NorrChemica™
D-Serine
D-Serine | CAS 312-84-5 | ≥95%
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Technical Specifications
| CAS Number | 312-84-5 |
| EC / EINECS Number | 206-229-4 |
| MDL Number | MFCD00004269 |
| SMILES | C([C@H](C(=O)O)N)O |
| InChI | InChI=1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)/t2-/m1/s1 |
| InChIKey | MTCFGRXMJLQNBG-UWTATZPHSA-N |
| PubChem CID | 71077 |
| Molecular Formula | C₃H₇NO₃ |
| Molecular Weight | 105.09 g/mol |
| Melting Point | 229–233 °C (dec.) |
| Solubility | Soluble in water (346 g/L at 20 °C) and in mineral acids; insoluble in ethanol, diethyl ether and benzene |
| Purity | ≥95% |
| Physical Form | White crystalline powder |
| HS Code | 2922.50 |
| Shelf Life | Retest period: 36 months from date of manufacture |
| Storage Conditions | Keep tightly closed in a cool, dry, dark place. Recommended temperature: (<15 °C) |
Product Description & Scientific Applications
D-Serine is the endogenous co-agonist of the NMDA receptor: a free d-amino acid enriched in the mammalian brain throughout life, where peripheral tissues and blood contain only low or trace levels.
NMDA receptor co-agonist. It binds the glycine-regulatory site stereoselectively and stimulates it more potently than glycine itself, with affinity and ED50 in the high nanomolar range. Selective enzymatic degradation identified it as the principal endogenous co-agonist of synaptic NMDA receptors at mature excitatory synapses of the prefrontal cortex, and it is the primary co-agonist at mature forebrain synapses generally — the physiological co-agonist required for synaptic plasticity.
The two enzymes that set the level. Cytosolic serine racemase converts l-serine to d-serine; peroxisomal d-amino acid oxidase degrades it. Upstream, blocking astrocytic 3-phosphoglycerate dehydrogenase suppresses de novo synthesis and reduces both NMDA receptor potentials and long-term potentiation at the Schaffer collateral–CA1 synapse.
Applications
- Preventing glycine-dependent desensitisation in NMDA receptor recordings
- d-amino acid oxidase assay substrate
- Serine palmitoyltransferase inhibition
- Bacterial spore germination studies
- Chiral intermediate in pharmaceutical synthesis
Shipping Destinations
- EU & UK: Priority delivery, 2–5 business days.
- United States (DDP): 3–7 business days, duties and taxes prepaid.
- EFTA Countries (DDP): 3–7 business days, duties and taxes prepaid.
- Worldwide: 7–14 business days, selected locations.
Safety Information
| Hazard Class | Not regulated for transport |
| Transport Category | Not classified as dangerous goods for transport (ADR/IATA/IMDG) |
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