{"product_id":"nfsi-cas-133745-75-2","title":"N-Fluorobenzenesulfonimide (NFSI) | CAS 133745-75-2 | ≥98%","description":"\u003cdiv style=\"margin-bottom: 28px;\"\u003e\n\u003cdiv style=\"background: #002147; padding: 10px 20px; margin-bottom: 0;\"\u003e  \u003ch3 style=\"margin: 0; font-family: 'Helvetica Neue', Helvetica, Arial, sans-serif; font-size: 0.70em; font-weight: 700; letter-spacing: 0.12em; text-transform: uppercase; color: #fff;\"\u003eTechnical Specifications\u003c\/h3\u003e\n\u003c\/div\u003e\n\u003ctable style=\"width: 100%; border-collapse: collapse; font-size: 0.95em; border: 1px solid #e4e8f0; border-top: none; font-family: 'Helvetica Neue', Helvetica, Arial, sans-serif;\"\u003e\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eCAS Number\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e133745-75-2\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eEC \/ EINECS Number\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e431-940-3\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eMDL Number\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003eMFCD00144885\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eSMILES\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0; word-break: break-all;\"\u003eC1=CC=C(C=C1)S(=O)(=O)N(F)S(=O)(=O)C2=CC=CC=C2\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eInChI\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0; word-break: break-all;\"\u003eInChI=1S\/C12H10FNO4S2\/c13-14(19(15,16)11-7-3-1-4-8-11)20(17,18)12-9-5-2-6-10-12\/h1-10H\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eInChIKey\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0; word-break: break-all;\"\u003eRLKHFSNWQCZBDC-UHFFFAOYSA-N\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003ePubChem CID\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e588007\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eMolecular Formula\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003eC₁₂H₁₀FNO₄S₂\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eMolecular Weight\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e315.3 g\/mol\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eMelting Point\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e110 °C (dec.)\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eSolubility\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003eVery soluble in acetonitrile, dichloromethane, and THF; less soluble in toluene\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003ePurity\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e≥98%\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003ePhysical Form\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003eWhite to light-yellow powder or crystal\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eHS Code\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e2935.90\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eShelf Life\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003eRetest period: 36 months from date of manufacture\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eStorage Conditions\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003eStore in a cool, dry place in a tightly sealed container, protected from light.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\u003c\/table\u003e\n\u003c\/div\u003e\u003cdiv style=\"margin-bottom: 28px;\"\u003e\n\u003cdiv style=\"background: #002147; padding: 10px 20px; margin-bottom: 0;\"\u003e  \u003ch3 style=\"margin: 0; font-family: 'Helvetica Neue', Helvetica, Arial, sans-serif; font-size: 0.70em; font-weight: 700; letter-spacing: 0.12em; text-transform: uppercase; color: #fff;\"\u003eProduct Description \u0026amp; Scientific Applications\u003c\/h3\u003e\n\u003c\/div\u003e\n\u003cdiv style=\"padding: 16px 20px; border: 1px solid #e4e8f0; border-top: none; font-family: Georgia, 'Times New Roman', serif; font-size: 0.95em; line-height: 1.65; color: #333;\"\u003e\n\u003cp\u003e\u003cstrong\u003eN-Fluorobenzenesulfonimide (NFSI),\u003c\/strong\u003e (PhSO2)2NF, is a bench-stable N–F reagent with two modes of reactivity: its electrophilic N–F bond is a fluorine (F+) source, and its benzenesulfonimide fragment is a nitrogen source for oxidative carbon–nitrogen bond formation. It is a strongly electrophilic second-generation fluorinating reagent.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eApplications\u003c\/strong\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eNFSI + enolate\u003c\/strong\u003e — Enantioselective α-fluorination of carbonyls: an activated ketene enolate reacts with NFSI to give α-fluorinated carbonyl derivatives of natural products, including chemotherapeutics and antibiotics.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eNFSI + enolate\u003c\/strong\u003e — Organocatalytic asymmetric fluorination: with a tertiary-amine–thiourea catalyst, NFSI is the terminal electrophile in a 1,4-addition\/dearomative-fluorination sequence, giving products in 72–95% yield with up to 99:1 d.r. and 98% ee, bearing adjacent tertiary and α-fluoro quaternary stereocentres.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eNFSI + active methine\u003c\/strong\u003e — α-Fluorination of 1,3-dicarbonyls: NFSI converts β-keto phosphonates to enantioenriched α-fluoro-β-keto phosphonates under chiral Lewis-acid catalysis (up to 91% ee), and fluorinates unprotected 3-substituted oxindoles to 3-fluoro-2-oxindoles (up to 98% yield, 99% ee), a route to MaxiPost.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eNFSI + aldehyde (enamine)\u003c\/strong\u003e — Organocatalytic α-fluorination of aldehydes: an imidazolidinone catalyst forms an enamine that reacts with NFSI to give α-fluoro aldehydes with high enantioselectivity (up to 99% ee).\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eNFSI + heteroarene\u003c\/strong\u003e — Regioselective late-stage monofluorination of N-protected pyridones, fluorine introduced opposite the carbonyl.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eNFSI + silyl enol ether\u003c\/strong\u003e — Selective mono- and difluorination of silyl enol ethers, with NFSI and its acyl-modified variants.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eNFSI + arene\u003c\/strong\u003e — Directed aromatic C–H fluorination: a Pd(OAc)2–NFSI–TFA system gives ortho-selective monofluorination directed by aryl N-heterocyclic groups (quinoxaline, pyrazole, benzo[d]oxazole, pyrazine).\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eNFSI + C–H (benzylic)\u003c\/strong\u003e — Copper-catalysed benzylic C(sp3)–H fluorination; the benzyl fluorides are electrophiles for cross-coupling, and changing the conditions switches the same Cu\/NFSI system from C–N to C–F coupling.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eNFSI + boron\u003c\/strong\u003e — Copper(I)-mediated borofluorination: alkynes are converted to cis-(β-fluorovinyl)boronates by an (NHC)copper(I) boryl followed by NFSI, giving anti-Markovnikov products.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eNFSI + alkene (aminofluorination)\u003c\/strong\u003e — Vicinal aminofluorination of styrenes, with NFSI as the source of both nitrogen and fluorine: a palladium-catalysed variant gives vicinal fluoroamines with high regioselectivity; a copper-catalysed radical variant, with NFSI as both radical nitrogen and fluorine source, gives the opposite regioselectivity.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eNFSI + N (amination)\u003c\/strong\u003e — Catalytic imidation and C–H amination, NFSI as the nitrogen source for oxidative C–N bond formation: copper-mediated C–H amination of imidazopyridines, and palladium-catalysed allylic C–H amination of alkenes.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eNFSI + sulfinate\u003c\/strong\u003e — Fluorine source in one-pot syntheses of aryl sulfonyl fluorides — from aryl bromides via DABSO, or from aryl thianthrenium salts — giving SuFEx-relevant products.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\u003cdiv style=\"margin-bottom: 28px;\"\u003e\n\u003cdiv style=\"background: #002147; padding: 10px 20px; margin-bottom: 0;\"\u003e  \u003ch3 style=\"margin: 0; font-family: 'Helvetica Neue', Helvetica, Arial, sans-serif; font-size: 0.70em; font-weight: 700; letter-spacing: 0.12em; text-transform: uppercase; color: #fff;\"\u003eShipping Destinations\u003c\/h3\u003e\n\u003c\/div\u003e\n\u003cdiv style=\"border: 1px solid #e4e8f0; border-top: none; padding: 12px 16px; font-family: 'Helvetica Neue', Helvetica, Arial, sans-serif; font-size: 0.95em;\"\u003e\u003cul style=\"margin: 0; padding: 0; list-style: none;\"\u003e\n\u003cli style=\"padding: 5px 0; border-bottom: 1px solid #f0f0f0;\"\u003e\n\u003cspan style=\"display: inline-block; width: 7px; height: 7px; background: #002147; border-radius: 50%; margin-right: 10px; vertical-align: middle;\"\u003e\u003c\/span\u003eEU \u0026amp; UK: Priority delivery, 2–5 business days.\u003c\/li\u003e\n\u003cli style=\"padding: 5px 0; border-bottom: 1px solid #f0f0f0;\"\u003e\n\u003cspan style=\"display: inline-block; width: 7px; height: 7px; background: #002147; border-radius: 50%; margin-right: 10px; vertical-align: middle;\"\u003e\u003c\/span\u003eUnited States (DDP): 3–7 business days, duties and taxes prepaid.\u003c\/li\u003e\n\u003cli style=\"padding: 5px 0; border-bottom: 1px solid #f0f0f0;\"\u003e\n\u003cspan style=\"display: inline-block; width: 7px; height: 7px; background: #002147; border-radius: 50%; margin-right: 10px; vertical-align: middle;\"\u003e\u003c\/span\u003eEFTA Countries (DDP): 3–7 business days, duties and taxes prepaid.\u003c\/li\u003e\n\u003cli style=\"padding: 5px 0; border-bottom: 1px solid #f0f0f0;\"\u003e\n\u003cspan style=\"display: inline-block; width: 7px; height: 7px; background: #002147; border-radius: 50%; margin-right: 10px; vertical-align: middle;\"\u003e\u003c\/span\u003eWorldwide: 7–14 business days, selected locations.\u003c\/li\u003e\n\u003c\/ul\u003e\u003c\/div\u003e\n\u003c\/div\u003e","brand":"NorrChemica™","offers":[{"title":"5.0 g","offer_id":54370315141457,"sku":"NOR-133745752-5g","price":34.2,"currency_code":"EUR","in_stock":true},{"title":"10 g","offer_id":54370315174225,"sku":"NOR-133745752-10g","price":47.2,"currency_code":"EUR","in_stock":true},{"title":"25 g","offer_id":54370315206993,"sku":"NOR-133745752-25g","price":64.8,"currency_code":"EUR","in_stock":true},{"title":"50 g","offer_id":54370315239761,"sku":"NOR-133745752-50g","price":89.2,"currency_code":"EUR","in_stock":true},{"title":"100 g","offer_id":54370315272529,"sku":"NOR-133745752-100g","price":129.2,"currency_code":"EUR","in_stock":true},{"title":"250 g","offer_id":54370315305297,"sku":"NOR-133745752-250g","price":179.2,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0954\/6357\/1793\/files\/NFSI_133745-75-2.png?v=1784552516","url":"https:\/\/www.norrchemica.com\/products\/nfsi-cas-133745-75-2","provider":"NorrChemica","version":"1.0","type":"link"}