NorrChemica™
TBS-Isopropylidene-D-Ribonolactone Powder | High Purity >97.0% Chiral Building Block | 75467-36-6 | EU Seller
TBS-Isopropylidene-D-Ribonolactone Powder | High Purity >97.0% Chiral Building Block | 75467-36-6 | EU Seller
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🧪 Technical Specifications
- CAS Number: 75467-36-6
- SMILES: CC1(OC2C(OC(=O)C2O1)CO[Si](C)(C)C(C)(C)C)C
- InChI: InChI=1S/C14H26O5Si/c1-13(2)22-11-7-23(12-8-16-24(4,5)6)9-10(11)14(3)21-10/h10-12H,7-9H2,1-6H3/t10-,11+,12+
- InChIKey: VBPYRQYBEKHPKA-GMTAPVOTSA-N
- Molecular Formula: C₁₄H₂₆O₅Si
- Molecular Weight: 302.44 g/mol
- Purity: ≥ 97.0%
- Physical Form: White crystalline powder
- HS Code: 2932.20
- Shelf Life: ≥ 36 months (when stored correctly)
- Storage Conditions: -20°C (Deep Freeze); store under Argon
🔬 Common Scientific Applications
C-modified nucleoside synthesis (C-nucleosides / C-glycosides): a protected ribose-equivalent used to build C–C bonds at the anomeric position (via nucleophilic addition/olefination to the lactone carbonyl), enabling “non-natural” nucleoside analogs.
LNA/BNA (and related constrained sugar) monomer routes: used as an advanced protected sugar intermediate in pathways toward locked/bridged nucleic-acid monomers and other conformationally constrained ribose scaffolds.
Protected ribose building block for nucleoside analogs: a practical starting point for regioselective functionalization (e.g., introducing substituents at C1/C5 and then carrying into nucleobase coupling sequences).
Carbohydrate chemistry / chiral pool synthesis: employed as a chiral building block to access stereodefined polyol frameworks and glycomimetic intermediates.
Natural product and medicinal chemistry intermediates: useful when a synthesis needs a pre-organized ribose-like stereochemical array with robust protecting groups already installed.
Method development for regioselective protection/deprotection: the TBS + isopropylidene pattern is often used to develop/validate selective transformations (stepwise deprotections, orthogonal PG strategies).
Route scouting & reference material: used in process development as a stable, isolable intermediate to benchmark yields/selectivity in sugar-functionalization sequences.
⚠️ Safety & Transport
- Hazard Class (UN/DG): Non-hazardous for transport
- GHS Signal Word: None (Not classified)
- GHS Hazard Statements: Not classified as hazardous under GHS/CLP (no H-statements)
- GHS Precautionary Statements: Handle as a laboratory chemical; avoid breathing dust; avoid contact with skin/eyes; wear appropriate PPE; wash hands after handling; dispose according to local regulations.
🔎 Advanced Identifiers
- PubChem CID: 10913693
(TBS)-Isopropylidene-D-ribonolactone | >97.0% Purity | CAS: 75467-36-6 | EU Seller
(TBS)-Isopropylidene-D-ribonolactone (also known as 5-O-TBS-2,3-O-isopropylidene-D-ribono-1,4-lactone) is a dual-protected key chiral intermediate used in advanced carbohydrate chemistry and nucleoside building-block synthesis, including routes toward C-nucleosides and LNA/BNA-related intermediates. Its TBS / isopropylidene protection pattern supports controlled regioselective transformations and improved handling in multistep synthesis workflows.
🧪 The NorrChemica™ Standard
- Analytical Verification: Identity confirmed by 1D/2D NMR (batch-specific documentation available).
- Direct EU Distribution: Dispatched from Finland, supporting fast delivery for EU-based laboratories.
- Professional Logistics: Tracked courier shipping (UPS/Posti).
🧰 Packaging & Storage
- Supplied in tightly sealed containers suitable for laboratory handling.
- Store tightly closed in a cool, dry place. (Cold storage recommended for long-term stability.)
- Shelf life: ≥ 36 months under recommended conditions.
📑 Technical Documentation
- Batch-specific Certificate of Analysis (CoA) provided.
- GHS-compliant SDS provided.
- NMR spectra available for technical evaluation.
🌍 Shipping & Compliance
We operate under strict compliance standards for specialty reagents:
- 🇪🇺 EU & UK: Priority delivery typically in 2–5 business days.
- 🇺🇸 United States (DDP): 3–7 business days with prepaid duties and taxes.
- 🏔️ EFTA Countries (DDP): 3–7 business days with prepaid duties and taxes.
- 🌍 Worldwide Selected Locations: 7–14 business days.
- Research Use Only (RUO): Not for human or veterinary use.
- Payment: Processed via Wise (Bank Transfer) or Manual Invoice to meet specialty chemical trade regulations.
NorrChemica™ is a Finnish supplier of high-purity specialty reagents and niche research materials, focused on reliable EU shipping, transparent labeling, and technical support.
⚖️ Disclaimer: Sold strictly for laboratory research, analysis, and technical applications. By purchasing this item, the buyer confirms professional or educational intent.
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