{"product_id":"3-methoxyphenylboronic-acid-powder-cas-10365-98-7-purity-98","title":"3-Methoxyphenylboronic Acid | CAS 10365-98-7 | ≥98%","description":"\u003cdiv style=\"margin-bottom: 28px;\"\u003e\n\u003cdiv style=\"background: #002147; padding: 10px 20px; margin-bottom: 0;\"\u003e  \u003ch3 style=\"margin: 0; font-family: 'Helvetica Neue', Helvetica, Arial, sans-serif; font-size: 0.70em; font-weight: 700; letter-spacing: 0.12em; text-transform: uppercase; color: #fff;\"\u003eTechnical Specifications\u003c\/h3\u003e\n\u003c\/div\u003e\n\u003ctable style=\"width: 100%; border-collapse: collapse; font-size: 0.95em; border: 1px solid #e4e8f0; border-top: none; font-family: 'Helvetica Neue', Helvetica, Arial, sans-serif;\"\u003e\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eCAS Number\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e10365-98-7\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eEC \/ EINECS Number\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e600-467-6\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eMDL Number\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003eMFCD00039111\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eSMILES\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0; word-break: break-all;\"\u003eB(C1=CC(=CC=C1)OC)(O)O\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eInChI\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0; word-break: break-all;\"\u003eInChI=1S\/C7H9BO3\/c1-11-7-4-2-3-6(5-7)8(9)10\/h2-5,9-10H,1H3\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eInChIKey\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0; word-break: break-all;\"\u003eNLLGFYPSWCMUIV-UHFFFAOYSA-N\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003ePubChem CID\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e2734370\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eMolecular Formula\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003eC₇H₉BO₃\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eMolecular Weight\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e151.96 g\/mol\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eMelting Point\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e160–163 °C\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eSolubility\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003eSlightly soluble in water; soluble in alcoholic solvents, acetonitrile, DMF, DMSO.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003ePurity\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e≥98%. May contain small variable amounts of boron anhydrides\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003ePhysical Form\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003eWhite to light beige crystalline powder\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eHS Code\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e2931.90\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eShelf Life\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003eRetest period: 36 months from date of manufacture.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eStorage Conditions\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003eStore at room temperature. Keep container tightly closed in a dry place. Mildly hygroscopic — protect from moisture\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eSDS \/ CoA\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333;\"\u003e\u003ca href=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0954\/6357\/1793\/files\/3-Methoxyphenylboronic_acid_SDS_NorrChemica_v2.0_2026.pdf?v=1775148205\" target=\"_blank\" rel=\"noopener noreferrer\" style=\"color: #002147; text-decoration: underline; font-weight: 500;\"\u003eDownload PDF\u003c\/a\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\u003c\/table\u003e\n\u003c\/div\u003e\u003cdiv style=\"margin-bottom: 28px;\"\u003e\n\u003cdiv style=\"background: #002147; padding: 10px 20px; margin-bottom: 0;\"\u003e  \u003ch3 style=\"margin: 0; font-family: 'Helvetica Neue', Helvetica, Arial, sans-serif; font-size: 0.70em; font-weight: 700; letter-spacing: 0.12em; text-transform: uppercase; color: #fff;\"\u003eProduct Description \u0026amp; Scientific Applications\u003c\/h3\u003e\n\u003c\/div\u003e\n\u003cdiv style=\"padding: 16px 20px; border: 1px solid #e4e8f0; border-top: none; font-family: Georgia, 'Times New Roman', serif; font-size: 0.95em; line-height: 1.65; color: #333;\"\u003e\n\u003cp\u003e\u003cstrong\u003e3-Methoxyphenylboronic Acid\u003c\/strong\u003e (\u003cem\u003em\u003c\/em\u003e-anisylboronic acid, \u003cem\u003em\u003c\/em\u003e-methoxybenzeneboronic acid) is an arylboronic acid often used in medicinal-chemistry, agrochemical, and fine-chemical synthesis. At the \u003cem\u003emeta\u003c\/em\u003e position, the methoxy group does not donate electron density to the boronic-acid-bearing carbon by resonance; its net Hammett effect is weakly electron-withdrawing (σm ≈ +0.12), giving a boronic-acid pKa estimated near 8.5 and close to phenylboronic acid. After cross-coupling, the methoxy substituent can serve as a masked phenol, allowing later access to 3-hydroxyaryl products.\u003c\/p\u003e\n\u003cp\u003eThe product may contain small amounts of the cyclic anhydride 3-methoxyphenylboroxine; under aqueous or basic coupling conditions the two forms re-equilibrate and the impact on yield is minor.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eApplications and Reactions\u003c\/strong\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eSuzuki–Miyaura coupling:\u003c\/strong\u003e couples with aryl, heteroaryl, vinyl, and alkenyl electrophiles to give 3-methoxybiaryls and related aryl-substituted products. The meta-methoxy group is usually carried through the coupling as an intact aryl ether, which makes the reagent useful for installing a masked 3-hydroxyphenyl motif on the coupled scaffold.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eMethoxy-to-phenol unmasking:\u003c\/strong\u003e after coupling, the methoxy ether on the 3-methoxybiaryl can be cleaved by BBr3, AlCl3, or thiolate-based demethylation to give the 3-hydroxybiaryl. The free phenol can be alkylated or acylated, or converted to an aryl sulfonate such as a triflate for subsequent C–C or C–N cross-coupling.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eRh-catalysed conjugate addition:\u003c\/strong\u003e 3-methoxyphenylboronic acid has been used as the aryl donor in rhodium-catalysed asymmetric 1,4-addition to β-aryl-α,β-unsaturated ketones and tert-butyl cinnamate-type esters. Under [Rh(nbd)2]BF4\/(S,S)-chiraphos catalysis, the 3-methoxyphenyl group is transferred to the β-carbon to give enantioenriched β-diaryl carbonyl products.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eOxidative ipso-hydroxylation:\u003c\/strong\u003e aqueous hydrogen peroxide under basic conditions can replace B(OH)2 with hydroxyl at the same carbon to give 3-methoxyphenol. This route is distinct from methoxy-to-phenol unmasking: ipso-hydroxylation cleaves the C–B bond on the boronic acid itself, while demethylation cleaves the methyl ether on a coupled product.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eChan–Lam N\/O arylation:\u003c\/strong\u003e arylboronic acids can undergo copper-mediated oxidative coupling with N- and O-nucleophiles under air. The 3-methoxyphenyl analogue may be used where the selected Chan–Lam method tolerates anisylboronic acids.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePetasis borono-Mannich:\u003c\/strong\u003e arylboronic acids can participate in metal-free three-component coupling with amines and carbonyl partners to give α-aryl amines, α-amino acids, or β-amino alcohols. Use of the 3-methoxyphenyl analogue depends on the chosen Petasis method and substrate set.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eIpso-halodeboronation:\u003c\/strong\u003e organoboron halodeboronation methods can replace B(OH)2 with Br, Cl, or I, providing a route to meta-haloanisole motifs (3-bromoanisole, 3-chloroanisole, 3-iodoanisole) when the substrate and halogenation method are compatible. This complements classical electrophilic aromatic substitution of anisole, where the methoxy group favours \u003cem\u003eortho\u003c\/em\u003e\/\u003cem\u003epara\u003c\/em\u003e substitution.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cstrong\u003eFurther Reading\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eFor boronic acids, boronic esters, protodeboronation, boroxine content, and Suzuki–Miyaura reagent selection, see NorrChemica's Lab Journal guide: \u003ca href=\"https:\/\/www.norrchemica.com\/blogs\/lab-journal\/boron-reagent-selection-suzuki-miyaura-coupling\"\u003eChoosing Your Boron Source for Suzuki–Miyaura Coupling\u003c\/a\u003e.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\u003cdiv style=\"margin-bottom: 28px;\"\u003e\n\u003cdiv style=\"background: #002147; padding: 10px 20px; margin-bottom: 0;\"\u003e  \u003ch3 style=\"margin: 0; font-family: 'Helvetica Neue', Helvetica, Arial, sans-serif; font-size: 0.70em; font-weight: 700; letter-spacing: 0.12em; text-transform: uppercase; color: #fff;\"\u003eShipping Destinations\u003c\/h3\u003e\n\u003c\/div\u003e\n\u003cdiv style=\"border: 1px solid #e4e8f0; border-top: none; padding: 12px 16px; font-family: 'Helvetica Neue', Helvetica, Arial, sans-serif; font-size: 0.95em;\"\u003e\u003cul style=\"margin: 0; padding: 0; list-style: none;\"\u003e\n\u003cli style=\"padding: 5px 0; border-bottom: 1px solid #f0f0f0;\"\u003e\n\u003cspan style=\"display: inline-block; width: 7px; height: 7px; background: #002147; border-radius: 50%; margin-right: 10px; vertical-align: middle;\"\u003e\u003c\/span\u003eEU \u0026amp; UK: Priority delivery, 2–5 business days.\u003c\/li\u003e\n\u003cli style=\"padding: 5px 0; border-bottom: 1px solid #f0f0f0;\"\u003e\n\u003cspan style=\"display: inline-block; width: 7px; height: 7px; background: #002147; border-radius: 50%; margin-right: 10px; vertical-align: middle;\"\u003e\u003c\/span\u003eUnited States (DDP): 3–7 business days, duties and taxes prepaid.\u003c\/li\u003e\n\u003cli style=\"padding: 5px 0; border-bottom: 1px solid #f0f0f0;\"\u003e\n\u003cspan style=\"display: inline-block; width: 7px; height: 7px; background: #002147; border-radius: 50%; margin-right: 10px; vertical-align: middle;\"\u003e\u003c\/span\u003eEFTA Countries (DDP): 3–7 business days, duties and taxes prepaid.\u003c\/li\u003e\n\u003cli style=\"padding: 5px 0; border-bottom: 1px solid #f0f0f0;\"\u003e\n\u003cspan style=\"display: inline-block; width: 7px; height: 7px; background: #002147; border-radius: 50%; margin-right: 10px; vertical-align: middle;\"\u003e\u003c\/span\u003eWorldwide: 7–14 business days, selected locations.\u003c\/li\u003e\n\u003c\/ul\u003e\u003c\/div\u003e\n\u003c\/div\u003e","brand":"NorrChemica™","offers":[{"title":"5.0 g","offer_id":53429587902801,"sku":"NOR-10365987-5g","price":21.95,"currency_code":"EUR","in_stock":true},{"title":"10 g","offer_id":53429587935569,"sku":"NOR-10365987-10g","price":34.95,"currency_code":"EUR","in_stock":true},{"title":"25 g","offer_id":53429587968337,"sku":"NOR-10365987-25g","price":54.2,"currency_code":"EUR","in_stock":true},{"title":"50 g","offer_id":53429588001105,"sku":"NOR-10365987-50g","price":98.2,"currency_code":"EUR","in_stock":true},{"title":"100 g","offer_id":53429588033873,"sku":"NOR-10365987-100g","price":179.2,"currency_code":"EUR","in_stock":true},{"title":"250 g","offer_id":53429588066641,"sku":"NOR-10365987-250g","price":329.2,"currency_code":"EUR","in_stock":true},{"title":"500 g","offer_id":53429588099409,"sku":"NOR-10365987-500g","price":579.2,"currency_code":"EUR","in_stock":true},{"title":"1 kg","offer_id":53429588132177,"sku":"NOR-10365987-1000g","price":995.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0954\/6357\/1793\/files\/NorrChemica_3-Methoxyphenylboronic_Acid.png?v=1782683321","url":"https:\/\/www.norrchemica.com\/products\/3-methoxyphenylboronic-acid-powder-cas-10365-98-7-purity-98","provider":"NorrChemica","version":"1.0","type":"link"}