{"product_id":"1-1-carbonyldiimidazole-cas-530-62-1","title":"CDI (1,1'-Carbonyldiimidazole) | CAS 530-62-1 | ≥98%","description":"\u003cdiv style=\"margin-bottom: 28px;\"\u003e\n\u003cdiv style=\"background: #002147; padding: 10px 20px; margin-bottom: 0;\"\u003e  \u003ch3 style=\"margin: 0; font-family: 'Helvetica Neue', Helvetica, Arial, sans-serif; font-size: 0.70em; font-weight: 700; letter-spacing: 0.12em; text-transform: uppercase; color: #fff;\"\u003eTechnical Specifications\u003c\/h3\u003e\n\u003c\/div\u003e\n\u003ctable style=\"width: 100%; border-collapse: collapse; font-size: 0.95em; border: 1px solid #e4e8f0; border-top: none; font-family: 'Helvetica Neue', Helvetica, Arial, sans-serif;\"\u003e\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eCAS Number\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e530-62-1\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eEC \/ EINECS Number\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e208-488-9\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eMDL Number\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003eMFCD00005286\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eSMILES\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0; word-break: break-all;\"\u003eC1=CN(C=N1)C(=O)N2C=CN=C2\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eInChI\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0; word-break: break-all;\"\u003eInChI=1S\/C7H6N4O\/c12-7(10-3-1-8-5-10)11-4-2-9-6-11\/h1-6H\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eInChIKey\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0; word-break: break-all;\"\u003ePFKFTWBEEFSNDU-UHFFFAOYSA-N\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003ePubChem CID\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e68263\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eMolecular Formula\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003eC₇H₆N₄O\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eMolecular Weight\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e162.15 g\/mol\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eMelting Point\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e115–121 °C\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eSolubility\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003eSoluble in THF, DMF, acetonitrile, dichloromethane; reacts with water (hydrolysis releasing CO₂ and imidazole)\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eLog P\u003csub\u003eow\u003c\/sub\u003e\n\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e-0.41\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003ePurity\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e≥98%\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003ePhysical Form\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003eWhite to pale yellow crystalline powder\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eHS Code\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e2933.29\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eShelf Life\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003eRetest period: 36 months from date of manufacture\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eStorage Conditions\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003eStore in a cool, dry place in a tightly sealed container, protected from moisture\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\u003c\/table\u003e\n\u003c\/div\u003e\u003cdiv style=\"margin-bottom: 28px;\"\u003e\n\u003cdiv style=\"background: #002147; padding: 10px 20px; margin-bottom: 0;\"\u003e  \u003ch3 style=\"margin: 0; font-family: 'Helvetica Neue', Helvetica, Arial, sans-serif; font-size: 0.70em; font-weight: 700; letter-spacing: 0.12em; text-transform: uppercase; color: #fff;\"\u003eProduct Description \u0026amp; Scientific Applications\u003c\/h3\u003e\n\u003c\/div\u003e\n\u003cdiv style=\"padding: 16px 20px; border: 1px solid #e4e8f0; border-top: none; font-family: Georgia, 'Times New Roman', serif; font-size: 0.95em; line-height: 1.65; color: #333;\"\u003e\n\u003cp\u003e\u003cstrong\u003eCarboxylic Acid Activation and Amide Bond Formation\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eCDI converts carboxylic acids into acyl imidazolides. The acyl imidazolide reacts with primary or secondary amines to give the amide under mild conditions. The only by-products are CO₂ and imidazole, both removed by aqueous wash. Yields are typically 80–95%, and racemisation at α-stereocentres is minimal. DBU accelerates the aminolysis step, particularly with electron-deficient anilines. Imidazole·HCl gives the same rate enhancement through acid catalysis. There are also known mechanochemical variants of this reaction which proceed by ball-milling without the need of a reaction solvent.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003ePeptide Synthesis\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eCDI activates N-protected amino acids as acyl imidazolides, which couple with the free amine of the next residue. The reagent scales well: soluble by-products and a clean workup give it an edge over carbodiimides on process scale. The αvβ3 integrin antagonist programme used CDI peptide coupling at hundreds of kilograms in the pilot plant.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003ePhosgene Substitute — Carbamate, Urea, and Carbonate Synthesis\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eCDI replaces phosgene (COCl2) in carbamate, urea, and carbonate synthesis. The carbonyl transfers to two nucleophiles in sequence. An alcohol or amine displaces the first imidazole to give an imidazolyl carbonate or carbamoyl-imidazole. A second nucleophile displaces the remaining imidazole to give the product. One pot, no phosgene. Mechanochemical variants of these transformations are also known, proceeding by ball-milling without solvent.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eEsterification and Cyclisation\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eCDI activates carboxylic acids for esterification with alcohols. A catalytic strong base (sodium alkoxide or NaH) or moderate heating drives alcoholysis of the acyl imidazolide. The method works on sterically hindered substrates and delivered the key ester in the total synthesis of halipeptin D. Acyl imidazolides also cyclise intramolecularly to macrolactones. In heterocycle chemistry, CDI carries out tandem coupling and cyclisation as a single reagent, including a continuous-flow route to [1,2,4]triazolo[4,3-a]pyridines.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003ePharmaceutical Intermediates and Bioconjugation\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eCDI appears in the process chemistry of several marketed drugs. Bayer's finerenone synthesis uses CDI with DMAP and aqueous ammonia for the final amide. The GSK\/ViiV cabotegravir route couples the acid intermediate with 2,4-difluorobenzylamine through CDI. The Pfizer abrocitinib route uses CDI in an azide-free Lossen rearrangement that takes a hydroxamic acid to the amine. CDI also prepares nucleoside phosphorimidazolides, β-keto sulfones, β-enamino acids, and tetronic acids. In bioconjugation, CDI activates hydroxyl groups on agarose, cellulose, and dextran to form imidazole carbamates. These react with primary amines at pH 9–11 to give stable N-alkylcarbamate linkages. This is the chemistry behind commercial CDI-activated agarose resins, used for immobilising enzymes, antibodies, and affinity ligands on chromatography supports, biosensor surfaces, and superparamagnetic nanoparticle vaccine carriers. \u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eFurther Reading\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eFor guidance on selecting between carbodiimides, aminium\/uronium salts, phosphonium salts, and other reagent classes for amide and peptide bond formation, see NorrChemica's Lab Journal guide: \u003ca href=\"https:\/\/www.norrchemica.com\/blogs\/lab-journal\/choosing-a-coupling-reagent-for-amide-and-peptide-bond-formation\"\u003eChoosing a Coupling Reagent for Amide and Peptide Bond Formation\u003c\/a\u003e.\u003c\/p\u003e\n\u003cp\u003e\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\u003cdiv style=\"margin-bottom: 28px;\"\u003e\n\u003cdiv style=\"background: #002147; padding: 10px 20px; margin-bottom: 0;\"\u003e  \u003ch3 style=\"margin: 0; font-family: 'Helvetica Neue', Helvetica, Arial, sans-serif; font-size: 0.70em; font-weight: 700; letter-spacing: 0.12em; text-transform: uppercase; color: #fff;\"\u003eShipping Destinations\u003c\/h3\u003e\n\u003c\/div\u003e\n\u003cdiv style=\"border: 1px solid #e4e8f0; border-top: none; padding: 12px 16px; font-family: 'Helvetica Neue', Helvetica, Arial, sans-serif; font-size: 0.95em;\"\u003e\u003cul style=\"margin: 0; padding: 0; list-style: none;\"\u003e\u003cli style=\"padding: 5px 0; border-bottom: 1px solid #f0f0f0;\"\u003e\n\u003cspan style=\"display: inline-block; width: 7px; height: 7px; background: #002147; border-radius: 50%; margin-right: 10px; vertical-align: middle;\"\u003e\u003c\/span\u003eEU \u0026amp; UK only: 3–7 business days. Classified as dangerous goods — shipping restrictions apply outside the EU\/UK\u003c\/li\u003e\u003c\/ul\u003e\u003c\/div\u003e\n\u003c\/div\u003e","brand":"NorrChemica™","offers":[{"title":"25 g","offer_id":53793638678865,"sku":"NOR-530621-25g","price":29.2,"currency_code":"EUR","in_stock":true},{"title":"50 g","offer_id":53793638711633,"sku":"NOR-530621-50g","price":47.2,"currency_code":"EUR","in_stock":true},{"title":"100 g","offer_id":53793638744401,"sku":"NOR-530621-100g","price":59.8,"currency_code":"EUR","in_stock":true},{"title":"250 g","offer_id":53793638777169,"sku":"NOR-530621-250g","price":89.8,"currency_code":"EUR","in_stock":true},{"title":"500 g","offer_id":53793638809937,"sku":"NOR-530621-500g","price":142.2,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0954\/6357\/1793\/files\/CDI-small.png?v=1782891379","url":"https:\/\/www.norrchemica.com\/products\/1-1-carbonyldiimidazole-cas-530-62-1","provider":"NorrChemica","version":"1.0","type":"link"}