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NorrChemica™

4-Methylphenylboronic Acid | CAS 5720-05-8 | ≥98%

4-Methylphenylboronic Acid | CAS 5720-05-8 | ≥98%

€24,95 EUR
€24,95 EUR
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Technical Specifications

CAS Number 5720-05-8
EC / EINECS Number 611-480-1
MDL Number MFCD00039138
SMILES B(C1=CC=C(C=C1)C)(O)O
InChI InChI=1S/C7H9BO2/c1-6-2-4-7(5-3-6)8(9)10/h2-5,9-10H,1H3
InChIKey BIWQNIMLAISTBV-UHFFFAOYSA-N
PubChem CID 79799
Molecular Formula C₇H₉BO₂
Molecular Weight 135.96 g/mol
Melting Point 256–263 °C
Solubility Soluble in alcoholic solvents, acetonitrile, DMF, DMSO
Purity ≥98%. May contain varying amounts of the corresponding boronic acid anhydrides
Physical Form White to off-white crystalline powder
HS Code 2931
Shelf Life Retest period: 36 months from date of manufacture
Storage Conditions Store in a cool, dry place in a tightly sealed container
SDS / CoA Download PDF

Applications

4-Tolylboronic acid is a versatile arylboronic acid building block for palladium-catalyzed carbon–carbon bond-forming reactions. It serves as a reliable coupling partner for introducing the 4-methylphenyl (p-tolyl) group into complex molecular architectures.

  • Suzuki-Miyaura cross-coupling with aryl and vinyl halides
  • Sonogashira and Heck coupling reactions
  • Synthesis of biaryl intermediates for pharmaceutical and agrochemical research
  • OLED and liquid crystal material development
  • β-Lactamase (AmpC) inhibition studies
  • Glycoprotein and carbohydrate recognition research

Structure & Properties

4-Tolylboronic acid features a para-methyl substituent on the phenyl ring, providing moderate electron-donating character that enhances reactivity in transmetalation steps. The compound is a high-melting crystalline solid (256–263 °C) and may contain varying amounts of the corresponding boronic acid anhydride (boroxine) in the solid state.

Handling

Handle under standard laboratory ventilation. Avoid contact with skin and eyes. Consult the Safety Data Sheet before use.

Common Scientific Applications

  • Benchmark coupling partner in Suzuki–Miyaura cross-coupling reactions for the synthesis of 4-methylbiaryl scaffolds via palladium catalysis.
  • Building block in medicinal chemistry and drug discovery, particularly for the preparation of para-methyl-substituted biaryl and heteroaryl compounds with enhanced lipophilicity.
  • Reagent in the synthesis of functionalised aromatic building blocks, including tolyl-substituted heterocycles, natural product analogues, and pharmaceutical intermediates.
  • Precursor for 4-methylphenyl boronate esters (pinacol, MIDA, neopentyl glycol) used in iterative cross-coupling strategies and complex molecule synthesis.

Shipping Destinations

  • EU & UK: Priority delivery, 2–5 business days.
  • United States (DDP): 3–7 business days, duties and taxes prepaid.
  • EFTA Countries (DDP): 3–7 business days, duties and taxes prepaid.
  • Worldwide: 7–14 business days, selected locations.

The NorrChemica™ Standard

Identity Verified — Batch-verified via analytical QC; documentation available on request.

Direct EU Distribution — Dispatched from Finland for fast delivery to EU-based laboratories.

Professional Logistics — Tracked courier shipping via UPS / Matkahuolto / Posti.

Packaging & Storage

  • Supplied in tightly sealed containers suitable for laboratory handling.
  • Store under recommended conditions as specified on the product label and SDS.
  • Retest period per lot-specific CoA / label under recommended conditions.

Technical Documentation

  • Batch-specific Certificate of Analysis (CoA) included with every order.
  • GHS-compliant Safety Data Sheet (SDS) provided with every shipment.
  • Batch documentation available for institutional procurement.
Payment: Wise (Bank Transfer) or Manual Invoice.
Disclaimer: Research Use Only (RUO) — not for human or veterinary use. Sold strictly for laboratory research and technical applications. By purchasing this item, the buyer confirms professional intent and compliance with applicable regulations.

Safety Information

GHS Pictograms
GHS07 Harmful/Irritant
Signal Word Warning
Hazard Class Not classified as dangerous for transport (ADR/IATA)
Transport Category Not regulated
H-Statements H315 (Causes skin irritation), H319 (Causes serious eye irritation), H335 (May cause respiratory irritation)
P-Statements P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P332+P317, P337+P317, P403+P233, P405, P501

NorrChemica™ is a Finnish supplier of niche research reagents — focused on reliable EU distribution, transparent analytical documentation, and specialist technical support.

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