{"product_id":"hbtu-cas-94790-37-1","title":"HBTU | CAS 94790-37-1 | ≥98%","description":"\u003cdiv style=\"margin-bottom: 28px;\"\u003e\n\u003cdiv style=\"background: #002147; padding: 10px 20px; margin-bottom: 0;\"\u003e  \u003ch3 style=\"margin: 0; font-family: 'Helvetica Neue', Helvetica, Arial, sans-serif; font-size: 0.70em; font-weight: 700; letter-spacing: 0.12em; text-transform: uppercase; color: #fff;\"\u003eTechnical Specifications\u003c\/h3\u003e\n\u003c\/div\u003e\n\u003ctable style=\"width: 100%; border-collapse: collapse; font-size: 0.95em; border: 1px solid #e4e8f0; border-top: none; font-family: 'Helvetica Neue', Helvetica, Arial, sans-serif;\"\u003e\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eCAS Number\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e94790-37-1\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eEC \/ EINECS Number\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e423-020-5\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eMDL Number\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003eMFCD00075445\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eSMILES\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0; word-break: break-all;\"\u003eCN(C)C(=[N+](C)C)N1C2=CC=CC=C2[N+](=N1)[O-].F[P-](F)(F)(F)(F)F\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eInChI\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0; word-break: break-all;\"\u003eInChI=1S\/C11H16N5O.F6P\/c1-13(2)11(14(3)4)15-9-7-5-6-8-10(9)16(17)12-15;1-7(2,3,4,5)6\/h5-8H,1-4H3;\/q+1;-1\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eInChIKey\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0; word-break: break-all;\"\u003eBSKUEERROYGAFF-UHFFFAOYSA-N\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003ePubChem CID\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e51341376\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eMolecular Formula\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003eC₁₁H₁₆F₆N₅OP\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eMolecular Weight\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e379.24 g\/mol\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eMelting Point\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e~200 °C (dec.)\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eSolubility\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003eSoluble in acetonitrile and DMF\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003ePurity\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e≥98%\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003ePhysical Form\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003eWhite to off-white crystalline powder\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eHS Code\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e2933.99\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eShelf Life\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003eRetest period: 36 months from date of manufacture\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eStorage Conditions\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003eStore refrigerated (2–8 °C) in a tightly sealed container, protected from light and moisture\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\u003c\/table\u003e\n\u003c\/div\u003e\u003cdiv style=\"margin-bottom: 28px;\"\u003e\n\u003cdiv style=\"background: #002147; padding: 10px 20px; margin-bottom: 0;\"\u003e  \u003ch3 style=\"margin: 0; font-family: 'Helvetica Neue', Helvetica, Arial, sans-serif; font-size: 0.70em; font-weight: 700; letter-spacing: 0.12em; text-transform: uppercase; color: #fff;\"\u003eProduct Description \u0026amp; Scientific Applications\u003c\/h3\u003e\n\u003c\/div\u003e\n\u003cdiv style=\"padding: 16px 20px; border: 1px solid #e4e8f0; border-top: none; font-family: Georgia, 'Times New Roman', serif; font-size: 0.95em; line-height: 1.65; color: #333;\"\u003e\n\u003cp\u003e\u003cstrong\u003eHBTU\u003c\/strong\u003e (commonly named O-(1\u003cem\u003eH\u003c\/em\u003e-benzotriazol-1-yl)-N,N,N′,N′-tetramethyluronium hexafluorophosphate; structurally the guanidinium N-oxide salt, 1-[bis(dimethylamino)methylene]-1\u003cem\u003eH\u003c\/em\u003e-benzotriazolium 3-oxide hexafluorophosphate) is a benzotriazole-based uronium\/guanidinium coupling reagent for Fmoc solid-phase and solution-phase peptide synthesis. X-ray and solution studies confirm the guanidinium N-oxide structure. HBTU activates carboxylic acids to reactive 1-hydroxybenzotriazolyl (OBt) active esters under mild conditions, giving high coupling yields with low racemisation.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eCommon Scientific Applications\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eFmoc solid-phase peptide synthesis (SPPS):\u003c\/strong\u003e a standard coupling reagent for the dominant methodology for assembling peptides of up to roughly fifty residues on polymeric resin supports. The Fmoc-amino acid is pre-activated with HBTU and a tertiary-amine base (DIPEA or NMM) in DMF to form a benzotriazolyl active ester that acylates the free α-amino group of the resin-bound chain. It is compatible with standard Fmoc-amino acid building blocks on manual and automated synthesisers; its fast, mild activation suits high-throughput parallel synthesis.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eRacemisation suppression with HOBt:\u003c\/strong\u003e adding 1-hydroxybenzotriazole (HOBt) as an auxiliary nucleophile further suppresses racemisation at the α-carbon during activation of sterically demanding or racemisation-prone residues such as cysteine and histidine.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eSolution-phase amide-bond formation:\u003c\/strong\u003e activates a broad range of carboxylic acids — N-protected amino acids, aromatic acids, and sterically hindered substrates — for coupling with primary and secondary amines under mild conditions. The water-soluble tetramethylurea by-product is removed by aqueous extraction, unlike the insoluble urea precipitates from carbodiimide reagents such as DCC and EDC.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eMacrolactamisation and cyclic peptides:\u003c\/strong\u003e drives head-to-tail intramolecular ring closure at high dilution, suppressing oligomerisation, to give cyclic peptides with distinct conformational and metabolic-stability properties relative to linear analogues.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eFragment condensation:\u003c\/strong\u003e enables convergent peptide synthesis by coupling protected fragments; it carries a risk of C-terminal epimerisation via oxazolone formation unless the activated residue is glycine or proline.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eAcyl azides, ureas, and carbamates:\u003c\/strong\u003e HBTU activates carboxylic acids toward reaction with an azide source such as sodium azide to give acyl azides; on warming, these undergo the Curtius rearrangement to isocyanates, trapped by amines or alcohols to furnish ureas and carbamates — including dipeptidyl urea esters and symmetric and asymmetric ureas in one-pot procedures. The chemistry tolerates Fmoc, Boc, and Cbz protecting groups across diverse functional groups.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eQuinoxaline synthesis:\u003c\/strong\u003e serves as a non-metal condensing catalyst for quinoxaline derivatives from 1,2-diamines and 1,2-diketones such as benzil, under mild, short-reaction-time conditions.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eComparison with related coupling reagents:\u003c\/strong\u003e HBTU and HATU share the same tetramethyl uronium\/guanidinium cation but differ in the heteroaromatic leaving group — benzotriazol-1-yl (OBt) for HBTU, 7-azabenzotriazol-1-yl (OAt) for HATU. HATU couples faster and gives lower epimerisation at higher cost; HBTU is the routine choice, HATU reserved for difficult sequences, hindered residues, and fragment condensations. Related reagents include TBTU (tetrafluoroborate counter-ion), HCTU (6-chloro-1-hydroxybenzotriazole-derived), and COMU (morpholino-based, improved safety profile).\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eFurther Reading\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\u003ca href=\"https:\/\/www.norrchemica.com\/blogs\/lab-journal\/choosing-a-coupling-reagent-for-amide-and-peptide-bond-formation\"\u003eChoosing a Coupling Reagent for Amide and Peptide Bond Formation\u003c\/a\u003e.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\u003cdiv style=\"margin-bottom: 28px;\"\u003e\n\u003cdiv style=\"background: #002147; padding: 10px 20px; margin-bottom: 0;\"\u003e  \u003ch3 style=\"margin: 0; font-family: 'Helvetica Neue', Helvetica, Arial, sans-serif; font-size: 0.70em; font-weight: 700; letter-spacing: 0.12em; text-transform: uppercase; color: #fff;\"\u003eShipping Destinations\u003c\/h3\u003e\n\u003c\/div\u003e\n\u003cdiv style=\"border: 1px solid #e4e8f0; border-top: none; padding: 12px 16px; font-family: 'Helvetica Neue', Helvetica, Arial, sans-serif; font-size: 0.95em;\"\u003e\u003cul style=\"margin: 0; padding: 0; list-style: none;\"\u003e\n\u003cli style=\"padding: 5px 0; border-bottom: 1px solid #f0f0f0;\"\u003e\n\u003cspan style=\"display: inline-block; width: 7px; height: 7px; background: #002147; border-radius: 50%; margin-right: 10px; vertical-align: middle;\"\u003e\u003c\/span\u003eEU \u0026amp; UK: Priority delivery, 2–5 business days.\u003c\/li\u003e\n\u003cli style=\"padding: 5px 0; border-bottom: 1px solid #f0f0f0;\"\u003e\n\u003cspan style=\"display: inline-block; width: 7px; height: 7px; background: #002147; border-radius: 50%; margin-right: 10px; vertical-align: middle;\"\u003e\u003c\/span\u003eUnited States (DDP): 3–7 business days, duties and taxes prepaid.\u003c\/li\u003e\n\u003cli style=\"padding: 5px 0; border-bottom: 1px solid #f0f0f0;\"\u003e\n\u003cspan style=\"display: inline-block; width: 7px; height: 7px; background: #002147; border-radius: 50%; margin-right: 10px; vertical-align: middle;\"\u003e\u003c\/span\u003eEFTA Countries (DDP): 3–7 business days, duties and taxes prepaid.\u003c\/li\u003e\n\u003cli style=\"padding: 5px 0; border-bottom: 1px solid #f0f0f0;\"\u003e\n\u003cspan style=\"display: inline-block; width: 7px; height: 7px; background: #002147; border-radius: 50%; margin-right: 10px; vertical-align: middle;\"\u003e\u003c\/span\u003eWorldwide: 7–14 business days, selected locations.\u003c\/li\u003e\n\u003c\/ul\u003e\u003c\/div\u003e\n\u003c\/div\u003e","brand":"NorrChemica™","offers":[{"title":"5.0 g","offer_id":53484366692689,"sku":"NOR-94790371-5g","price":25.0,"currency_code":"EUR","in_stock":true},{"title":"10 g","offer_id":53484366725457,"sku":"NOR-94790371-10g","price":33.0,"currency_code":"EUR","in_stock":true},{"title":"25 g","offer_id":53484366758225,"sku":"NOR-94790371-25g","price":40.0,"currency_code":"EUR","in_stock":true},{"title":"50 g","offer_id":53484366790993,"sku":"NOR-94790371-50g","price":50.0,"currency_code":"EUR","in_stock":true},{"title":"100 g","offer_id":53484366823761,"sku":"NOR-94790371-100g","price":60.0,"currency_code":"EUR","in_stock":true},{"title":"250 g","offer_id":53484366856529,"sku":"NOR-94790371-250g","price":119.0,"currency_code":"EUR","in_stock":true},{"title":"500 g","offer_id":53484366889297,"sku":"NOR-94790371-500g","price":189.0,"currency_code":"EUR","in_stock":true},{"title":"1 kg","offer_id":53484366922065,"sku":"NOR-94790371-1000g","price":279.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0954\/6357\/1793\/files\/NorrChemica_HBTU.png?v=1782622025","url":"https:\/\/www.norrchemica.com\/products\/hbtu-cas-94790-37-1","provider":"NorrChemica","version":"1.0","type":"link"}