NorrChemica
HATU Peptide Coupling Reagent | CAS 148893-10-1 | Powder High Purity ≥ 99.0% 3rd-Party Tested | Amide Bond Formation
HATU Peptide Coupling Reagent | CAS 148893-10-1 | Powder High Purity ≥ 99.0% 3rd-Party Tested | Amide Bond Formation
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🧪 Technical Specifications
- CAS Number: 148893-10-1
- EC Number: N/A
- Molecular Formula: C₁₀H₁₅F₆N₆OP
- Molecular Weight: 380.23 g/mol
- Purity: ≥ 99.0 % (High Purity)
- Physical Form: Off-white to light yellow crystalline powder
- HS Code: 2925.29
- Country of Origin: Finland
- Shelf Life: ≥ 24 months (Under adequate storing conditions)
- Storage Conditions: Store in tightly sealed container under dry, cool conditions (2–8 °C). Protect from moisture and light.
🔬 Common Scientific Applications
⚗️ High-efficiency amide formation: Go-to uronium reagent for solid-phase and solution-phase peptide coupling.
🧬 OAt active ester pathway: Activates carboxylic acids as OAt esters, giving fast couplings with low racemization vs. carbodiimides (DCC/DIC).
🧱 Difficult sequences: Useful for hindered/β-branched residues, sterically crowded segments, and late-stage couplings after Fmoc/tBu cycles.
🔗 Cyclizations & macrocycles: Promotes lactamization and head-to-tail peptide macrocyclization with improved yields/cleaner profiles.
🧪 Small-molecule amide installs: General amide bond formation in medicinal/organic synthesis where mild, rapid activation is desired.
🧲 Cleaner profiles: Typically fewer urea by-products and reduced epimerization relative to CDI/DCC routes.
⚙️ Typical media & base: Works in DMF/NMP/DMSO with tertiary bases (e.g., DIPEA/TEA)—widely used in automated SPPS.
🧰 Capping & recoupling strategies: Compatible with double-coupling/recouple passes and capping steps to suppress deletion sequences.
R&D use only. Moisture-sensitive; PF₆⁻ salts can release HF under strongly acidic/hot conditions—use appropriate PPE, dry handling, and consult the SDS/CoA for your lot.
⚠️ Safety & Transport
- Hazard Class (UN/DG): UN 1325 – Flammable solid, organic, n.o.s.
- GHS Signal Word: Danger
- GHS Hazard Statements: H228 (Flammable solid), H315 (Causes skin irritation), H319 (Causes serious eye irritation), H335 (May cause respiratory irritation)
- GHS Precautionary Statements: P210, P261, P280, P305+P351+P338P273, P280, P305+P351+P338, P337+P313
- Dangerous Goods Notes: Regulated as Dangerous Goods under ADR; ground transport only within EU
🔎 Advanced Identifiers
- PubChem CID: 10060066
HATU Peptide Coupling Reagent | CAS 148893-10-1 | Powder High Purity ≥ 99.0% 3rd-Party Tested
🧪 The NorrChemica™ Standard
- European Certified Origin: Sourced exclusively from accredited EU manufacturers. Full supply chain traceability.
- Analytical Purity: Identity-verified material. Strictly meets or exceeds defined grade specifications.
- 🇪🇺 EU Delivery Only: Distributed within the European Union via DG-compliant services.
- Professional Logistics: Shipped from Finland via premium tracked couriers (UPS/Posti) with DG handling.
🧰 Packaging & Storage
- Supplied in sealed HDPE or amber glass containers
- Store tightly closed in a cool, dry place
- Shelf life: ≥ 24 months under recommended conditions
- Batch-specific CoA and SDS provided
⚠️ Compliance & Safety
- Not for human or veterinary use.
- Mandatory Safety: Always follow the safety instructions and required Personal Protective Equipment (PPE) as detailed in the Safety Data Sheet (SDS).
- Regulatory Status: Classified as Dangerous Goods for transport. Specific transport and hazard classification is product-dependent; see the SDS supplied with your order.
- Documentation: A Certificate of Analysis (CoA) and GHS-compliant SDS are available for every order.
- Payment: To ensure regulatory compliance for specialty chemicals, we process orders via Wise (Bank Transfer) or Manual Invoice.
Shipping & Delivery
We ship from our facility in Finland (EU). Availability: European Union only via DG-compliant services; air transport may be restricted. 🇺🇸 United States: shipping unavailable.
- 🇪🇺 European Union: timelines depend on carrier DG lanes (typically 2–5 business days).
- 🧾 Full documentation (CoA + GHS-compliant SDS) included.
🧬 About NorrChemica™
NorrChemica™ is a Finnish supplier of high-purity specialty reagents and niche research materials. We focus on reliable EU shipping, transparent labeling, and accessible pricing for technical users worldwide.
⚖️ Terms of Sale & Disclaimer Sold strictly for laboratory research, analysis, and technical applications. Not for human consumption or food use. By purchasing this item, you confirm professional or educational intent.
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