NorrChemica™
Girard's Reagent T
CAS 123-46-6
≥98%
Girard's Reagent T | CAS 123-46-6 | ≥98%
| Pack size | Excl. VAT | Incl. VAT | Add to cart |
|---|---|---|---|
| 25 g | €39,20 | ||
| 50 g | €49,20 | ||
| 100 g | €74,20 | ||
| 250 g | €98,20 | ||
| 500 g | €134,20 |
Taxes and fees, e.g. VAT, included in the price. Shipping calculated at checkout.Free shipping on EU, UK and EFTA orders above €250, and above €400 to the rest of the world.
Technical Specifications
| CAS Number | 123-46-6 |
| EC / EINECS Number | 204-629-3 |
| MDL Number | MFCD00012009 |
| RTECS Number | CP3150000 |
| SMILES | C[N+](C)(C)CC(=O)NN.[Cl-] |
| InChI | InChI=1S/C5H13N3O.ClH/c1-8(2,3)4-5(9)7-6;/h4,6H2,1-3H3;1H |
| InChIKey | YSULOORXQBDPCU-UHFFFAOYSA-N |
| PubChem CID | 67156 |
| Molecular Formula | C₅H₁₄ClN₃O |
| Molecular Weight | 167.64 g/mol |
| Melting Point | 188–192 °C (dec.) |
| Solubility | Soluble in water. |
| Purity | ≥98% |
| Physical Form | White to Almost white powder to crystal |
| HS Code | 2928.00 |
| Shelf Life | Retest period: 36 months from date of manufacture |
| Storage Conditions | Store in a cool, dark place (below 15 °C) in a tightly sealed container, protected from moisture. |
Product Description & Scientific Applications
Girard's reagent T, 1-(carboxymethyl)trimethylammonium chloride hydrazide, belongs to the Girard reagents, a family of quaternary ammonium hydrazides. It reacts specifically with aldehyde and keto groups.
The resulting hydrazone carries a precharged quaternary ammonium group, which enables its detection by positive-ion electrospray mass spectrometry. In tandem mass spectrometry, Girard T hydrazones undergo facile neutral loss of trimethylamine, a transition used for multiple reaction monitoring.
Applications and Reactions
- Ecdysteroid analysis: Derivatization of the 6-ketone group allows LC-MS/MS detection of endogenous ecdysteroids in crude, lipid-rich extracts from Drosophila larvae and pupae.
- Glycan analysis: It labels reducing glycans as stable hydrazones directly on the MALDI target, and MALDI-TOF-MS then shows only [M]+ ions, free of sodium and potassium adducts. The method applies to reducing glycans from milk, N- and O-glycans from glycoproteins and glycans derived from glycosphingolipids, and it suppresses desialylation during MALDI analysis. The non-reducing saccharides sucrose and raffinose and the sugar alcohol sorbitol do not react.
- DNA damage analysis: It conjugates the 5-formyl group of 5-formyl-2′-deoxyuridine, a major thymidine lesion generated by reactive oxygen species, for its LC-MS/MS quantification in cellular DNA.
Shipping Destinations
- EU & UK: Priority delivery, 2–5 business days.
- United States (DDP): 3–7 business days, duties and taxes prepaid.
- EFTA Countries (DDP): 3–7 business days, duties and taxes prepaid.
- Worldwide: 7–14 business days, selected locations.
Safety Information
| GHS Pictograms |
|
| Signal Word | Warning |
| Hazard Class | Not classified as dangerous goods |
| Transport Category | Not dangerous goods (ADR/IATA/IMDG) |
| H-Statements | H315 - H319 - H335 |
| P-Statements | P261 - P264 - P264+P265 - P271 - P280 - P302+P352 - P304+P340 - P305+P351+P338 - P319 - P321 - P332+P317 - P337+P317 - P362+P364 - P403+P233 - P405 - P501 |
Documentation
| Safety Data Sheet | Download PDF |
