3',5'-Di-O-Pivaloyl Thymidine | ≥98% Purity | Protected Nucleoside Intermediate | RUO | EU Seller

3′,5′-Di-O-pivaloylthymidine is a protected nucleoside building block designed for controlled, regioselective thymidine chemistry in advanced synthetic workflows. Typical scientific uses include:

1) Nucleoside intermediate for multistep organic synthesis

• Enables selective transformations on the thymidine scaffold by temporarily masking the 3′- and 5′-hydroxyl groups with robust pivaloyl protection.
  
• Useful when unprotected thymidine is incompatible with reaction conditions or purification workflows.
  

2) Precursor to oligonucleotide building blocks

• Serves as a protected starting material for preparing downstream thymidine-derived monomers used in oligonucleotide chemistry (after appropriate deprotection and functional group installation).
  
• Supports development of modified nucleoside intermediates for nucleic-acid related synthesis routes.
  

3) Regioselective 5′- and 3′-functionalization strategies

• The dual pivaloyl pattern is frequently used to support stepwise activation/derivatization of sugar positions (e.g., controlled access to 5′-functional handles after selective manipulations or staged deprotection).
  

4) Protecting-group method development & analytical reference

• Suitable for protecting-group stability/deprotection screening (acid/base sensitivity, transesterification resistance, etc.).
  
• Used as a synthetic reference material for method development in LC-MS/HPLC and NMR-based structural confirmation.
  

Research Use Only (RUO). Not for human or veterinary use.