{"product_id":"5-methylcytidine-cas-2140-61-6","title":"5-Methylcytidine | CAS 2140-61-6 | ≥97%","description":"\u003cdiv style=\"margin-bottom: 28px;\"\u003e\n\u003cdiv style=\"background: #002147; padding: 10px 20px; margin-bottom: 0;\"\u003e\u003ch3 style=\"margin: 0; font-family: 'Helvetica Neue', Helvetica, Arial, sans-serif; font-size: 0.70em; font-weight: bold; letter-spacing: 0.12em; text-transform: uppercase; color: #fff;\"\u003eTechnical Specifications\u003c\/h3\u003e\u003c\/div\u003e\n\u003ctable style=\"width: 100%; border-collapse: collapse; font-size: 0.95em; border: 1px solid #e4e8f0; border-top: none; font-family: 'Helvetica Neue', Helvetica, Arial, sans-serif;\"\u003e\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eCAS Number\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e2140-61-6\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eEC \/ EINECS Number\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e218-390-8\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eMDL Number\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003eMFCD00006548\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eSMILES\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0; word-break: break-all;\"\u003eCC1=CN(C(=O)N=C1N)[C@H]2[C@@H]([C@@H]([C@H](O2)CO)O)O\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eInChI\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0; word-break: break-all;\"\u003eInChI=1S\/C10H15N3O5\/c1-4-2-13(10(17)12-8(4)11)9-7(16)6(15)5(3-14)18-9\/h2,5-7,9,14-16H,3H2,1H3,(H2,11,12,17)\/t5-,6-,7-,9-\/m1\/s1\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eInChIKey\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0; word-break: break-all;\"\u003eZAYHVCMSTBRABG-JXOAFFINSA-N\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003ePubChem CID\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e92918\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eMolecular Formula\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003eC₁₀H₁₅N₃O₅\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eMolecular Weight\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e257.24 g\/mol\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eMelting Point\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e212–215 °C (dec.)\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eSolubility\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003eSoluble in water, DMSO, DMF and phosphate-buffered saline (pH 7.2).\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eLog Pow\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e-2.01\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003ePurity\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e≥97%\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003ePhysical Form\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003eWhite to almost white powder or crystals\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eHS Code\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e2934.99\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eShelf Life\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003eRetest period: 36 months from date of manufacture\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eStorage Conditions\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333;\"\u003eStore in a cool, dry place in a tightly sealed container.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\u003c\/table\u003e\n\u003c\/div\u003e\n\u003cdiv style=\"margin-bottom: 28px;\"\u003e\n\u003cdiv style=\"background: #002147; padding: 10px 20px; margin-bottom: 0;\"\u003e\u003ch3 style=\"margin: 0; font-family: 'Helvetica Neue', Helvetica, Arial, sans-serif; font-size: 0.70em; font-weight: bold; letter-spacing: 0.12em; text-transform: uppercase; color: #fff;\"\u003eProduct Description \u0026amp; Scientific Applications\u003c\/h3\u003e\u003c\/div\u003e\n\u003cdiv style=\"padding: 16px 20px; border: 1px solid #e4e8f0; border-top: none; font-family: Georgia, 'Times New Roman', serif; font-size: 0.95em; line-height: 1.65; color: #333;\"\u003e\u003cdiv\u003e\n\u003cp\u003e\u003cstrong\u003e5-Methylcytidine\u003c\/strong\u003e (m\u003csup\u003e5\u003c\/sup\u003eC) is cytidine with a methyl group at C5 of the cytosine ring. It occurs naturally in RNA, and it has long been known to occur in the tRNA and rRNA of a wide variety of organisms. Transcriptome-wide mapping has also reported m\u003csup\u003e5\u003c\/sup\u003eC sites in the mRNAs of an archaeon and, in one study of human cells, candidate sites in mRNAs and in non-coding RNAs.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eFormation in RNA.\u003c\/strong\u003e In RNA, m\u003csup\u003e5\u003c\/sup\u003eC is formed by m\u003csup\u003e5\u003c\/sup\u003eC RNA methyltransferases, which transfer a methyl group from S-adenosyl-L-methionine (SAM) to C5 of a cytidine residue. A cysteine of the enzyme first adds to C6. This makes C5 nucleophilic, so it takes the methyl group from SAM, and β-elimination of the cysteine and the C5 hydrogen then releases the enzyme. In animals, the methyltransferase NSUN2 is known to modify specific tRNAs. One study of human RNA found further NSUN2 targets: another tRNA, the RPPH1 subunit of RNase P and two mRNAs. Another study found that human DNMT2, which closely resembles DNA cytosine methyltransferases, did not methylate DNA but methylated cytosine 38 in the anticodon loop of tRNA\u003csup\u003eAsp\u003c\/sup\u003e.\u003c\/p\u003e\n\u003cdiv style=\"margin:8px 0 18px 0;\"\u003e\n\u003cdiv style=\"display:flex;flex-wrap:wrap;align-items:center;justify-content:flex-start;gap:2px;\"\u003e\n\u003cdiv style=\"display:flex;align-items:center;\"\u003e\u003csvg role=\"img\" style=\"max-width:100%;height:auto;\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" fill=\"none\" stroke=\"#000\" stroke-width=\"1.6\" width=\"166px\" height=\"105px\" viewbox=\"0 0 166 105\"\u003e\u003cpath d=\"M 43.3,39.3 L 60.2,49.0\"\u003e\u003c\/path\u003e\u003cpath d=\"M 46.3,37.6 L 60.2,45.6\"\u003e\u003c\/path\u003e\u003cpath d=\"M 60.2,49.0 L 72.7,41.7\"\u003e\u003c\/path\u003e\u003cpath d=\"M 76.9,35.1 L 76.9,19.9\"\u003e\u003c\/path\u003e\u003cpath d=\"M 76.9,21.6 L 90.2,13.9\"\u003e\u003c\/path\u003e\u003cpath d=\"M 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sans-serif;fill:#000;stroke:none\"\u003eO\u003c\/text\u003e\u003ctext x=\"120.4\" y=\"28.2\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eH\u003c\/text\u003e\u003c\/svg\u003e\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cp style=\"font-size:12px;margin:4px 0 0 0;\"\u003e\u003cem\u003eFormation of 5-methylcytidine (m\u003csup\u003e5\u003c\/sup\u003eC, right) from cytidine (left) by an m\u003csup\u003e5\u003c\/sup\u003eC RNA methyltransferase, with S-adenosyl-L-methionine (SAM) as the methyl donor. In RNA the reaction takes place on cytidine residues; the structures are drawn as nucleosides.\u003c\/em\u003e\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cp\u003e\u003cstrong\u003eDetection by bisulfite sequencing.\u003c\/strong\u003e Sodium bisulfite converts cytosine residues in single-stranded DNA to uracil. At acidic pH, bisulfite adds to C6, with protonation at C5, to give a 5,6-dihydrocytosine-6-sulfonate. This is deaminated to 5,6-dihydrouracil-6-sulfonate. Treatment under basic conditions then restores the 5,6-double bond by β-elimination, which gives uracil. The reaction is selective for cytosine over 5-methylcytosine, the base of 5-methylcytidine. This selectivity is the basis of bisulfite sequencing, which locates m\u003csup\u003e5\u003c\/sup\u003eC sites. One study adapted the method to RNA and detected cytosine methylation in tRNAs and rRNAs reproducibly and quantitatively.\u003c\/p\u003e\n\u003cdiv style=\"margin:8px 0 18px 0;\"\u003e\n\u003cdiv style=\"display:flex;flex-wrap:wrap;align-items:center;justify-content:flex-start;gap:2px;\"\u003e\n\u003cdiv style=\"display:flex;align-items:center;\"\u003e\u003csvg role=\"img\" style=\"max-width:100%;height:auto;\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" fill=\"none\" stroke=\"#000\" stroke-width=\"1.6\" width=\"110px\" height=\"58px\" viewbox=\"0 0 110 58\"\u003e\u003cpath d=\"M 14.6,43.5 L 25.0,41.1\"\u003e\u003c\/path\u003e\u003cpath d=\"M 33.4,44.6 L 42.5,54.2\"\u003e\u003c\/path\u003e\u003cpath d=\"M 42.5,54.2 L 61.4,49.8\"\u003e\u003c\/path\u003e\u003cpath d=\"M 43.4,51.0 L 59.1,47.3\"\u003e\u003c\/path\u003e\u003cpath d=\"M 61.4,49.8 L 67.0,31.2\"\u003e\u003c\/path\u003e\u003cpath d=\"M 67.0,31.2 L 81.6,27.8\"\u003e\u003c\/path\u003e\u003cpath d=\"M 67.0,31.2 L 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4px;text-align:center;font-size:12px;line-height:1.3;\"\u003e\n\u003cdiv\u003edeamination\u003c\/div\u003e\n\u003cdiv style=\"font-size:30px;line-height:1;\"\u003e⟶\u003c\/div\u003e\n\u003cdiv\u003e\u003c\/div\u003e\n\u003c\/div\u003e\u003c\/div\u003e\n\u003cdiv style=\"display:flex;align-items:center;\"\u003e\u003csvg role=\"img\" style=\"max-width:100%;height:auto;\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" fill=\"none\" stroke=\"#000\" stroke-width=\"1.6\" width=\"95px\" height=\"109px\" viewbox=\"0 0 95 109\"\u003e\u003cpath d=\"M 13.7,47.4 L 24.1,45.0\"\u003e\u003c\/path\u003e\u003cpath d=\"M 32.6,48.5 L 41.6,58.1\"\u003e\u003c\/path\u003e\u003cpath d=\"M 41.6,58.1 L 37.2,72.4\"\u003e\u003c\/path\u003e\u003cpath d=\"M 39.8,79.4 L 49.9,82.4\"\u003e\u003c\/path\u003e\u003cpath d=\"M 40.6,76.6 L 50.7,79.6\"\u003e\u003c\/path\u003e\u003cpath d=\"M 32.1,74.0 L 22.1,71.0\"\u003e\u003c\/path\u003e\u003cpath d=\"M 31.3,76.8 L 21.2,73.7\"\u003e\u003c\/path\u003e\u003cpath d=\"M 34.0,83.3 L 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sans-serif;fill:#000;stroke:none\"\u003eR\u003c\/text\u003e\u003ctext x=\"24.8\" y=\"46.5\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eN\u003c\/text\u003e\u003ctext x=\"81.2\" y=\"33.3\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eO\u003c\/text\u003e\u003ctext x=\"49.2\" y=\"23.7\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eN\u003c\/text\u003e\u003ctext x=\"49.2\" y=\"13.1\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eH\u003c\/text\u003e\u003ctext x=\"17.2\" y=\"14.0\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eO\u003c\/text\u003e\u003c\/svg\u003e\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cp style=\"font-size:12px;margin:4px 0 0 0;\"\u003e\u003cem\u003eBisulfite-mediated deamination of a cytidine residue to a uridine residue (R = ribose of the RNA). At acidic pH, bisulfite adds at C6 to give 5,6-dihydrocytosine-6-sulfonate, deamination gives 5,6-dihydrouracil-6-sulfonate, and β-elimination under basic conditions restores the 5,6-double bond. The reaction is selective for cytidine over 5-methylcytidine.\u003c\/em\u003e\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cp\u003e\u003cstrong\u003eOxidation to 5-hydroxymethylcytidine.\u003c\/strong\u003e In one study, the catalytic domain of Tet1, one of the Tet enzymes that oxidise 5-methylcytosine in DNA, converted 5-methylcytidine in a single-stranded RNA to 5-hydroxymethylcytidine in vitro. Overexpressing the catalytic domains of the three Tet enzymes in human cells raised the level of 5-hydroxymethylcytidine in their RNA. In another study, isotope-tracing experiments showed that 5-methylcytidine is oxidised in mammals to 5-hydroxymethylcytidine and 5-formylcytidine. 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y=\"59.6\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eO\u003c\/text\u003e\u003ctext x=\"148.7\" y=\"59.6\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eH\u003c\/text\u003e\u003ctext x=\"112.2\" y=\"28.2\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eO\u003c\/text\u003e\u003ctext x=\"120.4\" y=\"28.2\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eH\u003c\/text\u003e\u003c\/svg\u003e\u003c\/div\u003e\n\u003cdiv style=\"display:flex;align-items:center;\"\u003e\u003cdiv style=\"display:flex;flex-direction:column;align-items:center;justify-content:center;min-width:90px;max-width:150px;padding:0 4px;text-align:center;font-size:12px;line-height:1.3;\"\u003e\n\u003cdiv\u003eTet1 catalytic domain\u003c\/div\u003e\n\u003cdiv style=\"font-size:30px;line-height:1;\"\u003e⟶\u003c\/div\u003e\n\u003cdiv\u003e(in RNA, in vitro)\u003c\/div\u003e\n\u003c\/div\u003e\u003c\/div\u003e\n\u003cdiv style=\"display:flex;align-items:center;\"\u003e\u003csvg 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sans-serif;fill:#000;stroke:none\"\u003eH\u003c\/text\u003e\u003ctext x=\"32.5\" y=\"20.8\" style=\"font:7px sans-serif;fill:#000;stroke:none\"\u003e2\u003c\/text\u003e\u003ctext x=\"36.3\" y=\"16.0\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eN\u003c\/text\u003e\u003ctext x=\"11.8\" y=\"45.4\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eH\u003c\/text\u003e\u003ctext x=\"19.5\" y=\"45.4\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eO\u003c\/text\u003e\u003c\/svg\u003e\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cp style=\"font-size:12px;margin:4px 0 0 0;\"\u003e\u003cem\u003eOxidation of a 5-methylcytidine residue (m\u003csup\u003e5\u003c\/sup\u003eC, left) to a 5-hydroxymethylcytidine residue (right) in RNA, shown in one study with the catalytic domain of Tet1 in vitro. The structures are drawn as nucleosides.\u003c\/em\u003e\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cp\u003e\u003cstrong\u003eModified mRNA.\u003c\/strong\u003e In one study, RNA made by in vitro transcription with 5-methylcytidine no longer stimulated the RNA sensors TLR7 and TLR8 in cell lines that express these receptors. For TLR3, the suppression was less marked than with some other modifications, or absent. This RNA still activated primary dendritic cells from blood as strongly as unmodified RNA. In work on reprogramming human cells with synthetic mRNA, complete replacement of cytidine by 5-methylcytidine in GFP-encoding transcripts improved cell viability and increased protein expression. The largest improvement came when 5-methylcytidine was combined with pseudouridine in place of uridine. These transcripts were made with 5-methylcytidine triphosphate. In a later study, mRNA carrying 5-methylcytidine together with N1-methylpseudouridine, another replacement for uridine, gave higher reporter protein expression than mRNA carrying 5-methylcytidine with pseudouridine. In transfected cells, this mRNA also caused less innate immune activation and gave better cell viability.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eAnalytical standard.\u003c\/strong\u003e Synthetic 5-methylcytidine has been used, together with other nucleosides, to prepare calibration solutions for the quantification of RNA modifications by LC-MS\/MS.\u003c\/p\u003e\n\u003c\/div\u003e\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cdiv style=\"margin-bottom: 28px;\"\u003e\n\u003cdiv style=\"background: #002147; padding: 10px 20px; margin-bottom: 0;\"\u003e\u003ch3 style=\"margin: 0; font-family: 'Helvetica Neue', Helvetica, Arial, sans-serif; font-size: 0.70em; font-weight: bold; letter-spacing: 0.12em; text-transform: uppercase; color: #fff;\"\u003eShipping Destinations\u003c\/h3\u003e\u003c\/div\u003e\n\u003cdiv style=\"border: 1px solid #e4e8f0; border-top: none; padding: 12px 16px; font-family: 'Helvetica Neue', Helvetica, Arial, sans-serif; font-size: 0.95em;\"\u003e\u003cul style=\"margin: 0; padding: 0; list-style: none;\"\u003e\n\u003cli style=\"padding: 5px 0; border-bottom: 1px solid #f0f0f0;\"\u003e\n\u003cspan style=\"display: inline-block; width: 7px; height: 7px; background: #002147; border-radius: 50%; margin-right: 10px; vertical-align: middle;\"\u003e\u003c\/span\u003eEU \u0026amp; UK: Priority delivery, 2–5 business days.\u003c\/li\u003e\n\u003cli style=\"padding: 5px 0; border-bottom: 1px solid #f0f0f0;\"\u003e\n\u003cspan style=\"display: inline-block; width: 7px; height: 7px; background: #002147; border-radius: 50%; margin-right: 10px; vertical-align: middle;\"\u003e\u003c\/span\u003eUnited States (DDP): 3–7 business days, duties and taxes prepaid.\u003c\/li\u003e\n\u003cli style=\"padding: 5px 0; border-bottom: 1px solid #f0f0f0;\"\u003e\n\u003cspan style=\"display: inline-block; width: 7px; height: 7px; background: #002147; border-radius: 50%; margin-right: 10px; vertical-align: middle;\"\u003e\u003c\/span\u003eEFTA Countries (DDP): 3–7 business days, duties and taxes prepaid.\u003c\/li\u003e\n\u003cli style=\"padding: 5px 0; border-bottom: 1px solid #f0f0f0;\"\u003e\n\u003cspan style=\"display: inline-block; width: 7px; height: 7px; background: #002147; border-radius: 50%; margin-right: 10px; vertical-align: middle;\"\u003e\u003c\/span\u003eWorldwide: 7–14 business days, selected locations.\u003c\/li\u003e\n\u003c\/ul\u003e\u003c\/div\u003e\n\u003c\/div\u003e","brand":"NorrChemica™","offers":[{"title":"1.0 g","offer_id":55166998741329,"sku":"NOR-2140616-1g","price":57.2,"currency_code":"EUR","in_stock":true},{"title":"2.0 g","offer_id":55358036050257,"sku":"NOR-2140616-2g","price":98.2,"currency_code":"EUR","in_stock":true},{"title":"5.0 g","offer_id":55259039007057,"sku":"NOR-2140616-5g","price":169.2,"currency_code":"EUR","in_stock":true},{"title":"10 g","offer_id":55166998774097,"sku":"NOR-2140616-10g","price":279.2,"currency_code":"EUR","in_stock":true},{"title":"25 g","offer_id":55166998806865,"sku":"NOR-2140616-25g","price":629.2,"currency_code":"EUR","in_stock":true},{"title":"50 g","offer_id":55259039039825,"sku":"NOR-2140616-50g","price":1149.0,"currency_code":"EUR","in_stock":true},{"title":"100 g","offer_id":55166998839633,"sku":"NOR-2140616-100g","price":1895.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0954\/6357\/1793\/files\/5-Methylcytidine.png?v=1791725125","url":"https:\/\/www.norrchemica.com\/products\/5-methylcytidine-cas-2140-61-6","provider":"NorrChemica","version":"1.0","type":"link"}