1 2

NorrChemica

3',5'-Bis-O-(tert-butyldimethylsilyl)thymidine (O,O-TBS-Thymidine) | CAS 40733-26-4 | >98% Purity | Research Use Only | EU Seller

3',5'-Bis-O-(tert-butyldimethylsilyl)thymidine (O,O-TBS-Thymidine) | CAS 40733-26-4 | >98% Purity | Research Use Only | EU Seller

€59,00 EUR
€59,00 EUR
Sale Sold out
Taxes included. Shipping calculated at checkout.
Weight

🧪 Technical Specifications

  • CAS Number: 40733-26-4
  • SMILES: CC1=CN(C(=O)NC1=O)[C@H]2C[C@@H]([C@H](O2)CO[Si](C)(C)C(C)(C)C)O[Si](C)(C)C(C)(C)C
  • InChI: InChI=1S/C22H42N2O5Si2/c1-15-13-24(21(26)23-20(15)25)19-14-18(28-30(8,9)16(2,3)4)17(29-19)12-27-31(10,11)22(5,6)7/h13,17-19H,12,14H2,1-11H3,(H,23,25,26)/t17-,18+,19+/m1/s1
  • InChIKey: OTNHTDRSPOHTKF-XOYMREIDSA-N
  • Molecular Formula: C₂₂H₄₂N₂O₅Si₂
  • Molecular Weight: 470.75 g/mol
  • Purity: ≥ 98.0%
  • Physical Form: White to off-white crystalline solid
  • HS Code: 2934.99.90
  • Shelf Life: 24 months stored under appropiate conditions
  • Storage Conditions: Store at +2°C to +8°C. Keep tightly closed. Protect from moisture.

🔬 Common Scientific Applications

  • Protected thymidine scaffold & organic synthesis — 3’,5’-bis-O-(tert-butyldimethylsilyl)thymidine is widely used as a di-silyl protected thymidine core for regioselective functionalization at C5 and on the sugar ring in multistep nucleoside synthesis. OUP Academic+1
  • Modified nucleosides & nucleotide building blocks — Key intermediate for preparing structurally modified 2'-deoxythymidines and deoxyuridines (e.g. C5-substituted, 5-formyl, 5-hydroxymethyl, thymine glycol and related derivatives) that are later transformed to phosphoramidites or triphosphates. Chemistry Europe+1
  • Oligonucleotide & DNA damage studies — Starting point for solid-phase synthesis of DNA oligonucleotides containing site-specific lesions or analogues (e.g. spore-photoproduct, thymine glycol) to study DNA damage, repair pathways, and structure–function relationships in vitro. PMC+1
  • Double-headed & conjugated nucleosides — Used as a protected thymidine precursor for installing additional aromatic or nucleobase units at the 5'-position, enabling the preparation of “double-headed” nucleosides and other conjugated scaffolds for nucleic-acid engineering and supramolecular studies. Semantic Scholar+1
  • Protecting-group strategy development — Representative tBDMS-protected nucleoside employed to optimize silyl-based protecting-group schemes, deprotection conditions, and compatibility with downstream phosphoramidite chemistry in DNA/RNA synthesis workflows. ResearchGate+1
  • Education & training — Useful example compound for advanced teaching labs that demonstrate nucleoside protection/deprotection, sugar-selective derivatization, and analytical characterization of silyl-protected nucleosides.

For laboratory research and technical use only. Not for human or veterinary use.

⚠️ Safety & Transport

  • Hazard Class (UN/DG): Non-regulated
  • GHS Signal Word: None
  • GHS Hazard Statements: Not classified as a hazardous substance under Regulation (EC) No 1272/2008 (CLP)
  • GHS Precautionary Statements: Handle in accordance with good laboratory practice. Avoid inhalation of dust. Avoid contact with eyes and skin. Use personal protective equipment as required

🔎 Advanced Identifiers

  • PubChem CID: 114878

3',5'-Bis-O-(tert-butyldimethylsilyl)thymidine (O,O-TBS Thymidine) | CAS 40733-26-4 | >98% Purity | Research Use Only | EU Seller

🧪 The NorrChemica™ Standard

  • Primary manufacturer – material produced and characterized in-house, not re-labeled or brokered.
  • Analytical Purity: Identity-verified material. Strictly meets or exceeds defined grade specifications.
🇪🇺 Intra-EU Trade: Frictionless, tariff-free shipping within the European Union (Single Market).🌍 Global Support: Full customs documentation provided for UK, Canada, and EFTA orders.Professional Logistics: Shipped from Finland via premium tracked couriers (UPS/Posti).

🧰 Packaging & Storage

  • Supplied in sealed HDPE or amber glass containers
  • Store tightly closed in a cool, dry place
  • Shelf life: ≥ 36 months under recommended conditions
  • Batch-specific CoA and SDS provided

⚠️ Compliance & Safety

  • Research Use Only (RUO): Not for human or veterinary use.
  • Mandatory Safety: Always follow the safety instructions and required Personal Protective Equipment (PPE) as detailed in the Safety Data Sheet (SDS).
  • Regulatory Status: The specific classification is product-dependent; see the SDS supplied with your order.
  • Documentation: A Certificate of Analysis (CoA) and GHS-compliant SDS are available for every order.
  • Payment: To ensure regulatory compliance for specialty chemicals, we process orders via Wise (Bank Transfer) or Manual Invoice.

Shipping & Delivery

We ship from our facility in Finland (EU).

  • 🇪🇺 EU & UK: typically 2–5 business days.
  • 🇺🇸 United States (DDP): typically 3–7 business days, duties and taxes prepaid.
  • 🌍 Selected destinations (e.g., Canada, Japan, Australia, EFTA): typically 4–12 business days.
  • 🧾 Full documentation (CoA + GHS-compliant SDS) included.

🧬 About NorrChemica™

NorrChemica™ is a Finnish supplier of high-purity specialty reagents and niche research materials. We focus on reliable EU shipping, transparent labeling, and accessible pricing for technical users worldwide.

⚖️ Terms of Sale & Disclaimer Sold strictly for laboratory research, analysis, and technical applications. Not for human consumption or food use. By purchasing this item, you confirm professional or educational intent.

View full details