3-Fluorophenylboronic Acid | CAS 768-35-4 | ≥98%

Suzuki–Miyaura Cross-Coupling

• Versatile meta-substituted coupling partner for the synthesis of 3-fluorobiaryl scaffolds via palladium catalysis
• The meta-fluoro position provides a distinctive electronic and steric profile complementary to para- and ortho-fluorinated isomers
• Compatible with a broad range of cross-coupling protocols including microwave-assisted and aqueous Suzuki conditions

Drug Discovery & Medicinal Chemistry

• Key building block for meta-fluorinated pharmaceuticals — the meta-fluoro substituent acts as a bioisostere improving metabolic stability and modulating binding interactions differently from the para-isomer
• Widely used in structure-activity relationship (SAR) studies and lead optimisation to explore the effect of fluorine regiochemistry on pharmacological activity
• Applied in the synthesis of anti-cancer agents, CNS-active compounds, and GPCR ligands where the meta-fluorine substitution pattern provides unique pharmacological profiles

Kinase Inhibitor & Chemical Biology Research

• Reagent in the synthesis of fluorinated heterocycles and biaryl frameworks used as kinase inhibitors
• Used in chemical biology to develop probes for real-time study of enzyme and receptor interactions

Boronate Esters & Iterative Synthesis

• Precursor for 3-fluorophenyl boronate esters (pinacol, MIDA, neopentyl glycol) used in iterative cross-coupling strategies
• Applied in complex molecule assembly where the meta-substitution pattern provides distinct reactivity from symmetrical isomers

Materials Science & Fluorinated Polymers

• Applied in materials science research where meta-fluorine substitution provides distinct electronic and structural properties vs para- and ortho-isomers
• Used in the development of fluorinated aromatic polymers and functional organic materials