4-(Trifluoromethyl)phenylboronic Acid | CAS 128796-39-4 | ≥98%

Suzuki–Miyaura Cross-Coupling

• One of the most widely used fluorinated arylboronic acid coupling partners for the synthesis of 4-(trifluoromethyl)biaryl scaffolds via palladium catalysis
• The para-CF₃ group combines strong electron withdrawal with exceptional chemical stability — electronically distinct from fluoro, chloro, and cyano substituted analogues
• Compatible with a broad range of Suzuki protocols including aqueous, microwave-assisted, and ligand-free conditions

Organic Synthesis & Building Block Chemistry

• Key building block for the synthesis of trifluoromethylated aromatic frameworks used across synthetic chemistry, agrochemistry, and fine chemical research
• The CF₃ group modulates lipophilicity, membrane permeability, and metabolic stability of target molecules — making it a highly valued substituent in structure-activity relationship studies
• Applied in agrochemistry for the synthesis of trifluoromethylated aromatic intermediates widely used in crop protection compounds

Materials Science & Functional Organic Chemistry

• Applied in the synthesis of fluorinated conjugated materials, organic semiconductors, and liquid crystal intermediates where the CF₃ group imparts strong electron-withdrawing character and enhanced chemical stability
• Used in the development of fluorinated functional polymers where the trifluoromethyl group modulates electronic and physical properties

Boronate Esters & Iterative Synthesis

• Precursor for 4-(trifluoromethyl)phenyl boronate esters (pinacol, MIDA, neopentyl glycol) used in iterative cross-coupling strategies
• Applied in systematic electronic effect studies where the CF₃ group represents a strongly electron-withdrawing yet metabolically stable substituent on the Hammett scale