{"product_id":"pd-peppsi-ipr-cas-905459-27-0-98","title":"Pd-PEPPSI-IPr | CAS 905459-27-0 | ≥98%","description":"\u003cdiv style=\"margin-bottom: 28px;\"\u003e\n\u003cdiv style=\"background: #002147; padding: 10px 20px; margin-bottom: 0;\"\u003e\u003ch3 style=\"margin: 0; font-family: 'Helvetica Neue', Helvetica, Arial, sans-serif; font-size: 0.70em; font-weight: bold; letter-spacing: 0.12em; text-transform: uppercase; color: #fff;\"\u003eTechnical Specifications\u003c\/h3\u003e\u003c\/div\u003e\n\u003ctable style=\"width: 100%; border-collapse: collapse; font-size: 0.95em; border: 1px solid #e4e8f0; border-top: none; font-family: 'Helvetica Neue', Helvetica, Arial, sans-serif;\"\u003e\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eCAS Number\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e905459-27-0\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eEC \/ EINECS Number\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e664-462-0\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eMDL Number\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003eMFCD08457656\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eSMILES\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0; word-break: break-all;\"\u003eCC(C)C1=CC=CC(C(C)C)=C1N2C=CN(C3=C(C(C)C)C=CC=C3C(C)C)C2=[Pd](Cl)Cl.ClC1=CC=CN=C1\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eInChI\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0; word-break: break-all;\"\u003eInChI=1S\/C27H36N2.C5H4ClN.2ClH.Pd\/c1-18(2)22-11-9-12-23(19(3)4)26(22)28-15-16-29(17-28)27-24(20(5)6)13-10-14-25(27)21(7)8;6-5-2-1-3-7-4-5;;;\/h9-16,18-21H,1-8H3;1-4H;2*1H;\/q;;;;+2\/p-2\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eInChIKey\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0; word-break: break-all;\"\u003eNLVKLFBIRDNQHR-UHFFFAOYSA-L\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003ePubChem CID\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e11607184\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eMolecular Formula\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003eC₃₂H₄₀Cl₃N₃Pd\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eMolecular Weight\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e679.46 g\/mol\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eMelting Point\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e230 °C\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003ePurity\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e≥98%\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003ePhysical Form\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003ePale yellow to yellow powder\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eHS Code\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e2843.90\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eShelf Life\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003eRetest period: 36 months from date of manufacture\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eStorage Conditions\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333;\"\u003eStore in a cool, dry place in a tightly sealed container.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\u003c\/table\u003e\n\u003c\/div\u003e\n\u003cdiv style=\"margin-bottom: 28px;\"\u003e\n\u003cdiv style=\"background: #002147; padding: 10px 20px; margin-bottom: 0;\"\u003e\u003ch3 style=\"margin: 0; font-family: 'Helvetica Neue', Helvetica, Arial, sans-serif; font-size: 0.70em; font-weight: bold; letter-spacing: 0.12em; text-transform: uppercase; color: #fff;\"\u003eProduct Description \u0026amp; Scientific Applications\u003c\/h3\u003e\u003c\/div\u003e\n\u003cdiv style=\"padding: 16px 20px; border: 1px solid #e4e8f0; border-top: none; font-family: Georgia, 'Times New Roman', serif; font-size: 0.95em; line-height: 1.65; color: #333;\"\u003e\u003cdiv\u003e\n\u003cp\u003e\u003cstrong\u003ePd-PEPPSI-IPr\u003c\/strong\u003e, [1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene](3-chloropyridyl)palladium(II) dichloride, is a palladium(II) precatalyst that carries the bulky N-heterocyclic carbene (NHC) IPr. PEPPSI stands for pyridine-enhanced precatalyst preparation, stabilisation and initiation. The complex is air- and moisture-stable and can be weighed and stored in air.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eHow it is activated.\u003c\/strong\u003e In Suzuki–Miyaura, Negishi and Kumada couplings, the organometallic reagent replaces both chlorides. Reductive elimination and loss of the 3-chloropyridine then leave the active (IPr)palladium(0) species.\u003c\/p\u003e\n\u003cdiv style=\"margin:8px 0 18px 0;\"\u003e\n\u003cdiv style=\"display:flex;flex-wrap:wrap;align-items:center;justify-content:flex-start;gap:2px;\"\u003e\n\u003cdiv style=\"display:flex;align-items:center;\"\u003e\u003csvg role=\"img\" style=\"max-width:100%;height:auto;\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" fill=\"none\" stroke=\"#000\" stroke-width=\"1.6\" width=\"300px\" height=\"300px\" viewbox=\"0 0 300 300\"\u003e\u003cpath d=\"M 176.6,179.3 L 200.0,178.1\"\u003e\u003c\/path\u003e\u003cpath d=\"M 200.0,178.1 L 212.9,211.4\"\u003e\u003c\/path\u003e\u003cpath d=\"M 200.0,178.1 L 222.5,150.2\"\u003e\u003c\/path\u003e\u003cpath d=\"M 222.5,150.2 L 257.2,158.9\"\u003e\u003c\/path\u003e\u003cpath d=\"M 257.2,158.9 L 282.0,133.1\"\u003e\u003c\/path\u003e\u003cpath d=\"M 255.5,153.0 L 276.1,131.6\"\u003e\u003c\/path\u003e\u003cpath d=\"M 282.0,133.1 L 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127.6,62.8\"\u003e\u003c\/path\u003e\u003cpath d=\"M 103.0,62.8 L 101.6,62.8 L 101.3,63.9\"\u003e\u003c\/path\u003e\u003cpath d=\"M 25.0,80.2 L 23.6,80.5 L 23.1,81.7\"\u003e\u003c\/path\u003e\u003cpath d=\"M 14.3,104.7 L 13.8,106.0 L 14.7,107.0\"\u003e\u003c\/path\u003e\u003cpath d=\"M 30.1,126.2 L 31.0,127.3 L 32.3,127.1\"\u003e\u003c\/path\u003e\u003cg style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003e\u003ctext x=\"137.2\" y=\"92.9\" text-anchor=\"middle\"\u003eN\u003c\/text\u003e\u003ctext x=\"93.4\" y=\"92.9\" text-anchor=\"middle\"\u003eN\u003c\/text\u003e\u003ctext x=\"115.3\" y=\"136.4\" text-anchor=\"middle\"\u003ePd\u003c\/text\u003e\u003c\/g\u003e\u003c\/svg\u003e\u003c\/div\u003e\n\u003cdiv style=\"display:flex;align-items:center;font-size:20px;padding:0 4px;\"\u003e+\u003c\/div\u003e\n\u003cdiv style=\"display:flex;align-items:center;\"\u003e\u003csvg role=\"img\" style=\"max-width:100%;height:auto;\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" fill=\"none\" stroke=\"#000\" stroke-width=\"1.6\" width=\"80px\" height=\"90px\" viewbox=\"0 0 80 90\"\u003e\u003cpath d=\"M 14.7,64.0 L 32.6,53.7\"\u003e\u003c\/path\u003e\u003cpath d=\"M 32.6,53.7 L 32.6,31.5\"\u003e\u003c\/path\u003e\u003cpath d=\"M 35.9,51.7 L 35.9,33.4\"\u003e\u003c\/path\u003e\u003cpath d=\"M 32.6,31.5 L 51.8,20.4\"\u003e\u003c\/path\u003e\u003cpath d=\"M 51.8,20.4 L 71.0,31.5\"\u003e\u003c\/path\u003e\u003cpath d=\"M 51.8,24.3 L 67.7,33.4\"\u003e\u003c\/path\u003e\u003cpath d=\"M 71.0,31.5 L 71.0,48.7\"\u003e\u003c\/path\u003e\u003cpath d=\"M 67.0,56.0 L 51.8,64.8\"\u003e\u003c\/path\u003e\u003cpath d=\"M 65.4,53.1 L 51.8,60.9\"\u003e\u003c\/path\u003e\u003cpath d=\"M 51.8,64.8 L 32.6,53.7\"\u003e\u003c\/path\u003e\u003cpath d=\"M 32.6,32.6 L 32.6,31.5 L 33.6,30.9\"\u003e\u003c\/path\u003e\u003cpath d=\"M 50.8,21.0 L 51.8,20.4 L 52.8,21.0\"\u003e\u003c\/path\u003e\u003cpath d=\"M 70.0,31.0 L 71.0,31.5 L 71.0,32.4\"\u003e\u003c\/path\u003e\u003cpath d=\"M 52.5,64.3 L 51.8,64.8 L 50.8,64.2\"\u003e\u003c\/path\u003e\u003cg style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003e\u003ctext x=\"10.4\" y=\"68.9\" text-anchor=\"middle\"\u003eCl\u003c\/text\u003e\u003ctext x=\"71.0\" y=\"57.9\" text-anchor=\"middle\"\u003eN\u003c\/text\u003e\u003c\/g\u003e\u003c\/svg\u003e\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cp style=\"font-size:12px;margin:4px 0 0 0;\"\u003e\u003cem\u003eActivation: the precatalyst gives (IPr)palladium(0) and free 3-chloropyridine. R–M is the organoboron, organozinc or Grignard reagent.\u003c\/em\u003e\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cp\u003e\u003cstrong\u003eSuzuki–Miyaura coupling.\u003c\/strong\u003e It couples arylboronic acids with aryl chlorides and bromides, including hindered partners and drug-like heteroaromatics. 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style=\"max-width:100%;height:auto;\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" fill=\"none\" stroke=\"#000\" stroke-width=\"1.6\" width=\"130px\" height=\"120px\" viewbox=\"0 0 130 120\"\u003e\u003cpath d=\"M 99.2,103.8 L 83.5,94.8\"\u003e\u003c\/path\u003e\u003cpath d=\"M 75.9,94.8 L 60.2,103.9\"\u003e\u003c\/path\u003e\u003cpath d=\"M 79.7,87.4 L 79.6,64.5\"\u003e\u003c\/path\u003e\u003cpath d=\"M 79.6,64.5 L 103.9,50.4\"\u003e\u003c\/path\u003e\u003cpath d=\"M 79.6,59.6 L 99.7,48.0\"\u003e\u003c\/path\u003e\u003cpath d=\"M 103.9,50.4 L 103.9,22.3\"\u003e\u003c\/path\u003e\u003cpath d=\"M 103.9,22.3 L 79.5,8.3\"\u003e\u003c\/path\u003e\u003cpath d=\"M 99.7,24.7 L 79.5,13.2\"\u003e\u003c\/path\u003e\u003cpath d=\"M 79.5,8.3 L 55.2,22.4\"\u003e\u003c\/path\u003e\u003cpath d=\"M 55.2,22.4 L 55.3,50.5\"\u003e\u003c\/path\u003e\u003cpath d=\"M 59.4,24.8 L 59.5,48.0\"\u003e\u003c\/path\u003e\u003cpath d=\"M 55.3,50.5 L 30.9,64.6\"\u003e\u003c\/path\u003e\u003cpath d=\"M 55.3,50.5 L 79.6,64.5\"\u003e\u003c\/path\u003e\u003cpath d=\"M 102.7,51.1 L 103.9,50.4 L 103.9,49.0\"\u003e\u003c\/path\u003e\u003cpath d=\"M 103.9,23.7 L 103.9,22.3 L 102.6,21.6\"\u003e\u003c\/path\u003e\u003cpath d=\"M 80.7,9.0 L 79.5,8.3 L 78.3,9.0\"\u003e\u003c\/path\u003e\u003cpath d=\"M 56.4,21.7 L 55.2,22.4 L 55.2,23.8\"\u003e\u003c\/path\u003e\u003cg style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003e\u003ctext x=\"100.4\" y=\"110.8\" text-anchor=\"start\"\u003eOH\u003c\/text\u003e\u003ctext x=\"79.7\" y=\"96.8\" text-anchor=\"middle\"\u003eB\u003c\/text\u003e\u003ctext x=\"59.0\" y=\"110.9\" text-anchor=\"end\"\u003eHO\u003c\/text\u003e\u003ctext x=\"24.9\" y=\"71.8\" text-anchor=\"middle\"\u003eR²\u003c\/text\u003e\u003c\/g\u003e\u003c\/svg\u003e\u003c\/div\u003e\n\u003cdiv style=\"display:flex;align-items:center;\"\u003e\u003cdiv style=\"display:flex;flex-direction:column;align-items:center;justify-content:center;min-width:80px;max-width:108px;padding:0 4px;text-align:center;font-size:12px;line-height:1.3;\"\u003e\n\u003cdiv\u003ePd-PEPPSI-IPr\u003c\/div\u003e\n\u003cdiv style=\"font-size:30px;line-height:1;\"\u003e⟶\u003c\/div\u003e\n\u003cdiv\u003ebase\u003c\/div\u003e\n\u003c\/div\u003e\u003c\/div\u003e\n\u003cdiv style=\"display:flex;align-items:center;\"\u003e\u003csvg role=\"img\" style=\"max-width:100%;height:auto;\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" fill=\"none\" stroke=\"#000\" stroke-width=\"1.6\" width=\"150px\" height=\"130px\" viewbox=\"0 0 150 130\"\u003e\u003cpath d=\"M 62.5,14.0 L 87.6,28.5\"\u003e\u003c\/path\u003e\u003cpath d=\"M 87.6,28.5 L 112.8,14.0\"\u003e\u003c\/path\u003e\u003cpath d=\"M 92.0,31.0 L 112.8,19.0\"\u003e\u003c\/path\u003e\u003cpath d=\"M 112.8,14.0 L 137.9,28.6\"\u003e\u003c\/path\u003e\u003cpath d=\"M 137.9,28.6 L 137.9,57.6\"\u003e\u003c\/path\u003e\u003cpath d=\"M 133.5,31.1 L 133.5,55.1\"\u003e\u003c\/path\u003e\u003cpath d=\"M 137.9,57.6 L 112.7,72.1\"\u003e\u003c\/path\u003e\u003cpath d=\"M 112.7,72.1 L 87.6,57.6\"\u003e\u003c\/path\u003e\u003cpath d=\"M 112.7,67.1 L 91.9,55.0\"\u003e\u003c\/path\u003e\u003cpath d=\"M 87.6,57.6 L 62.4,72.0\"\u003e\u003c\/path\u003e\u003cpath d=\"M 62.4,72.0 L 37.3,57.5\"\u003e\u003c\/path\u003e\u003cpath d=\"M 58.1,74.6 L 37.3,62.5\"\u003e\u003c\/path\u003e\u003cpath d=\"M 37.3,57.5 L 12.1,72.0\"\u003e\u003c\/path\u003e\u003cpath d=\"M 12.1,72.0 L 12.1,101.0\"\u003e\u003c\/path\u003e\u003cpath d=\"M 16.5,74.5 L 16.5,98.5\"\u003e\u003c\/path\u003e\u003cpath d=\"M 12.1,101.0 L 37.2,115.6\"\u003e\u003c\/path\u003e\u003cpath d=\"M 37.2,115.6 L 62.4,101.1\"\u003e\u003c\/path\u003e\u003cpath d=\"M 37.2,110.6 L 58.0,98.6\"\u003e\u003c\/path\u003e\u003cpath d=\"M 62.4,101.1 L 83.7,113.4\"\u003e\u003c\/path\u003e\u003cpath d=\"M 87.6,57.6 L 87.6,28.5\"\u003e\u003c\/path\u003e\u003cpath d=\"M 62.4,101.1 L 62.4,72.0\"\u003e\u003c\/path\u003e\u003cpath d=\"M 111.5,14.7 L 112.8,14.0 L 114.0,14.7\"\u003e\u003c\/path\u003e\u003cpath d=\"M 136.6,27.8 L 137.9,28.6 L 137.9,30.0\"\u003e\u003c\/path\u003e\u003cpath d=\"M 137.9,56.1 L 137.9,57.6 L 136.6,58.3\"\u003e\u003c\/path\u003e\u003cpath d=\"M 114.0,71.4 L 112.7,72.1 L 111.5,71.4\"\u003e\u003c\/path\u003e\u003cpath d=\"M 38.5,58.2 L 37.3,57.5 L 36.0,58.2\"\u003e\u003c\/path\u003e\u003cpath d=\"M 13.4,71.3 L 12.1,72.0 L 12.1,73.5\"\u003e\u003c\/path\u003e\u003cpath d=\"M 12.1,99.6 L 12.1,101.0 L 13.4,101.8\"\u003e\u003c\/path\u003e\u003cpath d=\"M 36.0,114.9 L 37.2,115.6 L 38.5,114.9\"\u003e\u003c\/path\u003e\u003cg style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003e\u003ctext x=\"56.4\" y=\"15.2\" text-anchor=\"middle\"\u003eR¹\u003c\/text\u003e\u003ctext x=\"93.6\" y=\"122.8\" text-anchor=\"middle\"\u003eR²\u003c\/text\u003e\u003c\/g\u003e\u003c\/svg\u003e\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cp style=\"font-size:12px;margin:4px 0 0 0;\"\u003e\u003cem\u003eX = Cl or Br. Substituents R¹ and R² next to the new bond make the biaryl hindered. Carbonate bases are used, and alkoxide bases for alkyl–alkyl coupling.\u003c\/em\u003e\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cp\u003e\u003cstrong\u003eNegishi coupling.\u003c\/strong\u003e With organozinc reagents it joins alkyl and aryl partners in all combinations. Chlorides, bromides, iodides, triflates, tosylates and mesylates all react, and it outperformed phosphine-based catalysts.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eKumada–Tamao–Corriu coupling.\u003c\/strong\u003e With Grignard reagents it gives hindered biaryls and drug-like heterocycles, with better yields than highly active phosphine ligands under identical conditions. Boc groups are tolerated, and successive couplings in one operation build polyaryl and polyheteroaryl structures.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eBuchwald–Hartwig amination.\u003c\/strong\u003e It couples amines with electron-rich and electron-poor aryl and heteroaryl chlorides and bromides, including hindered partners. Solvent, base and temperature can be varied.\u003c\/p\u003e\n\u003cdiv style=\"margin:8px 0 18px 0;\"\u003e\n\u003cdiv style=\"display:flex;flex-wrap:wrap;align-items:center;justify-content:flex-start;gap:2px;\"\u003e\n\u003cdiv style=\"display:flex;align-items:center;\"\u003e\u003csvg role=\"img\" style=\"max-width:100%;height:auto;\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" fill=\"none\" stroke=\"#000\" stroke-width=\"1.6\" width=\"150px\" height=\"70px\" viewbox=\"0 0 150 70\"\u003e\u003cpath d=\"M 19.4,34.7 L 45.0,34.7\"\u003e\u003c\/path\u003e\u003cpath d=\"M 45.0,34.7 L 60.2,8.3\"\u003e\u003c\/path\u003e\u003cpath d=\"M 60.2,8.3 L 90.7,8.3\"\u003e\u003c\/path\u003e\u003cpath d=\"M 62.9,12.9 L 88.0,12.9\"\u003e\u003c\/path\u003e\u003cpath d=\"M 90.7,8.3 L 105.9,34.7\"\u003e\u003c\/path\u003e\u003cpath d=\"M 105.9,34.7 L 132.4,34.7\"\u003e\u003c\/path\u003e\u003cpath d=\"M 105.9,34.7 L 90.7,61.1\"\u003e\u003c\/path\u003e\u003cpath d=\"M 100.6,34.7 L 88.0,56.5\"\u003e\u003c\/path\u003e\u003cpath d=\"M 90.7,61.1 L 60.2,61.1\"\u003e\u003c\/path\u003e\u003cpath d=\"M 60.2,61.1 L 45.0,34.7\"\u003e\u003c\/path\u003e\u003cpath d=\"M 62.9,56.5 L 50.3,34.7\"\u003e\u003c\/path\u003e\u003cpath d=\"M 59.5,9.7 L 60.2,8.3 L 61.8,8.3\"\u003e\u003c\/path\u003e\u003cpath d=\"M 89.1,8.3 L 90.7,8.3 L 91.4,9.7\"\u003e\u003c\/path\u003e\u003cpath d=\"M 91.4,59.7 L 90.7,61.1 L 89.1,61.1\"\u003e\u003c\/path\u003e\u003cpath d=\"M 61.8,61.1 L 60.2,61.1 L 59.5,59.7\"\u003e\u003c\/path\u003e\u003cg style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003e\u003ctext x=\"7.6\" y=\"38.9\" text-anchor=\"middle\"\u003eX\u003c\/text\u003e\u003ctext x=\"143.3\" y=\"38.9\" text-anchor=\"middle\"\u003eR\u003c\/text\u003e\u003c\/g\u003e\u003c\/svg\u003e\u003c\/div\u003e\n\u003cdiv style=\"display:flex;align-items:center;font-size:20px;padding:0 4px;\"\u003e+\u003c\/div\u003e\n\u003cdiv style=\"display:flex;align-items:center;font-size:14px;padding:0 4px;\"\u003eHNR¹R²\u003c\/div\u003e\n\u003cdiv style=\"display:flex;align-items:center;\"\u003e\u003cdiv style=\"display:flex;flex-direction:column;align-items:center;justify-content:center;min-width:80px;max-width:108px;padding:0 4px;text-align:center;font-size:12px;line-height:1.3;\"\u003e\n\u003cdiv\u003ePd-PEPPSI-IPr\u003c\/div\u003e\n\u003cdiv style=\"font-size:30px;line-height:1;\"\u003e⟶\u003c\/div\u003e\n\u003cdiv\u003ebase\u003c\/div\u003e\n\u003c\/div\u003e\u003c\/div\u003e\n\u003cdiv style=\"display:flex;align-items:center;\"\u003e\u003csvg role=\"img\" style=\"max-width:100%;height:auto;\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" fill=\"none\" stroke=\"#000\" stroke-width=\"1.6\" width=\"190px\" height=\"110px\" viewbox=\"0 0 190 110\"\u003e\u003cpath d=\"M 23.2,54.6 L 50.1,54.6\"\u003e\u003c\/path\u003e\u003cpath d=\"M 50.1,54.6 L 65.5,81.3\"\u003e\u003c\/path\u003e\u003cpath d=\"M 65.5,81.3 L 96.3,81.3\"\u003e\u003c\/path\u003e\u003cpath d=\"M 68.2,76.7 L 93.6,76.7\"\u003e\u003c\/path\u003e\u003cpath d=\"M 96.3,81.3 L 111.7,54.6\"\u003e\u003c\/path\u003e\u003cpath d=\"M 111.7,54.6 L 138.3,54.6\"\u003e\u003c\/path\u003e\u003cpath d=\"M 145.5,59.9 L 154.9,76.0\"\u003e\u003c\/path\u003e\u003cpath d=\"M 145.5,49.3 L 154.9,33.2\"\u003e\u003c\/path\u003e\u003cpath d=\"M 111.7,54.6 L 96.3,27.9\"\u003e\u003c\/path\u003e\u003cpath d=\"M 106.4,54.6 L 93.6,32.5\"\u003e\u003c\/path\u003e\u003cpath d=\"M 96.3,27.9 L 65.5,27.9\"\u003e\u003c\/path\u003e\u003cpath d=\"M 65.5,27.9 L 50.1,54.6\"\u003e\u003c\/path\u003e\u003cpath d=\"M 68.2,32.5 L 55.4,54.6\"\u003e\u003c\/path\u003e\u003cpath d=\"M 64.7,79.9 L 65.5,81.3 L 67.0,81.3\"\u003e\u003c\/path\u003e\u003cpath d=\"M 94.8,81.3 L 96.3,81.3 L 97.1,79.9\"\u003e\u003c\/path\u003e\u003cpath d=\"M 97.1,29.3 L 96.3,27.9 L 94.8,27.9\"\u003e\u003c\/path\u003e\u003cpath d=\"M 67.0,27.9 L 65.5,27.9 L 64.7,29.3\"\u003e\u003c\/path\u003e\u003cg style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003e\u003ctext x=\"12.3\" y=\"58.8\" text-anchor=\"middle\"\u003eR\u003c\/text\u003e\u003ctext x=\"142.5\" y=\"58.8\" text-anchor=\"middle\"\u003eN\u003c\/text\u003e\u003ctext x=\"161.4\" y=\"90.7\" text-anchor=\"middle\"\u003eR¹\u003c\/text\u003e\u003ctext x=\"161.4\" y=\"26.9\" text-anchor=\"middle\"\u003eR²\u003c\/text\u003e\u003c\/g\u003e\u003c\/svg\u003e\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cp style=\"font-size:12px;margin:4px 0 0 0;\"\u003e\u003cem\u003eX = Cl or Br. Alkoxide bases are typical; carbonate bases work for some substrates.\u003c\/em\u003e\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cp\u003e\u003cstrong\u003eKetones from amides and esters.\u003c\/strong\u003e It cleaves the C–N bond of activated amides and couples them with arylboronic acids to give ketones, more efficiently than palladium–phosphine catalysts. Phenyl esters react in the same way through the C–O bond.\u003c\/p\u003e\n\u003cdiv style=\"margin:8px 0 18px 0;\"\u003e\n\u003cdiv style=\"display:flex;flex-wrap:wrap;align-items:center;justify-content:flex-start;gap:2px;\"\u003e\n\u003cdiv style=\"display:flex;align-items:center;\"\u003e\u003csvg role=\"img\" style=\"max-width:100%;height:auto;\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" fill=\"none\" stroke=\"#000\" stroke-width=\"1.6\" width=\"100px\" height=\"100px\" viewbox=\"0 0 100 100\"\u003e\u003cpath d=\"M 50.6,27.0 L 50.6,61.3\"\u003e\u003c\/path\u003e\u003cpath d=\"M 44.9,27.0 L 44.9,61.2\"\u003e\u003c\/path\u003e\u003cpath d=\"M 47.7,59.6 L 76.0,75.9\"\u003e\u003c\/path\u003e\u003cpath d=\"M 47.7,59.6 L 19.2,76.0\"\u003e\u003c\/path\u003e\u003cpath d=\"M 49.2,60.4 L 47.7,59.6 L 46.3,60.4\"\u003e\u003c\/path\u003e\u003cg style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003e\u003ctext x=\"47.8\" y=\"25.5\" text-anchor=\"middle\"\u003eO\u003c\/text\u003e\u003ctext 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139.4,54.6\"\u003e\u003c\/path\u003e\u003cpath d=\"M 142.1,54.6 L 154.8,76.5\"\u003e\u003c\/path\u003e\u003cpath d=\"M 142.1,54.6 L 110.8,54.6\"\u003e\u003c\/path\u003e\u003cpath d=\"M 110.8,54.6 L 95.1,27.5\"\u003e\u003c\/path\u003e\u003cpath d=\"M 95.1,27.5 L 63.8,27.5\"\u003e\u003c\/path\u003e\u003cpath d=\"M 92.4,32.2 L 66.5,32.2\"\u003e\u003c\/path\u003e\u003cpath d=\"M 63.8,27.5 L 48.1,54.6\"\u003e\u003c\/path\u003e\u003cpath d=\"M 48.1,54.6 L 20.8,54.6\"\u003e\u003c\/path\u003e\u003cpath d=\"M 48.1,54.6 L 63.8,81.8\"\u003e\u003c\/path\u003e\u003cpath d=\"M 53.6,54.6 L 66.5,77.1\"\u003e\u003c\/path\u003e\u003cpath d=\"M 63.8,81.8 L 95.1,81.8\"\u003e\u003c\/path\u003e\u003cpath d=\"M 95.1,81.8 L 110.8,54.6\"\u003e\u003c\/path\u003e\u003cpath d=\"M 92.4,77.1 L 105.4,54.6\"\u003e\u003c\/path\u003e\u003cpath d=\"M 142.8,55.7 L 142.1,54.6 L 140.6,54.6\"\u003e\u003c\/path\u003e\u003cpath d=\"M 95.9,28.8 L 95.1,27.5 L 93.6,27.5\"\u003e\u003c\/path\u003e\u003cpath d=\"M 65.4,27.5 L 63.8,27.5 L 63.0,28.8\"\u003e\u003c\/path\u003e\u003cpath d=\"M 63.0,80.4 L 63.8,81.8 L 65.4,81.8\"\u003e\u003c\/path\u003e\u003cpath d=\"M 93.6,81.8 L 95.1,81.8 L 95.9,80.4\"\u003e\u003c\/path\u003e\u003cg style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003e\u003ctext x=\"157.8\" y=\"31.7\" text-anchor=\"middle\"\u003eO\u003c\/text\u003e\u003ctext x=\"161.3\" y=\"91.2\" text-anchor=\"middle\"\u003eAr\u003c\/text\u003e\u003ctext x=\"9.8\" y=\"58.8\" text-anchor=\"middle\"\u003eR\u003c\/text\u003e\u003c\/g\u003e\u003c\/svg\u003e\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cp style=\"font-size:12px;margin:4px 0 0 0;\"\u003e\u003cem\u003eY = the nitrogen of an activated amide, or OPh for a phenyl ester.\u003c\/em\u003e\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cdiv style=\"margin-bottom: 28px;\"\u003e\n\u003cdiv style=\"background: #002147; padding: 10px 20px; margin-bottom: 0;\"\u003e\u003ch3 style=\"margin: 0; font-family: 'Helvetica Neue', Helvetica, Arial, sans-serif; font-size: 0.70em; font-weight: bold; letter-spacing: 0.12em; text-transform: uppercase; color: #fff;\"\u003eShipping Destinations\u003c\/h3\u003e\u003c\/div\u003e\n\u003cdiv style=\"border: 1px solid #e4e8f0; border-top: none; padding: 12px 16px; font-family: 'Helvetica Neue', Helvetica, Arial, sans-serif; font-size: 0.95em;\"\u003e\u003cul style=\"margin: 0; padding: 0; list-style: none;\"\u003e\n\u003cli style=\"padding: 5px 0; border-bottom: 1px solid #f0f0f0;\"\u003e\n\u003cspan style=\"display: inline-block; width: 7px; height: 7px; background: #002147; border-radius: 50%; margin-right: 10px; vertical-align: middle;\"\u003e\u003c\/span\u003eEU \u0026amp; UK: Priority delivery, 2–5 business days.\u003c\/li\u003e\n\u003cli style=\"padding: 5px 0; border-bottom: 1px solid #f0f0f0;\"\u003e\n\u003cspan style=\"display: inline-block; width: 7px; height: 7px; background: #002147; border-radius: 50%; margin-right: 10px; vertical-align: middle;\"\u003e\u003c\/span\u003eUnited States (DDP): 3–7 business days, duties and taxes prepaid.\u003c\/li\u003e\n\u003cli style=\"padding: 5px 0; border-bottom: 1px solid #f0f0f0;\"\u003e\n\u003cspan style=\"display: inline-block; width: 7px; height: 7px; background: #002147; border-radius: 50%; margin-right: 10px; vertical-align: middle;\"\u003e\u003c\/span\u003eEFTA Countries (DDP): 3–7 business days, duties and taxes prepaid.\u003c\/li\u003e\n\u003cli style=\"padding: 5px 0; border-bottom: 1px solid #f0f0f0;\"\u003e\n\u003cspan style=\"display: inline-block; width: 7px; height: 7px; background: #002147; border-radius: 50%; margin-right: 10px; vertical-align: middle;\"\u003e\u003c\/span\u003eWorldwide: 7–14 business days, selected locations.\u003c\/li\u003e\n\u003c\/ul\u003e\u003c\/div\u003e\n\u003c\/div\u003e","brand":"NorrChemica™","offers":[{"title":"1 g","offer_id":54353109877073,"sku":"NOR-905459270-1g","price":98.2,"currency_code":"EUR","in_stock":true},{"title":"5 g","offer_id":54353109909841,"sku":"NOR-905459270-5g","price":319.2,"currency_code":"EUR","in_stock":true},{"title":"25 g","offer_id":54353109942609,"sku":"NOR-905459270-25g","price":1375.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0954\/6357\/1793\/files\/NorrChemica_Pd-PEPPSI-IPr.png?v=1791035162","url":"https:\/\/www.norrchemica.com\/products\/pd-peppsi-ipr-cas-905459-27-0-98","provider":"NorrChemica","version":"1.0","type":"link"}