003e\n\u003ctable style=\"width: 100%; border-collapse: collapse; font-size: 0.95em; border: 1px solid #e4e8f0; border-top: none; font-family: 'Helvetica Neue', Helvetica, Arial, sans-serif;\"\u003e\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eCAS Number\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e171268-84-1\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eMDL Number\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003eMFCD28976151\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eSMILES\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0; word-break: break-all;\"\u003eCC(C)(C)[Si](C)(C)O[C@@H]1[C@H](O[C@H]([C@@H]1OC)N2C=CC(=O)NC2=O)CO\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eInChI\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0; word-break: break-all;\"\u003eInChI=1S\/C16H28N2O6Si\/c1-16(2,3)25(5,6)24-12-10(9-19)23-14(13(12)22-4)18-8-7-11(20)17-15(18)21\/h7-8,10,12-14,19H,9H2,1-6H3,(H,17,20,21)\/t10-,12-,13-,14-\/m1\/s1\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eInChIKey\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0; word-break: break-all;\"\u003eVWMFRWSCFRRALN-FMKGYKFTSA-N\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003ePubChem CID\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e66869720\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eMolecular Formula\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003eC₁₆H₂₈N₂O₆Si\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eMolecular Weight\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e372.49 g\/mol\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003ePurity\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e≥99%\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eShelf Life\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003eRetest period: 36 months from date of manufacture\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eStorage Conditions\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333;\"\u003eStore in a cool, dry place in a tightly sealed container.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\u003c\/table\u003e\n\u003c\/div\u003e","brand":"NorrChemica™","offers":[{"title":"250 mg","offer_id":55556087251281,"sku":"NOR-171268841-250mg","price":78.2,"currency_code":"EUR","in_stock":true},{"title":"1.0 g","offer_id":55556087284049,"sku":"NOR-171268841-1g","price":93.2,"currency_code":"EUR","in_stock":true},{"title":"5.0 g","offer_id":55556087316817,"sku":"NOR-171268841-5g","price":239.2,"currency_code":"EUR","in_stock":true},{"title":"25 g","offer_id":55556087349585,"sku":"NOR-171268841-25g","price":769.2,"currency_code":"EUR","in_stock":false},{"title":"100 g","offer_id":55556087382353,"sku":"NOR-171268841-100g","price":2569.2,"currency_code":"EUR","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0954\/6357\/1793\/files\/3-O-TBDMS-2-O-methyluridine.png?v=1793365225"},{"product_id":"n6-n6-dimethyladenine-cas-938-55-6","title":"N6,N6-Dimethyladenine | CAS 938-55-6 | ≥97%","description":"\u003cdiv style=\"margin-bottom: 28px;\"\u003e\n\u003cdiv style=\"background: #002147; padding: 10px 20px; margin-bottom: 0;\"\u003e\u003ch3 style=\"margin: 0; font-family: 'Helvetica Neue', Helvetica, Arial, sans-serif; font-size: 0.70em; font-weight: bold; letter-spacing: 0.12em; text-transform: uppercase; color: #fff;\"\u003eTechnical Specifications\u003c\/h3\u003e\u003c\/div\u003e\n\u003ctable style=\"width: 100%; border-collapse: collapse; font-size: 0.95em; border: 1px solid #e4e8f0; border-top: none; font-family: 'Helvetica Neue', Helvetica, Arial, sans-serif;\"\u003e\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eCAS Number\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e938-55-6\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eEC \/ EINECS Number\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e213-344-3\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eMDL Number\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003eMFCD00005573\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eSMILES\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0; word-break: break-all;\"\u003eCN(C)C1=NC=NC2=C1NC=N2\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eInChI\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0; word-break: break-all;\"\u003eInChI=1S\/C7H9N5\/c1-12(2)7-5-6(9-3-8-5)10-4-11-7\/h3-4H,1-2H3,(H,8,9,10,11)\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eInChIKey\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0; word-break: break-all;\"\u003eBVIAOQMSVZHOJM-UHFFFAOYSA-N\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003ePubChem CID\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e3134\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eMolecular Formula\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003eC₇H₉N₅\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eMolecular Weight\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e163.18 g\/mol\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eMelting Point\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e260 °C\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003ePurity\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e≥97%\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003ePhysical Form\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003ePowder\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eHS Code\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e2933.59\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eShelf Life\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003eRetest period: 36 months from date of manufacture\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eStorage Conditions\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333;\"\u003eStore at −20 °C in a tightly sealed container.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\u003c\/table\u003e\n\u003c\/div\u003e","brand":"NorrChemica™","offers":[{"title":"1.0 g","offer_id":55557690229073,"sku":"NOR-938556-1g","price":98.2,"currency_code":"EUR","in_stock":true},{"title":"5.0 g","offer_id":55557690261841,"sku":"NOR-938556-5g","price":229.2,"currency_code":"EUR","in_stock":false},{"title":"10 g","offer_id":55557690294609,"sku":"NOR-938556-10g","price":349.2,"currency_code":"EUR","in_stock":false},{"title":"25 g","offer_id":55557690327377,"sku":"NOR-938556-25g","price":589.2,"currency_code":"EUR","in_stock":true},{"title":"100 g","offer_id":55557690360145,"sku":"NOR-938556-100g","price":1649.2,"currency_code":"EUR","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0954\/6357\/1793\/files\/N6_N6-Dimethyladenine.png?v=1793374254"},{"product_id":"n6-benzoyladenine-cas-4005-49-6","title":"N6-Benzoyladenine | CAS 4005-49-6 | ≥98%","description":"\u003cdiv style=\"margin-bottom: 28px;\"\u003e\n\u003cdiv style=\"background: #002147; padding: 10px 20px; margin-bottom: 0;\"\u003e\u003ch3 style=\"margin: 0; font-family: 'Helvetica Neue', Helvetica, Arial, sans-serif; font-size: 0.70em; font-weight: bold; letter-spacing: 0.12em; text-transform: uppercase; color: #fff;\"\u003eTechnical Specifications\u003c\/h3\u003e\u003c\/div\u003e\n\u003ctable style=\"width: 100%; border-collapse: collapse; font-size: 0.95em; border: 1px solid #e4e8f0; border-top: none; font-family: 'Helvetica Neue', Helvetica, Arial, sans-serif;\"\u003e\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eCAS Number\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e4005-49-6\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eMDL Number\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003eMFCD00037927\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eSMILES\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0; word-break: break-all;\"\u003eC1=CC=C(C=C1)C(=O)NC2=NC=NC3=C2NC=N3\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eInChI\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0; word-break: break-all;\"\u003eInChI=1S\/C12H9N5O\/c18-12(8-4-2-1-3-5-8)17-11-9-10(14-6-13-9)15-7-16-11\/h1-7H,(H2,13,14,15,16,17,18)\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eInChIKey\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0; word-break: break-all;\"\u003eQQJXZVKXNSFHRI-UHFFFAOYSA-N\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003ePubChem CID\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e97075\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eMolecular Formula\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003eC₁₂H₉N₅O\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eMolecular Weight\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e239.23 g\/mol\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eMelting Point\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e239.0–245.0 °C\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eSolubility\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003eInsoluble in water.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003ePurity\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e≥98%\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003ePhysical Form\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003ePowder\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eHS Code\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e2933.59\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eShelf Life\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003eRetest period: 36 months from date of manufacture\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eStorage Conditions\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333;\"\u003eStore at 2–8 °C in a tightly sealed container.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\u003c\/table\u003e\n\u003c\/div\u003e","brand":"NorrChemica™","offers":[{"title":"5.0 g","offer_id":55557713264977,"sku":"NOR-4005496-5g","price":49.2,"currency_code":"EUR","in_stock":true},{"title":"10 g","offer_id":55557713297745,"sku":"NOR-4005496-10g","price":64.2,"currency_code":"EUR","in_stock":true},{"title":"25 g","offer_id":55557713330513,"sku":"NOR-4005496-25g","price":74.8,"currency_code":"EUR","in_stock":true},{"title":"50 g","offer_id":55576062984529,"sku":"NOR-4005496-50g","price":98.2,"currency_code":"EUR","in_stock":true},{"title":"100 g","offer_id":55557713363281,"sku":"NOR-4005496-100g","price":134.8,"currency_code":"EUR","in_stock":true},{"title":"250 g","offer_id":55576063017297,"sku":"NOR-4005496-250g","price":298.2,"currency_code":"EUR","in_stock":true},{"title":"500 g","offer_id":55557713396049,"sku":"NOR-4005496-500g","price":529.2,"currency_code":"EUR","in_stock":true},{"title":"1 kg","offer_id":55557713428817,"sku":"NOR-4005496-1kg","price":950.0,"currency_code":"EUR","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0954\/6357\/1793\/files\/N6-Benzoyladenine.png?v=1793373843"},{"product_id":"thymine-1-acetic-acid-cas-20924-05-4","title":"Thymine-1-acetic acid | CAS 20924-05-4 | ≥98%","description":"\u003cdiv style=\"margin-bottom: 28px;\"\u003e\n\u003cdiv style=\"background: #002147; padding: 10px 20px; margin-bottom: 0;\"\u003e\u003ch3 style=\"margin: 0; font-family: 'Helvetica Neue', Helvetica, Arial, sans-serif; font-size: 0.70em; font-weight: bold; letter-spacing: 0.12em; text-transform: uppercase; color: #fff;\"\u003eTechnical Specifications\u003c\/h3\u003e\u003c\/div\u003e\n\u003ctable style=\"width: 100%; border-collapse: collapse; font-size: 0.95em; border: 1px solid #e4e8f0; border-top: none; font-family: 'Helvetica Neue', Helvetica, Arial, sans-serif;\"\u003e\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eCAS Number\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e20924-05-4\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eMDL Number\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003eMFCD00274250\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eSMILES\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0; word-break: break-all;\"\u003eCC1=CN(C(=O)NC1=O)CC(=O)O\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eInChI\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0; word-break: break-all;\"\u003eInChI=1S\/C7H8N2O4\/c1-4-2-9(3-5(10)11)7(13)8-6(4)12\/h2H,3H2,1H3,(H,10,11)(H,8,12,13)\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eInChIKey\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0; word-break: break-all;\"\u003eTZDMCKHDYUDRMB-UHFFFAOYSA-N\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003ePubChem CID\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e853753\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eMolecular Formula\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003eC₇H₈N₂O₄\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eMolecular Weight\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e184.15 g\/mol\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eMelting Point\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e272–278 °C (dec.)\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003ePurity\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e≥98%\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003ePhysical Form\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003eSolid\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eShelf Life\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003eRetest period: 36 months from date of manufacture\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eStorage Conditions\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333;\"\u003eStore in a cool, dry place in a tightly sealed container.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\u003c\/table\u003e\n\u003c\/div\u003e","brand":"NorrChemica™","offers":[{"title":"1.0 g","offer_id":55569940087121,"sku":"NOR-20924054-1g","price":39.2,"currency_code":"EUR","in_stock":true},{"title":"5.0 g","offer_id":55557728698705,"sku":"NOR-20924054-5g","price":54.2,"currency_code":"EUR","in_stock":true},{"title":"10 g","offer_id":55557728731473,"sku":"NOR-20924054-10g","price":74.2,"currency_code":"EUR","in_stock":true},{"title":"25 g","offer_id":55557728764241,"sku":"NOR-20924054-25g","price":98.2,"currency_code":"EUR","in_stock":true},{"title":"50 g","offer_id":55569947296081,"sku":"NOR-20924054-50g","price":179.2,"currency_code":"EUR","in_stock":true},{"title":"100 g","offer_id":55557728797009,"sku":"NOR-20924054-100g","price":229.0,"currency_code":"EUR","in_stock":true},{"title":"250 g","offer_id":55569947328849,"sku":"NOR-20924054-250g","price":449.2,"currency_code":"EUR","in_stock":false},{"title":"500 g","offer_id":55557728829777,"sku":"NOR-20924054-500g","price":829.2,"currency_code":"EUR","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0954\/6357\/1793\/files\/Thymine-1-acetic_acid.png?v=1793373466"},{"product_id":"2-chloroadenine-cas-31458-56-7","title":"2-Chloroadenine | CAS 31458-56-7 | ≥98%","description":"\u003cdiv style=\"margin-bottom: 28px;\"\u003e\n\u003cdiv style=\"background: #002147; padding: 10px 20px; margin-bottom: 0;\"\u003e\u003ch3 style=\"margin: 0; font-family: 'Helvetica Neue', Helvetica, Arial, sans-serif; font-size: 0.70em; font-weight: bold; letter-spacing: 0.12em; text-transform: uppercase; color: #fff;\"\u003eTechnical Specifications\u003c\/h3\u003e\u003c\/div\u003e\n\u003ctable style=\"width: 100%; border-collapse: collapse; font-size: 0.95em; border: 1px solid #e4e8f0; border-top: none; font-family: 'Helvetica Neue', Helvetica, Arial, sans-serif;\"\u003e\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eCAS Number\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e31458-56-7\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eMDL Number\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003eMFCD00037925\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eSMILES\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0; word-break: break-all;\"\u003eC1=NC2=NC(=NC(=C2N1)N)Cl\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eInChI\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0; word-break: break-all;\"\u003eInChI=1S\/C5H4ClN5\/c6-5-10-3(7)2-4(11-5)9-1-8-2\/h1H,(H3,7,8,9,10,11)\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eInChIKey\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0; word-break: break-all;\"\u003eHBJGQJWNMZDFKL-UHFFFAOYSA-N\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003ePubChem CID\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e94904\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eMolecular Formula\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003eC₅H₄ClN₅\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eMolecular Weight\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e169.57 g\/mol\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eMelting Point\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e384–389 °C\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003ePurity\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e≥98%\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003ePhysical Form\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003eSolid\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eShelf Life\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003eRetest period: 36 months from date of manufacture\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eStorage Conditions\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333;\"\u003eStore in a cool, dry place in a tightly sealed container.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\u003c\/table\u003e\n\u003c\/div\u003e","brand":"NorrChemica™","offers":[{"title":"1.0 g","offer_id":55557843255633,"sku":"NOR-31458567-1g","price":79.2,"currency_code":"EUR","in_stock":true},{"title":"5.0 g","offer_id":55557843288401,"sku":"NOR-31458567-5g","price":198.2,"currency_code":"EUR","in_stock":true},{"title":"10 g","offer_id":55557843321169,"sku":"NOR-31458567-10g","price":329.2,"currency_code":"EUR","in_stock":true},{"title":"25 g","offer_id":55557843353937,"sku":"NOR-31458567-25g","price":549.2,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0954\/6357\/1793\/files\/2-Chloroadenine.png?v=1793372138"},{"product_id":"2-methyladenine-cas-1445-08-5","title":"2-Methyladenine | CAS 1445-08-5 | ≥95%","description":"\u003cdiv style=\"margin-bottom: 28px;\"\u003e\n\u003cdiv style=\"background: #002147; padding: 10px 20px; margin-bottom: 0;\"\u003e\u003ch3 style=\"margin: 0; font-family: 'Helvetica Neue', Helvetica, Arial, sans-serif; font-size: 0.70em; font-weight: bold; letter-spacing: 0.12em; text-transform: uppercase; color: #fff;\"\u003eTechnical Specifications\u003c\/h3\u003e\u003c\/div\u003e\n\u003ctable style=\"width: 100%; border-collapse: collapse; font-size: 0.95em; border: 1px solid #e4e8f0; border-top: none; font-family: 'Helvetica Neue', Helvetica, Arial, sans-serif;\"\u003e\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eCAS Number\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e1445-08-5\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eMDL Number\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003eMFCD01674065\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eSMILES\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0; word-break: break-all;\"\u003eCC1=NC(=C2C(=N1)N=CN2)N\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eInChI\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0; word-break: break-all;\"\u003eInChI=1S\/C6H7N5\/c1-3-10-5(7)4-6(11-3)9-2-8-4\/h2H,1H3,(H3,7,8,9,10,11)\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eInChIKey\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0; word-break: break-all;\"\u003eSMADWRYCYBUIKH-UHFFFAOYSA-N\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003ePubChem CID\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e15048\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eMolecular Formula\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003eC₆H₇N₅\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eMolecular Weight\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e149.15 g\/mol\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003ePurity\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e≥95%\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eShelf Life\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003eRetest period: 36 months from date of manufacture\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eStorage Conditions\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333;\"\u003eStore in a cool, dry place in a tightly sealed container.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\u003c\/table\u003e\n\u003c\/div\u003e","brand":"NorrChemica™","offers":[{"title":"100 mg","offer_id":55558627361105,"sku":"NOR-1445085-100mg","price":164.2,"currency_code":"EUR","in_stock":true},{"title":"250 mg","offer_id":55558627393873,"sku":"NOR-1445085-250mg","price":249.2,"currency_code":"EUR","in_stock":true},{"title":"1.0 g","offer_id":55558627426641,"sku":"NOR-1445085-1g","price":398.2,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0954\/6357\/1793\/files\/2-Methyladenine.png?v=1793371895"},{"product_id":"5-aminouracil-cas-932-52-5","title":"5-Aminouracil | CAS 932-52-5 | ≥97%","description":"\u003cdiv style=\"margin-bottom: 28px;\"\u003e\n\u003cdiv style=\"background: #002147; padding: 10px 20px; margin-bottom: 0;\"\u003e\u003ch3 style=\"margin: 0; font-family: 'Helvetica Neue', Helvetica, Arial, sans-serif; font-size: 0.70em; font-weight: bold; letter-spacing: 0.12em; text-transform: uppercase; color: #fff;\"\u003eTechnical Specifications\u003c\/h3\u003e\u003c\/div\u003e\n\u003ctable style=\"width: 100%; border-collapse: collapse; font-size: 0.95em; border: 1px solid #e4e8f0; border-top: none; font-family: 'Helvetica Neue', Helvetica, Arial, sans-serif;\"\u003e\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eCAS Number\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e932-52-5\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eEC \/ EINECS Number\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e213-252-3\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eMDL Number\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003eMFCD00006025\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eRTECS Number\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003eYQ8740000\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eSMILES\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0; word-break: break-all;\"\u003eC1=C(C(=O)NC(=O)N1)N\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eInChI\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0; word-break: break-all;\"\u003eInChI=1S\/C4H5N3O2\/c5-2-1-6-4(9)7-3(2)8\/h1H,5H2,(H2,6,7,8,9)\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eInChIKey\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0; word-break: break-all;\"\u003eBISHACNKZIBDFM-UHFFFAOYSA-N\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003ePubChem CID\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e13611\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eMolecular Formula\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003eC₄H₅N₃O₂\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eMolecular Weight\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e127.10 g\/mol\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eMelting Point\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e\u0026gt;300 °C\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003ePurity\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e≥97%\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003ePhysical Form\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003ePowder\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eShelf Life\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003eRetest period: 36 months from date of manufacture\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eStorage Conditions\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333;\"\u003eStore at ambient temperatures in a tightly sealed container.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\u003c\/table\u003e\n\u003c\/div\u003e","brand":"NorrChemica™","offers":[{"title":"5.0 g","offer_id":55558742081873,"sku":"NOR-932525-5g","price":69.2,"currency_code":"EUR","in_stock":true},{"title":"10 g","offer_id":55558742114641,"sku":"NOR-932525-10g","price":89.2,"currency_code":"EUR","in_stock":false},{"title":"25 g","offer_id":55558742147409,"sku":"NOR-932525-25g","price":119.2,"currency_code":"EUR","in_stock":false},{"title":"100 g","offer_id":55558742180177,"sku":"NOR-932525-100g","price":269.2,"currency_code":"EUR","in_stock":false},{"title":"500 g","offer_id":55558742212945,"sku":"NOR-932525-500g","price":1345.0,"currency_code":"EUR","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0954\/6357\/1793\/files\/5-Aminouracil.png?v=1793371819"},{"product_id":"6-methyluracil-cas-626-48-2","title":"6-Methyluracil | CAS 626-48-2 | ≥98%","description":"\u003cdiv style=\"margin-bottom: 28px;\"\u003e\n\u003cdiv style=\"background: #002147; padding: 10px 20px; margin-bottom: 0;\"\u003e\u003ch3 style=\"margin: 0; font-family: 'Helvetica Neue', Helvetica, Arial, sans-serif; font-size: 0.70em; font-weight: bold; letter-spacing: 0.12em; text-transform: uppercase; color: #fff;\"\u003eTechnical Specifications\u003c\/h3\u003e\u003c\/div\u003e\n\u003ctable style=\"width: 100%; border-collapse: collapse; font-size: 0.95em; border: 1px solid #e4e8f0; border-top: none; font-family: 'Helvetica Neue', Helvetica, Arial, sans-serif;\"\u003e\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eCAS Number\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e626-48-2\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eEC \/ EINECS Number\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e210-949-4\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eMDL Number\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003eMFCD00006028\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eRTECS Number\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003eYR0700000\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eSMILES\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0; word-break: break-all;\"\u003eCC1=CC(=O)NC(=O)N1\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eInChI\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0; word-break: break-all;\"\u003eInChI=1S\/C5H6N2O2\/c1-3-2-4(8)7-5(9)6-3\/h2H,1H3,(H2,6,7,8,9)\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eInChIKey\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0; word-break: break-all;\"\u003eSHVCSCWHWMSGTE-UHFFFAOYSA-N\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003ePubChem CID\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e12283\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eMolecular Formula\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003eC₅H₆N₂O₂\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eMolecular Weight\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e126.11 g\/mol\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eMelting Point\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e318 °C (dec.)\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003ePurity\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e≥98%\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003ePhysical Form\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003ePowder\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eHS Code\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e2933.59\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eShelf Life\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003eRetest period: 36 months from date of manufacture\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eStorage Conditions\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333;\"\u003eStore at room temperature (recommended in a cool and dark place, \u0026lt;15 °C) in a tightly sealed container.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\u003c\/table\u003e\n\u003c\/div\u003e","brand":"NorrChemica™","offers":[{"title":"25 g","offer_id":55559096926545,"sku":"NOR-626482-25g","price":39.2,"currency_code":"EUR","in_stock":true},{"title":"50 g","offer_id":55600626630993,"sku":"NOR-626482-50g","price":47.2,"currency_code":"EUR","in_stock":true},{"title":"100 g","offer_id":55559096959313,"sku":"NOR-626482-100g","price":54.2,"currency_code":"EUR","in_stock":true},{"title":"250 g","offer_id":55600626663761,"sku":"NOR-626482-250g","price":74.2,"currency_code":"EUR","in_stock":true},{"title":"500 g","offer_id":55559096992081,"sku":"NOR-626482-500g","price":94.2,"currency_code":"EUR","in_stock":true},{"title":"1 kg","offer_id":55559097024849,"sku":"NOR-626482-1000g","price":149.2,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0954\/6357\/1793\/files\/6-Methyluracil.png?v=1793375124"},{"product_id":"7-methyladenine-cas-935-69-3","title":"7-Methyladenine | CAS 935-69-3 | ≥95%","description":"\u003cdiv style=\"margin-bottom: 28px;\"\u003e\n\u003cdiv style=\"background: #002147; padding: 10px 20px; margin-bottom: 0;\"\u003e\u003ch3 style=\"margin: 0; font-family: 'Helvetica Neue', Helvetica, Arial, sans-serif; font-size: 0.70em; font-weight: bold; letter-spacing: 0.12em; text-transform: uppercase; color: #fff;\"\u003eTechnical Specifications\u003c\/h3\u003e\u003c\/div\u003e\n\u003ctable style=\"width: 100%; border-collapse: collapse; font-size: 0.95em; border: 1px solid #e4e8f0; border-top: none; font-family: 'Helvetica Neue', Helvetica, Arial, sans-serif;\"\u003e\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eCAS Number\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e935-69-3\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eMDL Number\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003eMFCD00127790\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eSMILES\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0; word-break: break-all;\"\u003eCN1C=NC2=NC=NC(=C21)N\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eInChI\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0; word-break: break-all;\"\u003eInChI=1S\/C6H7N5\/c1-11-3-10-6-4(11)5(7)8-2-9-6\/h2-3H,1H3,(H2,7,8,9)\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eInChIKey\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0; word-break: break-all;\"\u003eHCGHYQLFMPXSDU-UHFFFAOYSA-N\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003ePubChem CID\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e71593\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eMolecular Formula\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003eC₆H₇N₅\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eMolecular Weight\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e149.15 g\/mol\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eMelting Point\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e346–350 °C\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003ePurity\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e≥95%\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003ePhysical Form\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003eSolid\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eShelf Life\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003eRetest period: 36 months from date of manufacture\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eStorage Conditions\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333;\"\u003eStore in a cool, dry place in a tightly sealed container.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\u003c\/table\u003e\n\u003c\/div\u003e","brand":"NorrChemica™","offers":[{"title":"100 mg","offer_id":55559164395857,"sku":"NOR-935693-100mg","price":198.2,"currency_code":"EUR","in_stock":true},{"title":"250 mg","offer_id":55559164428625,"sku":"NOR-935693-250mg","price":289.2,"currency_code":"EUR","in_stock":true},{"title":"1.0 g","offer_id":55559164461393,"sku":"NOR-935693-1g","price":875.0,"currency_code":"EUR","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0954\/6357\/1793\/files\/7-Methyladenine.png?v=1793375062"}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0954\/6357\/1793\/collections\/Thymidine.jpg?v=1789512635","url":"https:\/\/www.norrchemica.com\/collections\/nucleosides-nucleobases.oembed?page=2","provider":"NorrChemica","version":"1.0","type":"link"}