NorrChemica™
1,3,5-Trimethoxybenzene
1,3,5-Trimethoxybenzene | CAS 621-23-8 | ≥98%
| Pack size | Excl. VAT | Incl. VAT | Add to cart |
|---|---|---|---|
| 5.0 g | €47,20 | ||
| 10 g | €69,20 | ||
| 25 g | €84,20 | ||
| 50 g | €98,20 | ||
| 100 g | €129,20 | ||
| 250 g | €169,20 | ||
| 500 g | €209,20 |
Taxes and fees, e.g. VAT, included in the price. Shipping calculated at checkout.Free shipping on EU, UK and EFTA orders above €250, and above €400 to the rest of the world.
Technical Specifications
| CAS Number | 621-23-8 |
| EC / EINECS Number | 210-673-4 |
| MDL Number | MFCD00008385 |
| RTECS Number | DC2810000 |
| SMILES | COC1=CC(=CC(=C1)OC)OC |
| InChI | InChI=1S/C9H12O3/c1-10-7-4-8(11-2)6-9(5-7)12-3/h4-6H,1-3H3 |
| InChIKey | LKUDPHPHKOZXCD-UHFFFAOYSA-N |
| PubChem CID | 69301 |
| Molecular Formula | C₉H₁₂O₃ |
| Molecular Weight | 168.19 g/mol |
| Melting Point | 50-53 °C (lit.) |
| Solubility | Soluble in methanol, ethanol, diethyl ether and benzene. Insoluble in water. |
| Purity | ≥98% |
| Physical Form | White to light yellow crystalline powder |
| HS Code | 2909.30 |
| Shelf Life | Retest period: 36 months from date of manufacture |
| Storage Conditions | Store in a cool, dark place (below 15 °C) in a tightly sealed container, away from oxidising agents. |
Shipping Destinations
- EU & UK: Priority delivery, 2–5 business days.
- United States (DDP): 3–7 business days, duties and taxes prepaid.
- EFTA Countries (DDP): 3–7 business days, duties and taxes prepaid.
- Worldwide: 7–14 business days, selected locations.
Product Description & Scientific Applications
1,3,5-Trimethoxybenzene (phloroglucinol trimethyl ether) is an electron-rich arene. It is a key component of the scent of the Chinese rose.
Quantitative NMR. 1,3,5-Trimethoxybenzene is used as an internal standard in quantitative ¹H NMR (qNMR) spectroscopy. In pharmaceutical analysis, it has been used as a qNMR standard for compliance testing of active substances and approved medicinal products, and for the analysis of suspected illegal medicines. In synthesis, it is added to reaction mixtures as an internal standard so that yields can be determined by ¹H NMR, and it is used to measure the purity of synthesised compounds by qNMR.
Removal of p-methoxybenzyl groups. Combined with a catalytic amount of silver(I) hexafluoroantimonate, 1,3,5-trimethoxybenzene removes the p-methoxybenzyl (PMB) protecting group from alcohols and from an acid. The method is mild and chemoselective.
General reaction: R–O–PMB (alcohol or acid protected as PMB) → R–OH, with catalytic AgSbF₆ and 1,3,5-trimethoxybenzene.
Electrophilic aromatic substitution. With N-fluorobenzenesulfonimide (NFSI) as the electrophile, 1,3,5-trimethoxybenzene gives fluorinated products, and no amidation products are detected.
substitution
General reaction: 1,3,5-trimethoxybenzene + NFSI → fluorinated products (no amidation products detected).
Safety Information
| GHS Pictograms |
|
| Signal Word | Warning |
| Hazard Class | Not regulated for transport |
| Transport Category | Not classified as dangerous goods for transport (ADR/IATA/IMDG) |
| H-Statements | H302 |
| P-Statements | P264 - P270 - P301+P312 - P330 - P501 |
Documentation
| Safety Data Sheet | Download PDF |
