{"product_id":"meldrums-acid-cas-2033-24-1","title":"Meldrum's Acid | CAS 2033-24-1 | ≥98%","description":"\u003cdiv style=\"margin-bottom: 28px;\"\u003e\n\u003cdiv style=\"background: #002147; padding: 10px 20px; margin-bottom: 0;\"\u003e\u003ch3 style=\"margin: 0; font-family: 'Helvetica Neue', Helvetica, Arial, sans-serif; font-size: 0.70em; font-weight: bold; letter-spacing: 0.12em; text-transform: uppercase; color: #fff;\"\u003eTechnical Specifications\u003c\/h3\u003e\u003c\/div\u003e\n\u003ctable style=\"width: 100%; border-collapse: collapse; font-size: 0.95em; border: 1px solid #e4e8f0; border-top: none; font-family: 'Helvetica Neue', Helvetica, Arial, sans-serif;\"\u003e\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eCAS Number\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e2033-24-1\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eEC \/ EINECS Number\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e217-992-8\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eMDL Number\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003eMFCD00006638\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eRTECS Number\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003eJH0800000\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eSMILES\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0; word-break: break-all;\"\u003eCC1(OC(=O)CC(=O)O1)C\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eInChI\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0; word-break: break-all;\"\u003eInChI=1S\/C6H8O4\/c1-6(2)9-4(7)3-5(8)10-6\/h3H2,1-2H3\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eInChIKey\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0; word-break: break-all;\"\u003eGXHFUVWIGNLZSC-UHFFFAOYSA-N\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003ePubChem CID\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e16249\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eMolecular Formula\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003eC₆H₈O₄\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eMolecular Weight\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e144.12 g\/mol\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eMelting Point\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e94–95 °C (dec.)\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eSolubility\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003eWater: 2.5 g\/100 mL (20 °C). Slightly soluble in ethanol and chloroform. Recrystallised from acetone, acetone–water or acetone–hexane.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003ePurity\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e≥98%\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003ePhysical Form\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003eWhite to beige-brown crystalline powder\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eHS Code\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e2932.99.9090\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eShelf Life\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003eRetest period: 36 months from date of manufacture\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eStorage Conditions\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333;\"\u003eStore refrigerated (2–8 °C) in a tightly sealed container.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\u003c\/table\u003e\n\u003c\/div\u003e\u003cdiv style=\"margin-bottom: 28px;\"\u003e\n\u003cdiv style=\"background: #002147; padding: 10px 20px; margin-bottom: 0;\"\u003e\u003ch3 style=\"margin: 0; font-family: 'Helvetica Neue', Helvetica, Arial, sans-serif; font-size: 0.70em; font-weight: bold; letter-spacing: 0.12em; text-transform: uppercase; color: #fff;\"\u003eShipping Destinations\u003c\/h3\u003e\u003c\/div\u003e\n\u003cdiv style=\"border: 1px solid #e4e8f0; border-top: none; padding: 12px 16px; font-family: 'Helvetica Neue', Helvetica, Arial, sans-serif; font-size: 0.95em;\"\u003e\u003cul style=\"margin: 0; padding: 0; list-style: none;\"\u003e\n\u003cli style=\"padding: 5px 0; border-bottom: 1px solid #f0f0f0;\"\u003e\n\u003cspan style=\"display: inline-block; width: 7px; height: 7px; background: #002147; border-radius: 50%; margin-right: 10px; vertical-align: middle;\"\u003e\u003c\/span\u003eEU \u0026amp; UK: Priority delivery, 2–5 business days.\u003c\/li\u003e\n\u003cli style=\"padding: 5px 0; border-bottom: 1px solid #f0f0f0;\"\u003e\n\u003cspan style=\"display: inline-block; width: 7px; height: 7px; background: #002147; border-radius: 50%; margin-right: 10px; vertical-align: middle;\"\u003e\u003c\/span\u003eUnited States (DDP): 3–7 business days, duties and taxes prepaid.\u003c\/li\u003e\n\u003cli style=\"padding: 5px 0; border-bottom: 1px solid #f0f0f0;\"\u003e\n\u003cspan style=\"display: inline-block; width: 7px; height: 7px; background: #002147; border-radius: 50%; margin-right: 10px; vertical-align: middle;\"\u003e\u003c\/span\u003eEFTA Countries (DDP): 3–7 business days, duties and taxes prepaid.\u003c\/li\u003e\n\u003cli style=\"padding: 5px 0; border-bottom: 1px solid #f0f0f0;\"\u003e\n\u003cspan style=\"display: inline-block; width: 7px; height: 7px; background: #002147; border-radius: 50%; margin-right: 10px; vertical-align: middle;\"\u003e\u003c\/span\u003eWorldwide: 7–14 business days, selected locations.\u003c\/li\u003e\n\u003c\/ul\u003e\u003c\/div\u003e\n\u003c\/div\u003e\u003cdiv style=\"margin-bottom: 28px;\"\u003e\n\u003cdiv style=\"background: #002147; padding: 10px 20px; margin-bottom: 0;\"\u003e\u003ch3 style=\"margin: 0; font-family: 'Helvetica Neue', Helvetica, Arial, sans-serif; font-size: 0.70em; font-weight: bold; letter-spacing: 0.12em; text-transform: uppercase; color: #fff;\"\u003eProduct Description \u0026amp; Scientific Applications\u003c\/h3\u003e\u003c\/div\u003e\n\u003cdiv style=\"padding: 16px 20px; border: 1px solid #e4e8f0; border-top: none; font-family: Georgia, 'Times New Roman', serif; font-size: 0.95em; line-height: 1.65; color: #333;\"\u003e\u003cdiv class=\"norr-csa\"\u003e\n\u003cp\u003e\u003cstrong\u003eMeldrum’s Acid\u003c\/strong\u003e (2,2-dimethyl-1,3-dioxane-4,6-dione) is widely used in organic synthesis, especially for C–C bond formation. In water it has a remarkably low pKa of about 4.9. Its C5 position readily takes part in electrophilic substitution, while the C4 and C6 positions are easily attacked by nucleophiles. When heated, it decomposes by distinctive pathways that are used in cycloaddition and acylation reactions.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eKnoevenagel condensation.\u003c\/strong\u003e Aryl aldehydes condense with Meldrum’s acid to give 5-arylidene Meldrum’s acids.\u003c\/p\u003e\n\u003cdiv style=\"margin:8px 0 18px 0;\"\u003e\n\u003cdiv style=\"display:flex;flex-wrap:wrap;align-items:center;justify-content:flex-start;gap:2px;\"\u003e\n\u003cdiv style=\"display:flex;align-items:center;\"\u003e\u003csvg role=\"img\" style=\"max-width:100%;height:auto;\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"110px\" height=\"90px\" viewbox=\"0 0 110 90\"\u003e\u003cpath d=\"M 66.2,44.6 L 51.8,52.9\" style=\"fill:none;stroke:#000;stroke-width:1.6px\"\u003e\u003c\/path\u003e\u003cpath d=\"M 51.8,52.9 L 37.5,44.6\" style=\"fill:none;stroke:#000;stroke-width:1.6px\"\u003e\u003c\/path\u003e\u003cpath d=\"M 51.8,49.1 L 39.1,41.7\" 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x=\"118.7\" y=\"59.6\" style=\"font-size:13px;font-style:normal;font-weight:normal;fill-opacity:1;stroke:none;font-family:sans-serif;text-anchor:start;fill:#000000\"\u003eO\u003c\/text\u003e\u003ctext x=\"99.6\" y=\"92.6\" style=\"font-size:13px;font-style:normal;font-weight:normal;fill-opacity:1;stroke:none;font-family:sans-serif;text-anchor:start;fill:#000000\"\u003eO\u003c\/text\u003e\u003ctext x=\"61.5\" y=\"92.5\" style=\"font-size:13px;font-style:normal;font-weight:normal;fill-opacity:1;stroke:none;font-family:sans-serif;text-anchor:start;fill:#000000\"\u003eO\u003c\/text\u003e\u003ctext x=\"42.5\" y=\"59.4\" style=\"font-size:13px;font-style:normal;font-weight:normal;fill-opacity:1;stroke:none;font-family:sans-serif;text-anchor:start;fill:#000000\"\u003eO\u003c\/text\u003e\u003c\/svg\u003e\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cp style=\"font-size:12px;margin:4px 0 0 0;\"\u003e\u003cem\u003eGeneral reaction: aryl aldehyde + Meldrum’s acid → 5-arylidene Meldrum’s acid.\u003c\/em\u003e\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cp\u003e\u003cstrong\u003eConjugate additions.\u003c\/strong\u003e Arylidene Meldrum’s acids act as acceptors in the rhodium-catalysed, enantioselective 1,4-addition of organoboron reagents. With a 2-(benzyloxy)phenyl group on the arylidene, the adducts are converted into 4-arylchroman-2-ones by hydrolysis and decarboxylation, removal of the benzyl group and intramolecular esterification.\u003c\/p\u003e\n\u003cdiv style=\"margin:8px 0 18px 0;\"\u003e\n\u003cdiv style=\"display:flex;flex-wrap:wrap;align-items:center;justify-content:flex-start;gap:2px;\"\u003e\n\u003cdiv style=\"display:flex;align-items:center;\"\u003e\u003csvg role=\"img\" style=\"max-width:100%;height:auto;\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"170px\" height=\"150px\" viewbox=\"0 0 170 150\"\u003e\u003cpath d=\"M 110.3,83.4 L 95.6,91.8\" style=\"fill:none;stroke:#000;stroke-width:1.6px\"\u003e\u003c\/path\u003e\u003cpath d=\"M 108.7,80.7 L 94.0,89.1\" style=\"fill:none;stroke:#000;stroke-width:1.6px\"\u003e\u003c\/path\u003e\u003cpath d=\"M 95.6,90.0 L 95.6,106.7\" style=\"fill:none;stroke:#000;stroke-width:1.6px\"\u003e\u003c\/path\u003e\u003cpath d=\"M 91.0,113.8 L 77.2,121.7\" 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style=\"fill:none;stroke:#000000;stroke-width:1.6px;stroke-linecap:butt;stroke-linejoin:miter;stroke-miterlimit:10;stroke-opacity:1;\"\u003e\u003c\/path\u003e\u003cpath d=\"M 115.0,16.4 L 114.1,15.9 L 113.2,16.4\" style=\"fill:none;stroke:#000000;stroke-width:1.6px;stroke-linecap:butt;stroke-linejoin:miter;stroke-miterlimit:10;stroke-opacity:1;\"\u003e\u003c\/path\u003e\u003ctext x=\"110.2\" y=\"85.8\" style=\"font-size:12px;font-style:normal;font-weight:normal;fill-opacity:1;stroke:none;font-family:sans-serif;text-anchor:start;fill:#000000\"\u003eO\u003c\/text\u003e\u003ctext x=\"91.7\" y=\"117.5\" style=\"font-size:12px;font-style:normal;font-weight:normal;fill-opacity:1;stroke:none;font-family:sans-serif;text-anchor:start;fill:#000000\"\u003eO\u003c\/text\u003e\u003ctext x=\"55.1\" y=\"117.5\" style=\"font-size:12px;font-style:normal;font-weight:normal;fill-opacity:1;stroke:none;font-family:sans-serif;text-anchor:start;fill:#000000\"\u003eO\u003c\/text\u003e\u003ctext x=\"36.8\" y=\"85.7\" style=\"font-size:12px;font-style:normal;font-weight:normal;fill-opacity:1;stroke:none;font-family:sans-serif;text-anchor:start;fill:#000000\"\u003eO\u003c\/text\u003e\u003ctext x=\"58.4\" y=\"22.2\" style=\"font-size:12px;font-style:normal;font-weight:normal;fill-opacity:1;stroke:none;font-family:sans-serif;text-anchor:start;fill:#000000\"\u003eO\u003c\/text\u003e\u003ctext x=\"67.2\" y=\"22.2\" style=\"font-size:12px;font-style:normal;font-weight:normal;fill-opacity:1;stroke:none;font-family:sans-serif;text-anchor:start;fill:#000000\"\u003eB\u003c\/text\u003e\u003ctext x=\"74.7\" y=\"22.2\" style=\"font-size:12px;font-style:normal;font-weight:normal;fill-opacity:1;stroke:none;font-family:sans-serif;text-anchor:start;fill:#000000\"\u003en\u003c\/text\u003e\u003c\/svg\u003e\u003c\/div\u003e\n\u003cdiv style=\"display:flex;align-items:center;\"\u003e\u003cdiv style=\"display:flex;flex-direction:column;align-items:center;justify-content:center;min-width:90px;max-width:150px;padding:0 4px;text-align:center;font-size:12px;line-height:1.3;\"\u003e\n\u003cdiv\u003eAr′–[B]\u003c\/div\u003e\n\u003cdiv style=\"font-size:30px;line-height:1;\"\u003e⟶\u003c\/div\u003e\n\u003cdiv\u003eRh catalyst\u003cbr\u003e1,4-addition\u003c\/div\u003e\n\u003c\/div\u003e\u003c\/div\u003e\n\u003cdiv style=\"display:flex;align-items:center;\"\u003e\u003csvg role=\"img\" style=\"max-width:100%;height:auto;\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"200px\" height=\"170px\" viewbox=\"0 0 200 170\"\u003e\u003cpath d=\"M 74.4,56.1 L 74.4,71.7\" style=\"fill:none;stroke:#000;stroke-width:1.6px\"\u003e\u003c\/path\u003e\u003cpath d=\"M 71.1,56.1 L 71.1,71.7\" style=\"fill:none;stroke:#000;stroke-width:1.6px\"\u003e\u003c\/path\u003e\u003cpath d=\"M 72.7,70.8 L 58.4,79.0\" style=\"fill:none;stroke:#000;stroke-width:1.6px\"\u003e\u003c\/path\u003e\u003cpath d=\"M 53.7,89.1 L 53.7,103.7\" style=\"fill:none;stroke:#000;stroke-width:1.6px\"\u003e\u003c\/path\u003e\u003cpath d=\"M 53.7,103.7 L 32.0,99.9\" style=\"fill:none;stroke:#000;stroke-width:1.6px\"\u003e\u003c\/path\u003e\u003cpath d=\"M 53.7,103.7 L 46.1,124.4\" style=\"fill:none;stroke:#000;stroke-width:1.6px\"\u003e\u003c\/path\u003e\u003cpath d=\"M 53.7,103.7 L 68.0,112.0\" style=\"fill:none;stroke:#000;stroke-width:1.6px\"\u003e\u003c\/path\u003e\u003cpath d=\"M 77.4,112.1 L 91.8,103.8\" style=\"fill:none;stroke:#000;stroke-width:1.6px\"\u003e\u003c\/path\u003e\u003cpath d=\"M 90.1,104.7 L 105.3,113.5\" style=\"fill:none;stroke:#000;stroke-width:1.6px\"\u003e\u003c\/path\u003e\u003cpath d=\"M 91.8,101.9 L 107.0,110.6\" style=\"fill:none;stroke:#000;stroke-width:1.6px\"\u003e\u003c\/path\u003e\u003cpath d=\"M 91.8,103.8 L 91.8,81.8\" style=\"fill:none;stroke:#000;stroke-width:1.6px\"\u003e\u003c\/path\u003e\u003cpath d=\"M 91.8,81.8 L 110.8,70.8\" 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style=\"fill:none;stroke:#000000;stroke-width:1.6px;stroke-linecap:butt;stroke-linejoin:miter;stroke-miterlimit:10;stroke-opacity:1;\"\u003e\u003c\/path\u003e\u003ctext x=\"68.8\" y=\"55.4\" style=\"font-size:13px;font-style:normal;font-weight:normal;fill-opacity:1;stroke:none;font-family:sans-serif;text-anchor:start;fill:#000000\"\u003eO\u003c\/text\u003e\u003ctext x=\"49.7\" y=\"88.3\" style=\"font-size:13px;font-style:normal;font-weight:normal;fill-opacity:1;stroke:none;font-family:sans-serif;text-anchor:start;fill:#000000\"\u003eO\u003c\/text\u003e\u003ctext x=\"68.7\" y=\"121.4\" style=\"font-size:13px;font-style:normal;font-weight:normal;fill-opacity:1;stroke:none;font-family:sans-serif;text-anchor:start;fill:#000000\"\u003eO\u003c\/text\u003e\u003ctext x=\"106.9\" y=\"121.4\" style=\"font-size:13px;font-style:normal;font-weight:normal;fill-opacity:1;stroke:none;font-family:sans-serif;text-anchor:start;fill:#000000\"\u003eO\u003c\/text\u003e\u003ctext x=\"106.9\" y=\"55.4\" style=\"font-size:13px;font-style:normal;font-weight:normal;fill-opacity:1;stroke:none;font-family:sans-serif;text-anchor:start;fill:#000000\"\u003eA\u003c\/text\u003e\u003ctext x=\"116.0\" y=\"55.4\" style=\"font-size:13px;font-style:normal;font-weight:normal;fill-opacity:1;stroke:none;font-family:sans-serif;text-anchor:start;fill:#000000\"\u003er\u003c\/text\u003e\u003ctext x=\"120.6\" y=\"55.4\" style=\"font-size:13px;font-style:normal;font-weight:normal;fill-opacity:1;stroke:none;font-family:sans-serif;text-anchor:start;fill:#000000\"\u003e'\u003c\/text\u003e\u003ctext x=\"145.0\" y=\"55.4\" style=\"font-size:13px;font-style:normal;font-weight:normal;fill-opacity:1;stroke:none;font-family:sans-serif;text-anchor:start;fill:#000000\"\u003eO\u003c\/text\u003e\u003ctext x=\"154.1\" y=\"55.4\" style=\"font-size:13px;font-style:normal;font-weight:normal;fill-opacity:1;stroke:none;font-family:sans-serif;text-anchor:start;fill:#000000\"\u003eB\u003c\/text\u003e\u003ctext x=\"161.9\" y=\"55.4\" style=\"font-size:13px;font-style:normal;font-weight:normal;fill-opacity:1;stroke:none;font-family:sans-serif;text-anchor:start;fill:#000000\"\u003en\u003c\/text\u003e\u003c\/svg\u003e\u003c\/div\u003e\n\u003cdiv style=\"display:flex;align-items:center;\"\u003e\u003cdiv style=\"display:flex;flex-direction:column;align-items:center;justify-content:center;min-width:90px;max-width:150px;padding:0 4px;text-align:center;font-size:12px;line-height:1.3;\"\u003e\n\u003cdiv\u003ehydrolysis, decarboxylation;\u003c\/div\u003e\n\u003cdiv style=\"font-size:30px;line-height:1;\"\u003e⟶\u003c\/div\u003e\n\u003cdiv\u003edebenzylation; intramolecular esterification\u003c\/div\u003e\n\u003c\/div\u003e\u003c\/div\u003e\n\u003cdiv style=\"display:flex;align-items:center;\"\u003e\u003csvg role=\"img\" style=\"max-width:100%;height:auto;\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"150px\" height=\"130px\" viewbox=\"0 0 150 130\"\u003e\u003cpath d=\"M 34.9,31.8 L 50.0,40.6\" style=\"fill:none;stroke:#000;stroke-width:1.6px\"\u003e\u003c\/path\u003e\u003cpath d=\"M 33.2,34.7 L 48.4,43.5\" style=\"fill:none;stroke:#000;stroke-width:1.6px\"\u003e\u003c\/path\u003e\u003cpath d=\"M 48.4,41.6 L 48.4,63.6\" style=\"fill:none;stroke:#000;stroke-width:1.6px\"\u003e\u003c\/path\u003e\u003cpath d=\"M 48.4,63.6 L 67.4,74.6\" style=\"fill:none;stroke:#000;stroke-width:1.6px\"\u003e\u003c\/path\u003e\u003cpath d=\"M 67.4,74.6 L 67.4,91.9\" style=\"fill:none;stroke:#000;stroke-width:1.6px\"\u003e\u003c\/path\u003e\u003cpath d=\"M 67.4,74.6 L 86.5,63.6\" style=\"fill:none;stroke:#000;stroke-width:1.6px\"\u003e\u003c\/path\u003e\u003cpath d=\"M 86.5,63.6 L 105.5,74.6\" style=\"fill:none;stroke:#000;stroke-width:1.6px\"\u003e\u003c\/path\u003e\u003cpath d=\"M 89.8,61.7 L 105.5,70.8\" style=\"fill:none;stroke:#000;stroke-width:1.6px\"\u003e\u003c\/path\u003e\u003cpath d=\"M 105.5,74.6 L 124.6,63.6\" style=\"fill:none;stroke:#000;stroke-width:1.6px\"\u003e\u003c\/path\u003e\u003cpath d=\"M 124.6,63.6 L 124.6,41.6\" style=\"fill:none;stroke:#000;stroke-width:1.6px\"\u003e\u003c\/path\u003e\u003cpath d=\"M 121.3,61.7 L 121.3,43.5\" style=\"fill:none;stroke:#000;stroke-width:1.6px\"\u003e\u003c\/path\u003e\u003cpath d=\"M 124.6,41.6 L 105.6,30.6\" style=\"fill:none;stroke:#000;stroke-width:1.6px\"\u003e\u003c\/path\u003e\u003cpath d=\"M 105.6,30.6 L 86.5,41.6\" style=\"fill:none;stroke:#000;stroke-width:1.6px\"\u003e\u003c\/path\u003e\u003cpath d=\"M 105.6,34.4 L 89.8,43.5\" style=\"fill:none;stroke:#000;stroke-width:1.6px\"\u003e\u003c\/path\u003e\u003cpath d=\"M 86.5,41.6 L 72.1,33.3\" style=\"fill:none;stroke:#000;stroke-width:1.6px\"\u003e\u003c\/path\u003e\u003cpath d=\"M 62.8,33.3 L 48.4,41.6\" style=\"fill:none;stroke:#000;stroke-width:1.6px\"\u003e\u003c\/path\u003e\u003cpath d=\"M 86.5,41.6 L 86.5,63.6\" style=\"fill:none;stroke:#000;stroke-width:1.6px\"\u003e\u003c\/path\u003e\u003cpath d=\"M 48.4,42.7 L 48.4,41.6 L 49.1,41.2\" style=\"fill:none;stroke:#000000;stroke-width:1.6px;stroke-linecap:butt;stroke-linejoin:miter;stroke-miterlimit:10;stroke-opacity:1;\"\u003e\u003c\/path\u003e\u003cpath d=\"M 48.4,62.5 L 48.4,63.6 L 49.3,64.1\" style=\"fill:none;stroke:#000000;stroke-width:1.6px;stroke-linecap:butt;stroke-linejoin:miter;stroke-miterlimit:10;stroke-opacity:1;\"\u003e\u003c\/path\u003e\u003cpath d=\"M 104.6,74.1 L 105.5,74.6 L 106.5,74.1\" style=\"fill:none;stroke:#000000;stroke-width:1.6px;stroke-linecap:butt;stroke-linejoin:miter;stroke-miterlimit:10;stroke-opacity:1;\"\u003e\u003c\/path\u003e\u003cpath d=\"M 123.6,64.2 L 124.6,63.6 L 124.6,62.5\" style=\"fill:none;stroke:#000000;stroke-width:1.6px;stroke-linecap:butt;stroke-linejoin:miter;stroke-miterlimit:10;stroke-opacity:1;\"\u003e\u003c\/path\u003e\u003cpath d=\"M 124.6,42.7 L 124.6,41.6 L 123.7,41.1\" style=\"fill:none;stroke:#000000;stroke-width:1.6px;stroke-linecap:butt;stroke-linejoin:miter;stroke-miterlimit:10;stroke-opacity:1;\"\u003e\u003c\/path\u003e\u003cpath d=\"M 106.5,31.2 L 105.6,30.6 L 104.6,31.2\" style=\"fill:none;stroke:#000000;stroke-width:1.6px;stroke-linecap:butt;stroke-linejoin:miter;stroke-miterlimit:10;stroke-opacity:1;\"\u003e\u003c\/path\u003e\u003ctext x=\"25.4\" y=\"37.2\" style=\"font-size:13px;font-style:normal;font-weight:normal;fill-opacity:1;stroke:none;font-family:sans-serif;text-anchor:start;fill:#000000\"\u003eO\u003c\/text\u003e\u003ctext x=\"63.4\" y=\"103.2\" style=\"font-size:13px;font-style:normal;font-weight:normal;fill-opacity:1;stroke:none;font-family:sans-serif;text-anchor:start;fill:#000000\"\u003eA\u003c\/text\u003e\u003ctext x=\"72.6\" y=\"103.2\" style=\"font-size:13px;font-style:normal;font-weight:normal;fill-opacity:1;stroke:none;font-family:sans-serif;text-anchor:start;fill:#000000\"\u003er\u003c\/text\u003e\u003ctext x=\"77.1\" y=\"103.2\" style=\"font-size:13px;font-style:normal;font-weight:normal;fill-opacity:1;stroke:none;font-family:sans-serif;text-anchor:start;fill:#000000\"\u003e'\u003c\/text\u003e\u003ctext x=\"63.5\" y=\"37.2\" style=\"font-size:13px;font-style:normal;font-weight:normal;fill-opacity:1;stroke:none;font-family:sans-serif;text-anchor:start;fill:#000000\"\u003eO\u003c\/text\u003e\u003c\/svg\u003e\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cp style=\"font-size:12px;margin:4px 0 0 0;\"\u003e\u003cem\u003eGeneral reaction: arylidene Meldrum’s acid + organoboron reagent (Rh catalyst) → 1,4-adduct → 4-arylchroman-2-one.\u003c\/em\u003e\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cp\u003e\u003cstrong\u003eβ-Keto esters.\u003c\/strong\u003e Acylated Meldrum’s acids act as synthetic equivalents of mixed ketenes and readily undergo alcoholysis to give β-keto esters. Fatty β-keto esters have been made from fatty acids and Meldrum’s acid, with DCC and DMAP as coupling reagents.\u003c\/p\u003e\n\u003cdiv style=\"margin:8px 0 18px 0;\"\u003e\n\u003cdiv style=\"display:flex;flex-wrap:wrap;align-items:center;justify-content:flex-start;gap:2px;\"\u003e\n\u003cdiv style=\"display:flex;align-items:center;\"\u003e\u003csvg role=\"img\" style=\"max-width:100%;height:auto;\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"170px\" height=\"130px\" viewbox=\"0 0 170 130\"\u003e\u003cpath d=\"M 42.3,59.4 L 56.7,51.1\" style=\"fill:none;stroke:#000;stroke-width:1.6px\"\u003e\u003c\/path\u003e\u003cpath d=\"M 58.3,52.0 L 58.3,36.4\" style=\"fill:none;stroke:#000;stroke-width:1.6px\"\u003e\u003c\/path\u003e\u003cpath d=\"M 55.0,52.0 L 55.0,36.4\" style=\"fill:none;stroke:#000;stroke-width:1.6px\"\u003e\u003c\/path\u003e\u003cpath d=\"M 56.7,51.1 L 75.7,62.1\" style=\"fill:none;stroke:#000;stroke-width:1.6px\"\u003e\u003c\/path\u003e\u003cpath d=\"M 75.7,62.1 L 75.8,84.1\" style=\"fill:none;stroke:#000;stroke-width:1.6px\"\u003e\u003c\/path\u003e\u003cpath d=\"M 75.8,82.2 L 60.6,90.9\" style=\"fill:none;stroke:#000;stroke-width:1.6px\"\u003e\u003c\/path\u003e\u003cpath d=\"M 77.4,85.0 L 62.2,93.8\" style=\"fill:none;stroke:#000;stroke-width:1.6px\"\u003e\u003c\/path\u003e\u003cpath d=\"M 75.8,84.1 L 90.1,92.4\" style=\"fill:none;stroke:#000;stroke-width:1.6px\"\u003e\u003c\/path\u003e\u003cpath d=\"M 99.5,92.3 L 113.9,84.0\" style=\"fill:none;stroke:#000;stroke-width:1.6px\"\u003e\u003c\/path\u003e\u003cpath d=\"M 113.9,84.0 L 135.5,80.2\" style=\"fill:none;stroke:#000;stroke-width:1.6px\"\u003e\u003c\/path\u003e\u003cpath d=\"M 113.9,84.0 L 121.4,104.7\" style=\"fill:none;stroke:#000;stroke-width:1.6px\"\u003e\u003c\/path\u003e\u003cpath d=\"M 113.9,84.0 L 113.9,69.4\" style=\"fill:none;stroke:#000;stroke-width:1.6px\"\u003e\u003c\/path\u003e\u003cpath d=\"M 109.2,59.3 L 94.8,51.1\" style=\"fill:none;stroke:#000;stroke-width:1.6px\"\u003e\u003c\/path\u003e\u003cpath d=\"M 96.4,52.0 L 96.4,36.4\" style=\"fill:none;stroke:#000;stroke-width:1.6px\"\u003e\u003c\/path\u003e\u003cpath d=\"M 93.1,52.0 L 93.1,36.4\" style=\"fill:none;stroke:#000;stroke-width:1.6px\"\u003e\u003c\/path\u003e\u003cpath d=\"M 94.8,51.1 L 75.7,62.1\" style=\"fill:none;stroke:#000;stroke-width:1.6px\"\u003e\u003c\/path\u003e\u003cpath d=\"M 56.0,51.5 L 56.7,51.1 L 57.6,51.6\" style=\"fill:none;stroke:#000000;stroke-width:1.6px;stroke-linecap:butt;stroke-linejoin:miter;stroke-miterlimit:10;stroke-opacity:1;\"\u003e\u003c\/path\u003e\u003cpath d=\"M 75.8,83.0 L 75.8,84.1 L 76.5,84.5\" style=\"fill:none;stroke:#000000;stroke-width:1.6px;stroke-linecap:butt;stroke-linejoin:miter;stroke-miterlimit:10;stroke-opacity:1;\"\u003e\u003c\/path\u003e\u003cpath d=\"M 95.5,51.5 L 94.8,51.1 L 93.8,51.6\" style=\"fill:none;stroke:#000000;stroke-width:1.6px;stroke-linecap:butt;stroke-linejoin:miter;stroke-miterlimit:10;stroke-opacity:1;\"\u003e\u003c\/path\u003e\u003ctext x=\"33.7\" y=\"68.7\" style=\"font-size:13px;font-style:normal;font-weight:normal;fill-opacity:1;stroke:none;font-family:sans-serif;text-anchor:start;fill:#000000\"\u003eR\u003c\/text\u003e\u003ctext x=\"52.7\" y=\"35.7\" style=\"font-size:13px;font-style:normal;font-weight:normal;fill-opacity:1;stroke:none;font-family:sans-serif;text-anchor:start;fill:#000000\"\u003eO\u003c\/text\u003e\u003ctext x=\"52.8\" y=\"101.7\" style=\"font-size:13px;font-style:normal;font-weight:normal;fill-opacity:1;stroke:none;font-family:sans-serif;text-anchor:start;fill:#000000\"\u003eO\u003c\/text\u003e\u003ctext x=\"90.9\" y=\"101.7\" style=\"font-size:13px;font-style:normal;font-weight:normal;fill-opacity:1;stroke:none;font-family:sans-serif;text-anchor:start;fill:#000000\"\u003eO\u003c\/text\u003e\u003ctext x=\"109.9\" y=\"68.6\" style=\"font-size:13px;font-style:normal;font-weight:normal;fill-opacity:1;stroke:none;font-family:sans-serif;text-anchor:start;fill:#000000\"\u003eO\u003c\/text\u003e\u003ctext x=\"90.8\" y=\"35.7\" style=\"font-size:13px;font-style:normal;font-weight:normal;fill-opacity:1;stroke:none;font-family:sans-serif;text-anchor:start;fill:#000000\"\u003eO\u003c\/text\u003e\u003c\/svg\u003e\u003c\/div\u003e\n\u003cdiv style=\"display:flex;align-items:center;\"\u003e\u003cdiv style=\"display:flex;flex-direction:column;align-items:center;justify-content:center;min-width:90px;max-width:150px;padding:0 4px;text-align:center;font-size:12px;line-height:1.3;\"\u003e\n\u003cdiv\u003eR′OH\u003c\/div\u003e\n\u003cdiv style=\"font-size:30px;line-height:1;\"\u003e⟶\u003c\/div\u003e\n\u003cdiv\u003ealcoholysis\u003c\/div\u003e\n\u003c\/div\u003e\u003c\/div\u003e\n\u003cdiv style=\"display:flex;align-items:center;\"\u003e\u003csvg role=\"img\" style=\"max-width:100%;height:auto;\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"190px\" height=\"110px\" viewbox=\"0 0 190 110\"\u003e\u003cpath d=\"M 140.8,67.2 L 126.5,59.0\" style=\"fill:none;stroke:#000;stroke-width:1.6px\"\u003e\u003c\/path\u003e\u003cpath d=\"M 128.1,59.9 L 128.1,44.3\" style=\"fill:none;stroke:#000;stroke-width:1.6px\"\u003e\u003c\/path\u003e\u003cpath d=\"M 124.8,59.9 L 124.8,44.3\" style=\"fill:none;stroke:#000;stroke-width:1.6px\"\u003e\u003c\/path\u003e\u003cpath d=\"M 126.5,59.0 L 107.4,70.0\" style=\"fill:none;stroke:#000;stroke-width:1.6px\"\u003e\u003c\/path\u003e\u003cpath d=\"M 107.4,70.0 L 88.4,59.0\" style=\"fill:none;stroke:#000;stroke-width:1.6px\"\u003e\u003c\/path\u003e\u003cpath d=\"M 90.0,59.9 L 90.0,44.3\" style=\"fill:none;stroke:#000;stroke-width:1.6px\"\u003e\u003c\/path\u003e\u003cpath d=\"M 86.7,59.9 L 86.7,44.3\" style=\"fill:none;stroke:#000;stroke-width:1.6px\"\u003e\u003c\/path\u003e\u003cpath d=\"M 88.4,59.0 L 74.0,67.3\" style=\"fill:none;stroke:#000;stroke-width:1.6px\"\u003e\u003c\/path\u003e\u003cpath d=\"M 64.6,67.3 L 52.2,60.1\" style=\"fill:none;stroke:#000;stroke-width:1.6px\"\u003e\u003c\/path\u003e\u003cpath d=\"M 127.2,59.4 L 126.5,59.0 L 125.5,59.5\" style=\"fill:none;stroke:#000000;stroke-width:1.6px;stroke-linecap:butt;stroke-linejoin:miter;stroke-miterlimit:10;stroke-opacity:1;\"\u003e\u003c\/path\u003e\u003cpath d=\"M 108.4,69.4 L 107.4,70.0 L 106.5,69.4\" style=\"fill:none;stroke:#000000;stroke-width:1.6px;stroke-linecap:butt;stroke-linejoin:miter;stroke-miterlimit:10;stroke-opacity:1;\"\u003e\u003c\/path\u003e\u003cpath d=\"M 89.3,59.5 L 88.4,59.0 L 87.6,59.4\" style=\"fill:none;stroke:#000000;stroke-width:1.6px;stroke-linecap:butt;stroke-linejoin:miter;stroke-miterlimit:10;stroke-opacity:1;\"\u003e\u003c\/path\u003e\u003ctext x=\"141.6\" y=\"76.5\" style=\"font-size:13px;font-style:normal;font-weight:normal;fill-opacity:1;stroke:none;font-family:sans-serif;text-anchor:start;fill:#000000\"\u003eR\u003c\/text\u003e\u003ctext x=\"122.5\" y=\"43.6\" style=\"font-size:13px;font-style:normal;font-weight:normal;fill-opacity:1;stroke:none;font-family:sans-serif;text-anchor:start;fill:#000000\"\u003eO\u003c\/text\u003e\u003ctext x=\"84.4\" y=\"43.6\" style=\"font-size:13px;font-style:normal;font-weight:normal;fill-opacity:1;stroke:none;font-family:sans-serif;text-anchor:start;fill:#000000\"\u003eO\u003c\/text\u003e\u003ctext x=\"65.3\" y=\"76.6\" style=\"font-size:13px;font-style:normal;font-weight:normal;fill-opacity:1;stroke:none;font-family:sans-serif;text-anchor:start;fill:#000000\"\u003eO\u003c\/text\u003e\u003ctext x=\"39.9\" y=\"65.6\" style=\"font-size:13px;font-style:normal;font-weight:normal;fill-opacity:1;stroke:none;font-family:sans-serif;text-anchor:start;fill:#000000\"\u003eR\u003c\/text\u003e\u003ctext x=\"49.0\" y=\"65.6\" style=\"font-size:13px;font-style:normal;font-weight:normal;fill-opacity:1;stroke:none;font-family:sans-serif;text-anchor:start;fill:#000000\"\u003e'\u003c\/text\u003e\u003c\/svg\u003e\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cp style=\"font-size:12px;margin:4px 0 0 0;\"\u003e\u003cem\u003eGeneral reaction: acyl Meldrum’s acid + alcohol → β-keto ester.\u003c\/em\u003e\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cp\u003e\u003cstrong\u003eFriedel–Crafts acylation.\u003c\/strong\u003e Meldrum’s acid derivatives act as acylating agents in intramolecular Friedel–Crafts reactions catalysed by metal trifluoromethanesulfonates. Benzyl Meldrum’s acids give polysubstituted 1-indanones in this way. These derivatives are easily prepared, functionalised, handled and purified.\u003c\/p\u003e\n\u003cdiv style=\"margin:8px 0 18px 0;\"\u003e\n\u003cdiv style=\"display:flex;flex-wrap:wrap;align-items:center;justify-content:flex-start;gap:2px;\"\u003e\n\u003cdiv style=\"display:flex;align-items:center;\"\u003e\u003csvg role=\"img\" style=\"max-width:100%;height:auto;\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"190px\" height=\"130px\" viewbox=\"0 0 190 130\"\u003e\u003cpath d=\"M 69.1,36.4 L 69.1,52.0\" style=\"fill:none;stroke:#000;stroke-width:1.6px\"\u003e\u003c\/path\u003e\u003cpath d=\"M 65.8,36.4 L 65.8,52.0\" style=\"fill:none;stroke:#000;stroke-width:1.6px\"\u003e\u003c\/path\u003e\u003cpath d=\"M 67.4,51.1 L 53.1,59.3\" style=\"fill:none;stroke:#000;stroke-width:1.6px\"\u003e\u003c\/path\u003e\u003cpath d=\"M 48.4,69.4 L 48.4,84.0\" style=\"fill:none;stroke:#000;stroke-width:1.6px\"\u003e\u003c\/path\u003e\u003cpath d=\"M 48.4,84.0 L 26.7,80.2\" style=\"fill:none;stroke:#000;stroke-width:1.6px\"\u003e\u003c\/path\u003e\u003cpath d=\"M 48.4,84.0 L 40.8,104.7\" style=\"fill:none;stroke:#000;stroke-width:1.6px\"\u003e\u003c\/path\u003e\u003cpath d=\"M 48.4,84.0 L 62.7,92.3\" style=\"fill:none;stroke:#000;stroke-width:1.6px\"\u003e\u003c\/path\u003e\u003cpath d=\"M 72.1,92.4 L 86.5,84.1\" style=\"fill:none;stroke:#000;stroke-width:1.6px\"\u003e\u003c\/path\u003e\u003cpath d=\"M 84.8,85.0 L 100.0,93.8\" style=\"fill:none;stroke:#000;stroke-width:1.6px\"\u003e\u003c\/path\u003e\u003cpath d=\"M 86.5,82.2 L 101.7,90.9\" style=\"fill:none;stroke:#000;stroke-width:1.6px\"\u003e\u003c\/path\u003e\u003cpath d=\"M 86.5,84.1 L 86.5,62.1\" style=\"fill:none;stroke:#000;stroke-width:1.6px\"\u003e\u003c\/path\u003e\u003cpath d=\"M 86.5,62.1 L 105.6,51.1\" style=\"fill:none;stroke:#000;stroke-width:1.6px\"\u003e\u003c\/path\u003e\u003cpath d=\"M 105.6,51.1 L 124.6,62.1\" style=\"fill:none;stroke:#000;stroke-width:1.6px\"\u003e\u003c\/path\u003e\u003cpath d=\"M 124.6,62.1 L 143.7,51.1\" style=\"fill:none;stroke:#000;stroke-width:1.6px\"\u003e\u003c\/path\u003e\u003cpath d=\"M 127.9,64.0 L 143.7,54.9\" style=\"fill:none;stroke:#000;stroke-width:1.6px\"\u003e\u003c\/path\u003e\u003cpath d=\"M 143.7,51.1 L 162.7,62.1\" style=\"fill:none;stroke:#000;stroke-width:1.6px\"\u003e\u003c\/path\u003e\u003cpath d=\"M 162.7,62.1 L 162.7,84.1\" style=\"fill:none;stroke:#000;stroke-width:1.6px\"\u003e\u003c\/path\u003e\u003cpath d=\"M 159.4,64.0 L 159.4,82.2\" style=\"fill:none;stroke:#000;stroke-width:1.6px\"\u003e\u003c\/path\u003e\u003cpath d=\"M 162.7,84.1 L 143.6,95.1\" style=\"fill:none;stroke:#000;stroke-width:1.6px\"\u003e\u003c\/path\u003e\u003cpath d=\"M 143.6,95.1 L 124.6,84.1\" style=\"fill:none;stroke:#000;stroke-width:1.6px\"\u003e\u003c\/path\u003e\u003cpath d=\"M 143.6,91.3 L 127.9,82.2\" style=\"fill:none;stroke:#000;stroke-width:1.6px\"\u003e\u003c\/path\u003e\u003cpath d=\"M 86.5,62.1 L 67.4,51.1\" style=\"fill:none;stroke:#000;stroke-width:1.6px\"\u003e\u003c\/path\u003e\u003cpath d=\"M 124.6,84.1 L 124.6,62.1\" style=\"fill:none;stroke:#000;stroke-width:1.6px\"\u003e\u003c\/path\u003e\u003cpath d=\"M 66.7,51.5 L 67.4,51.1 L 68.4,51.6\" style=\"fill:none;stroke:#000000;stroke-width:1.6px;stroke-linecap:butt;stroke-linejoin:miter;stroke-miterlimit:10;stroke-opacity:1;\"\u003e\u003c\/path\u003e\u003cpath d=\"M 85.8,84.5 L 86.5,84.1 L 86.5,83.0\" style=\"fill:none;stroke:#000000;stroke-width:1.6px;stroke-linecap:butt;stroke-linejoin:miter;stroke-miterlimit:10;stroke-opacity:1;\"\u003e\u003c\/path\u003e\u003cpath d=\"M 104.6,51.6 L 105.6,51.1 L 106.5,51.6\" style=\"fill:none;stroke:#000000;stroke-width:1.6px;stroke-linecap:butt;stroke-linejoin:miter;stroke-miterlimit:10;stroke-opacity:1;\"\u003e\u003c\/path\u003e\u003cpath d=\"M 142.7,51.7 L 143.7,51.1 L 144.6,51.7\" style=\"fill:none;stroke:#000000;stroke-width:1.6px;stroke-linecap:butt;stroke-linejoin:miter;stroke-miterlimit:10;stroke-opacity:1;\"\u003e\u003c\/path\u003e\u003cpath d=\"M 161.7,61.6 L 162.7,62.1 L 162.7,63.2\" style=\"fill:none;stroke:#000000;stroke-width:1.6px;stroke-linecap:butt;stroke-linejoin:miter;stroke-miterlimit:10;stroke-opacity:1;\"\u003e\u003c\/path\u003e\u003cpath d=\"M 162.7,83.0 L 162.7,84.1 L 161.7,84.7\" style=\"fill:none;stroke:#000000;stroke-width:1.6px;stroke-linecap:butt;stroke-linejoin:miter;stroke-miterlimit:10;stroke-opacity:1;\"\u003e\u003c\/path\u003e\u003cpath d=\"M 144.6,94.6 L 143.6,95.1 L 142.7,94.6\" style=\"fill:none;stroke:#000000;stroke-width:1.6px;stroke-linecap:butt;stroke-linejoin:miter;stroke-miterlimit:10;stroke-opacity:1;\"\u003e\u003c\/path\u003e\u003cpath d=\"M 125.5,84.7 L 124.6,84.1 L 124.6,83.0\" style=\"fill:none;stroke:#000000;stroke-width:1.6px;stroke-linecap:butt;stroke-linejoin:miter;stroke-miterlimit:10;stroke-opacity:1;\"\u003e\u003c\/path\u003e\u003ctext x=\"63.5\" y=\"35.7\" style=\"font-size:13px;font-style:normal;font-weight:normal;fill-opacity:1;stroke:none;font-family:sans-serif;text-anchor:start;fill:#000000\"\u003eO\u003c\/text\u003e\u003ctext x=\"44.4\" y=\"68.6\" style=\"font-size:13px;font-style:normal;font-weight:normal;fill-opacity:1;stroke:none;font-family:sans-serif;text-anchor:start;fill:#000000\"\u003eO\u003c\/text\u003e\u003ctext x=\"63.5\" y=\"101.7\" style=\"font-size:13px;font-style:normal;font-weight:normal;fill-opacity:1;stroke:none;font-family:sans-serif;text-anchor:start;fill:#000000\"\u003eO\u003c\/text\u003e\u003ctext x=\"101.6\" y=\"101.7\" style=\"font-size:13px;font-style:normal;font-weight:normal;fill-opacity:1;stroke:none;font-family:sans-serif;text-anchor:start;fill:#000000\"\u003eO\u003c\/text\u003e\u003c\/svg\u003e\u003c\/div\u003e\n\u003cdiv style=\"display:flex;align-items:center;\"\u003e\u003cdiv style=\"display:flex;flex-direction:column;align-items:center;justify-content:center;min-width:90px;max-width:150px;padding:0 4px;text-align:center;font-size:12px;line-height:1.3;\"\u003e\n\u003cdiv\u003emetal triflate\u003c\/div\u003e\n\u003cdiv style=\"font-size:30px;line-height:1;\"\u003e⟶\u003c\/div\u003e\n\u003cdiv\u003ecatalyst\u003c\/div\u003e\n\u003c\/div\u003e\u003c\/div\u003e\n\u003cdiv style=\"display:flex;align-items:center;\"\u003e\u003csvg role=\"img\" style=\"max-width:100%;height:auto;\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"130px\" height=\"110px\" viewbox=\"0 0 130 110\"\u003e\u003cpath d=\"M 94.0,34.3 L 89.2,49.0\" style=\"fill:none;stroke:#000;stroke-width:1.6px\"\u003e\u003c\/path\u003e\u003cpath d=\"M 90.8,33.3 L 86.0,48.0\" style=\"fill:none;stroke:#000;stroke-width:1.6px\"\u003e\u003c\/path\u003e\u003cpath d=\"M 88.0,47.4 L 100.9,65.2\" style=\"fill:none;stroke:#000;stroke-width:1.6px\"\u003e\u003c\/path\u003e\u003cpath d=\"M 100.9,65.2 L 87.9,82.9\" style=\"fill:none;stroke:#000;stroke-width:1.6px\"\u003e\u003c\/path\u003e\u003cpath d=\"M 87.9,82.9 L 67.0,76.1\" style=\"fill:none;stroke:#000;stroke-width:1.6px\"\u003e\u003c\/path\u003e\u003cpath d=\"M 67.0,76.1 L 48.0,87.1\" style=\"fill:none;stroke:#000;stroke-width:1.6px\"\u003e\u003c\/path\u003e\u003cpath d=\"M 63.7,74.2 L 48.0,83.3\" style=\"fill:none;stroke:#000;stroke-width:1.6px\"\u003e\u003c\/path\u003e\u003cpath d=\"M 48.0,87.1 L 28.9,76.1\" style=\"fill:none;stroke:#000;stroke-width:1.6px\"\u003e\u003c\/path\u003e\u003cpath d=\"M 28.9,76.1 L 28.9,54.1\" style=\"fill:none;stroke:#000;stroke-width:1.6px\"\u003e\u003c\/path\u003e\u003cpath d=\"M 32.2,74.2 L 32.2,56.0\" style=\"fill:none;stroke:#000;stroke-width:1.6px\"\u003e\u003c\/path\u003e\u003cpath d=\"M 28.9,54.1 L 48.0,43.1\" style=\"fill:none;stroke:#000;stroke-width:1.6px\"\u003e\u003c\/path\u003e\u003cpath d=\"M 48.0,43.1 L 67.0,54.1\" style=\"fill:none;stroke:#000;stroke-width:1.6px\"\u003e\u003c\/path\u003e\u003cpath d=\"M 48.0,46.9 L 63.7,56.0\" style=\"fill:none;stroke:#000;stroke-width:1.6px\"\u003e\u003c\/path\u003e\u003cpath d=\"M 67.0,54.1 L 88.0,47.4\" style=\"fill:none;stroke:#000;stroke-width:1.6px\"\u003e\u003c\/path\u003e\u003cpath d=\"M 67.0,54.1 L 67.0,76.1\" style=\"fill:none;stroke:#000;stroke-width:1.6px\"\u003e\u003c\/path\u003e\u003cpath d=\"M 88.6,48.2 L 88.0,47.4 L 86.9,47.7\" style=\"fill:none;stroke:#000000;stroke-width:1.6px;stroke-linecap:butt;stroke-linejoin:miter;stroke-miterlimit:10;stroke-opacity:1;\"\u003e\u003c\/path\u003e\u003cpath d=\"M 100.2,64.3 L 100.9,65.2 L 100.2,66.1\" style=\"fill:none;stroke:#000000;stroke-width:1.6px;stroke-linecap:butt;stroke-linejoin:miter;stroke-miterlimit:10;stroke-opacity:1;\"\u003e\u003c\/path\u003e\u003cpath d=\"M 88.6,82.1 L 87.9,82.9 L 86.9,82.6\" style=\"fill:none;stroke:#000000;stroke-width:1.6px;stroke-linecap:butt;stroke-linejoin:miter;stroke-miterlimit:10;stroke-opacity:1;\"\u003e\u003c\/path\u003e\u003cpath d=\"M 48.9,86.6 L 48.0,87.1 L 47.0,86.6\" style=\"fill:none;stroke:#000000;stroke-width:1.6px;stroke-linecap:butt;stroke-linejoin:miter;stroke-miterlimit:10;stroke-opacity:1;\"\u003e\u003c\/path\u003e\u003cpath d=\"M 29.9,76.7 L 28.9,76.1 L 28.9,75.0\" style=\"fill:none;stroke:#000000;stroke-width:1.6px;stroke-linecap:butt;stroke-linejoin:miter;stroke-miterlimit:10;stroke-opacity:1;\"\u003e\u003c\/path\u003e\u003cpath d=\"M 28.9,55.2 L 28.9,54.1 L 29.9,53.6\" style=\"fill:none;stroke:#000000;stroke-width:1.6px;stroke-linecap:butt;stroke-linejoin:miter;stroke-miterlimit:10;stroke-opacity:1;\"\u003e\u003c\/path\u003e\u003cpath d=\"M 47.0,43.7 L 48.0,43.1 L 48.9,43.7\" style=\"fill:none;stroke:#000000;stroke-width:1.6px;stroke-linecap:butt;stroke-linejoin:miter;stroke-miterlimit:10;stroke-opacity:1;\"\u003e\u003c\/path\u003e\u003ctext x=\"90.8\" y=\"33.0\" style=\"font-size:13px;font-style:normal;font-weight:normal;fill-opacity:1;stroke:none;font-family:sans-serif;text-anchor:start;fill:#000000\"\u003eO\u003c\/text\u003e\u003c\/svg\u003e\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cp style=\"font-size:12px;margin:4px 0 0 0;\"\u003e\u003cem\u003eGeneral reaction: benzyl Meldrum’s acid (metal triflate catalyst) → 1-indanone.\u003c\/em\u003e\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cp\u003e\u003cstrong\u003eHeterocycles.\u003c\/strong\u003e Meldrum’s acid is a starting material for the synthesis of heterocycles. Together with isocyanides, it is a basic component of multicomponent reactions that give many classes of heterocycles in one pot.\u003c\/p\u003e\n\u003cdiv style=\"margin:8px 0 18px 0;\"\u003e\n\u003cdiv style=\"display:flex;flex-wrap:wrap;align-items:center;justify-content:flex-start;gap:2px;\"\u003e\n\u003cdiv style=\"display:flex;align-items:center;\"\u003e\u003csvg role=\"img\" style=\"max-width:100%;height:auto;\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"120px\" height=\"70px\" viewbox=\"0 0 120 70\"\u003e\u003cpath d=\"M 43.4,41.5 L 53.1,36.0\" style=\"fill:none;stroke:#000;stroke-width:1.6px\"\u003e\u003c\/path\u003e\u003cpath d=\"M 65.9,28.6 L 72.2,25.0\" style=\"fill:none;stroke:#000;stroke-width:1.6px\"\u003e\u003c\/path\u003e\u003cpath d=\"M 64.3,25.8 L 70.6,22.2\" style=\"fill:none;stroke:#000;stroke-width:1.6px\"\u003e\u003c\/path\u003e\u003cpath d=\"M 67.5,31.5 L 73.8,27.9\" style=\"fill:none;stroke:#000;stroke-width:1.6px\"\u003e\u003c\/path\u003e\u003ctext x=\"34.7\" y=\"50.8\" style=\"font-size:13px;font-style:normal;font-weight:normal;fill-opacity:1;stroke:none;font-family:sans-serif;text-anchor:start;fill:#000000\"\u003eR\u003c\/text\u003e\u003ctext x=\"53.8\" y=\"39.9\" style=\"font-size:13px;font-style:normal;font-weight:normal;fill-opacity:1;stroke:none;font-family:sans-serif;text-anchor:start;fill:#000000\"\u003eN\u003c\/text\u003e\u003ctext x=\"62.9\" y=\"34.6\" style=\"font-size:8px;font-style:normal;font-weight:normal;fill-opacity:1;stroke:none;font-family:sans-serif;text-anchor:start;fill:#000000\"\u003e+\u003c\/text\u003e\u003ctext x=\"72.9\" y=\"29.0\" style=\"font-size:13px;font-style:normal;font-weight:normal;fill-opacity:1;stroke:none;font-family:sans-serif;text-anchor:start;fill:#000000\"\u003eC\u003c\/text\u003e\u003ctext x=\"82.0\" y=\"23.7\" style=\"font-size:8px;font-style:normal;font-weight:normal;fill-opacity:1;stroke:none;font-family:sans-serif;text-anchor:start;fill:#000000\"\u003e-\u003c\/text\u003e\u003c\/svg\u003e\u003c\/div\u003e\n\u003cdiv style=\"display:flex;align-items:center;\"\u003e\u003cdiv style=\"font-size:20px;padding:0 4px;align-self:center;\"\u003e+\u003c\/div\u003e\u003c\/div\u003e\n\u003cdiv style=\"display:flex;align-items:center;\"\u003e\u003csvg role=\"img\" style=\"max-width:100%;height:auto;\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"170px\" height=\"130px\" viewbox=\"0 0 170 130\"\u003e\u003cpath d=\"M 126.0,80.2 L 104.3,84.0\" style=\"fill:none;stroke:#000;stroke-width:1.6px\"\u003e\u003c\/path\u003e\u003cpath d=\"M 104.3,84.0 L 111.9,104.7\" style=\"fill:none;stroke:#000;stroke-width:1.6px\"\u003e\u003c\/path\u003e\u003cpath d=\"M 104.3,84.0 L 104.3,69.4\" style=\"fill:none;stroke:#000;stroke-width:1.6px\"\u003e\u003c\/path\u003e\u003cpath d=\"M 99.6,59.3 L 85.2,51.1\" style=\"fill:none;stroke:#000;stroke-width:1.6px\"\u003e\u003c\/path\u003e\u003cpath d=\"M 86.9,52.0 L 86.9,36.4\" style=\"fill:none;stroke:#000;stroke-width:1.6px\"\u003e\u003c\/path\u003e\u003cpath d=\"M 83.6,52.0 L 83.6,36.4\" style=\"fill:none;stroke:#000;stroke-width:1.6px\"\u003e\u003c\/path\u003e\u003cpath d=\"M 85.2,51.1 L 66.2,62.1\" style=\"fill:none;stroke:#000;stroke-width:1.6px\"\u003e\u003c\/path\u003e\u003cpath d=\"M 66.2,62.1 L 66.2,84.1\" style=\"fill:none;stroke:#000;stroke-width:1.6px\"\u003e\u003c\/path\u003e\u003cpath d=\"M 66.2,82.2 L 51.0,90.9\" style=\"fill:none;stroke:#000;stroke-width:1.6px\"\u003e\u003c\/path\u003e\u003cpath d=\"M 67.9,85.0 L 52.7,93.8\" style=\"fill:none;stroke:#000;stroke-width:1.6px\"\u003e\u003c\/path\u003e\u003cpath d=\"M 66.2,84.1 L 80.6,92.4\" style=\"fill:none;stroke:#000;stroke-width:1.6px\"\u003e\u003c\/path\u003e\u003cpath d=\"M 90.0,92.3 L 104.3,84.0\" style=\"fill:none;stroke:#000;stroke-width:1.6px\"\u003e\u003c\/path\u003e\u003cpath d=\"M 86.0,51.5 L 85.2,51.1 L 84.3,51.6\" style=\"fill:none;stroke:#000000;stroke-width:1.6px;stroke-linecap:butt;stroke-linejoin:miter;stroke-miterlimit:10;stroke-opacity:1;\"\u003e\u003c\/path\u003e\u003cpath d=\"M 67.2,61.5 L 66.2,62.1 L 66.2,63.2\" style=\"fill:none;stroke:#000000;stroke-width:1.6px;stroke-linecap:butt;stroke-linejoin:miter;stroke-miterlimit:10;stroke-opacity:1;\"\u003e\u003c\/path\u003e\u003cpath d=\"M 66.2,83.0 L 66.2,84.1 L 66.9,84.5\" style=\"fill:none;stroke:#000000;stroke-width:1.6px;stroke-linecap:butt;stroke-linejoin:miter;stroke-miterlimit:10;stroke-opacity:1;\"\u003e\u003c\/path\u003e\u003ctext x=\"100.3\" y=\"68.6\" style=\"font-size:13px;font-style:normal;font-weight:normal;fill-opacity:1;stroke:none;font-family:sans-serif;text-anchor:start;fill:#000000\"\u003eO\u003c\/text\u003e\u003ctext x=\"81.3\" y=\"35.7\" style=\"font-size:13px;font-style:normal;font-weight:normal;fill-opacity:1;stroke:none;font-family:sans-serif;text-anchor:start;fill:#000000\"\u003eO\u003c\/text\u003e\u003ctext x=\"43.2\" y=\"101.7\" style=\"font-size:13px;font-style:normal;font-weight:normal;fill-opacity:1;stroke:none;font-family:sans-serif;text-anchor:start;fill:#000000\"\u003eO\u003c\/text\u003e\u003ctext x=\"81.3\" y=\"101.7\" style=\"font-size:13px;font-style:normal;font-weight:normal;fill-opacity:1;stroke:none;font-family:sans-serif;text-anchor:start;fill:#000000\"\u003eO\u003c\/text\u003e\u003c\/svg\u003e\u003c\/div\u003e\n\u003cdiv style=\"display:flex;align-items:center;\"\u003e\u003cdiv style=\"display:flex;flex-direction:column;align-items:center;justify-content:center;min-width:90px;max-width:150px;padding:0 4px;text-align:center;font-size:12px;line-height:1.3;\"\u003e\n\u003cdiv\u003efurther components\u003c\/div\u003e\n\u003cdiv style=\"font-size:30px;line-height:1;\"\u003e⟶\u003c\/div\u003e\n\u003cdiv\u003eone pot\u003c\/div\u003e\n\u003c\/div\u003e\u003c\/div\u003e\n\u003cdiv style=\"display:flex;align-items:center;\"\u003e\u003cdiv style=\"align-self:center;border:1px solid #888;border-radius:4px;padding:10px 12px;font-size:13px;\"\u003eheterocycles\u003c\/div\u003e\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cp style=\"font-size:12px;margin:4px 0 0 0;\"\u003e\u003cem\u003eGeneral reaction: isocyanide + Meldrum’s acid + further components → heterocycles (one pot).\u003c\/em\u003e\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\u003c\/div\u003e\n\u003c\/div\u003e","brand":"NorrChemica™","offers":[{"title":"50 g","offer_id":54356145570129,"sku":"NOR-2033241-50g","price":45.0,"currency_code":"EUR","in_stock":true},{"title":"100 g","offer_id":55250507006289,"sku":"NOR-2033241-100g","price":84.2,"currency_code":"EUR","in_stock":true},{"title":"250 g","offer_id":55250507039057,"sku":"NOR-2033241-250g","price":109.2,"currency_code":"EUR","in_stock":true},{"title":"500 g","offer_id":55250507071825,"sku":"NOR-2033241-500g","price":129.2,"currency_code":"EUR","in_stock":true},{"title":"1 kg","offer_id":55250507104593,"sku":"NOR-2033241-1000g","price":149.2,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0954\/6357\/1793\/files\/Meldrums_acid_2033-24-1.png?v=1784553279","url":"https:\/\/www.norrchemica.com\/products\/meldrums-acid-cas-2033-24-1","provider":"NorrChemica","version":"1.0","type":"link"}