NorrChemica
Ethyl (thymin-1-yl)acetate | CAS: 55036-34-5 | PNA Monomer Precursor | Purity: ≥ 98.0%
Ethyl (thymin-1-yl)acetate | CAS: 55036-34-5 | PNA Monomer Precursor | Purity: ≥ 98.0%
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🧪 Technical Specifications
- CAS Number: 55036-34-5
- SMILES: CCOC(=O)CN1C=C(C)C(=O)NC1=O
- InChI: InChI=1S/C9H12N2O4/c1-3-15-8(13)5-11-4-6(2)7(12)10-9(11)14/h4H,3,5H2,1-2H3,(H,10,12,14)
- InChIKey: XGZREAFGAKWRLY-UHFFFAOYSA-N
- Molecular Formula: C₉H₁₂N₂O₄
- Molecular Weight: 212.2 g/mol
- Purity: ≥ 98.0%
- Physical Form: White crystalline solid
- HS Code: 2933.59
- Shelf Life: ≥36 months when stored under recommended conditions
- Storage Conditions: Store tightly closed in a cool, dry place; recommended 2–8 °C; protect from light and moisture.
🔬 Common Scientific Applications
• Nucleobase functionalization & linkers — N1-substituted thymine acetate used as a versatile intermediate for installing thymine units onto spacers, polymers, and small-molecule scaffolds in medicinal and materials chemistry.
• PNA & nucleic-acid-mimic synthesis — Protected ethyl ester form of thymin-1-ylacetic acid, employed in the preparation of peptide nucleic acid (PNA) monomers and thymine-containing conjugates in solid- and solution-phase synthesis.
• Prodrug & conjugate design — Building block for N1-acetic thymine derivatives in prodrug studies, nucleobase–peptide conjugates, and receptor/ligand design.
• Organic synthesis & method development — Reference intermediate for developing acylation, esterification, and deprotection protocols on pyrimidine bases, and for benchmarking chromatographic and spectroscopic methods.
• Analytical reference material — Well-defined small molecule for validating NMR, LC–MS and HPLC methods focused on thymine acetic esters and related pyrimidin-1-yl derivatives.
⚠️ Safety & Transport
- Hazard Class (UN/DG): Non-hazardous (Not subject to UN regulations)
- GHS Signal Word: None
- GHS Hazard Statements: Not classified as a hazardous substance under Regulation (EC) No 1272/2008 (CLP)
- GHS Precautionary Statements: Handle in accordance with good laboratory practice. Avoid inhalation of dust. Avoid contact with eyes and skin. Use personal protective equipment as required
🔎 Advanced Identifiers
- PubChem CID: 215443
Ethyl (thymin-1-yl)acetate | CAS: 55036-34-5 | PNA Monomer Precursor | Purity: ≥ 97.0%
Ethyl (thymin-1-yl)acetate is the essential, protected N1-derivative of Thymine, serving as a critical building block for **Peptide Nucleic Acid (PNA)** synthesis. This stable, highly pure intermediate is the preferred starting point for creating PNA monomers, minimizing labor and purification steps in the oligonucleotide lab.
💰 Pricing Rationale (High-Value Intermediate)
This intermediate is classified as a rare specialty chemical, requiring complex, regioselective synthesis. Our pricing reflects the high cost of synthesis and guaranteed purity, positioning us as the premier EU supplier for R&D and pilot scale production.
🧪 The NorrChemica™ Purity Guarantee
- Purity Verification: Purity ≥98.0% confirmed by **clean 1H NMR analysis** (Free from N3-isomer contamination).
- Ideal PNA Precursor: Stable, crystalline solid ideal for direct hydrolysis and coupling reactions in automated synthesis.
- EU Stocked: Available for immediate dispatch from Finland. Avoid delays and customs risk associated with global sourcing.
- Primary manufacturer – material produced and characterized in-house, not re-labeled or brokered.
🧪 The NorrChemica™ Standard
- European Certified Origin: Sourced exclusively from accredited EU manufacturers. Full supply chain traceability.
- Analytical Purity: Identity-verified material. Strictly meets or exceeds defined grade specifications.
- 🇪🇺 Intra-EU Trade: Frictionless, tariff-free shipping within the European Union (Single Market).
- 🌍 Global Support: Full customs documentation provided for UK, Canada, and EFTA orders.
- Professional Logistics: Shipped from Finland via premium tracked couriers (UPS/Posti).
🧰 Packaging & Storage
- Supplied in sealed HDPE or amber glass containers
- Store tightly closed in a cool, dry place
- Shelf life: ≥ 36 months under recommended conditions
- Batch-specific CoA and SDS provided
⚠️ Compliance & Safety
- Research Use Only (RUO): Not for human or veterinary use.
- Mandatory Safety: Always follow the safety instructions and required Personal Protective Equipment (PPE) as detailed in the Safety Data Sheet (SDS).
- Regulatory Status: The specific classification is product-dependent; see the SDS supplied with your order.
- Documentation: A Certificate of Analysis (CoA) and GHS-compliant SDS are available for every order.
- Payment: To ensure regulatory compliance for specialty chemicals, we process orders via Wise (Bank Transfer) or Manual Invoice.
Shipping & Delivery
We ship from our facility in Finland (EU).
- 🇪🇺 EU & UK: typically 2–5 business days.
- 🇺🇸 United States (DDP): typically 3–7 business days, duties and taxes prepaid.
- 🌍 Selected destinations (e.g., Canada, Japan, Australia, EFTA): typically 4–12 business days.
- 🧾 Full documentation (CoA + GHS-compliant SDS) included.
🧬 About NorrChemica™
NorrChemica™ is a Finnish supplier of high-purity specialty reagents and niche research materials. We focus on reliable EU shipping, transparent labeling, and accessible pricing for technical users worldwide.
⚖️ Terms of Sale & Disclaimer Sold strictly for laboratory research, analysis, and technical applications. Not for human consumption or food use. By purchasing this item, you confirm professional or educational intent.
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