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NorrChemica™

TMAF–MeOH Adduct (Tetramethylammonium Fluoride–MeOH) | CAS 2649021-27-0 | Active Fluoride Assay: 91 mol% (q¹H/q¹⁹F NMR, d1=30 s) | Moisture-Optimized | RUO | EU Seller

TMAF–MeOH Adduct (Tetramethylammonium Fluoride–MeOH) | CAS 2649021-27-0 | Active Fluoride Assay: 91 mol% (q¹H/q¹⁹F NMR, d1=30 s) | Moisture-Optimized | RUO | EU Seller

€77,00 EUR
€77,00 EUR
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🧪 Technical Specifications

  • CAS Number: 2649021-27-0
  • SMILES: C[N+](C)(C)C.CO.[F-]
  • InChI: InChI=1S/C4H12N.CH4O.FH/c1-5(2,3)4;1-2;/h1-4H3;2H,1H3;1H/q+1;;/p-1
  • InChIKey: UVUVGQOGLUMTQC-UHFFFAOYSA-M
  • Molecular Formula: C₅H₁₆FNO
  • Molecular Weight: 125.19 g/mol
  • Purity: Active Fluoride Assay: 91 mol% (q¹H/q¹⁹F NMR, d1=30 s)
  • Physical Form: White solid
  • HS Code: 3824.99
  • Country of Origin: Finland
  • Shelf Life: 24 months under recommended storage conditions
  • Storage Conditions: Store tightly closed in a dry, well-ventilated place at 2–8 °C, under inert atmosphere

🔬 Common Scientific Applications

Nucleophilic Fluorination & Organic Synthesis:

Anhydrous fluoride source used for controlled nucleophilic fluorination reactions in laboratory-scale organic synthesis. The TMAF·MeOH adduct provides enhanced handling stability and solubility compared to dry inorganic fluoride salts.

Late-Stage Functionalization & Method Development:

Applied in reaction development and optimization studies for late-stage introduction of fluorine into complex small molecules during multistep synthesis workflows.

Heterocyclic & Medicinal Chemistry Building Blocks:

Used as a technical fluorination reagent in the preparation of fluorinated heterocycles and functional intermediates for exploratory structure–property studies in synthetic chemistry.

Analytical Chemistry & Reaction Screening:

Reference fluoride source for reaction screening, method validation, and comparative studies in fluorination protocol development using HPLC, LC–MS, and NMR monitoring.

Process Chemistry & Reagent Evaluation:

Utilized in small-scale feasibility testing of fluorination routes during early-stage process development and reagent compatibility assessment.

Education & Training:

Demonstration reagent for teaching nucleophilic substitution, fluorination chemistry, and reagent handling principles in advanced organic chemistry laboratory courses.

For laboratory research and technical use only. Not for human or veterinary use.

⚠️ Safety & Transport

  • Hazard Class (UN/DG): Not regulated as Dangerous Goods
  • GHS Signal Word: Warning
  • GHS Hazard Statements: H302 – Harmful if swallowed H315 – Causes skin irritation H319 – Causes serious eye irritation H335 – May cause respiratory irritation
  • GHS Precautionary Statements: P261 – Avoid breathing dust/fume/vapour P280 – Wear protective gloves/protective clothing/eye protection P301+P312 – If swallowed, call a poison center if unwell P302+P352 – If on skin, wash with plenty of soap and water P305+P351+P338 – If in eyes, rinse cautiously with water
  • Dangerous Goods Notes: Not classified as Dangerous Goods for transport. Standard chemical handling precautions apply.

🔎 Advanced Identifiers

  • PubChem CID: 161207599

TMAF–MeOH Adduct (Tetramethylammonium Fluoride–MeOH) | CAS 2649021-27-0 | Active Fluoride Assay: 91 mol% (q1H/q19F NMR, d1=30 s) | Moisture-Optimized | RUO | EU Seller

TMAF–MeOH is a highly versatile nucleophilic fluorinating agent. Its primary challenge in commercial supply is residual moisture, which destroys fluoride activity. Our product is processed to ensure clean, reliable C–F bond formation.

🧪 The NorrChemica™ Gold Standard

  • Moisture-Optimized Formula: Proprietary process supports maximum active fluoride performance, addressing inconsistent yields commonly associated with higher-moisture grades.
  • qNMR-Verified Active Fluoride (mol% relative to Me4N+): Determined by combined quantitative 1H/19F NMR in CD3OD under fully relaxed conditions (90° pulse; d1 = 30 s for both nuclei), using 1,3,5-trifluorobenzene as a reference. Reported as F/Me4N+ (ratio; shown as mol% relative to Me4N+).

Why our active-fluoride assay is reliable

Many fluoride assay workflows use acquisition settings optimized for speed rather than quantification. Because quantitative NMR requires sufficient recycle delay (typically ≥5×T1), we acquire both 1H and 19F spectra under fully relaxed conditions (d1 = 30 s) and apply baseline-controlled integration. This prevents the large apparent assay swings that can occur when d1 is shortened or baseline drift is not handled rigorously. A downloadable qNMR report is provided with spectra, integrals, and the F/Me4N+ calculation.

 

Q: Why is d1 = 30 s used?
A: Quantitative NMR requires sufficient recycle delay to avoid saturation bias in integrals. Because ¹⁹F T1 values may be longer than typical routine settings, we use d1 = 30 s (90°) for both ¹H and ¹⁹F to support fully relaxed acquisition and reliable assay ratios.

Q: Why use 1,3,5-trifluorobenzene (TFB)?
A: TFB provides clean, non-overlapping signals in both ¹H and ¹⁹F spectra in CD₃OD, enabling a direct calculation of F/Me₄N⁺ from the same solution without external calibration.

  • Primary manufacturer: Material produced and characterized in-house (not re-labeled or brokered).

📄 Documentation (download)

CoA and SDS: available per batch / provided with order.

⚠️ Research Use Only

This product is sold strictly for research and development purposes only. Not for human or animal use. Safety Data Sheet (SDS) supplied with your order.

Shipping & Delivery

We ship from our facility in Finland (EU).

  • 🇪🇺 EU & UK: typically 2–5 business days.
  • 🇺🇸 United States (DDP): typically 3–7 business days, duties and taxes prepaid.
  • 🌍 Selected destinations (e.g., Canada, Japan, Australia, EFTA): typically 4–12 business days.
  • 🧾 Full documentation (qNMR assay report + CoA + GHS-compliant SDS) included.

Payment

To ensure regulatory compliance for specialty chemicals, we process orders via Wise (Bank Transfer) or Manual Invoice.

🧬 About NorrChemica™

NorrChemica™ is a Finnish supplier of high-purity specialty reagents and niche research materials. We focus on reliable EU shipping, transparent labeling, and accessible pricing for technical users worldwide.

⚖️ Terms of Sale & Disclaimer Sold strictly for laboratory research, analysis, and technical applications. Not for human consumption or food use. By purchasing this item, you confirm professional or educational intent.

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