{"product_id":"spdp-cas-68181-17-9","title":"SPDP | CAS 68181-17-9 | ≥97%","description":"\u003cdiv style=\"margin-bottom: 28px;\"\u003e\n\u003cdiv style=\"background: #002147; padding: 10px 20px; margin-bottom: 0;\"\u003e\u003ch3 style=\"margin: 0; font-family: 'Helvetica Neue', Helvetica, Arial, sans-serif; font-size: 0.70em; font-weight: bold; letter-spacing: 0.12em; text-transform: uppercase; color: #fff;\"\u003eTechnical Specifications\u003c\/h3\u003e\u003c\/div\u003e\n\u003ctable style=\"width: 100%; border-collapse: collapse; font-size: 0.95em; border: 1px solid #e4e8f0; border-top: none; font-family: 'Helvetica Neue', Helvetica, Arial, sans-serif;\"\u003e\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eCAS Number\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e68181-17-9\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eEC \/ EINECS Number\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e269-034-3\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eMDL Number\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003eMFCD00009636\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eSMILES\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0; word-break: break-all;\"\u003eC1CC(=O)N(C1=O)OC(=O)CCSSC2=CC=CC=N2\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eInChI\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0; word-break: break-all;\"\u003eInChI=1S\/C12H12N2O4S2\/c15-10-4-5-11(16)14(10)18-12(17)6-8-19-20-9-3-1-2-7-13-9\/h1-3,7H,4-6,8H2\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eInChIKey\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0; word-break: break-all;\"\u003eJWDFQMWEFLOOED-UHFFFAOYSA-N\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003ePubChem CID\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e100682\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eMolecular Formula\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003eC₁₂H₁₂N₂O₄S₂\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eMolecular Weight\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e312.4 g\/mol\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eMelting Point\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e84–86 °C\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eSolubility\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003eSoluble in DMF and DMSO. Insoluble in water.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003ePurity\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e≥97%\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003ePhysical Form\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003eWhite crystalline solid powder\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eHS Code\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003e2933.39\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; border-bottom: 1px solid #e4e8f0; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eShelf Life\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333; border-bottom: 1px solid #e4e8f0;\"\u003eRetest period: 36 months from date of manufacture\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"padding: 9px 16px; font-weight: 600; color: #002147; width: 200px; background: #f7f8fb; font-size: 0.95em; vertical-align: top;\"\u003eStorage Conditions\u003c\/td\u003e\n\u003ctd style=\"padding: 9px 16px; color: #333;\"\u003eStore frozen (−20 °C) under inert gas.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\u003c\/table\u003e\n\u003c\/div\u003e\n\u003cdiv style=\"margin-bottom: 28px;\"\u003e\n\u003cdiv style=\"background: #002147; padding: 10px 20px; margin-bottom: 0;\"\u003e\u003ch3 style=\"margin: 0; font-family: 'Helvetica Neue', Helvetica, Arial, sans-serif; font-size: 0.70em; font-weight: bold; letter-spacing: 0.12em; text-transform: uppercase; color: #fff;\"\u003eProduct Description \u0026amp; Scientific Applications\u003c\/h3\u003e\u003c\/div\u003e\n\u003cdiv style=\"padding: 16px 20px; border: 1px solid #e4e8f0; border-top: none; font-family: Georgia, 'Times New Roman', serif; font-size: 0.95em; line-height: 1.65; color: #333;\"\u003e\u003cdiv\u003e\n\u003cp\u003e\u003cstrong\u003eSPDP\u003c\/strong\u003e (N-succinimidyl 3-(2-pyridyldithio)propionate) is a heterobifunctional reagent: its N-hydroxysuccinimide ester reacts with amino groups, and its 2-pyridyl disulfide group reacts with aliphatic thiols. Reaction with a thiol releases pyridine-2-thione, and its absorbance at 343 nm can be measured to follow the reaction.\u003c\/p\u003e\n\u003cdiv style=\"margin:8px 0 18px 0;\"\u003e\n\u003cdiv style=\"display:flex;flex-wrap:wrap;align-items:center;justify-content:flex-start;gap:2px;\"\u003e\n\u003cdiv style=\"display:flex;align-items:center;\"\u003e\u003csvg role=\"img\" style=\"max-width:100%;height:auto;\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" fill=\"none\" stroke=\"#000\" stroke-width=\"1.6\" width=\"49px\" height=\"18px\" viewbox=\"0 0 49 18\"\u003e\u003cpath d=\"M 12.7,5.3 L 23.1,5.3\"\u003e\u003c\/path\u003e\u003ctext x=\"4.9\" y=\"11.3\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eR\u003c\/text\u003e\u003ctext x=\"23.7\" y=\"11.3\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eN\u003c\/text\u003e\u003ctext x=\"32.0\" y=\"11.3\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eH\u003c\/text\u003e\u003ctext x=\"40.3\" y=\"16.1\" 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49.5,25.5\"\u003e\u003c\/path\u003e\u003cpath d=\"M 50.2,27.1 L 56.4,16.2\"\u003e\u003c\/path\u003e\u003cpath d=\"M 47.7,25.7 L 53.9,14.8\"\u003e\u003c\/path\u003e\u003cpath d=\"M 49.5,25.5 L 57.3,43.0\"\u003e\u003c\/path\u003e\u003cpath d=\"M 57.3,43.0 L 43.2,55.9\"\u003e\u003c\/path\u003e\u003cpath d=\"M 43.2,55.9 L 26.5,46.4\"\u003e\u003c\/path\u003e\u003cpath d=\"M 26.9,44.6 L 12.7,51.0\"\u003e\u003c\/path\u003e\u003cpath d=\"M 28.1,47.3 L 13.9,53.7\"\u003e\u003c\/path\u003e\u003cpath d=\"M 26.5,46.4 L 29.1,34.3\"\u003e\u003c\/path\u003e\u003cpath d=\"M 48.7,25.6 L 49.5,25.5 L 49.8,26.4\"\u003e\u003c\/path\u003e\u003cpath d=\"M 56.9,42.1 L 57.3,43.0 L 56.6,43.6\"\u003e\u003c\/path\u003e\u003cpath d=\"M 43.9,55.2 L 43.2,55.9 L 42.3,55.4\"\u003e\u003c\/path\u003e\u003cpath d=\"M 27.4,46.9 L 26.5,46.4 L 26.7,45.8\"\u003e\u003c\/path\u003e\u003ctext x=\"6.3\" y=\"19.5\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eH\u003c\/text\u003e\u003ctext x=\"13.9\" y=\"19.5\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eO\u003c\/text\u003e\u003ctext x=\"26.8\" y=\"33.6\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eN\u003c\/text\u003e\u003ctext x=\"55.3\" y=\"14.9\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eO\u003c\/text\u003e\u003ctext x=\"5.5\" y=\"60.3\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eO\u003c\/text\u003e\u003c\/svg\u003e\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cp style=\"font-size:12px;margin:4px 0 0 0;\"\u003e\u003cem\u003eGeneral reaction: R–NH₂ + SPDP → 2-pyridyl disulfide amide + N-hydroxysuccinimide; R–NH₂ = an amino group, for example of a protein or of a solid support.\u003c\/em\u003e\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cp\u003e\u003cstrong\u003eThiolation of proteins.\u003c\/strong\u003e SPDP introduces thiol groups into proteins in two steps: acylation of amino groups, then reduction of the protein-bound 2-pyridyl disulfides with dithiothreitol (DTT). The reduction can leave the native disulfide bonds of the protein intact.\u003c\/p\u003e\n\u003cdiv style=\"margin:8px 0 18px 0;\"\u003e\n\u003cdiv style=\"display:flex;flex-wrap:wrap;align-items:center;justify-content:flex-start;gap:2px;\"\u003e\n\u003cdiv style=\"display:flex;align-items:center;\"\u003e\u003csvg role=\"img\" style=\"max-width:100%;height:auto;\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" fill=\"none\" stroke=\"#000\" stroke-width=\"1.6\" width=\"185px\" height=\"73px\" viewbox=\"0 0 185 73\"\u003e\u003cpath d=\"M 23.6,31.1 L 31.8,35.8\"\u003e\u003c\/path\u003e\u003cpath d=\"M 40.2,35.7 L 52.6,28.6\"\u003e\u003c\/path\u003e\u003cpath d=\"M 54.0,29.4 L 54.0,16.1\"\u003e\u003c\/path\u003e\u003cpath d=\"M 51.2,29.4 L 51.2,16.1\"\u003e\u003c\/path\u003e\u003cpath d=\"M 52.6,28.6 L 69.2,38.2\"\u003e\u003c\/path\u003e\u003cpath d=\"M 69.2,38.2 L 85.8,28.6\"\u003e\u003c\/path\u003e\u003cpath d=\"M 85.8,28.6 L 98.2,35.7\"\u003e\u003c\/path\u003e\u003cpath d=\"M 106.6,35.7 L 114.7,31.0\"\u003e\u003c\/path\u003e\u003cpath d=\"M 123.2,31.0 L 135.6,38.1\"\u003e\u003c\/path\u003e\u003cpath d=\"M 135.6,38.1 L 135.6,57.3\"\u003e\u003c\/path\u003e\u003cpath d=\"M 138.5,39.8 L 138.5,55.6\"\u003e\u003c\/path\u003e\u003cpath d=\"M 135.6,57.3 L 152.2,66.8\"\u003e\u003c\/path\u003e\u003cpath d=\"M 152.2,66.8 L 168.8,57.3\"\u003e\u003c\/path\u003e\u003cpath d=\"M 152.2,63.5 L 165.9,55.6\"\u003e\u003c\/path\u003e\u003cpath d=\"M 168.8,57.3 L 168.8,38.1\"\u003e\u003c\/path\u003e\u003cpath d=\"M 168.8,38.1 L 156.4,31.0\"\u003e\u003c\/path\u003e\u003cpath d=\"M 165.9,39.8 L 155.0,33.5\"\u003e\u003c\/path\u003e\u003cpath d=\"M 147.9,31.0 L 135.6,38.1\"\u003e\u003c\/path\u003e\u003cpath d=\"M 52.0,29.0 L 52.6,28.6 L 53.4,29.1\"\u003e\u003c\/path\u003e\u003cpath d=\"M 68.4,37.7 L 69.2,38.2 L 70.0,37.7\"\u003e\u003c\/path\u003e\u003cpath d=\"M 85.0,29.1 L 85.8,28.6 L 86.4,28.9\"\u003e\u003c\/path\u003e\u003cpath d=\"M 135.6,56.3 L 135.6,57.3 L 136.4,57.8\"\u003e\u003c\/path\u003e\u003cpath d=\"M 151.4,66.4 L 152.2,66.8 L 153.0,66.4\"\u003e\u003c\/path\u003e\u003cpath d=\"M 168.0,57.7 L 168.8,57.3 L 168.8,56.3\"\u003e\u003c\/path\u003e\u003cpath d=\"M 168.8,39.0 L 168.8,38.1 L 168.2,37.7\"\u003e\u003c\/path\u003e\u003ctext x=\"15.8\" y=\"34.6\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eR\u003c\/text\u003e\u003ctext x=\"32.4\" y=\"44.2\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eN\u003c\/text\u003e\u003ctext x=\"32.4\" y=\"54.8\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eH\u003c\/text\u003e\u003ctext x=\"49.0\" y=\"15.4\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eO\u003c\/text\u003e\u003ctext x=\"98.8\" y=\"44.1\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eS\u003c\/text\u003e\u003ctext x=\"115.4\" y=\"34.5\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eS\u003c\/text\u003e\u003ctext x=\"148.6\" y=\"34.5\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eN\u003c\/text\u003e\u003c\/svg\u003e\u003c\/div\u003e\n\u003cdiv style=\"display:flex;align-items:center;\"\u003e\u003cdiv style=\"display:flex;flex-direction:column;align-items:center;justify-content:center;min-width:90px;max-width:150px;padding:0 4px;text-align:center;font-size:12px;line-height:1.3;\"\u003e\n\u003cdiv\u003eDTT\u003c\/div\u003e\n\u003cdiv style=\"font-size:30px;line-height:1;\"\u003e⟶\u003c\/div\u003e\n\u003cdiv\u003e\u003c\/div\u003e\n\u003c\/div\u003e\u003c\/div\u003e\n\u003cdiv style=\"display:flex;align-items:center;\"\u003e\u003csvg role=\"img\" style=\"max-width:100%;height:auto;\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" fill=\"none\" stroke=\"#000\" stroke-width=\"1.6\" width=\"118px\" height=\"59px\" viewbox=\"0 0 118 59\"\u003e\u003cpath d=\"M 17.7,30.0 L 25.8,34.7\"\u003e\u003c\/path\u003e\u003cpath d=\"M 34.3,34.7 L 46.7,27.5\"\u003e\u003c\/path\u003e\u003cpath d=\"M 48.1,28.4 L 48.1,15.0\"\u003e\u003c\/path\u003e\u003cpath d=\"M 45.2,28.4 L 45.2,15.0\"\u003e\u003c\/path\u003e\u003cpath d=\"M 46.7,27.5 L 63.3,37.1\"\u003e\u003c\/path\u003e\u003cpath d=\"M 63.3,37.1 L 79.9,27.5\"\u003e\u003c\/path\u003e\u003cpath d=\"M 79.9,27.5 L 92.6,34.8\"\u003e\u003c\/path\u003e\u003cpath d=\"M 46.0,27.9 L 46.7,27.5 L 47.5,28.0\"\u003e\u003c\/path\u003e\u003cpath d=\"M 62.5,36.6 L 63.3,37.1 L 64.1,36.6\"\u003e\u003c\/path\u003e\u003cpath d=\"M 79.1,28.0 L 79.9,27.5 L 80.5,27.9\"\u003e\u003c\/path\u003e\u003ctext x=\"9.8\" y=\"33.6\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eR\u003c\/text\u003e\u003ctext x=\"26.5\" y=\"43.1\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eN\u003c\/text\u003e\u003ctext x=\"26.5\" y=\"53.7\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eH\u003c\/text\u003e\u003ctext x=\"43.1\" y=\"14.3\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eO\u003c\/text\u003e\u003ctext x=\"93.2\" y=\"43.1\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eS\u003c\/text\u003e\u003ctext x=\"100.8\" y=\"43.1\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eH\u003c\/text\u003e\u003c\/svg\u003e\u003c\/div\u003e\n\u003cdiv style=\"display:flex;align-items:center;\"\u003e\u003cdiv style=\"font-size:20px;padding:0 4px;align-self:center;\"\u003e+\u003c\/div\u003e\u003c\/div\u003e\n\u003cdiv style=\"display:flex;align-items:center;\"\u003e\u003csvg role=\"img\" style=\"max-width:100%;height:auto;\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" fill=\"none\" stroke=\"#000\" stroke-width=\"1.6\" width=\"64px\" height=\"50px\" viewbox=\"0 0 64 50\"\u003e\u003cpath d=\"M 13.7,9.0 L 26.6,16.5\"\u003e\u003c\/path\u003e\u003cpath d=\"M 12.2,11.5 L 25.2,18.9\"\u003e\u003c\/path\u003e\u003cpath d=\"M 25.2,17.3 L 41.6,7.8\"\u003e\u003c\/path\u003e\u003cpath d=\"M 41.6,7.8 L 58.1,17.3\"\u003e\u003c\/path\u003e\u003cpath d=\"M 41.6,11.1 L 55.3,18.9\"\u003e\u003c\/path\u003e\u003cpath d=\"M 58.1,17.3 L 58.1,36.3\"\u003e\u003c\/path\u003e\u003cpath d=\"M 58.1,36.3 L 41.7,45.8\"\u003e\u003c\/path\u003e\u003cpath d=\"M 55.3,34.6 L 41.7,42.5\"\u003e\u003c\/path\u003e\u003cpath d=\"M 41.7,45.8 L 29.4,38.7\"\u003e\u003c\/path\u003e\u003cpath d=\"M 25.2,32.1 L 25.2,17.3\"\u003e\u003c\/path\u003e\u003cpath d=\"M 26.0,16.8 L 25.2,17.3 L 25.2,18.0\"\u003e\u003c\/path\u003e\u003cpath d=\"M 40.8,8.3 L 41.6,7.8 L 42.5,8.3\"\u003e\u003c\/path\u003e\u003cpath d=\"M 57.3,16.8 L 58.1,17.3 L 58.1,18.2\"\u003e\u003c\/path\u003e\u003cpath d=\"M 58.1,35.3 L 58.1,36.3 L 57.3,36.8\"\u003e\u003c\/path\u003e\u003cpath d=\"M 42.5,45.3 L 41.7,45.8 L 41.1,45.4\"\u003e\u003c\/path\u003e\u003ctext x=\"5.1\" y=\"13.8\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eS\u003c\/text\u003e\u003ctext x=\"13.3\" y=\"42.3\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eH\u003c\/text\u003e\u003ctext x=\"21.6\" y=\"42.3\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eN\u003c\/text\u003e\u003c\/svg\u003e\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cp style=\"font-size:12px;margin:4px 0 0 0;\"\u003e\u003cem\u003eGeneral reaction: 2-pyridyl disulfide amide → thiol + pyridine-2-thione.\u003c\/em\u003e\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cp\u003e\u003cstrong\u003eProtein–protein conjugates.\u003c\/strong\u003e A protein without free thiols, once modified with SPDP, reacts by thiol–disulfide exchange with a protein that carries a native or introduced thiol, giving a disulfide-linked conjugate. Enzyme–enzyme, enzyme–albumin and enzyme–antibody conjugates have been prepared in this way. Ricin A chain and gelonin have each been coupled to a monoclonal antibody with SPDP through a disulfide linkage. The disulfide bond between the two proteins can be split by reduction or by thiol–disulfide exchange, so the conjugation is reversible.\u003c\/p\u003e\n\u003cdiv style=\"margin:8px 0 18px 0;\"\u003e\n\u003cdiv style=\"display:flex;flex-wrap:wrap;align-items:center;justify-content:flex-start;gap:2px;\"\u003e\n\u003cdiv style=\"display:flex;align-items:center;\"\u003e\u003csvg role=\"img\" style=\"max-width:100%;height:auto;\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" fill=\"none\" stroke=\"#000\" stroke-width=\"1.6\" width=\"185px\" height=\"73px\" viewbox=\"0 0 185 73\"\u003e\u003cpath d=\"M 23.6,31.1 L 31.8,35.8\"\u003e\u003c\/path\u003e\u003cpath d=\"M 40.2,35.7 L 52.6,28.6\"\u003e\u003c\/path\u003e\u003cpath d=\"M 54.0,29.4 L 54.0,16.1\"\u003e\u003c\/path\u003e\u003cpath d=\"M 51.2,29.4 L 51.2,16.1\"\u003e\u003c\/path\u003e\u003cpath d=\"M 52.6,28.6 L 69.2,38.2\"\u003e\u003c\/path\u003e\u003cpath d=\"M 69.2,38.2 L 85.8,28.6\"\u003e\u003c\/path\u003e\u003cpath d=\"M 85.8,28.6 L 98.2,35.7\"\u003e\u003c\/path\u003e\u003cpath d=\"M 106.6,35.7 L 114.7,31.0\"\u003e\u003c\/path\u003e\u003cpath d=\"M 123.2,31.0 L 135.6,38.1\"\u003e\u003c\/path\u003e\u003cpath d=\"M 135.6,38.1 L 135.6,57.3\"\u003e\u003c\/path\u003e\u003cpath d=\"M 138.5,39.8 L 138.5,55.6\"\u003e\u003c\/path\u003e\u003cpath d=\"M 135.6,57.3 L 152.2,66.8\"\u003e\u003c\/path\u003e\u003cpath d=\"M 152.2,66.8 L 168.8,57.3\"\u003e\u003c\/path\u003e\u003cpath d=\"M 152.2,63.5 L 165.9,55.6\"\u003e\u003c\/path\u003e\u003cpath d=\"M 168.8,57.3 L 168.8,38.1\"\u003e\u003c\/path\u003e\u003cpath d=\"M 168.8,38.1 L 156.4,31.0\"\u003e\u003c\/path\u003e\u003cpath d=\"M 165.9,39.8 L 155.0,33.5\"\u003e\u003c\/path\u003e\u003cpath d=\"M 147.9,31.0 L 135.6,38.1\"\u003e\u003c\/path\u003e\u003cpath d=\"M 52.0,29.0 L 52.6,28.6 L 53.4,29.1\"\u003e\u003c\/path\u003e\u003cpath d=\"M 68.4,37.7 L 69.2,38.2 L 70.0,37.7\"\u003e\u003c\/path\u003e\u003cpath d=\"M 85.0,29.1 L 85.8,28.6 L 86.4,28.9\"\u003e\u003c\/path\u003e\u003cpath 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style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eN\u003c\/text\u003e\u003c\/svg\u003e\u003c\/div\u003e\n\u003cdiv style=\"display:flex;align-items:center;\"\u003e\u003cdiv style=\"font-size:20px;padding:0 4px;align-self:center;\"\u003e+\u003c\/div\u003e\u003c\/div\u003e\n\u003cdiv style=\"display:flex;align-items:center;\"\u003e\u003csvg role=\"img\" style=\"max-width:100%;height:auto;\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" fill=\"none\" stroke=\"#000\" stroke-width=\"1.6\" width=\"49px\" height=\"11px\" viewbox=\"0 0 49 11\"\u003e\u003cpath d=\"M 16.2,4.2 L 28.2,4.2\"\u003e\u003c\/path\u003e\u003ctext x=\"5.2\" y=\"10.2\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eR\u003c\/text\u003e\u003ctext x=\"13.5\" y=\"10.2\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003e′\u003c\/text\u003e\u003ctext x=\"28.8\" y=\"10.2\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eS\u003c\/text\u003e\u003ctext x=\"36.5\" y=\"10.2\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eH\u003c\/text\u003e\u003c\/svg\u003e\u003c\/div\u003e\n\u003cdiv style=\"display:flex;align-items:center;\"\u003e\u003cdiv style=\"display:flex;flex-direction:column;align-items:center;justify-content:center;min-width:90px;max-width:150px;padding:0 4px;text-align:center;font-size:12px;line-height:1.3;\"\u003e\n\u003cdiv\u003ethiol–disulfide\u003c\/div\u003e\n\u003cdiv style=\"font-size:30px;line-height:1;\"\u003e⟶\u003c\/div\u003e\n\u003cdiv\u003eexchange\u003c\/div\u003e\n\u003c\/div\u003e\u003c\/div\u003e\n\u003cdiv style=\"display:flex;align-items:center;\"\u003e\u003csvg role=\"img\" style=\"max-width:100%;height:auto;\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" fill=\"none\" stroke=\"#000\" stroke-width=\"1.6\" width=\"153px\" height=\"59px\" viewbox=\"0 0 153 59\"\u003e\u003cpath d=\"M 20.7,30.0 L 28.8,34.7\"\u003e\u003c\/path\u003e\u003cpath d=\"M 37.3,34.7 L 49.7,27.5\"\u003e\u003c\/path\u003e\u003cpath d=\"M 51.1,28.4 L 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41.1,45.4\"\u003e\u003c\/path\u003e\u003ctext x=\"5.1\" y=\"13.8\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eS\u003c\/text\u003e\u003ctext x=\"13.3\" y=\"42.3\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eH\u003c\/text\u003e\u003ctext x=\"21.6\" y=\"42.3\" style=\"font:12px sans-serif;fill:#000;stroke:none\"\u003eN\u003c\/text\u003e\u003c\/svg\u003e\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cp style=\"font-size:12px;margin:4px 0 0 0;\"\u003e\u003cem\u003eGeneral reaction: 2-pyridyl disulfide amide + R′–SH → disulfide-linked conjugate + pyridine-2-thione; R′–SH = a native or introduced thiol of a second molecule.\u003c\/em\u003e\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cp\u003e\u003cstrong\u003ePeptide–carrier conjugates.\u003c\/strong\u003e SPDP has been used to link a synthetic peptide to an immunogenic carrier protein through the thiol of a cysteine residue.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eLiposomes and nanoparticles.\u003c\/strong\u003e A monoclonal antibody, itself modified with SPDP, has been coupled to liposomes that contain SPDP-substituted phosphatidylethanolamine. Amino-functionalised nanoparticles activated with SPDP have been coupled to a protein carrying an introduced thiol.\u003c\/p\u003e\n\u003c\/div\u003e\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cdiv style=\"margin-bottom: 28px;\"\u003e\n\u003cdiv style=\"background: #002147; padding: 10px 20px; margin-bottom: 0;\"\u003e\u003ch3 style=\"margin: 0; font-family: 'Helvetica Neue', Helvetica, Arial, sans-serif; font-size: 0.70em; font-weight: bold; letter-spacing: 0.12em; text-transform: uppercase; color: #fff;\"\u003eShipping Destinations\u003c\/h3\u003e\u003c\/div\u003e\n\u003cdiv style=\"border: 1px solid #e4e8f0; border-top: none; padding: 12px 16px; font-family: 'Helvetica Neue', Helvetica, Arial, sans-serif; font-size: 0.95em;\"\u003e\u003cul style=\"margin: 0; padding: 0; list-style: none;\"\u003e\n\u003cli style=\"padding: 5px 0; border-bottom: 1px solid #f0f0f0;\"\u003e\n\u003cspan style=\"display: inline-block; width: 7px; height: 7px; background: #002147; border-radius: 50%; margin-right: 10px; vertical-align: middle;\"\u003e\u003c\/span\u003eEU \u0026amp; UK: Priority delivery, 2–5 business days.\u003c\/li\u003e\n\u003cli style=\"padding: 5px 0; border-bottom: 1px solid #f0f0f0;\"\u003e\n\u003cspan style=\"display: inline-block; width: 7px; height: 7px; background: #002147; border-radius: 50%; margin-right: 10px; vertical-align: middle;\"\u003e\u003c\/span\u003eUnited States (DDP): 3–7 business days, duties and taxes prepaid.\u003c\/li\u003e\n\u003cli style=\"padding: 5px 0; border-bottom: 1px solid #f0f0f0;\"\u003e\n\u003cspan style=\"display: inline-block; width: 7px; height: 7px; background: #002147; border-radius: 50%; margin-right: 10px; vertical-align: middle;\"\u003e\u003c\/span\u003eEFTA Countries (DDP): 3–7 business days, duties and taxes prepaid.\u003c\/li\u003e\n\u003cli style=\"padding: 5px 0; border-bottom: 1px solid #f0f0f0;\"\u003e\n\u003cspan style=\"display: inline-block; width: 7px; height: 7px; background: #002147; border-radius: 50%; margin-right: 10px; vertical-align: middle;\"\u003e\u003c\/span\u003eWorldwide: 7–14 business days, selected locations.\u003c\/li\u003e\n\u003c\/ul\u003e\u003c\/div\u003e\n\u003c\/div\u003e","brand":"NorrChemica™","offers":[{"title":"100 mg","offer_id":55166390567249,"sku":"NOR-68181179-100mg","price":43.2,"currency_code":"EUR","in_stock":true},{"title":"250 mg","offer_id":55166390600017,"sku":"NOR-68181179-250mg","price":54.2,"currency_code":"EUR","in_stock":true},{"title":"1.0 g","offer_id":55262513791313,"sku":"NOR-68181179-1g","price":119.2,"currency_code":"EUR","in_stock":false},{"title":"5.0 g","offer_id":55262513824081,"sku":"NOR-68181179-5g","price":298.2,"currency_code":"EUR","in_stock":false},{"title":"25 g","offer_id":55262513856849,"sku":"NOR-68181179-25g","price":629.2,"currency_code":"EUR","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0954\/6357\/1793\/files\/SPDP.png?v=1792188821","url":"https:\/\/www.norrchemica.com\/products\/spdp-cas-68181-17-9","provider":"NorrChemica","version":"1.0","type":"link"}